Curriculum Vitae Sabera Sultana

Present address:

Sabera Sultana
Department of Chemical Engineering
Yeungnam University
South Korea
Phone: 010-2374-8771
Email:
Permanent address:
Sabera Sultana
Raja Maidam New colony
Ward No.1,
Jorhat district,
Assam-785001, India. /

Education:

Post doctorate(September 2016-Present) Organic Chemistry fromYeungnam University, Republic of Korea

Ph. D. (July 2011-April 2016)Organic Chemistry from Indian Institute of Technology Guwahati, India.

M.Sc. (2008-2010) Organic ChemistryfromGauhati University, India with first class first (79.15%)

B. Sc. (2005-2008)fromDibrugarh University, India with first class first (74.6%)

 PhD Thesis:

Thesis title:“Synthesis of Alkenols and their Use in Construction of Oxygen Heterocyclic Compounds.”

Ph. D Supervisor: Prof. Anil Kumar Saikia

Achievements and Awards:

Qualified National Eligibility Test, organized by Council of Scientific and Industrial Research (CSIR), India, held on December2011.

Qualified Graduate Aptitude Test (GATE) held on February, 2011 in CHEMISTRY, organized by Ministry of Human Resource Development, Government of India.

Selected for Post Doctoral position in Yeungnam University, South Korea, 2016.

Research Experience:

26th May 2016 -31St August: Research Associate at Department of Chemistry, IIT Guwahati, India.

2013-Present: Senior Research Fellowatthe Department of Chemistry, Indian Institute of Technology Guwahati, India.

2011-2013: Junior Research Fellowat the Department of Chemistry, Indian Institute of Technology Guwahati, India.

Research and Instrumental skills:

Expertise in design and execution of multistep organic reactions from milligram to gram scale, handling air and moisture sensitive compounds usingprotective atmosphere (Schlenk line, Glove box) and Crystallization techniques.

Operated Varian 400 MHz NMR instrument for the past three years and well versed with 1H, 13C and 2D NMR (COSY, NOESY, DEPT, HMQC) techniques and their interpretation.

Operated both Agilent and Waters-QTOF mass spectrometers.

Familiar with other instruments such as FT-IR spectroscopy, HPLC and Polari meter .

Main Skills:

Teaching Experiences:

Since 2012: BothTutorialandTeachingAssistantshipatIITGuwahati,India(B.TechandM. Sc.).

Languages:

 Hindi:Native (fluent)

 English:Good level of spoken and written

 Assamese:good level of spoken and written

Publications:

  1. “BF3·OEt2-Promoted Annulation for Substituted 2-Arylpyridines asPotent UV Filters and Antibacterial Agents” Sultana, S.; Maezono, S. M. B.; Akhtar, M. S.; Shim, J-J.; Wee, Y. J.; Kim, S. H.; Lee, Y. R.Adv. Synth. Catal. 2018, 360, 751-761. (IF:5.6)
  2. “Synthesis and Evaluation of Methyl 4-(7-Hydroxy-4,4,8-Trimethyl-3-Oxabicyclo[3.3.1]Nonan-2-yl)Benzoate as an Antileishmanial Agent and Its Synergistic Effect with Miltefosine” Bhalla, P.; Sultana, S.; Chiranjivi, A. K.; Saikia, A. K.; Dubey, V. K. Antimicrobial Agents and Chemotherapy2018, 2, e01810-17.(IF:4.4)
  3. “Diastereoselective Synthesis of Substituted Hexahydrobenzo[de]isochromans and Evaluation of their Antileishmanial Activity” Saikia, A. K.; Sultana, S.; Devi, N. R.; Deka, M. J.; Tiwari , K.; Dubey, V. K. Org. Biomol. Chem. 2016, 14, 970. (IF:3.4)
  4. “Synthesis of Substituted Tetrahydro-pyran and –furan via Intramolecular Hydroalkoxylation of Alkenols” Sultana, S.; Devi, N. R.; Saikia, A. K. Asian J. Org. Chem. 2015, 4, 1281.(IF:2.7)
  5. “Diastereoselective Synthesis of Dihydropyrans via Prins Cyclization of Enol Ethers: Total Asymmetric Synthesis of (+)-Civet Cat Compound” Sultana, S.; Indukuri, K.; Deka, M. J.; Saikia, A. K. J. Org. Chem. 2013, 78, 12182.(IF:4.8)
  6. “Scandium (III) triflate Catalyzed Synthesis of Primary Homoallylic Alcohols via Carbonyl-Ene Reaction” Sultana, S.; Bondalapati, S.; Indukuri, K.; Gogoi, P.; Saha, P.; Saikia A. K. Tetrahedron Lett. 2013, 54, 1576.( IF:2.1)
  7. “Synthesis of Five‑, Six‑, and Seven-Membered 1,3- and 1,4- Heterocyclic Compounds via Intramolecular Hydroalkoxylation/ Hydrothioalkoxylation of Alkenols/Thioalkenols” Deka, M. J.; Indukuri, K.; Sultana, S.; Borah, M.; Saikia, A. K. J. Org. Chem. 2015, 80, 4349.(IF:4.8)
  8. “Diastereoselective Synthesis of Substituted Dihydropyrans via an oxonium-ene Cyclization Reaction” Saha, P.; Ghosh, P.; Sultana, S.; Saikia, A. K. Org. Biomol. Chem. 2012, 10, 8730.(IF:3.4)
  9. “Synthesis of 2,3-dihydro-4-pyranones from Epoxides via Intermolecular [4+2]-Cycloaddition Reaction” Indukuri, K.; Bondalapati, S.; Sultana, S.; Saikia, A. K. RSC Adv. 2012, 29, 9398.(IF:3.1)
  10. “Synthesis of Substituted Isochromans via Oxa-Pictet Spengler Reaction of Acrylyl Enol Ethers: Formal Synthesis of (+) –Sonepiprazole (U-101387) and (+)-U-54537” Sarkar, S.; Sultana, S.; Indukuri, K.; Unnavaa , R.; Saikia, A. K. Synthesis2016, 48, A-G.(IF:2.6)
  11. “Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid” Das, P. J.; Das, J.; Ghosh, M.; Sultana, S. Green and Sustainable Chemistry, 2013, 3, 6. (IF:1.7)

Symposia and Conference(s):

1. FICS -2012 held at IIT Guwahati, Guwahati, India

2.J-NOST-2013 held at IISER Bhopal, Bhopal, India.

3. 8th Mid-year CRSI national symposium in chemistry- 2014 held at CSIR-NEIST, Jorhat, India.

4. Frontier lecture series-2009, Tezpur University.

Research Interests:

 Heterocyclic Chemistry, Organocatalysis and Asymmetric Synthesis

 C-H activation and Cross Coupling Reactions

 Total Synthesis of Natural Products and Bioactive Molecules

 Medicinal Chemistry and Drug Discovery

 Supramolecular organic chemistry

Research Summary:

During my doctoral studies, we have mainly focused on the synthesis of alkenols, design and synthesis of newer strategies for the synthesis of biologically relevant oxygen and nitrogen containing heterocyclic molecules of medium complexityusing Prinscyclization, oxa-Pictet-Spengler reaction and hydroalkoxylation of alkenolsand its application in natural product synthesis. We have also studied their biological acitivities.

First we developedan efficient methodology for the synthesis of alkenols e.g. primary homoallylic alcohols via carbonyl-ene reaction from the reaction of paraformaldehyde with olefins catalyzed by scandium trifluoromethanesulfonate(Scheme 1).

Scheme 1:Synthesis of Homoallylic alcohols

In continuation of our research for the synthesis of oxygen containing hetrocyclic compounds, we describedan efficient method for the stereo- and regio-selective synthesis of dihydropyrans using Prins enol-ether cyclization reaction from enol ethers mediated by trimethylsilyl trifluoromethanesulfonate (TMSOTf ) in good yields under mild conditions. We further utilized this methodology in the total synthesis of natural product (+)-Civet cat compound, which starting from commercially available (S)-pent-4-en-2-ol in 4 steps with an overall yield of 17% respectively (Scheme 2).

Scheme 2:Synthesis of substituted dihydropyrans and its application in natural product synthesis

In continuation of ourinterest for the synthesis of oxygen heterocyclic compounds, we developed an efficient intramolecular hydroalkoxylation of alkenols mediated by boron trifluoride etherate leads to bothsubstituted tetrahydrofurans and tetrahydropyrans in good yields(Scheme 3).

Scheme 3: Synthesis of substituted tetrahydrpyrans and tetrahydrofurans

We have also developed an efficient methodology for the synthesis of tricyclic compound hexahydrobenzo[de]isochromans via Friedel Crafts and oxa-Pictet-Spengler type reaction from aryl and alkene substituted acrylyl enol ethers catalyzed by triflic acid in good yields under mild conditions. The method is also extended for the synthesis of ABC ring of Stephaoxocanes. We have also studied the antileishmanial activity of some hexahydrobenzo[de]isochromans (Scheme 4).

Scheme 4: Synthesis of some hexahydrobenzo[de]isochromans and hexahydropyrano[3,4,5-ij]isoquinoline

We have also developed A simple and efficient BF3.OEt2 mediated methodology for the construction of diverse substituted 2-phenylpyridines from readily available 3-formylchromones and phenylacetylenes in acetonitrile. The nitrogen source for pyridine construction is derived from the used solvent, acetonitrile. This one-pot protocol proceeds via cascade nucleophilic addition, alkyne hydration, Michael-type reaction, ring opening, hydrolysis, intramolecular cycloaddition, and elimination.

Scheme 5:Novel strategy for the construction of 2-arylpyridines

In conclusion we have developed some methods for the synthesis alkenols and using these alkenols we have synthesized various five, six membered oxygen and nitrogen heterocyclic compounds using Prins, oxa-Pictet-Spengler, Friedel-crafts reactions and hydroalkoxylation of alkenols and successfully applied one of these methodologies in total synthesis of natural product such as (+)-Civet cat compound. These highly diastereoselective mild and efficient procedures with broad scope and high level of functionality present in the end products contributes a greatdeal of potential towards the synthesis of simple and moderately complexbiologically important molecules.