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Supplemental list of references S4 – Selection of articles discussing the use of “omics” in food safety assessment (not cited in the text).

1.  Baginsky S, Hennig L, Zimmermann P, Gruissem W (2010) Update on GeneExpression Analysis, Proteomics, and Network Discovery. Plant Physiol 152: 402-410

2.  Barros E (2010) Molecular Profiling Techniques Detect UnintendedEffects in Genetically Engineered Maize. ISB News Report: 4-7

3.  Batista R, Margarida O (2010) Plant natural variability may affect safety assessment data. Regul Toxicol Pharmacol 58: 8-12

4.  Batista R, Saibo N, Lourenço T, Oliveira M (2010) Mutagenesis vs. Transgenesis: What's beyond the phenotype? Symposium on Contributions from scientific research to the risk assessment of GMOs - Belgian Scientific Institute of Public Health - 21-22 October 2010, Brussels, Belgium

5.  Cellini F, Chesson A, Colquhoun I, Constable A, Davies HV, Engel KH, Gatehouse AMR, Kärenlampi S, Kok EJ, Leguay JJ, Lehesranta S, Noteborn HPJM, Pedersen J, Smith M (2004) Unintended effects and their detection in genetically modified crops. Food Chem Toxicol 42: 1089-1125

6.  Colquhoun IJ, le Gall G, Elliott KA, Mellon F A,Michael AJ (2006) Shall I compare thee to a GM potato? Trends Genet 22: 525-528

7.  Davies H (2010). A role for omics technologies in food safety assessment. Food Control 21: 1601-1610

8.  Davies HV, Shepherd LVT, Stewart D, Thomas F, Röhlig RM, Engel KH (2010) Metabolome variability in crop plant species - When, where, how much and so what? Regul Toxicol Pharmacol 58: 54-61

9.  Deng PJ, Zhou XY, Yang DY, Hou HL, Yang XK, Li YH, Yang YC, Wang XL, Fang SS, Wu SQ, Liu J (2008) The definition source, manifestation of andassessment of unintended effects in genetically modified plants. J Sci Food Agri 88: 2401-2413

10.  Dijk van JP, Leifert C, Barros E, Kok EJ (2010) Gene expression profiling for food safety assessment: Examples in potato and maize. Regul Toxicol Pharmacol 58: 21-25

11.  Doerrer N, Ladics G, McClain S, Herouet-Guicheney C, Poulsen LK., Privalle L, Stagg N (2010) Evaluating biological variation in non-transgenic crops: Executive summary from the ILSI Health and Environmental Sciences Institute workshop. Regul Toxicol Pharmacol 58: 2-7

12.  Enot DP, Draper J (2007) Statistical measures forvalidating plant genotype similarity assessments followingmultivariate analysis of metabolome fingerprint data. Metabolomics 3: 349-355

13.  Frank T, Engel KH (2010) Potential contributions of metabolite profiling to the safety assessment of crops. Symposium on Contributions from scientific research to the risk assessment of GMOs - Belgian Scientific Institute of Public Health - 21-22 October 2010, Brussels, Belgium

14.  Fukushima A, Kusano M, Redestig H, Arita M, Saito K (2009) Integratedomics approaches in plant systems biology. Curr Opin Chem Biol.13:532-538

15.  Harrigan GG, KC. Glenn, Ridley WP (2010) Assessing the naturalvariability in crop composition. Regul Toxicol Pharmacol 58: 13-20

16.  Kiambi DK, Fortin M, Stromvick M (2008) Linking transcript profiles to metabolites and metabolic pathways: a systems biology approach to transgene risk assessment. Plant Omics 1: 26-36

17.  Kough JL (2010) HESI Workshop on Evaluating Biological Variation in Non-Transgenic Crops: Introduction. Regul Toxicol Pharmacol 58: 1

18.  Langridge P, Fleury D (2010) Making the most of 'omics' for cropbreeding. PMID: 21030098

19.  Larkin P, Harrigan GG (2007) Opportunities and surprises in crops modified by transgenic technology: metabolic engineering of benzylisoquinoline alkaloid, gossypol and lysine biosynthetic pathways. Metabolomics 3: 371-382

20.  Leeuwe-Kok EJ van (2008) The application of transcriptomicsin the comparative safety assessment of (GMO-derived) plant products. The application of transcriptomics in the comparative safetyassessment of (GMO-derived) plant products. PhD dissertation, 200 pp

21.  Miki B, Abdeen A, Manabe Y, MacDonald P (2009) Selectable marker genes and unintended changes tothe plant transcriptome. Plant Biotech J 7: 211–218

22.  Moreno-Risueno MA, Busch W, Benfey PN (2010) Omics meet networks -using systems approaches to infer regulatory networks in plants. CurrOpin Plant Biol 13:126-31

23.  Rischer H, Oksman-Caldentey KM (2006) Unintended effects in genetically modified crops: revealed by metabolomics? Trends Biotech 24: 102-104

24.  Wheelock CE, Miyagawa H (2006) The omicization of agrochemical research? J Pestic Sci 31: 240-244