Revised February 6, 2009Jan-Åke Gustafsson, M.D., Ph.D.
CURRICULUM VITAE
Name:Jan-Åke Gustafsson, M.D., Ph.D.
Date of Birth:August 4, 1943
Education:Ph.D., Dept of Chemistry, Karolinska Institutet, 1968
M.D., Karolinska Institutet, 1971
Career/Academic Appointments:
1964Bachelor of Medicine, Karolinska Institutet, Stockholm
1971Associate Professor in Chemistry, Karolinska Institutet
1976Professor of Chemistry, Karolinska Institutet
1978Professor of Chemistry, University of Gothenburg
1979Professor of Medical Nutrition and Chairman of the Dept of Medical Nutrition, Huddinge University Hospital, Karolinska Institutet
2006-presentProfessor of Medical Nutrition and Chairman of the Dept of Biosciences and Nutrition, Karolinska Institutet
Administrative Positions:
1985Director of the Center for Biotechnology, Huddinge University Hospital, Karolinska Institutet
1987Founder of KaroBio AB (a campus-situated biotechnology company sponsored by pension and governmental funds with about 80 employees).
1979 – 1991 Project leader of the Swedish EPA research program on Air Pollution in Urban Areas
2004-presentCoordinator for the EU funded CASCADE Network of Excellence
Professional Honors & Recognition
A)International/National/Regional
2008 Foreign Member Finnish Scientific Society
2008 EMD Serono President’s Distinguished Lecture. Annual Meeting of the Society for Gynecological Investigation, San Diego.
2008International Member American Philosophical Society
2005Descartes Research Prize for excellence in scientific collaborative research
20052nd Ernst Knobil Memorial Lecture, San Diego, USA
2004Medal from Biomedicum Helsinki
2004Bristol-Meyers Squibb/Mead Johnson Award for Nutrition Research
2003FEBS Lectureship Datta Award
2003 McDowell Lecture in Physiology, King’s College, London, U.K.
2002Commandeur dans l’Ordre des Palmes Académiques
2002Foreign Honorary Member of the US National Academy of Sciences
2002Chairman of the Nobel Assembly of the Karolinska Institutet
2002Fred Conrad Koch Award (Endocrine Soceity USA)
2001The AF Group Prize for the creation of Novum Research Park
2001Lorenzini Gold Medal, Lorenzini Foundation
2001Vice chairman of the Nobel Assembly of the Karolinska Institutet
2000One of ISI Top 258 Researchers in Biology & Biochemistry
2000Garvan International Fellow
2000Burroughs Wellcome Fund Lecture
2000Foreign Honorary Member of the American Academy of Arts and Sciences
2000European Medal, British Society for Endocrinology
2000Curt Nicolin’s Prize for Achievements for the Development of South Stockholm
1999Medal of the IngaBritt and Arne Lundberg’s Research Foundation
1999Fogarty Scholar NIH
1998Adjunct Member of the Nobel Committee of the Karolinska Institutet
1998The Söderberg Prize in Medicine
1998Member of the Swedish Academy of Engineering Sciences
1997Member of the Swedish Academy of Sciences
1994Gregory Pincus Medal and Award, Worcester Foundation
1992Keith Harris Lecture, Australian Endocrine Society, Adelaide
1992 The Anders Jahre Prize, Oslo
1992Medal from Collège de France, Paris
1990Honorary Member of the American Society for Biochemistry and Molecular Biology
1986Honorary Member of the Japanese Biochemical Society
1986Member of the Nobel Assembly of the Karolinska Institutet
1983The Fernström Prize of the Karolinska Institutet
1982The Svedberg Prize in Chemistry, Stockholm
B)University
2008Honorary Professor at the Beijing Normal University
2008Honorary doctorate in Medicinal and Pharmaceutical Chemistry at the University of Milan
2007Honorary Professor at the University of Chongquin, China
2004Guest Professor at the University of Science and Technology of China, Hefei
2003J.G. Moore Visiting Professor, UCLA, USA
2003Marius Tausk Visiting Professor at the Leiden University Medical Centre (LUMC)
2002Burroughs Wellcome Fund Visiting Professor in the Basic Medical Sciences at the University of Texas Medical Branch School of Medicine
2000Center for Bioenvironmental Research Distinguished Visiting Professor, Tulane University, New Orleans
1995Sterling Visiting Professor, University of Pennsylvania, Philadelphia
1991Consultant to The Rockefeller University Hospital
1987Adjunct Full Professor at the Department of Cell Biology, Baylor College of
Medicine, Houston, Texas
Has participated in several international reviewing panels, e.g.:
1995Chairman of a board evaluating the Center for Biotechnology, University of Oslo.
1994Member of a board evaluating the Center for Biotechnology, Helsinki.
1991As chairman of a board evaluating the Norwegian Biotechnology Program.
Peer Review Groups/Grant Study Sections:
2007Member of the LTA (LAM Treatment Alliance) SAB (Scientific Advisory Board, Boston.
2007Member of the IRB Barcelona External Advisory Board.
2007Member of the selection committee for The King Faisal International Prize in Science.
2005-2007 Member of the International Academic Advisory Committee (IAAC), Hefei,
Peoples’s Republic of China.
1995-Member of the International Advisory Board of the WHO Center in Oulu.
Journal Service:
Member, currently and/or previously, of the editorial board or similar position in Steroids, The Journal of Steroid Biochemistry and Molecular Biology, Molecular Endocrinology, Breast Cancer Research and Treatment, The Prostate, Anticancer Research, Japanese Journal of Cancer Research, Journal of Molecular Medicine, Molecular Pharmacology, Cell Metabolism, Experimental Biology and Medicine and the International Journal of Oncology.
Board Certification:
Elected Councillor/Board Member of the Swedish Medical Research Council during the 1990´ies (for 6 years).
Member of the Research Board of the Swedish Cancer Society during the 1980´ies and 1990´ies (for 6 years).
Member of the Research Board of the Swedish Council for Planning and Coordination of Research during the 1980´ies and 1990´ies (for 6 years).
Has been member of the Faculty Board of the Karolinska Institutet and regularly carries out various assignments for the President’s Office of the Karolinska Institutet.
Awards Committee Member, Endocrine Society, USA 2002-06.
Elected Member of Council (Board) of Endocrine Society, USA, 2007 –
Organisation of International conferences:
1983 Nobel symposium “Steroid hormone receptors: Structure and function”.
1988 2nd CBT Symposium “The steroid/thyroid hormone receptor family and gene regulation”.
1993 5th CBT Symposium “Intracellular hormone receptors and ligand-dependent transcriptional regulation”.
1995 7th CBT Symposium “Nuclear orphan receptors: Novel regulators in physiology and pathology”.
1995 EMBO Workshop; Structure and Function of Steroid and Nuclear Receptors, Alghero, Sardinia, Italy.
19979th CBT (Centre for Biotechnology) Symposium “Steroid and orphan nuclear receptors”, Huddinge, Sweden.
1999Nobel symposium “Estrogens and women’s health – benefit or threat?”, Karlskoga, Sweden.
1999EMBO Workshop; Steroids and Nuclear receptors, Villefranche, France.
2000FEBS Advanced Study Institute, International Summer School on “New Dimensions in the Regulation of Gene Expression, Island of Spetses, Greece.
200010th CBT symposium “Nuclear receptors in health and disease”, Huddinge, Sweden.
2001EMBO Workshop on Nuclear Receptor Structure and Function, Erice, Italy.
2002“Nuclear Receptors 2002”, A joint International Symposium arranged by CBT, Karolinska Institutet, in collaboration with the Summer University of Southern Stockholm, Huddinge, Sweden.
2003EMBO Conference, Biology of Nuclear Receptors, Villefranche-sur-Mer, France.
2003Nobel Conference No 40: “Transcriptional control of lipid homeostasis”, Huddinge, Sweden.
2003FEBS Advanced Study Institute, International Summer School on “From Transcription to Physiology: Regulation of Gene Expression and Protein Function in an Integrated Context”, Island of Spetses, Greece.
2004“Nuclear Receptors 2004” An International Symposium arranged by CBT, Karolinska Institutet, Huddinge, Sweden.
2006“Nuclear Receptors 2006” An International Symposium arranged by CBT, Karolinska Institutet, Huddinge, Sweden.
2007 Spetses Summer School on “Nuclear Receptor Signaling: From Molecular Mechanisms to Integrative Physiology”, Island of Spetses, Greece.
2008 Nobel Conference No 52 on “Recent advances in understanding estrogen signaling: From molecular insights to clinical implications”, Sånga-Säby, Stockholm, Sweden.
Patents, Softwares, Databases
Estrogen receptor -based hypertension treatment and assay.
Patent No: GB 2374412
Estrogen receptors and their ligands for treating obesity and lowering lipoprotein levels
Patent No: US 2002151732
Cloning, characterization and pharmaceutical use of a mammalian nuclear receptor coactivator RAP250.
Patent No: US 2002151477
Estrogen receptor beta (ER) agonists for use in cancer treatment.
Patent No: GB 2361642
Method of estrogen receptor isoform detection via immunostaining and correlation with breast cancer.
Patent No: GB 2361769
Cancer treatment and prognosis involving HES-1 protein.
Patent No: WO 2001062792
Estrogen receptor agonists and antagonists for the treatment of growth or bone mineral density disorders.
Patent No: WO 2000076529
Osteoporosis treatment with an estrogen receptor antagonists.
Patent No: WO 2000061230
Estrogen receptor ER ligands for Vasculoprotectors.
Patent No: WO 2000001716
Differential activation of estrogen receptors ERand ER at ap1 sites.
Patent No: WO 9911760
Molecular cloning, cDNA sequences, and therapeutic uses of mammalian estrogen receptor.
Patent No: WO 9709348
OR-1 orphan receptors belonging to the nuclear receptor family.
Patent No: WO 605300
Other Activities:
Has participated in the supervision of 96 Ph.D. students to the presentation of their thesis.
Has supervised 129 postdocs/visiting scientists.
Has 1319 peer-reviewed publications. Can be sent upon request.
Has so far been cited 61 912times.
H-index: 108
Grant History:
A)Current Grants
Agency:Swedish Research Council
I.D.#701192301
Title:“The oxysterol receptors LXRα and LXRβ in pathophysiology and molecular
mechanisms of metabolic, autoimmune and neurodegenerative disorders”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:15%
Direct costs per year: SEK 1,700,000/ $240,452
Total costs for project period: SEK 5,100,000/ $721,358
Project period:01/01/2008 – 12/31/2010
Agency:Swedish Cancer Society
I.D.#07 0090
Title:“Estrogen receptor beta and estrogen related forms of cancer”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:20%
Direct costs per year: SEK 2,000,000/ $283,006
Total costs for project period: SEK 6,000,000/ $849,017
Project period:01/01/2007 – 12/31/2009
Agency:EU
I.D.#FOOD-CT-2004-506319
Title:CASCADE “Chemicals as contaminants in the food chain: An NOE for research, risk assessment and education”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:15%
Direct costs per year: EUR 195,810:80/ $265,030
Total costs for project period: EUR 979,054/ $1,325,150 (our part)
Project Period:02/01/2004 – 01/31/2009
Agency:EU
I.D.#LSHM-CT-2005-518245
Title:EWA “Estrogens and women ageing”
P.I.:Adriana Maggi, Ph.D., Professor
Role on Project:Partner
Percent Effort:5%
Direct costs per year: EUR 70,000 / $94,745
Total costs for the project period: EUR 210,000/ $284,235 (our part)
Project Period:01/01/2006 – 12/31/2008
Agency:EU
I.D.#LSHM-CT-2005-018652
Title:CRESCENDO “Consortium for Research into Nuclear Receptors in Development and Aging”
P.I.:Barbara Demeneix, Ph.D., D.Sc., Professor
Role on Project:Partner
Percent Effort:5%
Direct costs per year: EUR 99,240/ $181,804
Total costs for the project period: EUR 496,200/ $909,020 (our part)
Project Period:03/01/2006 – 02/28/2011
Agency:EU
I.D.#FOOD-CT-2005-513991
Title:PIONEER “Puberty onset – influence on nutritional, environmental and endogenous regulators”
P.I.:Sari Mäkelä, M.D., Ph.D., Professor
Role on Project:Partner
Percent Effort: 5%
Direct costs per year: EUR 54,400/ $73,630
Total costs for the project period: EUR 163,200/ $220,890 (our part)
Project Period:03/01/2005 – 02/28/2008
Agency:KaroBio AB
I.D.#Cooperation grant
Title:“Orphan Receptors”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:10%
Direct costs per year: SEK 2,000,000 - SEK10,000,000/$ 282,885 - $1,414,427
Total costs for project period: SEK 77,741,725/$10,996,000
Project period: 1987 -
B)Past Grants*
*Professor Gustafsson has been a grant holder for the last 35 years. It is an almost impossible work to list them all. This shows the last five years of past grants.
Agency:Swedish Research Council
I.D.#K2002-03X-02819-33
Title:“Mechanism of action of nuclear receptors: biological function of the orphan receptors LXRalpha and LXRbeta”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:15%
Direct costs per year: SEK 1,400,000/ $198,104
Total costs for project period: SEK 8,400,000/ $1,188,624
Project period:01/01/2002 – 12/31/2007
Agency:Swedish Cancer Society
I.D.#05 0212
Title:“The role of estrogen receptor in cancer”
P.I.:Jan-Åke Gustafsson, M.D., Ph.D., Professor
Percent effort:20%
Total costs for project period: SEK 6,900,000/ $976,369
Project period:01/01/2004-12/31/2006
Agency:EU
I.D.#FOOD-CT-2003-506143
Title:DEVNERTOX “Toxic threats to the developing nervous system: In vivo and in vitro studies on the effects of mixture of neurotoxic substances potentially contaminating food”
P.I.:Sandra Ceccatelli, M.D., Ph.D., Professor
Role on project:Partner
Percent effort:5%
Total costs for project period: EUR 240,000/ $324,840 (our part)
Project period:12/01/2003-11/30/2006
Agency:EU
I.D.#QLK4-CT-2002-02528
Title:BONETOX “Bone development and homeostasis-critical targets in toxicology”
P.I.:Helen Håkansson, Ph.D., Professor
Role on project:Partner
Percent effort:5%
Total costs for project period: EUR 263,813/ $357,071 (our part)
Project period:01/01/2003-12/31/2006
Agency:EU
I.D.#QLK4-CT-2002-02221
Title:EDERA “Development and implementation of new in vivo and in vitro systems for the characterization of endocrine disrupters”
P.I.:Adriana Maggi, Ph.D., Professor
Role on project:Partner
Percent effort:5%
Total costs for project period: EUR 172,500/ $233,479 (our part)
Project period:01/01/2003-06/30/2006
Participated in the supervision of the following Ph.D. and M.Sci students to the presentation of their theses
1.Håkan Eriksson: Studies on the metabolism of steroid hormones in rat liver. Thesis, 1971.
2.Sven A. Gustafsson: Sexual differentation of corticosteroid metabolism in the rat. Thesis, 1974.
3.Åke Stenberg: Mechanisms of sexual differentiation of steroid metabolism in rat liver. Thesis, 1974.
4.Magnus Ingelman-Sundberg: Hepatic metabolism of steroid sulphates with special reference to cytochrome P-450-catalyzed reactions. Thesis, 1975.
5.Åke Pousette: Studies on the control of androgen responsiveness in rat. Thesis, 1976.
6.Örjan Wrange: Studies on the glucocorticoid receptor in rat liver and the estradiol receptor in human breast cancer. Thesis, 1977.
7.Paul Skett: Hypophyseal control of hepatic steroid metabolism in the rat. Thesis, 1977.
8.Anders Berg: Studies on cytochrome P-450-dependent steroid hydroxylations in mammalian and bacterial systems. Thesis, 1978.
9.Peter Ekman: Steroid receptors in the human prostate. Thesis, 1978.
10.Jan Carlstedt-Duke: Studies on two hepatic intracellular receptor proteins in the rat: The glucocorticoid receptor and the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Thesis, 1979.
11.Björn Forsgren: Studies on a major protein in the ventral prostate of the rat that interacts with metabolites of estramustine phosphate and related steroid-cytostatic complexes. Thesis, 1979.
12.Erik Dahlberg: Studies on steroid hormone receptors in rat skeletal muscle. Thesis, 1980.
13.Zhao-Ying Yu: Studies of steroid hormone receptors in brain. Thesis, 1981.
14.Gunnar Norstedt: Regulations of prolactin and estrogen receptors in rat liver. Thesis, 1981.
15.Tiiu Hansson: Studies on hepatic steroid metabolism in rainbow trout, Salmo gairdneri. Thesis, 1981.
16.Livia Alm: The effect of fermentation on nutrients in milk and some properties of fermented liquid milk products. Thesis, 1982.
17.Rune Toftgård: Xylene, an inducer of hepatic cytochrome P-450 and xenobiotic biotransformation in the rat. Thesis, 1982.
18.Joseph J. Rafter: Role of the intestinal microflora in the formation of sulphur-containing conjugates of xenobiotics. Thesis, 1982.
19.Tapio Haaparanta: Isolation of subcellular fractions from the rat ventral prostate and characterization of prostacic cytochrome P-450. Thesis, 1983.
20.Agneta Mode: Growth hormone - a regulator of the sexually differentiated steroid metabolism in rat liver. Thesis, 1983.
21.Tönu Saartok: Steroid receptors as prediction of direct hormonal response in human and rabbit skeletal muscle. Thesis, 1983.
22.Sam Okret: Immunochemical studies on glucocorticoid receptor structure and function. Thesis, 1983.
23.Lorenz Poellinger: Characterization of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Thesis, 1985.
24.Catriona MacGeoch: Characterization and growth hormone regulation of sexually differentiated cytochrome P-450 isozymes in rat liver. Thesis, 1986.
25.Johan Lund: Methyl sulfone metabolites of polychlorinated biphenyls: studies on the mechanism of accumulation in lung. Thesis, 1986.
26.Ann-Charlotte Wikström: Production and use of monoclonal antibodies against the glucocorticoid receptor. Thesis, 1986.
27.Agneta Blanck: The hypothalamo-pituitary-liver axis - a possible determinant of sex differences in chemical hepatocarcinogenesis in the rat? Thesis, 1987.
28.Peter Söderkvist: Studies on regulation and enzymatic activity of drug-induced cytochrome P-450 in rat ventral prostate. Thesis, 1987.
29.Mikael Gillner: Studies on the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Thesis, 1988.
30.Lennart Möller: 2-Nitrofluorence, in vivo metabolism and assessment of cancer risk of an air pollutant. Thesis, 1988.
31.Mikael Brönnegård: Studies on the structure and function of the human and the rat glucocorticoid receptor. Thesis, 1988.
32.Bolette Husman: Characterization of the somatogenic receptor in rat liver. Thesis, 1988.
33.Sam Törnquist: Uptake, metabolism and DNA-binding of the chemical carcinogens benzo(a)-pyrene and 2-nitrofluorene in the rat lung. Thesis, 1989.
34.Marc Denis: The non-activated glucocorticoid receptor: structure and activation. Thesis, 1989.
35.Lars-Arne Haldosén: Characterization of the prolactin receptor in rat liver. Thesis, 1989.
36.Anders Berkenstam: Estrogen and progesterone receptors in human breast cancer cells: studies on mechanisms for steroid dependent versus constitutive gene expression. Thesis, 1989.
37.Eva Övervik: Formation and biological effects of cooked-food mutagens. Thesis, 1989.
38.Yu Dong: Transcriptional and post-transcriptional regulation of gene expression: Studies on glucocorticoid receptor and alcohol dehydrogenase. Thesis, 1990.
39.Pia Lindeskog: Effects of diet on rat small intestinal cytochrome P-450 IA1. Thesis, 1990.
40.Scott Cuthill: The mechanism of action of the dioxin receptor. Thesis, 1990.
41.Gunnar Johansson: Effects of a shift from a mixed diet to a lactovegetarian diet on some colon cancer associated characteristics. Thesis , 1990.
42.Karin Dahlman-Wright: DNA-binding by the glucocorticoid receptor: a structural and functional analysis. Thesis, 1991.
43.Ann Lidbeck: Studies on the impact of Lactobacillus acidophilus on human microflora and some cancer-related intestinal ecological variables. Thesis, 1991.
44.Carol Cairns: Mechanisms and role of DNA-binding in steroid hormone receptor action. Thesis, 1993.
45.Gunnar Akner: Localization of glucocorticoid receptor (GR) and heat shock protein Mr 90,000 (Hsp90) in mammalian cells. Thesis, 1993.
46.Maria Strömstedt: Characterization of cytochrome P450 in rat ventral prostate and brain. Thesis, 1993.
47.Olof Andersson: Structure and function of a Clara cell-specific, PCB-binding protein. Thesis, 1993.
48.Per-Erik Strömstedt: Molecular analysis of glucocorticoid receptor-hormone interaction. Thesis, 1993.
49.Anna Wilhelmsson: Mechanism of activation of the dioxin receptor. Thesis, 1993.
50.Wilhelm Cairns: A study of mechanisms involved in the control of glucocorticoid receptor function. Thesis, 1993.
51.Anders Ström: Cloning, characterization and regulation of CYP2C genes expressed in rat liver. Thesis, 1994.
52.Johanna Zilliacus: Structural determinants of DNA-binding specificity by the glucocorticoid receptor. Thesis, 1994.
53.Petra Tollet: Growth hormone signal transduction and regulation of CYP2C12 expression in primary rat hepatocytes. Thesis, 1995.
54.Carol Soontjens: Ligands for nuclear receptors development and application of methods for identification. Thesis, 1995.
55.Dezhong Liao: Hormonal regulation of sex differentiated liver carcinogenesis in the rat. Thesis, 1996.
56.Stefan Westin: Regulation of cytochrome P4502C7: Effects of growth hormone and vitamin A. Thesis, 1996.
57.Marika Kleman: Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles. Thesis, 1996.
58.Kaj Grandien: The estrogen receptor gene; promoter organization and expression. Thesis 1996.
59.Magnus Nord: Regulation and function of the Clara cell secretory protein. Thesis 1997.
60.Jacqueline McGuire: Mechanism of conditional regulation of the bHLH/PAS dioxin receptor. Thesis, 1997.
61.Yang Yang: The in vivo metabolism of benzo[a]pyrene studied by chromatography in combination with mass spectrometry. Thesis, 1997.
62.Tova Almlöf: Gene regulation by the glucocorticoid receptor: Post-DNA binding mechanisms of transcriptional activation. Thesis, 1997.
63.Heike Hellmold: Toxicological and endocrinological aspects of cytochrome P450 in breast and lung. Thesis, 1998.
64.Thomas Meyer: Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids. Thesis, 1998.
65.Tony Pircher: Regulation of STAT5 activity by growth hormone. Thesis, 1998.
66.Annika Wallberg: Chromatin remodeling complexes involved in gene activation by the glucocorticoid receptor. Thesis, 1999.
67.Ulrika Lind: Functional analysis of ligand recognition by the glucocorticoid receptor. Thesis, 2000.
68.Katarina Pettersson: Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs). Thesis, 2000.
69.Thomas Barkhem: Molecular mechanisms of estrogen/antiestrogen action. M.Sci. thesis, 2000.
70.Johan Lidén: Repression of transcription factor NF-B by glucocorticods. A molecular mechanism for their anti-inflammatory and immuno-modulatory effects. Thesis, 2000.
71. Eva Hedlund: Cytochrome P450 in the rat brain: Characterization and regulation. Thesis, 2000.
72.Tobias Cassel: Transcriptional regulation of differentiation markers in the distal lung epithelium – A role for C/EBP factors. Thesis, 2001.