References to Water and Homeopathic Medicines

High Quality Basic Sciences and

Clinical Research in Homeopathic Medicine

Dana Ullman, MPH, CCH

People who want access to reference to and description of approximately 200 clinical trials using homeopathic medicine should get Dana Ullman’s ebook, Evidence Based Homeopathic Family Medicine, available at leading resource for homeopathic research, books, medicines, and courses).

Because many close-minded skeptics commonly insist that homeopathic medicines are “simply water,” real scientists and academically-inclined individuals will benefit from reviewing the writings of Professor Martin Chaplin, a world renowned expert on water:

The most comprehensive review of clinical and laboratory research was commissioned by the Swiss government:

Bornhöft G., Wolf U., Ammon K., et al. Effectiveness, Safety and Cost-Effectiveness of Homeopathy in General Practice – Summarized Health Technology Assessment. ForschKomplementärmed 2006;13(suppl 2):19-29. Other reports.

Enserink M, Newsmaker Interview: Luc Montagnier, French Nobelist Escapes "Intellectual Terror" to Pursue Radical Ideas in China. Science 24 December 2010: 330, 6012, 1732. A summary of this article is providedhere.

High Quality Clinical Research:

Mathie RT, Lloyd SM, Legg LA, Clausen J, Moss S, Davidson JR, Ford I. Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Systematic Reviews 2014; 3:142.

Macías-Cortés EdC, Llanes-González L, Aguilar-Faisal L, Asbun-Bojalil J (2015) Individualized Homeopathic Treatment and Fluoxetine for Moderate to Severe Depression in Peri- and Postmenopausal Women (HOMDEP-MENOP Study): A Randomized, Double-Dummy, Double-Blind, Placebo-Controlled Trial. PLoSONE 10(3): e0118440. doi:10.1371/journal.pone.0118440

-- Lüdtke R, RuttenALB. The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. Journal of Clinical Epidemiology. October 2008. doi: 10.1016/j.jclinepi.2008.06/015. This article published in a highly respected journal that evaluates research provides a compelling critique of the Shang review and shows that positive or negative conclusions are dependent upon the various ways you evaluate the body of evidence.

Taylor, MA, Reilly, D, Llewellyn-Jones, RH, et al., Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial Series, BMJ, August 19, 2000, 321:471-476. (This review of FOUR studies on the homeopathic treatment of people with respiratory allergies)

Ullman, D, Frass, M. A Review of Homeopathic Research in the Treatment of Respiratory Allergies.Alternative Medicine Review. 2010:15,1:48-58..

This review provides strong and compelling evidence for homeopathy in the treatment of respiratory allergies.

Mathie RT, Frye J, Fisher P. Homeopathic Oscillococcinum® for preventing and treating influenza and influenza-like illness. Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD001957. (4 large double-blind trials show efficacy but not enough for first line of treatment)

Jacobs J, Jonas WB, Jimenez-Perez M, Crothers D, Homeopathy for Childhood Diarrhea: Combined Results and Metaanalysis from Three Randomized, Controlled Clinical Trials, Pediatr Infect Dis J, 2003;22:229-34. This metaanalysis of 242 children showed a highly significant result in the duration of childhood diarrhea (P=0.008). A 4th trial testing a “homeopathic formula” had a negative result.

Linde L, Clausius N, Ramirez G, et al., "Are the Clinical Effects of Homoeopathy Placebo Effects? A Meta-analysis of Placebo-Controlled Trials," Lancet, September 20, 1997, 350:834-843. (Although a later review by some of these authors found a reduced significance, the authors never asserted that the significance was no longer present.)

Frass,M,Dielacher, C, Linkesch, M, et al. Influence of potassium dichromate on tracheal secretions in critically ill patients, Chest,March, 2005;127:936-941. Published in the leading journal on respiratory medicine, this study shows remarkable results in treating the #4 reason that people in the USA die. Conducted at the University of Vienna Hospital.

Bell IR, Lewis II DA, Brooks AJ, et al. Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo, Rheumatology. 2004:1111-5.Published in the leading journal on its subject, this study showed clinically relevant improvements from homeopathy as well as influences on objective EEG readings.

Frei H, Everts R, von Ammon K, Kaufmann F, Walther D, Hsu-Schmitz SF, Collenberg M, Fuhrer K, Hassink R, Steinlin M, Thurneysen A. Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial. Eur J Pediatr. 2005 Dec;164(12):758-67. Epub 2005 Jul 27.

Adler UC, Paiva NMP, Cesar AT, Adler MS, Molina A, Padula AE, Calil HM. Homeopathic individualized Q-potencies versus fluoxetine for moderate to severe depression: double-blind, randomized non-inferiority trial. Evid Based Complement Alternat Med. 2009 Aug 17.

Kassab S, Cummings M, Berkovitz S, van Haselen R, Fisher P. Homeopathic medicines for adverse effects of cancer treatments. Cochrane Database of Systematic Reviews 2009, Issue 2.

High Quality Basic Sciences Work:

Bell IR, Koithan M. A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system. BMC Complement Altern Med. 2012 Oct 22;12(1):191.

is an exceptional review of the basic sciences literature that explains how homeopathic medicines may work)

Bell IR, Sarter B, Koithan M, et al. Integrative Nanomedicine: Treating Cancer with Nanoscale Natural Products. Global Advances in Health and Medicine, January 2014. 36-53.

Iris R. Bell, John A. Ives, and Wayne B. Jonas. Nonlinear Effects of Nanoparticles: Biological Variability FromHormetic Doses, Small Particle Sizes, and Dynamic Adaptive Interactions. Dose Response. May 2014; 12(2): 202–232.

Bell IR, Schwartz GE, Boyer NN, Koithan M, Brooks AJ.Advances in Integrative Nanomedicine for Improving Infectious Disease Treatment in Public Health. European journal of integrative medicine 2013;5(2):126-140. doi:10.1016/j.eujim.2012.11.002.

Chikramane PS, Kalita D, Suresh AK, Kane SG, Bellare JR. Why Extreme Dilutions Reach Non-zero Asymptotes: A Nanoparticulate Hypothesis Based on Froth Flotation.Langmuir. 2012 Nov 1.

Eskinazi, D., Homeopathy Re-revisited: Is Homeopathy Compatible with Biomedical Observations? Archives in Internal Medicine, 159, Sept 27, 1999:1981-7.

Marzotto M, Olioso D, Bellavite P. Gene expression and highly diluted molecules. Front Pharmacol.2014; 5: 237.2014 November 12. doi: 10.3389/fphar.2014.00237

Endler PC, Thieves K, Reich C, Matthiessen P, Bonamin L, Scherr C, Baumgartner S. Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study.Homeopathy, 2010; 99: 25-36.

Homeopathy.January, 2010, issue. This entire issue is devoted to basic sciences research. Of special interest is: Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study; as well as Animal models for studying homeopathy and high dilutions: Conceptual critical review

Witt CM, Bluth M, Albrecht H, Weisshuhn TE, Baumgartner S, Willich SN.The in vitro evidence for an effect of high homeopathic potencies--a systematic review of the literature. Complement Ther Med. 2007 Jun;15(2):128-38. Epub 2007 Mar 28. From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and nearly 3/4 of all replications were positive.

An impressive review of articles on homeopathy and hormesis (low-dose effects) was published in the journal, Human and Experimental Toxicology, July 2010:

To access free copies of these articles, see:

Sunila ES, Kuttan R, Preethi KC, and Kttan G. Dynamized Preparations in Cell Culture, eCAM.October 3, 2007;

Chikramane PS, Suresh AK, Bellare JR, and Govind S. Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy. Volume 99, Issue 4, October 2010, 231-242.

Chatterjee A, Biswas J, Chatterjee A, Bhattacharya S, Mukhopadhyay B, Mandal S.Psorinum therapy in treating stomach, gall bladder, pancreatic, and liver cancers: a prospective clinical study. Evid Based Complement Alternat Med. 2011;2011:724743.

An abstract of the above study was published in the JOURNAL OF CLINICAL ONCOLOGY, one of the most respected cancer journals in the world (impact factor = 17.793)

Advanced non-small cell lung cancer:

Banerjee D. New drug hope for cancer patients, The Times of India, August 23, 2011.

Banerjee, P.;Biswas, S. J.;Belon, P.;Khuda-Bukhsh, A. R. A Potentized Homeopathic Drug, Arsenicum Album 200, Can Ameliorate Genotoxicity Induced by Repeated Injections of Arsenic Trioxide in Mice. Journal of Veterinary Medicine, Series A, Volume 54,Number 7, September 2007 , pp. 370-376(7).DOI: 10.1111/j.1439-0442.2007.00945.x

Elia V, and Niccoli M. Thermodynamics of Extremely Diluted Aqueous Solutions, Annals of the New YorkAcademy of Sciences, 879, 1999:241-248.

Rey L. Thermoluminescence of Ultra-High Dilutions of Lithium Chloride and Sodium Chloride.Physica A, 323(2003)67-74.

Hofbauer R, Pasching E, Moser D, Frass M. Heparin-binding epidermal growth factor expression in KATO-III cells after Helicobacter pylori stimulation under the influence of strychnosNux vomica and Calendula officinalis.Homeopathy.Jul 2010;99(3):177-182.

Piolot M, Fagot JP, Rivière S, Fagot-Campagna A, Debeugny G, Couzigou P, Alla F. Homeopathy in France in 2011-2012 according to reimbursements in the French national health insurance database (SNIIRAM). Family Practice.2015 Apr 28.