Refer to Section 2 of the OICR Cancer Therapeutics Innovation Pipeline Request for Applications

INSTRUCTIONS

Refer to section 2 of the OICR Cancer Therapeutics Innovation Pipeline Request for Applications for further instructions.

All sections are mandatory and must be completed using 11-point Verdana font and single spacing. Margins cannot be modified. The completed form must not exceed five pages. Delete all instructions prior to submission. Page/word limits must be strictly followed.

1. Project information
Project title / Project type
☐ Early Accelerator
☐ Late Accelerator
☐ Incubator
2. Applicant information
Name / Institution/ organization / Email
PI
Co-PI(s)
(if applicable)
Co-Investigators
Other collaborators
(if applicable)
3. Project details
Provide high level details of the proposed project. Maximum 25 words per bullet point.
·  Target and/or pathway:
·  Mechanistic class (e.g., kinase, protein-protein interaction, GPCR, protease, histone methyltransferase, etc.):
·  Cancer cell type(s) targeted:
·  Route of administration:
4. Background
Provide a summary of your work and any relevant published work which describes unmet need, target validation, therapeutic rationale, and differentiation from other approaches. Maximum 400 words.
5. Research plan
Describe your research plan. Where available, include the development and validation of required assays, screening strategy and decision tree, and potential major challenges. Maximum 400 words.
6. Key deliverables
List key deliverable(s) of your research plan with timelines. Deliverables are pre-defined outcomes that describe what success looks like for the project (e.g., results of a functional genomic screen, generating a validated primary or secondary assay, selection of a cell line for large molecule generation, Hit, Lead, etc.) Maximum three deliverables.
Deliverable / Projected date
(Quarter/
calendar year)
7. Additional questions
1.  Has this work been published/patented? ☐ Yes ☐ No
2.  Highlight which, if any, assays have been developed (check all that apply).
☐ Primary biochemical assay
☐ Secondary/orthogonal assay
☐ Selectivity assay(s)
☐ Cell-based functional assay
☐ Proliferation assay
3.  Has a screen already been carried out? ☐ Yes ☐ No
a.  If yes, under which assay conditions (specify for any of the applicable assays in #2 above)? Maximum 25 words per assay.
b.  If yes, were hits identified? Maximum 25 words per assay.
8. Proposed budget
Describe the high-level budgetary requirements and any current funding allocated to the project. Maximum 100 words (numbers are considered words).
9. Relevant references
List the references sited above. Maximum five references.
Primary author / Title / PubMed ID (PMID) or Digital Object Identifier (DOI)

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