OOA COURSE
Preclinical assays in cancer therapy
September 19, 20 and 21, 2012 and 26, 27 and 28
Location: The Netherlands Cancer Institute (
Organizers: Jos Jonkers and Sven Rottenberg
Divisions of Molecular Pathology and Molecular Oncology, NKI-AVL - Amsterdam
Friday September 14Room Z4 / 16.00 - 17.00 h / Briefing course
Wednesday September 19
Room H8 / 13.00 – 15.00 h
15.00 – 15.30 15.30 - 17.30 h / Literature discussion
Tea/coffee break
Literature discussion
Thursday September 20
Room Z4 / 13.00 – 15.00 h
15.00 – 15.30
15.30 - 17.30 h / Literature discussion
Tea/coffee break
Literature discussion
Friday September 21
Room Z4 / 13.00 – 15.00 h
15.00 – 15.30
15.30 - 17.30 h / Literature discussion
Tea/coffee break
Literature discussion
Bar / 17.00 - ? / Drinks @ Research Borrel in bar NKI
This course also includes the symposium on September 26, 27 and 28.
The OOA course is open for OOA members of NKI, VU and AMC, registered by the website
The symposium website: click here
PROGRAM SYMPOSIUM
Preclinical assays in cancer therapy
Wednesday, September 26, 2012
Session 1: Technology09.00 – 09.40 / Organ Structures / Hans Clevers – Hubrecht Institute, Utrecht
09.40 – 10.20 / Cell Line derived xenograft models / Patricia Vrignaud – Sanofi Aventis
10.20 – 10.50 / Coffee break / Foyer
10.50 – 11.30 / Human Xenograft in mice: technical aspects / Marie-France Poupon– Institute Curie, Paris
11.30 – 12.10 / Fast-track production of GEM models of human cancer / Ivo Huijbers – NKI-AVL, Amsterdam
12.10 – 12.50 / Preclinical Imaging / Peter Friedl – NCMLS, Nijmegen
12.50 – 14.00 / Lunch - posters in bar / Foyer
Session 2: GEMMs
14.00 – 14.40 / GEM models of intestinal cancer / Owen Sansom – Beatson Institute, Glasgow
14.40 – 15.20 / GEM models of pancreas and non small cell lung cancer / Mariano Barbacid – CNIO, Madrid
15.20 – 15.50 / Coffee/tea break / Foyer
15.50 – 16.30 / GEM models of small cell lung cancer and mesothelioma / Anton Berns – NKI-AVL, Amsterdam
16.30 – 17.10 / GEM models of breast cancer / Jos Jonkers – NKI-AVL, Amsterdam
17.10 – 17.50 / Humanized GEM models / Alfred Schinkel – NKI-AVL, Amsterdam
17.50 – 19.00 / posters and drinks / Bar
Thursday, September 27, 2012
Session 3: PDX models
09.00 – 09.40 / PDX models of colorectal cancer / Virginie Dangles-Marie – Institute Curie,Paris
09.40 – 10.20 / Targeted therapies in PDX models of colorectal cancer / Livio Trusolino– University of Torino, Italy
10.20 – 10.50 / Coffee/tea break / Foyer
10.50 – 11.30 / PDX models of glioblastoma / Joan Seoane – VHIO, Vall d’Hebron
11.30 - 12.10 / PDX models of breast cancer / Elisabetta Marangoni – Institute Curie, Paris
12.10 - 12.50 / Histopathology of xenograft models / Jean-Jacques Fontaine – ENVA, Paris
12.50 – 14.00 / Lunch - posters in bar / Foyer
Session 4: Applications
14.00 – 14.40 / Angiogenesis / Kari Alitalo – University of Helsinki, Finland
14.40 – 15.20 / Metastasis in xenograft models / Suzanne Eccles - ICR, LondonUK
15.20 – 15.50 / Coffee/tea break / Foyer
15.50 – 16.30 / Ethics / Suzanne Eccles – ICR,LondonUK
16.30 – 17.10 / Chemoresistance in GEMMs / Sven Rottenberg - NKI-AVL,Amsterdam
17.10 - 17.50 / Use of humanized mouse models for drug development / Holger Kissel– Taconic Artemis
17.50 – 19.00 / posters and drinks / Bar
19.00 - ? / Social event / Amsterdam
Friday, September 28, 2012
Session 5: Applications09.00 – 09.40 / Impact of the immune system on chemotherapy response / Karin de Visser– NKI-AVL, Amsterdam
09.40 – 10.20 / Antibodies to target cancer / Frank Herting – Roche
10.20 – 10.50 / Coffee/tea break / Foyer
11.00 – 12.00 / Keynote lecture: protection of telomeres / Titia de Lange – Rockefeller Institute, New York, USA
12.10 - 12.50 / Mouse Clinic / Ken Olive – Colombia University, New York, USA
12.50 – 14.00 / Lunch / Foyer
14.00 / End of program
Program OOA course Preclinical Assays -September 2012