PHS 398 (Rev. 9/04), Biographical Sketch Format Page s15

Principal Investigator/Program Director (Last, First, Middle): Homann, Dirk

BIOGRAPHICAL SKETCH

PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page

Principal Investigator/Program Director (Last, First, Middle): Homann, Dirk

NOTE: The Biographical Sketch may not exceed four pages.

A. Positions and Honors.

1992-1994 Instructor for Anatomy, Physiology, Microbiology, Internal Medicine and Neurology

Urban Hospital and Jüdisches Hospital, Berlin

1995-2000 Research Associate, Viral Immunobiology Laboratory (Head: Dr. M. Oldstone),

The Scripps Research Institute

2000-2002  Senior Research Associate/Instructor, The Scripps Research Institute

2003-present Assistant Professor, Department of Pediatrics,

University of Colorado at Denver and Health Sciences Center (UCDHSC)

2003-present Visiting Professor, The Scripps Research Institute

2003-present Director, Flow Cytometry Core Facility, Barbara Davis Center/UCDHSC

2004-present Assistant Professor, Integrated Department of Immunology,

National Jewish Medical and Research Center & UCDHSC

2005-present Assistant Professor, Department of Microbiology, UCDHSC

2006-present Assistant Professor, Biomedical Sciences Program, UCDHSC

Honors: Medical thesis: summa cum laude

Piano/Music diploma: summa cum laude

Grants by the Studienstiftung des Deutschen Volkes, Ludwig-Maximilians-Universität Munich

and German Academic Exchange Service

Multiple awards for attendance of national and international conferences (ASCI/AAP Joint Meeting, 5th International Congress of the Immunology of Diabetes Society, XIIth International Congress of Virology and others)

Memberships: UCDHSC Cancer Center, American Association of Immunologists, American Society for Microbiology

B. Selected Peer-Reviewed Publications (in chronological order).

von Herrath, M.G., D. Homann. Treatment of virus-induced IDDM by oral administration of insulin: Study on the mechanism by which oral antigens can abrogate autoimmunity. Endocrinol. and Diabetes 105:24-25 (1997)

von Herrath M.G., A. Holz, D. Homann, M.B.Oldstone. Role of viruses in type I diabetes. Semin Immunol. 10:87-100 (1998)

Homann, D., A. Tishon, D.P. Berger, W.O. Weigle, M.G. von Herrath, M.B.A. Oldstone. Evidence for an underlying CD4 helper and CD8 T cell defect in B cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from mMT/mMT mice. J. Virol. 72:9208-9216 (1998)

von Herrath, M., B. Coon, D. Homann, T. Wolfe, L.G. Guidotti. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningits virus-induced immunopathology and increases survival in perforin-deficient mice. J. Virol. 73:5918-5925(1999)

Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldstone, M.G. von Herrath. Insulin in oral immune "tolerance": A one amino acid change in the B-chain makes the difference. J. Immunol. 163:1833-1838 (1999)

Oldstone, M.B.A., H. Lewicki, D. Thomas, A. Tishon, D. White, S. Dales, J. Patterson, M. Manchester, D. Homann, D. Naniche, A. Holz. Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease. Cell 98:629-640 (1999)

Homann, D., A. Holz, A. Bot, B. Coon, T. Wolfe, J. Petersen, T.P. Dyrberg, M.J. Grusby, M.G. von Herrath. Autoreactive CD4+ lymphocytes protect from autoimmune diabetes via bystander suppression using the IL-4/stat6 pathway. Immunity 11:463-472 (1999)

Homann, D., D.P. Berger, M.B.A. Oldstone. Defining parameters for successful immunocytotherapy of persistent viral infection. Virology 266:257-263 (2000)

von Herrath, M.G., D.P. Berger, D. Homann, T. Tishon, A. Sette, M.B. Oldstone. Vaccination to treat persistent viral infection. Virology 268:411-419 (2000)

Sevilla, N., D. Homann, M. von Herrath, F. Rodriguez, S. Harkins, J.L. Whitton, M.B. Oldstone. Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease. J. Virol. 74:3284-3292 (2000)

Sevilla, N., S. Kunz, A. Holz, H. Lewicki, D. Homann, H. Yamada, K.P. Campell, J.C. de la Torre, M.B.A. Oldstone. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J. Exp. Med. 192:1249-1260 (2000)

Holz, A., T. Dyrberg, W. Hagopian, D. Homann, M. Von Herrath, Michael B.A. Oldstone. Neither B-lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes. J. Immunol. 165:5945-5953 (2000)

Homann, D., D.P. Berger, M.B.A. Oldstone. Immunocytotherapy for persistent viral infection. In: New Concepts in the Immunopathogenesis of CNS Infections. P.K. Peterson, J.S. Remington, eds., Blackwell Science, Boston. (2000)

von Herrath, M.G., D. Homann, M.B.A. Oldstone. The role of viruses. In: Immunologically Mediated Endocrine Diseases. R. Gill et al., eds., Lippincott Raven, Philadelphia. (2000)

Bureau, J.-F., S. Le Goff, D. Thomas, A.F. Parlow, J.C. de la Torre, D. Homann, M. Brahic, M.B.A. Oldstone. Disruption of differentiated functions during viral infection in vivo. V. Mapping of a locus involved in susceptibility of mice to growth hormone deficiency due to persistent lymphocytic choriomeningitis virus infection. Virology 281:61-66 (2001)

Pertl, U., A.D. Luster, N.M. Varki, D. Homann, G. Gaedicke, R.A. Reisfeld, H.N. Lode. IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy. J. Immunol. 166:6944-6951 (2001)

Oldstone, M.B., H. Lewicki, D. Homann, C. Nguyen, S. Julien, J.E. Gairin. Common antiviral cytotoxic T-lymphocyte epitope for diverse arenaviruses. J. Virol. 75:6273-6278 (2001)

Homann, D., L. Teyton, M.B.A. Oldstone. Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat. Med. 7:913-919 (2001)

von Herrath, M.G., M. Oldstone, D. Homann, U. Christen. Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity. In: Molecular Pathology of Type 1 Diabetes mellitus. Curr. Dir. Autoimmun. Vol.4, M.G. von Herrath, ed., Basel, Karger (2001)

Homann, D., M.B.A. Oldstone. Maintaining immunity: a tale of two T cell populations. Directions in Science 1:21-24 (2002)

Hugues, S., E. Mougneau, W. Ferlin, D. Jeske, P Hofman, D. Homann, L. Beaudoin, C. Schrike, M. von Herrath, A. Lehuen, N. Glaichenhaus. Tolerance to islet antigens and prevention of diabetes induced by limited apoptosis of pancreatic b cells. Immunity 16:169-181 (2002)

Homann, D., A. Jahreis, T. Wolfe, A. Hughes, B. Coon, M. van Stipdonk, K.R. Prilliman, S.P. Schoenberger, and M.G. von Herrath. CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 16:403-415 (2002)

Arbour, N., D. Naniche, D. Homann, R.J. Davis, R.A. Flavell, M.B.A. Oldstone. c-Jun NH2-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8+ T cell-mediated antiviral immunity. J. Exp. Med. 195:801-810 (2002)

Oldstone. M.B., D. Homann, H. Lewicki, D. Stevenson. One, two, or three step: measles virus receptor dance. Virology. 299:162-163 (2002)

McGavern, D., D. Homann, M.B.A. Oldstone. T cells in the central nervous system: the delicate balance between viral clearance and disease. J. Infect. Dis. 186:S145-S151 (2002)

Homann, D. Immunocytotherapy. In: Arenaviruses II, Curr. Top. Microbiol. Immunol. 263:43-65, M.B.A. Oldstone, ed., (2002)

Mallet-Designé, V., T. Stratmann, D. Homann, F. Carbone, M.B.A. Oldstone, L. Teyton. Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the anti-ovalbumin immune response. J. Immunol. 170:123-131 (2003)

Lewicki, H., A. Tishon, D. Homann, H. Mazarguil, F. Laval, VC. Asensio, I.L. Campbell, S. DeArmond, B. Coon, C. Teng, J.E. Gairin, M.B. Oldstone. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. J. Virol. 77:3799-3808 (2003)

Hahm, B., N. Arbour, D. Naniche, D. Homann, M. Manchester, M.B.A. Oldstone. Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule. J. Virol. 77:3505-3515 (2003)

Slifka, M.K., D. Homann, A. Tishon, R. Pagarigan, M.B.A. Oldstone. Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection. J. Clin. Invest. 111:805-810 (2003)

Petersen, J.S., S. Bregenholt, V. Apostolopolous, D. Homann, T. Wolfe, A. Hughes, K. De Jongh, M. Wang, T. Dyrberg, M.G. von Herrath. Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes. Clin. Exp. Immunol. 134:38-45 (2003)

De Boer, R.J., D. Homann, A.S. Perelson. Different dynamics of CD4+ and CD8+ T cell responses during and after acute LCMV infection. J. Immunol. 171:3928-3935 (2003)

von Herrath, M.G., D. Homann. Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity. Trends Immunol. 24:540-545 (2003)

Homann, D., M.G. von Herrath. Interfacing dendritic and natural killer cells: a tool for targeted tolerance induction? Transplantation. 76:1657-1661 (2003)

von Herrath, M.G., D. Homann. Organ-specific autoimmunity. In: Fundamental Immunology. W.E. Paul, ed., 5th edition, Lippincott Williams & Wilkins, Philadelphia (2003)

Christen, U., Juedes, A., Homann, D., von Herrath, M.G. Virally induced inflammation and therapeutic avenues in type 1 diabetes mellitus. Endocrinol. Metab. Clin. North Am. 33:45-58 (2004)

Homann, D., D. McGavern, M.B.A. Oldstone. Visualizing the viral burden: phenotypic and functional alterations of T cells and antigen-presenting cells during persistent infection. J. Immunol. 172:6239-6250 (2004)

von Herrath, M.G., D. Homann. Tolerance tag team. Nat. Med. 10:585-587 (2004)

Lenz, D.C., S.K. Kurz, E. Lemmens, S.P. Schoenberger, J. Sprent, M.B.A. Oldstone, D. Homann. IL-7

regulates basal homeostatic proliferation of antiviral CD4+ T cell memory. Proc. Natl. Acad. Sci. USA. 101:9357-9362 (2004)

Homann, D., von Herrath M.G. Regulatory T cells and type 1 diabetes. Clin. Immunol. 112:202-209 (2004)

Homann, D., Gill, R.G. To help and help not. Nat. Immunol. 5:878-880 (2004)

von Herrath, M.G., D. Homann. Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes. Pediatr. Diabetes. Suppl. 2:23-28 (2004)

Homann, D., M.G. von Herrath. “Natural” and “induced” regulatory T cells – purpose and problems associated with an emerging distinction. In: Regulatory T cells in inflammation. Progress in Inflammation Research. L. Taams et al., eds., Birkhäuser Verlag, Basel (2005)

Homann, D., W. Dummer, T. Wolfe, E. Rodrigo, A.N. Theofilopoulos, M.B.A. Oldstone, M.G. von Herrath. Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T cell immunity. J. Virol. 80:270-280 (2006)

Homann, D., G. S. Eisenbarth. An Immunologic Homunculus for Type 1 Diabetes of the NOD Mouse. J. Clin. Invest. 116:1212-1215 (2006)

Martinic, M.M., A.E. Juedes, D. Bresson, D. Homann, K. Skak, C. Huber, E. Ling, M. Ejrnaes, T. Wolfe, L. Togher, E. Rodrigo, M. Kotturi, R. Tan, X. Wang, U. Christen, and M.G. von Herrath. Minimal impact of a de novo-expressed β-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes 56:1059-1068 (2007)

Homann, D., H. Lewicki, D. Brooks, J. Eberlein, V. Mallet-Designé, L. Teyton, M.B.A. Oldstone. Mapping and restriction of a dominant viral CD4+T cell core epitope by both MHC class I and MHC class II. Virology in press (2007)

von Herrath, M.G., D. Homann. Organ-specific autoimmunity. In: Fundamental Immunology. W.E. Paul, ed., 6th edition, Lippincott Williams & Wilkins, Philadelphia in press

C. Research Support.

Completed and active:

·  BDC start up funds

Role PI Funding period: 09/01/03 – 08/31/06

·  BDC P&F grant: “On the pathogenesis of type 1 diabetes: an RNA interference approach”

Role: PI Funding period: 04/01/04 – 03/31/05

Goals: Use of retrovirus-based RNA interference to modulate selected properties of pathogenic CD8+T cells in an in vivo model for type 1 diabetes.

·  NIH 1R21 AG026518-01: “Maturation of established antiviral CD8+T cell memory”

Role: PI Funding period: 07/01/05 – 06/30/07

Goals: Molecular and functional characterization of improved CD8+ memory T cell properties acquired during an extended maturation period.

·  NIH 1R01AI059777-01A1: “Cell cycle inhibition in systemic autoimmunity” (Dwight Kono, PI)

Role: Collaborator Funding period: 02/15/05 – 01/31/10

Goals: Defining the role of the cell cycle inhibitor p21 in normal immune and autoimmune responses.

·  NIH 2R01 DK055969-08 “In vivo NOD evaluation of a “pathogenic” insulin peptide” (G. Eisenbarth, PI)

Role: Co-Investigator Funding period: 03/01/06 – 02/28/10

·  JDRF CDA 2-2007-240: “Chemokine signatures in pathogenesis and prevention of type 1 diabetes”

Role: PI Funding period: 04/01/07 – 03/31/12

Goals: Deliniation of “chemokine signatures” of diabetogenic T cells and islet cells, evaluation of the pathogenetic role of selected chemokines and identification of chemokine/receptors as therapeutic targets.

PHS 398/2590 (Rev. 09/04) Page 4 Biographical Sketch Format Page