Peer Reviewed Publications: (Update document with info below)

  • Moore T.J., de Broer-Brouwer M. and van Dissel-Emiliani F.M.F. (2002), Purified Gonocytes from the Neonatal Rat form Foci of Proliferating Germ Cells in vitro. Endocrinology 143(8): 3171-3174
  • Hawkins D. and Abrahamse H. (2003) Detection of integrated Human Papillomavirus in SNO Oesophageal Carcinoma cell DNA. Soc. of Medical Laboratory Technologists Association. Dec.17(1): 380-386
  • Houreld N., Hind J., Slabbert K. and Abrahamse H. (2004) Adaptive Response To High-Let Radiation Induced By Cobalt60. Asian .J of Microbiology, Biotechnology and Environmental Sci. 6(2): 169-173
  • Moore, T.J. (2004). Manipulation of Germ Cells from the Neonatal Rat Testis. Published by Labor Grafimedia BV, Utrecht, The Netherlands, September, 2004, ISBN 90-393-3866-3, 109p.
  • Houreld N. and Abrahamse H. (2004) DNA Damage Assessment In South African Gold Mineworkers And Radiographers Using The Comet Assay. Asian Journal of Microbiology, Biotechnology and Environmental Sciences. 6(2): 163-167
  • Hawkins D. and Abrahamse H. (2004) The release of interleukin-6 after Low Level Laser Therapy (LLLT) and the effect on migration and proliferation of human skin fibroblasts – An in vitro study. Medical Technology S.A 18(1): 11-15
  • Denise Hawkins and Heidi Abrahamse (2005) Cellular and Molecular Changes to Normal and Wounded Human Skin Fibroblasts following He-Ne laser Irradiation – an In Vitro Study. Journal for Endocrinology Metabolism and Diabetes of South Africa. 10(1): 35
  • Nicolette Houreld and Heidi Abrahamse (2005) Structural, Cellular and Molecular Effects of Low Level Laser Therapy on Wounded Diabetic Induced Human Skin Fibroblasts – an In Vitro Study. Journal for Endocrinology, Metabolism and Diabetes of South Africa. 10(1): 29
  • Heidi Abrahamse, Nicolette Houreld and Denise Hawkins. (2005) Changes in cell morphology, viability, proliferation and cytotoxicity associated with helium-neon laser irradiation of diabetic wounded human skin fibroblasts. (F2-007P) FEBS Journal 272 (1): 339. ISSN 1474-3833
  • Hawkins D., Houreld N. and Abrahamse H. (2005) Low level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Annals New York Academy of Sciences 1056: 486-493
  • Malatsi, N., Hind J. and Abrahamse H. (2005) Effect of Cobalt-60 Radiation on Dormant Mycobacterium smegmatis in vitro. Asian Journal of Microbiology, Biotechnology & Environmental Sciences 7(3): 583-590
  • Hawkins D. and Abrahamse H. (2005) Laboratory methods employed to evaluate the effects of Low Level Laser Therapy (LLLT) in wound healing. A review. African Journal of Biomedical Research 8(1): 1-14
  • Hawkins D. and Abrahamse H. (2005) Biological effects of HeNe laser irradiation on normal and wounded human skin fibroblasts. Photomedicine and Laser Surgery 23(3): 251-259
  • Houreld N. and Abrahamse H. (2005) Low level laser therapy as a treatment modality for diabetic wound healing: A review. The Diabetic Foot. 8(4): 182-193
  • Hawkins D. and Abrahamse H. (2006) The role of fluence in cell viability, proliferation and membrane integrity of wounded human skin fibroblasts following Helium-Neon laser irradiation. Lasers in Surgery and Medicine 38(1): 74-83
  • Seotsanyana-Mokhosi I., Kresfelder T., Abrahamse H., and Nyokong T. (2006) The Effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells. Journal of Photochemistry and Photobiology B: Biology. 83(1): 55-62
  • Mbene A.B., Zungu I. L., Hawkins D.H., Houreld N.N. and Abrahamse H. (2006) Adaptive Response After 632.8 nm Laser Irradiation Decreases Cellular Damage in Diabetic Wounded Fibroblast Cells. Medical Technology S.A. 20(1): 21-24
  • Hawkins D. and Abrahamse H. (2006) The effect of multiple exposures of Low Level Laser Therapy on the cellular responses of wounded human skin fibroblasts. Photomedicine and Laser Surgery. 24(6): 705-714
  • Hawkins D. and Abrahamse H. (2007) How long after laser irradiation should cellular responses be measured to determine the laser effect? Journal of Laser Applications. 19(2): 74-83
  • Hawkins D. and Abrahamse H. (2007) Changes in cell viability of wounded fibroblasts following laser irradiation in broad-spectrum or infrared light. Laser Chemistry. DOI:10.115/2007/71039
  • Hawkins D. and Abrahamse H. (2007) How should an increase in alkaline phosphatise activity be interpreted? Laser Chemistry. DOI:10.1155/2007/49608
  • Houreld N. and Abrahamse H. (2007) In Vitro exposure of wounded diabetic fibroblast cells to HeNe laser at 5J/cm2 and 16J/cm2. Photomedicine and Laser Surgery. 25(2): 78-84
  • Houreld N. and Abrahamse H. (2007) Effectiveness of HeNe Laser Irradiation on Viability and Cytotoxicity of Diabetic Wounded Fibroblast Cells. Photomedicine and Laser Surgery. 25(6): 472-479
  • Houreld N. and Abrahamse H. (2007) Irradiation with a 632.8 nm Helium-Neon laser with 5 J/cm2 stimulates proliferation and expression of Interleukin-6 in diabetic wounded fibroblast cells. Diabetes Technology and Therapeutics. 9(5): 451-459
  • Hawkins D. and Abrahamse H. (2007) Influence of broad-spectrum and infrared light in combination with laser irradiation on the proliferation of wounded skin fibroblasts. Photomedicine and Laser Surgery. 25(3): 159-169
  • Bresler A., Hawkins D., Razlog R. and Abrahamse H. (2007) Effect of Low Level Laser Therapy and Calendula officinalis 3cH on wound healing in human skin fibroblasts. American Journal of Homeopathic Medicine. 100(2): 110-118
  • Hawkins D.H. and Abrahamse H. (2007) Time-dependent responses of wounded human skin fibroblasts following phototherapy. Journal of Photochemistry and Photobiology B Biology 88: 147-155
  • Zungu I.L., Hawkins Evans D., Houreld N. and Abrahamse H. (2007) Biological responses of injured human skin fibroblasts to assess the efficacy of in vitro models for cell stress studies. African Journal of Biochemistry Research 1(4): 60-71
  • Houreld N.N. and Abrahamse H. (2007) Cellular Damage in Diabetic Wounded Fibroblast Cells following Phototherapy at 632.8, 830, and 1064nm. Laser Chemistry. DOI 10.1155/2007/80536
  • Hawkins D. and Abrahamse H. (2007) Phototherapy – A treatment modality for wound healing and pain relief. African Journal of Biomedical Research 10: 99-109
  • Mvula B., Mathope T. Moore T. and Abrahamse H. (2008) The effect of low level laser irradiation on adult human adipose derived stem cells. Lasers in Medical Science 23(3): 277–282
  • Houreld N. and Abrahamse H. (2008) Laser light influences cellular viability and proliferation in diabetic-wounded fibroblast cells in a dose- and wavelength dependent manner. Lasers in Medical Science. 23(1): 11-18
  • Hawkins D. and Abrahamse H. (2008) Efficacy of three different laser wavelengths for in-vitro wound healing. Photodermatology, Photoimmunology & Photomedicine. 24(4): 199-210
  • de Villiers J.A., Khumalo F., Sefalafala S, Nelson L.R., Abrahamse H. (2008) The Effect of Laser Irradiation on Wounded Mycotoxin Exposed Human Skin Fibroblast Cells. Medical Technology SA. 22(2): 7-14
  • Zungu I.L., Mbene A.B., Hawkins Evans D.H., Houreld N.N. and Abrahamse H. (2009) Phototherapy Promotes Cell Migration in the Presence of Hydroxyurea. Lasers in Medical Science. 24(2): 144- 150
  • Mbene A., Houreld N. N. and Abrahamse H. (2009) DNA Damage after Phototherapy in Wounded Fibroblast Cells Irradiated with 16 J/cm2. Journal of Photochemistry and Photobiology B. Biology 94: 131-137
  • Kresfelder T., Cronje M. and Abrahamse H. (2009) The Effect of two Metallophthalocyanines on the Viability and Proliferation of an Oesophageal cancer cell line. Photomedicine and Laser Surgery. 27(4): 625-631
  • Zungu I., Hawkins Evans D. and Abrahamse H. (2009) Mitochondrial Responses of Normal and Injured Human Skin Fibroblasts Following Low Level Laser Irradiation: An In Vitro Study. Photochemistry and Photobiology. 85: 987–996
  • Robertson C., Evans D. and Abrahamse H. (2009) Photodynamic Therapy (PDT): A Short Review on Cellular Mechanisms and Cancer Research Applications for PDT. Journal of Photochemistry and Photobiology B. Biology 96:1–8
  • Abrahamse H. (2009) Molecular perspectives of Wound healing – Cellular models. Photomedicine and Laser Surgery 27(5): 693-694
  • Houreld N.N., Sekhejane P. and Abrahamse H. (2010) Irradiation At 830nm Stimulates Nitric Oxide Production And Inhibits Pro-Inflammatory Cytokines In Diabetic Wounded Fibroblast Cells. Lasers in Surgery and Medicine 42: 494-502
  • Mvula B., Moore T.J. and Abrahamse H. (2010) Effect of low-level laser irradiation and epidermal growth factor on adult human adipose-derived stem cells. Lasers in Medical Science. 25: 33-39
  • Houreld N.N., Sekhejane P.R. and Abrahamse H., (2010) Irradiation at 830nm Stimulates Nitric Oxide Production and Inhibits Pro-Inflammatory Cytokines in Diabetic Wounded Fibroblast Cells. Lasers in Surgery and Medicine 42(6):494-502
  • Robertson C., Evans D. and Abrahamse H. (2010) The In Vitro PDT Efficacy of a Novel Metallophthalocyanine (MPc) Derivative and Established 5-ALA Photosensitizing Dyes Against Human Metastatic Melanoma Cells. Lasers in Surgery and Medicine 42: 766-776
  • Abrahamse H., Houreld N.N., Muller S. and Ndlovu L. (2010) Fluence and Wavelength of Low Intensity Laser Irradiation Affect Activity and Proliferation of Human Adipose Derived Stem Cells. Medical Technology SA 24(2) 9-14
  • Terblanche U., Evans D.H. and Abrahamse H. (2010) Effect of Low Level Laser Therapy on human skin keratinocytes. Medtech SA 23(2): 23-29
  • Houreld N.N. and Abrahamse H. (2010) Low Intensity Laser Irradiation (LILI) Stimulates Wound Healing in Diabetic Wounded Fibroblast Cells (WS1). Diabetes Technology and Therapeutics. 12(12): 971-978
  • Sekhejane P., Houreld N. and Abrahamse H. (2011) Irradiation at 636 nm Positively Affects Diabetic Wounded and Hypoxic Cells In Vitro. Photomedicine and Laser Surgery 29(8): 521-530
  • Saayman L., Hay C. and Abrahamse H. (2011) Chiropractic manipulative therapy and low level laser therapy in the management of cerviceal facet syndrome: A randomised controlled study. Journal of Manipulative and Physiological Therapeutics 34(3):153-163
  • Manoto S. and Abrahamse H. (2011) Effect of a newly synthesised Zn Sulfophthalocyanine derivative on cell morphology, viability, proliferation and cytotoxicity in a human lung cancer cell line (A549). Lasers in Medical Science 26:523-530
  • De Villiers J.A., Houreld N. and Abrahamse H. (2011) Influence of Low Intensity Laser Irradiation on Isolated Human Adipose Derived Stem Cells Over 72 Hours and Their Differentiation Potential into Smooth Muscle Cells Using Retinoic Acid. Stem Cell Reviews and Reports 7: 869-882
  • Abrahamse H. (2011) Inducing stem cell differentiation using low intensity laser irradiation: a possible novel therapeutic intervention. Central European Journal of Biology 6(5): 695-698
  • El-Hussein A., Abdel-Harith M. and Abrahamse H. (2011) Assessment of DNA Damage after Photodynamic therapy using a metallophthalocyanine photosensitizer. International Journal of Photoenergy. Volume 2011, Article ID 281068, 10 pages doi:10.1155/2011/281068
  • Manoto S., Sekhejane P., Houreld N.N. and Abrahamse H. (2012) Localization and phototoxic effect of zinc sulfophthalocyanine photosensitizer in human colon (DLD-1) and lung (A549) carcinoma cells in vitro. Photodiagnosis and Photodynamic Therapy. 9: 52-59
  • Houreld N.N., Masha R. and Abrahamse H. (2012) Low-Intensity Laser Irradiation At 660 nm Stimulates Cytochrome C Oxidase In Stressed Fibroblast Cells. Lasers in Surgery and Medicine 44:429-434
  • Horne T.K., Abrahamse H. and Cronje M.J. (2012) Investigating novel metallophthalocyanine PDT-induced MCF-7 cell death efficiency. Photodiagnosis and Photodynamic Therapy. 9: 215-224.
  • Evans D., Maskew M. and Abrahamse H. (2012) Laser irradiation with 648nm light stimulates autophagic human skin keratinocytes. Medtech SA 26(1): 35-43
  • Ayuk S.M., Houreld N. and Abrahamse H. (2012) The associates between the immune system and malignancy. Medtech SA. 26 (2): 49-55
  • Ayuk S.M., Houreld N. and Abrahamse H. (2012) Collagen Production in Diabetic Wounded Fibroblasts in Response to Low Intensity Laser Irradiation (LILI) at 660nm. Diabetes Technology and Therapeutics. 14 (12):1110-1117
  • Nteleki B. and Houreld N.N (2012)The Use of Phototherapy in the treatment of Diabetic Ulcers. JEMDSA. 17(3): 128-132
  • Masha R.T., Houreld N.N and Abrahamse H. (2013) Low Intensity Laser Irradiation at 660 nm Stimulates Transcription of Genes Involved in the Electron Transport Chain. Photomedicine and Laser Surgery. 31(2):47-50
  • Tynga I.M., Houreld N.N and Abrahamse H. (2013) The primary subcellular localization of Zinc Phthalocyanine and its cellular impacts on viability proliferation in structures of breast cancer (MCF-7) cells. Journal of Photochemistry and Photobiology B: Biology. 5:171-176
  • Manoto S.L., Houreld N. and Abrahamse H. (2013) Phototoxic effect of photodynamic therapy on lung cancer cells grown as a monolayer and three dimensional multicelluar spheroid. Lasers in Surgery and Medicine. 45 (3):189-194
  • Mvula B. and Abrahamse H. (2013) The Role of Adipose Derived Stem Cells, Smooth Muscle Cells and Low Intensity Laser Irradiation (LILI) in Tissue Engineering and Regenerative Medicine. Central European Journal of Biology 8(4): 331-336
  • Crous A. and Abrahamse H. (2013) Lung Cancer Stem Cells and Low Intensity Laser Irradiation (LILI): A Potential Future Therapy? Stem Cell Research and Therapy 4(5):129.
  • Houreld N.N. (2014) Shedding Light on A New Treatment for Diabetic Wound Healing. The Scientific World Journal Vol 2014:
  • Tynga I.M., Houreld N.N. and Abrahamse H. (2014) Induced cell death pathway post photodynamic therapy using a metallophthalocyanine photosensitizer in breast cancer cells. Photomedicine and Laser Surgery 32(4): 205-211
  • Houreld N., Ayuk S., and Abrahamse H. (2014) Expression Of Genes Involved In Wound Healing In Response to Irradiation at 660 nm. Journal of Photochemistry and Photobiology B: Biology 130:149-152
  • Sekhejane P., Houreld N. and Abrahamse H. (2014) Multiorganelle Localization of Metallated Phthalocyanine Photosensitizer in Colorectal Cancer Cells (DLD-1 and CaCo-2) Enhances Efficacy of Photodynamic Therapy. International Journal of Photoenergy. Volume 2014, Article ID 383027, 10 pages,
  • Tynga I., Hussein A., Abdel-Harith M. and Abrahamse H. (2014) Photodynamic Ability of Silver Nanoparticles in Inducing Cytotoxic Effects in Breast and Lung Cancer Cell Lines. International Journal of Nanomedicine 9: 3771-3780
  • Moore T.J. and Abrahamse H. (2014) The Neuronal Differentiation of ADSCs: Progress so far. A Mini-Review. International Journal of Photoenergy. Volume 2014: Article ID 827540, 8 pages
  • Ayuk S., Houreld N.N. and Abrahamse H. (2014) Laser Irradiation At 660 nm Alters The Expression Pattern Or Profile Of Genes Involved In The Extracellular Matrix In Wounded And Diabetic Wounded Fibroblast Cells. International Journal of Photoenergy. Volume 2014: Article ID 604518,
  • Mvula B. and Abrahamse H. (2014) Low Intensity Laser Irradiation and Growth Factors Influences Differentiation of Adipose Derived Stem Cells into Smooth Muscle Cells in a Co-culture Environment Over a Period of 72 hours. International Journal of Photoenergy Volume 2014: Article ID 598793,
  • Nanjundaswamy H.M. and Abrahamse H. (2014) Green Synthesis of 5-Substituted- 1H- 1,2,3,4-Tetrazoles and 1-Substituted-1H-1,2,3,4-Tetrazoles via [3+2] Cycloaddition by Reusable Immobilized AlCl3 ON ᵞ-Al2O3. Heterocycles 89(9): 1-14
  • Houreld N.N. (2015) Healing of Diabetic Ulcers Using Photobiomodulation. Photomedicine and Laser Surgery 33(5): 237-239
  • Fekrazada R., Ghuchanib M.S., Eslaminejadc M.B., Taghiyarc L., Kalhorid K.A.M., Pedrame M.S., Shayanf A.M., Aghdamic N. and Abrahamse H. (2015) The effects of combined low level laser therapy and mesenchymal stem cells on bone regeneration in rabbit calvarial defects. Journal of Photochemistry and Photobiology B. Biology 151: 180–185
  • Tynga I. and Abrahamse H. (2015) Cell Death Pathways and Phthalocyanine as an Effective Agent for Photodynamic Cancer Therapy. International Journal of Molecular Science 16, 10228-10241; doi:10.3390/ijms160510228
  • Knyazev N.A., Samoilova K.A., Abrahamse H. and Filatova N.A. (2015) Downregulation of Tumorogenicity And Changes In The Actin Cytoskeleton Of Murine Hepatoma After Irradiation With Polychromatic Visible And IR Light. Photomedicine and Laser Surgery 16(4): 185-192
  • Pamar M. G., Govender P., Pillay K., Abrahamse H. and Nanjundaswamy H.M. (2015) A fast and benign synthesis of α-aminonitriles by reusable immobilized AlCl3 on γ-Al2O3. Indian Journal of Chemistry B 54(B): 110-116
  • Nanjundaswamy H.M and Abrahamse H. (2015) Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable Immobilized AlCl3 on γ-Al2O3. Synthetic Communications. 45: 967-974.
  • Manoto S., Houreld N. and Abrahamse H. (2015) Resistance of lung cancer cells grown as multicellular tumour spheroids to zinc sulfophthalocyanine photosensitization. International Journal of Molecular Sciences 16: 10185-10200; doi:10.3390/ijms160510185
  • George B., MfouoTynga I. and Abrahamse H. (2015) In vitro antiproliferative effect of the acetone extract of Rubus fairholmianus Gard. root on human colorectal cancer (Caco-2) cells. Biomed Research International. Volume 2015, Article ID 165037, 8 pages
  • Abrahamse H. (2015) Stimulation of Cellular Proliferation and Migration. Is it a Viable Measure of Photobiomodulation? Photomedicine and Laser Surgery. 33(7):1-2
  • El-Husseiny A., Tynga I., Abdel-Harith M. and Abrahamse H. (2015) Comparative study between the photodynamic ability of gold and silver nanoparticles in mediating cell death in breast and lung cancer cell lines. Journal of Photochemistry and Photobiology. B Biology. 153: 67-75.
  • Nanjundaswamy H.M and Abrahamse H. (2015) Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable Immobilized AlCl3 on γ-Al2O3. Synthetic Communications 45:967-974
  • Abrahamse H. and Hamblin M.R. (2016) New Photosensitizers for Photodynamic Therapy. Biochemical Journal. 473(4): 347-364.
  • Crous A. and Abrahamse H. (2016) Low Intensity Laser Irradiation at 636 nm Induces Increased Viability and Proliferation in Isolated Lung Cancer Stem Cells. Photomedicine and Laser Surgery. In Press
  • George B.P and Abrahamse H. (2016) A review on novel breast cancer therapies: Photodynamic therapy and plant derived agents induced cell death mechanisms. Anti-Cancer Agents in Medicinal Chemistry. In Press
  • George B.P., Abrahamse H. and Parimelazhagan, T. (2016) Caspase dependent apoptotic activity of Rubus fairholmianus Gard. on MCF-7 human breast cancer cell lines. Journal of Applied Biomedicine. In Press
  • Mvula B. and Abrahamse H. (2016) Differentiation Potential of Adipose Derived Stem Cells When Co-cultured with Smooth Muscle Cells and the Role of Low Intensity Laser Irradiation. Photomedicine and Laser Surgery. In Press
  • Nanjundaswamy M H, Abrahamse H, George B, Ramesh G, and Govender P (2016) Functionalized silver nanoparticle catalyzed [3+2] cycloaddition reaction: Greener route to substituted-1,2,3-triazolines. Catalysis Letters. 146(2): 464-473.
  • Nanjundaswamy M.H., Abrahamse H. and Pillay K. (2016) Functionalization and N-methylation of β-amyloid residue (32–37): active on gram positive bacterium. Applied Biochemistry and Microbiology. In Press
  • Nteleki B., Abrahamse H. and Houreld N. (2016) Conventional Podiatric Interventions and Phototherapy in the Treatment of Diabetic Ulcers: A Pilot Study. Seminars in Vascular Surgery, In Press.