PAPERS UTILISING THE INTESTINAL CELL LINES DERIVED FROM THE "IMMORTOMOUSE"

(SV40 LARGE T TRANSGENIC MICE)

  1. Whitehead RH, VanEedenPE, Noble MD, Ataliotis P, Jat PS (1993) The establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. PNAS, 90:587-591.
  2. Whitehead RH, Joseph J (1994) Derivation of conditionally immortalized cell lines containing the Min mutation from the normal colonic mucosa and other tissues of F1 mouse (Immortomouse/Min). Epithelial Cell Biology, 3:119-125.
  3. Whitehead RH, Joseph R(1995) Development of intestinal cell lines using a transgenic mouse. Methods in Cell Sci, 17:97-102.
  4. D’Abaco G,Whitehead RH, Burgess AW (1996) Synergy between Apc and an activated ras mutation is sufficient to induce colon carcinomas. Mol Cell Biol. 16:884-891.
  5. Polk, D.B. (1996) Phospholipase C and tyrosine kinase activities are required for EGF-mediated intestinal cell migration and adhesion. Proceedings of the American Gastroenterology Association.
  6. Aukema HM, Davidson LA, Pence BC, Jiang Y-H, Lupton JR, Chapkin RS (1997) Butyrate alters activity of specific cAMP-receptor proteins in a transgenic mouse colonic cell line. J. Nutrition, 127:18-24.
  7. Kaiser GC, Polk DB (1997) Tumor necrosis factor  regulates proliferation in a mouse intestinal cell line. Gastroenterology, 112:1231-1240.
  8. Whitehead RH, Watson NK (1996)Gastrointestinal cell lines as a model for differentiation. In: The Gut as a Model in Cell and Molecular Biology. Falk Symposium No. 94 ed: F. Halter, D. Winton and N.A. Wright.
  9. Hollande F, Imdahl A, Mantamadiotis T, Ciccotosto G, Shulkes A, Baldwin G (1997) Glycine-extended gastrin acts as an autocrine growth factor in a non-transformed cell line. Gastroenterology, 113:1576-1588.
  10. Polk DB (1998)Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity. Gastroenterology, 114:493-502.
  11. Fan Y-Y, Zhang J, Barhoumi R, Burghardt R, Turner ND, Lupton J, Chapkin R (1999) Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells. Am J Physiol, 277:C310-319.
  12. Davidson LA, Lupton J, Jiang Y-H, Chapkin R (1999) Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. Carcinogenesis, 20:785-791.
  13. Mei, J.M., Hord, N.G., Winterstein, D.F., Donald, S.P., Phang, J.M. (1999) Differential expression of prostoglandin endoperoxidase H synthase-2 and formation of activated b-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. Carcinogenesis, 20:737-740.
  14. Allen,K.J., Reyes,R., Demmler,K., Mercer, J.F., Williamson, R., WHITEHEAD, R.H. (2000) Conditionally immortalised mouse hepatocytes for use in liver gene therapy. J Hepatol Gastro, 15:1325-1332.
  15. Polk, D.B., Tong, W. (1999) Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line. A J Physiol, 277:C1149-C1159 (Cell Physiol, 46).
  16. Yan, F., Polk, D.B. (1999) Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J Biol Chem, 274:36631-36636.
  17. Imdahl A, Hock M, Kuzeawu A, Mantamadiotis T, Baldwin G (1999) Expression of gastrin/CCK-B receptors does not lead to a mitogenic response to gastrin in two colon cell lines. J Surg Res, 86:108-115.
  18. Kaiser GC, Yan F, Polk DB (1999) Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal eepithelial cells by regulating mitogen-activated protein kinase. Exp Cell Res, 249:349-58.
  19. Kaiser GC, Yan F, Polk DB (1999) Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology, 116:602-9.
  20. Szabo, I., Rumi, G., Bodis, B., Nemeth, P., Mozsik, G. (2000) Gastrin and pentagastrin enhance the tumour proliferation of stable cultured gastric adenocarcinoma cells. J Physiol Paris, 94:71-74.
  21. Mei J, Hord N, Winterstein DF, Donald S,Phang J (2000) Expression of prostaglandin endoperoxidase H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells. FASEB, 14:1188-1201.
  22. Mei, J.M., Hord, N.G., Winterstein, D.F., Donald, S.P., Phang, J.M. (2000) Differential formation of beta-catenin/ lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (APC) genotype. Cancer Res, 60:3379-3383.
  23. Baldwin G, Hollande F, Yang Z, Kkarelina Y, Paterson A, Strang R, Fourmy D, Neumann G, Shulkes A (2001) Biologically active recombinant human progastrin 6-80 contains a tightly bound calcium ion. Biol Chem, 276:7791-7796.
  24. Wagenaar R, Crawford H, MatrisianL (2001) Stabilized β-catenin immortalizes colonic epithelial cells. Cancer Res,61:2097-2104.
  25. Chapkin R, Fan Y, Lupton J (2000) Effect of diet on colonic-programmed cell death: molecular mechanism of action. Toxicol Lett, 15:112-113.
  26. Collett ED, Davidson LA, Fan YY, Lupton JR, Chapkin RS (2001) n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in Colonocytes. Am J Physiol Cell Physiol, 280:C1066-1075.
  27. Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM (2001) Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res, 61:1810-1815.
  28. Roman CD, Morrow J, Whitehead R,Beauchamp RD (2002) Induction of COX-2 and invasiveness by TGF-β1 in immortalized mouse colonocytes expressing oncogenic Ras. JGI Surgery, 6:304-309.
  29. Yan, F., John, S.K., Polk, D.B. (2001) Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Research, 61:8668-8675.
  30. Nambiar, P.R., Giardina, C., Guda, K., Aizu, W., Raja, R., Rosenberg, D.W. (2002) Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model. Cancer Res, 62:3667-74.
  31. Fenton JI, Wolff MS, Orth MW, Hord NG (2002) Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in apc genotype. Carcinogenesis, 23:1065-1070.
  32. Yan F, Polk DB (2002) Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cell. Biol Chem, 27:50959-50965.
  33. Dong, M. ,Guda, K., Nambiar, P.R., Rezaie, A., Belinsky, G.S., Lambeau, G., Giardina, C., Rosenberg, D.W. (2003) Inverse associastion between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis. Carcinogenesis, 24:307-315.
  34. Cui, H., Dong, M. Sadhu, D.N., Rosenberg, D.W. (2003) Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects β-catenin turnover in young mouse colon (YAMC) epithelial cells. Experimental Cell Research, 280:12-23.
  35. Corredor Buchmann J, Fang Y, Tong W, John S, Whitehead, R.H., Wilson, G., Shen, C., Polk, D.B. (2003) Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. AJP,284:C953-C961.
  36. Husoy, T., Cruciani, V., Knutsen. H.K., Mikalsen, S.O., Olstorn, H.B., Alexander, J. (2003) Cells heterozygous for the APC(Min) mutationm have decreased gap junctional intercellular communication and connexion 43 level, and reduced microtubule polymerization. Carcinogenesis, 24:643-650.
  37. Kojima K, Musch M, Ren H, Boone D, Hendrickson B, Chang E (2003) Enteric flora and lymphocyte derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology, 124:1395-1407.
  38. Fan,Y.Y., Spencer, T.E., Wang, N., Moyer, M.P., Chapkin, R.S. (2003) Chemopreventive n-3 fatty acids activate RXR {alpha} in colonocytes. Carcinogenesis, 24:1541-1548.
  39. Garton K, Gough P, Philalay J, Wille P, Blobel C, Whitehead R, Dempsey P, RainesE (2003) Stimulated shedding of VCAM-1 is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM17). J Biol Chem, 278:37459-37464.
  40. Hollande F., Lee, D.J., Choquet, A., Roche, S., Baldwin, G.S. (2003) Adherans junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. J Cell Sci, 116:1187-1197.
  41. Toback, F.G., Walsh-Reitz, M.M., Musch, M.W., Chang, E.B., Del Valle, J., Ren, H., Martin, T.E. (2003) Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am. J. Physiol. Gastrointest. Liver Physiol, 285:G344-G353.
  42. Kojima K, Musch M, Ropelski M, Boone D, Ma A, Chang E (2004) Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation. Am J Physiol Gastrointest Liver Physiol, 286:G645-G652.
  43. Liu, Y., Borchert, G.L., Phang, J.M. (2004) PEA3, an ETS transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J Biol Chem, 279:18694-18700.
  44. Bateman, N.W., Tan, D., Pestell, R.G., Black, J.D., Black, A.R. (2004) Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem, 279:12093-12101.
  45. Mithani, S.K., Balch, G.C., Shiou, S.R., Whitehead, R.H., Datta, P.K., Beauchamp, D.D. (2004) Smad3 has a critical role in TGF-beta-mediated growth inhibition and aspoptosis in colonic epithelial cells. Surg Res, 117:296-305.
  46. Reichelt WH, De Angelis P, Knutsen H, Husoy T, Elgio K, Reichelt K (2004)The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits the growth of nmon-tumorigenic colonic epithelial cells. Anticancer Res, 24:587-591.
  47. Reichelt WH, Iversen JG, Paulsen JE, Elgjo K, Reichelt K (2004) Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic ANP level in non-tumorigenic colonic epithelial cells. Anticancer Res, 24:1465-1468.
  48. Fenton, J.I., Hord, N.G. (2004) Flavanoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: Implications of matrix metalloproteinase activity. Nutr Cancer, 48:182-188.
  49. Yan F, John SK, Wilson G, Jones DS, Washington MK, Polk DB (2004) Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest, 114:1233-1237.
  50. Ramsay, R.G., Micallef, S., Williams, B., Lightowler, S., Vincan, E., Heath, J.K., Mantamadiotis, T., Bertoncello, I. (2004) Colony-stimulating factor-1 promotes clonogenic growth of normal murine colonic crypt epithelial cells in vitro. J Interferon and Cytokine Res, 24:416-427.
  51. Petrof E, Kojima K, Ropeleski M, Musch M, Tao Y, deSimone C, Chang E (2004) Probiotics inhibit nuclear factor-κB and induce heat shock proteins in colonic epithelial cells through proteosome inhibition. Gastro, 127:1474-1487.
  52. Frey MR, Golovin A, Polk DB. Epidermal growth factor-stimulated intestinal epithgelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J Biol Chem, 279:44513-44521.
  53. Romero-Gallo, J., Sozeman, E., Chytil, A. Russell, W.E., Whitehead, R., Parks, W.T., Gautam, S., Magnuson, M., Moses, H.L., Gady, W.M. (2005) Inactivation of TGFb signalling in hepatocytes results in increased proliferative response after partial hepatectomy. Oncogene,24:3028-41.
  54. Ramsay R, Ciznadija D, Sicurella C, Reyes N, Mitchelhill K, Darcy P, D’Abaco G, Mantamadiotis T (2005) Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS. DNA Cell Biol, 24:21-29.
  55. Musch MW, Petrov E, Kojima K, Reh H, McKay D, Chang E (2004) Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun, 72:3187-3194.
  56. Ito, D., Fujimoto, K., Doi, R., Koizumi, M., Toyodam e., Mori, T., Kami, K., Kawaguchi, M., Whitehead, R., Imamura, M. (2004) Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21 WAF1/CIP1 in conditionally immortalized pancreatic epithelial cells. Surgery, 136:364-374.
  57. Ng Y, Barhoumi R, Tjalkens R, Fan YY, Kolar S, Wang N, Lupton JR, Chapkin RS (2005) The role of docasahexanoic acid in mediating mitochondrial membrane lipid oxidation and apoptoisis in colonocytes. Carcinogenesis, 191:4-21.
  58. Franco, AT, Israel, DA, Washingtopn, MK, Krishna, U, Fox, JG, Rogers, AB, Neish, AS, Collier-Hyams, L, Perez-Perez, GI, Hatekeyama, M, Whitehead, R, Gaus, K, O’Brien, DP, Romero-Gallo, J, Peek, RM. (2005) Activation of beta-catenin by carcinogenic Helicobacter pylori. PNAS,102:1046-1051.
  59. Fenton, JI, Hord, NG, Lavigne, JA, Perkins, SN, Hursting, SD.(2005)Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in Apc/Min +/- but not Apc +/+ colonic epithelial cell lines. Cancer Epidemiol Biomarkers Prev, 14:1646-1652.
  60. Yang R, Bie, W, Haegebarth A, Tyner AL (2006) Differential regulation of D-type cyclins in the mouse intestine. Cell Cycle, 5:180-183.
  61. Fenton JI, Hord NG. (2006) Stage matters:choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research. Carcinogenesis, 27:893-902.
  62. Fenton JI, HurstingSD, Perkins SN, Hord NG (2006) Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min +/-) colon epithelial cell line. Carcinogenesis, 27:1507-1515.
  63. Andreassen A, Vikse R, Mikalsen A, Adamovic T, Steffensen IL, Hjertholm H, Levan G, Alexander J. (2006) 1-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with Apc(Min) mutation. Mutat Res, 604:60-70.
  64. Wai, PY, Mi Z, Gai C, Guo H, Marroquin C, Kuo PC (2006) Ets-1 and Runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. J. Biol. Chem, 281:18973-19882.
  65. Yan, F., Cao, H., Cover, T.L., Whitehead, R., Washington, M.K., Polk, D.B. (2006) Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology, 132:562-575.
  66. Frey MR, Dise RS, Polk DB (2006) P38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. The EMBO Journal, 25:5683-5692.
  67. Ho S, Dvorak L, Moor R, Jacobson A, Frey M, Corredor J, Polk D, Shekels L (2006) Cysteine-rich domains of Muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastro, 131:1501-1517.
  68. Fenton JI, HurstingSD, Perkins SN, Hord NG (2007) Leptin induces an Apc genotype associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. Carcionogenesis 28:455-464.
  69. Marchbank T, Mahmood A, Fitzgerald AJ, Domin J, Butler M, Goodlad RA, Elia G, Cox HM, van Heel DA, Ghosh S, Playford RJ (2007) Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents. Am J Pathol, 171:1462-1473.
  70. Whitehead RH, Robinson PS, Williams JA, Bie W, Tyner AL, Franklin JL (2008) A conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro. J Gastro Hepatol, 23:1119-1124.
  71. Dise RS, Frey MR, Whitehead RH, Polk DB (2008) Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol, 294:G276-G285.
  72. Fenton JI, Lavigne JA, Perkins SN, Liu H, Chandramouli GV, Shih JH, Hord NG, Hursting SD (2008) Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. Mol Carcinog,47:9-21.
  73. Tanaka M,Jin G, Yamazaki Y, Takahara T, Takuwa M, Nakamura T (2008) Identification of cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis. Cancer Sci, 99:979-985.
  74. Said ZM, Subramanian VS, VaziriND, Said HM (2008) Pyroxidine uptake by colonocytes: A specific and regulated carrier-mediated process. Am J Physiol Cell Physiol, 294:C1192-C1197.
  75. Fenton JI, Birmingham JM, Hursting SD, Hord NG (2008) Adiponectin blocks multiple signalling cascades associated with leptin-induced cell proliferation in Apc(Min/+) colon epithelial cells. Int J Cancer, 122:2437-2445.
  76. Singh K, Chaturvedi R, Asim M, Barry DP, Lewis ND Vitek MP. Wilson KT (2008) The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to citrobacter rodentium in colonic epithelial cells by preventing NF-Kappa B activation. J. Biol Chem,283:16752-16761.
  77. McMurray H, Sampson E, Compitello G, Kinsey C, Newman L, Smith B, Chen S-R, Klebanov L, Yalolev A, Land H (2008) Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature, 453:1112-1117.
  78. Constancio-Lund SS, Brabek J, Hanks SK (2008) Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. Mol Carcinog,in press.
  79. Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB (2008) Raf protects against colitis by promoting mouse colonic epithelial cell survuval through NF-kB. Gastroenterology, 135:539-551.
  80. Antanasov A, Leiser D,Roesselet C, Noti M, Corazza N, Schoonjans K, Brunner T (2008) Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. FASEBJ, in press.
  81. Frey MR, Edelblum KL, Mullane MT, Liang D, Polk DB (2008) The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology, in press.