Papers Published in Refereed Journals

Papers published in refereed journals

1.Tang C.M., Rolfe M., Wells J.C., Cham K. Outbreak of beri-beri in The Gambia. Lancet. 1989 ii: 206-207.

2.Rolfe M., Tang C.M.,Walker R.W., Bassey E., George M. Diabetes mellitus in The Gambia, West Africa. Diabet. Med. 1992 9: 484-488.

3.Rolfe M., Tang C.M.,Walker R.W., Bassey E., George M. Peripartum cardiac failure in The Gambia. J. Trop. Med. Hyg. 1992 95: 192-196.

4.Tang C.M., Cohen J. Diagnosing fungal infections in immunocompromised hosts. J. Clin. Pathol. 1992 45: 1-5.

5.Tang C.M., Cohen J., Holden D.W. An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity. Mol. Microbiol. 1992 6: 1663-71.

6.Tang C.M., Macfarlane J.T. Early management of younger adults dying of community-acquired pneumonia. Resp. Med. 1993 148: 1313-1317.

7.Tang C.M. Successful treatment of Candida albicans osteomyelitis with fluconazole. J. Infect. 1993 26: 89-92.

8.Tang C.M., van Noorden S., Cohen J., Holden D.W. The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis. Infect. Immun. 1993 61: 1650-6.

9.Tang C.M., Holden D.W., Cohen J. The detection of Aspergillus spp. by the polymerase chain reaction and its evaluation in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 1993 148: 1313-1317.

10.Rolfe M., Tang C.M., Sabally S., Todd J.E., Sam E.B., Hatib N'Jie A.B. Psychosis and cannabis abuse in The Gambia. A case-control study. Br. J. Psych. 1993 163: 798-801.

11.Aufauvre-Brown A., Tang C.M., Holden D.W. Detection of gene-disruption events in Aspergillus transformants by polymerase chain reaction direct from conidiospores. Curr. Genet. 1993 24: 177-178.

12.Ventkatesan P., Sole K., Tang C., Macfarlane J.T., Finch R.G. Oropharyngeal production of pneumococcal capsular antigen and the potential for contamination of expectorated sputum samples in pneumococcal pneumonia. Epidemiol. Infect. 1993 110:621-631.

13.Tang C.M.,Cohen J., Rees A.J., Holden D.W. Molecular epidemiological study of invasive pulmonary aspergillosis in a renal transplantation unit. Eur. J. Clin. Microbiol. Infect. Dis. 1994 13: 318-321.

14.Tang C.M.,Smith J.M., Arst H.N. Jr, Holden D.W. Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis. Infect. Immun. 1994 62: 5255-60.

15.Smith J.M., Tang C.M.,Van Noorden S., Holden D.W. Virulence of Aspergillus fumigatus double mutants lacking restrictocin and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis. Infect. Immun. 1994 62: 5247-54.

16.Holden D.W., Tang C.M., Smith J.M. Molecular genetics of Aspergillus pathogenicity. Antonie Van Leeuwenhoek 1994 65: 251-255.

17.Tang C.M., Crook D.W. The treatment of candidemia. N. Engl. J. Med. 1995 332: 1101.

18.Hensel M., Tang C.M., Arst, Jr. H.N., Holden D.W. Regulation of fungal extracellular proteases and their role in pathogenesis. Can. J. Bot. 1995 73: 1065-1070.

19.Tang C.M., Conlon C.P., Miller R.F. Pyrexia of undetermined origin in advanced HIV disease. Genitourin. Med. 1997 73:308-13.

20.Tang C.M., Bowler I.C. Do the new lipid formulations of amphotericin B really work? Clin. Microbiol. Infect. 1997 3: 283-288.

21.Tang C.M., Hood, D.W., Moxon, E.R. Haemophilus influence: the impact of whole genome sequencing on microbiology. Trends Genet. 1997 13: 399-404.

22.Tang C.M., Hood, D.W., Moxon, E.R. Microbial genome sequencing and pathogenesis. Curr. Opin. Microbiol. 1998 1: 12-16.

23.Tang C.M., Moxon, E.R., Levine, M.M. Live attenuated vaccines for group B meningococcal disease. Vaccine. 1998 17: 114-117.

24.McShane H., Tang C.M., Conlon C.P. Disseminated Penicillium marneffei infection presenting as a right upper lobe mass in an HIV positive patient. Thorax. 1998 53: 905-6.

25.Tang C.M., Holden D.W. Pathogen virulence genes-implications for vaccines and drug therapy. Brit. Med. Bull. 1999 55: 387-400.

26.Tang C.M., Kwiatowski, D. Mannose binding lectin and meningococcal disease. Lancet. 1999 354: 336.

27.Plested, J., Makepeace, K., Hood, D.W., Tang, C.M.,Makepeace K., Coull P.A., Wright J.C., Chalmers R., Hood D.W., Richards J.C., Moxon E.R.Identification of a conserved inner core lipopolysaccharide epitope in Neisseria meningitidis. Infect. Immun. 1999 67: 5417-26.

28.Martindale J., Stroud D., Moxon E.R., Tang C.M. Genetic analysis of Escherichia coli K1 gastrointestinal colonisation. Mol. Microbiol. 2000 37: 1293-305.

*29.Sim R.J., Harrison M.M., Moxon E.R., Tang C.M. Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing. Lancet. 2000 356: 1653-4.

30.Lestrate P., Delrue R.M., Danese I., Didembourg C., Taminiau B., Mertens P., De Bolle X., Tibor A., Tang C.M., Letesson J.J. Identification and characterization of in vivo attenuated mutants of Brucella melitensis. Mol. Microbiol. 2000 38: 543-51.

*31.Sun Y.H., Bakshi S., Chalmers R., Tang C.M. Functional genomics of Neisseria meningitidis pathogenesis. Nature Med. 2000 6: 1269-73.

32.Moxon E.R., Tang C.M. Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens. Philos. Trans R. Soc. Lond. B Biol. Sci. 2000 355: 643-56.

33.Tang C.M., Bakshi S., Sun Y.H. Identification of bacterial genes required for in-vivo survival. J. Pharm. Pharmacol. 2001 53: 1575-9.

34.Tang C.M., Moxon E.R. The impact of microbial genomics on antimicrobial drug development. Annu. Rev. Genomics Hum. Genet. 2001 2: 259-69.

35.Mackinnon F.G., Cox A.D., Plested J.S., Tang C.M., Makepeace K., Coull P.A., Wright J.C., Chalmers R., Hood D.W., Richards J.C., Moxon E.R. Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis. Mol. Microbiol. 2002 43: 931-43.

36.Winzer K., Sun Y.H., Green A., Delory M., Blackley D., Hardie K.R., Baldwin T.J., Tang C.M. Role of Neisseria meningitidis luxS in cell-to-cell signaling and bacteremic infection. Infect. Immun. 2002 70: 2245-8.

37.Tang C.M., Stroud D., Mackinnon F., Makepeace K., Plested J., Moxon E.R., Chalmers R. Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide. Gene. 2002 284: 133-4.

38.Buisine N., Tang C.M., Chalmers R. Transposon-like Correia elements: structure, distribution and genetic exchange between pathogenic Neisseria spp. FEBS Lett. 2002 522: 52-8.

39.Bahrani-Mougeot F.M., BucklesE.L., LockatellC.V., HebelJ.R., JohnsonD.E., TangC.M., DonnenbergM.S. Type-1 fimbriae and extracellular polysaccharides are pre-eminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Mol. Microbiol. 2002 45:1079-93.

40.Greiner O., Berger C., Day P.J., Meier G., Tang C.M., Nadal D. Rates of detection of Neisseria meningitidis in tonsils differ in relation to local incidence of invasive disease. J. Clin. Microbiol. 2002 40: 3917-21.

41.West N.P., Sansonetti P.J., Frankel G., Tang C.M. Finding your niche: what has been learnt from STM studies on GI colonization. Trends Microbiol. 2003 11: 338-44.

42.Corbett A., Exley R., Bourdoulous S., Tang C.M. Interactions between Neisseria meningitidis and human cells that promote colonisation and disease. Expert Rev. Mol. Med. 2004 6: 1-14.

43.Li Y., Sun Y.H., Ison C., Levine M.M., Tang C.M. Vaccination with attenuated Neisseria meningitidis strains protects against challenge with live meningococci. Infect. Immun. 2004 72:345-51.

44.Stabler R.A., Marsden G.L., Witney A.A., Li Y., Bentley S.D., Tang C.M., Hinds J. Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. Microbiology. 2005 151: 2907-22.

*45.Exley R.M., Goodwin L., Mowe E., Shaw J., Smith H., Read R.C., Tang C.M.Neisseria meningitidis lactate permease is required for nasopharyngeal colonization. Infect. Immun. 2005 73: 5762-6.

46.Sun Y., Li Y., Exley R.M., Winterbotham M., Ison C., Smith H., Tang C.M. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 2005 23: 4136-41.

*47.Exley R.M., Shaw J., Mowe E., Sun Y.H., West N.P., Williamson M., Botto M., Smith H., Tang C.M. Available carbon source influences the resistance of Neisseria meningitidis against complement. J. Exp. Med. 2005 201: 1637-45.

48.Sun Y.H., Exley R., Li Y., Goulding D., Tang C. Identification and characterization of genes required for competence in Neisseria meningitidis. J. Bacteriol. 2005 187: 3273-6.

*49.West N.P., Sansonetti P., Mounier J., Exley R.M., Parsot C., Guadagnini S., Prévost M.C., Prochnicka-Chalufour A., Delepierre M., Tanguy M., Tang C.M. Optimization of virulence functions through glucosylation of Shigella LPS. Science. 2005 307: 1313-7.

50.Li Y., Zhang Q., Winterbotham M., Mowe E., Gorringe A., Tang C.M. Immunization with live Neisseria lactamica protects mice against meningococcal challenge and can elicit serum bactericidal antibodies. Infect. Immun. 2006 74: 6348-55.

51. Mazurkiewicz P., Tang C.M., Boone C., Holden D.W. Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat. Rev. Genet. 2006 7: 929-39.

*52.Schneider M.C., Exley R.M., Chan H., Feavers I., Kang Y.H., Sim R.B., Tang C.M. Functional significance of factor H binding to Neisseria meningitidis. J. Immunol. 2006 176: 7566-75.

53.Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X. Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254. Proteomics. 2006 6: 3400-13.

54.Smith H., Tang C.M., Exley R.M. Effect of host lactate on gonococci and meningococci: new concepts on the role of metabolites in pathogenicity. Infect Immun. 2007 75: 4190-8.

55.Schneider M.C., Exley R.M., Ram S., Sim R.B., Tang C.M. Interactions between Neisseria meningitidis and the complement system. Trends Microbiol. 2007 15: 233-40.

*56.Carpenter E.P., Corbett A., Thomson H., Adacha J., Jensen K., Bergeron J., Kasampalidis I., Exley R., Winterbotham M., Tang C.M.,† Baldwin G.S., Freemont P. AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. EMBO J. 2007 26:1363-72. †joint corresponding author

*57.Exley R.M., Wu H., Shaw J., Schneider M.C., Smith H., Jerse A.E., Tang C.M. Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae. Infect. Immun. 2007 75: 1318-24.

58.Uria M.J., Zhang Q., Li Y., Chan A., Exley R.M., Gollan B., Chan H., Feavers I., Yarwood A., Abad R., Borrow R., Fleck R.A., Mulloy B., Vazquez J.A., Tang C.M. A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies. J. Exp. Med. 2008 205:1423-34.

59.Kugelberg E., Gollan B., Tang C.M. Mechanisms for avoidance of complement mediated lysis in N. meningitidis. Vaccine. 2008 S8: I34-9.

60. Exley R.M., Sim R., Goodwin L., Schneider M.C., Read R.C., Tang C.M. Identification of meningococcal genes required for colonisation of human upper airway tissue. Infect. Immun. 2009 77:45-51

66.Heurlier K., Vendeville A., Halliday N., Green A., Winzer K., Tang C.M., Hardie K.R. Growth deficiencies of Neisseria meningitidis pfs and luxS mutants are not due to inactivation of quorum sensing. J. Bacteriol. 2009 191: 1293-302.

*61.Schneider M.C., Prosser B.E., Caesar J., Kugelberg E., Li S., Quoraishi, S., Lovette J., Sim R.B., Roversi P., Johnson S., Tang C.M.,† Lea S†. Immune evasion through protein mimicry of charged host carbohydrates by Neisseria meningitidis. Nature. 2009 458:890-3. †joint corresponding authors.

62. Li Y., Wooldridge K.G., Javed M.A., Tang C.M., Ala'aldeen D.A. Secreted proteins of Neisseria meningitidis protect mice against infection. Vaccine. 2009 271: 2320-5.

63.Ray K., Marteyn B., Sansonetti P.J., Tang C.M. Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat. Rev. Microbiol. 2009 7: 333-40.

64.Lo H., Tang C.M., Exley R.M. Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development. Lancet Infect. Dis. 2009 9:418-27.

65.Lucidarme J., Comanducci M., Findlow J., Gray S.J., Kaczmarski E.B., Guiver M., Kugelberg E., Vallely P.J., Oster P., Pizza M., Bambini S., Muzzi A., Tang C.M., Borrow R. Characterization of fHbp, nhba (gna2132), nadA, porA, sequence type (ST), and genomic presence of IS1301 in group B meningococcal ST269 clonal complex isolates from England and Wales. J. Clin. Microbiol. 2009 47:3577-85.

66.Ray K., Bobard A., Danckaert A., Paz-Haftel I., Clair C., Ehsani S., Tang C., Sansonetti P., Tran Van Nhieu G., Enninga J. Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time. Cell. Microbiol. 2009 12:545-56.

67.Kugelberg E., Gollan B., Farrance C., Bratcher H., Lucidarme J., Ibarz-Pavón A.B., Maiden M.C., Borrow R., Tang C.M.The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease. PLoS One. 2010 5:e9413.

68.Tsolakos N., Lie K., Bolstad K., Maslen S., Kristiansen P.A., Høiby E.A., Wallington A., Vipond C., Skehel M., Tang C.M., Feavers I.M., Wedege E., Wheeler J.X. Characterization of meningococcal serogroup B outer membrane vesicle vaccines from strain 44/76 after growth in different media. Vaccine. 2010 28:3211-8.

69.Chaudhuri R.R., Sebaihia M., Hobman J.L., Webber M.A., Leyton D.L., Goldberg M.D., Cunningham A.F., Scott-Tucker A., Ferguson P.R., Thomas C.M., Frankel G., Tang C.M., Dudley E.G., Roberts I.S., Rasko D.A., Pallen M.J., Parkhill J., Nataro J.P., Thomson N.R., Henderson I.R. Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One. 2010 5:e8801.

*70.Marteyn B., West N.P., Browning D.F., Cole J.A., Shaw J.G., Palm F., Mounier J., Prévost M.C., Sansonetti P., Tang C.M. Modulation of Shigella virulence in response to available oxygen in vivo. Nature 2010 465:355-8.

72. Eilers B., Mayer-Scholl A., Walker T., Tang C., Weinrauch Y., Zychlinsky A. Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion Cell. Microbiol. 2010 8: 1134–1143

73.Cehovin A., Winterbotham M., Lucidarme J., Borrow R., Tang C.M., Exley R.M., Pelicic V. Sequence conservation of pilus subunits in Neisseria meningitidis. Vaccine. 2010 28:4817-4826.

74.Sutherland T.C., Quattroni P., Exley R.M., Tang C.M. Transcellular passage of Neisseria meningitidis across a polarised respiratory epithelium. Infect. Immun. 2010 78:3832-3847.

75.Zhang Q., Li .Y, Tang C.M.The role of PPX in avoidance by Neisseria meningitidis of complement-mediated killing. J. Biol. Chem. 2010 285:34259-34268

76. Marteyn B., Scorza F.B., Sansonetti P.J., Tang C.M. Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell. Microbiol. 2011 13:171-6.

77. Lucidarme J., Tan L., Exley R.M., Findlow J., Borrow R., Tang C.M.Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein. Clin. Vaccine Immunol. 2011 18:1002-101.

78. Trivedi K., Tang C.M., Exley R.M. Mechanisms of meningococcal colonisation. Trends Microbiol. 2011 19: 456-63.

79.Quattroni P., Exley R.M., Tang C.M. New insights into pathogen recognition. Expert Rev. Anti. Infect. Ther. 2011 9: 577-9.

*80. Talà A., Monaco C., Nagorska K., Exley R.M., Corbett A., Zychlinsky A., Alifano P., Tang C.M. Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst. Mol. Microbiol. 2011 81:1330-42.

*81.Silhan J., Nagorska K., Zhao Q., Jensen K., Freemont P.S., Tang C.M.,† Baldwin G.S. Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis. Nucleic Acids Res. 2012 40:2065-75 †joint corresponding author

*82. Nagorska K., Silhan J., Li Y., Pelicic V., Freemont P.S., Baldwin G.S, Tang C.M. A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis. Mol. Microbiol. 2012 83:1064-79.

83.Quattroni P., Li Y, Lucchesi D., Lucas S., Hood D.W., Herrmann M., Gabius H.J., Tang C.M., Exley R.M. Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells. Cell. Microbiol. 2012 14:1657-75.

84.Teo I., Toms S.M., Marteyn B., Barata T.S., Simpson P., Johnston K.A., Schnupf P.,Puhar A., Bell T., Tang C.,Zloh M., Matthews S., Rendle P.M., Sansonetti P.J., Shaunak S. Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers. EMBO Mol. Med. 2012 9:866-81.

85.Lu D., Silhan J., MacDonald J.T., Carpenter E.P., Jensen K., Tang C.M.,† Baldwin G.S., Freemont P.S. Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.Proc. Natl. Acad. Sci. U S A. 2012 109: 16852-7 †joint corresponding author

*86. JohnsonS, TanL, van der VeenS, CaesarJ, Goicoechea De JorgeE, EverettR, BaiX, ExleyR.M, WardP.N., Ruivo N., TrivediK., CumberE., JonesR., NewhamL., StauntonD., Ufret-VincentyR., BorrowR., PickeringM.C., LeaL., Tang C.M.Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules PLoS Pathog. 2012 8: e1002981.

87.Abrusci P., Vergara-Irigaray M., Johnson S., Beeby M.D., Hendrixson D.R., Roversi P., Friede M.E., Deane J.E., Jensen G.J., Tang C.M.,Lea S.M. Architecture of the major component of the type III secretion system export apparatus. Nat. Struct. Mol. Biol. 2013 20: 99-104.

88.Malito E., Faleri A., Lo Surdo P., Veggi D., Maruggi G., Grassi E., Cartocci E., Bertoldi I., Genovese A., Santini L., Romagnoli G., Borgogni E., Brier S., Lo Passo C., Domina M., Castellino F., Felici F., van der Veen S., Johnson S., Lea S.M., Tang C.M., Pizza M., Savino S., Norais N., Rappuoli R., Bottomley M.J., Masignani V. Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen. Proc. Natl. Acad. Sci. U S A.2013 110: 3304-9.

89. Jongerius I., LavenderH., TanL., Ruivo. N., ExleyR.M., Caesar J., LeaS.M., JohnsonS., Tang C.M. Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor H binding protein. PLoS Pathog. 2013 9:e1003528.

*90.Loh E., Kugelberg E., Tracy A., Zhang Q., Gollan B., Ewles H., Chalmers R., Pelicic V., Tang C.M. Temperature triggers immune evasion by Neisseria meningitidis. Nature. 2013 502: 237-40.

91. Tsolakos N., Brookes C., Taylor S., Gorringe A., Tang C.M., Feavers I.M., Wheeler J.X. Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis. J. Proteomics. 2014 101: 63-76.

92. Scotti J., Leung I., Ge W., Bentley M., Paps J., Kramer H., Lee J., Aik W., Choi H., Paulsen S., Bowman L., Loik N., Horita S., Ho C., Kershaw N., Tang C.M., Claridge T., Preston G., McDonough M., Schofield C.. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proc. Natl. Acad. Sci. U S A. 2014 37: 13331-6.

93.Vergara-Irigaray M., Fookes M., Thomson N., Tang C.M. RNA-seq analysis of the influence of anaerobiosis and FNR on Shigella flexneri. BMC Genomics. 2014 15: 438.

94.Wörmann M., Horien C., Bennett J., Jolley K., Maiden M., Tang C.M., Aho E.L., Exley R.M. Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences. BMC Genomics. 2014 15: 253.

95.Marteyn B., Karimova G., Fenton A., Gazi A., West N., Touqui L., Prevost M., Betton J., Poyraz O., Ladant D., Gerdes K., Sansonetti P., Tang C.M. ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. MBio. 2014 5: e00022-14.

*96.van der Veen S., Johnson S., Jongerius I., Malik T., Genovese A., Santini L., Staunton D., Ufret-Vincenty R.L., Pickering M.C., Lea S.M., Tang C.M. Non-functional variant 3 factor H binding proteins as meningococcal vaccine candidates. Infect. Immun. 2014 82: 1157-63.

97.Faleri A., Santini L., Brier S., Pansegrau W., Lo Surdo P., Scarselli M., Buricchi F., Volpini G., Genovese A., van der Veen S., Lea S., Tang C.M., Savino S., Pizza M., Finco O., Norais N., Masignani V. Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties. FASEB J. 2014 28: 1644-53.

*98. Caesar J., LavenderH., WardP., ExleyR.M, EatonJ., ChittockE., MalikT., Goicoechea De JorgeE., PickeringM., Tang C.M.,† Lea S.M. Competition between antagonistic complement factors for a single protein on N. meningitidis governs disease susceptibility eLife 2014 3. doi: 10.7554 †joint corresponding author

99. Lam O., Wheeler J., Tang C.M. Thermal control of virulence factors in bacteria: a hot topic. Virulence. 2014 5: 852-62.

100.van der Veen S., Tang C.M.The BER necessities: the repair of DNA damageinhuman-adapted pathogens Nat. Rev. Micro. 2015 13: 83-94.

*101.Hill D.M., Lucidarme J., Gray S.J., Newbold L.S., Ure R., Brehony C., Harrison O.B., Bray J.E., Jolley K.A., Bratcher H.B., Parkhill J., Tang C.M., Borrow R., Maiden M.C. Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study. Lancet Infect. Dis. 2015 15: 1420-8.

102.Tan F.Y., Tang C.M., Exley R.M. Sugar coating: bacterial protein glycosylation and host-microbe interactions. Trends Biochem. Sci. 2015 40: 342-50.

103.Liu G., Tang C.M., Exley R.M. Non-pathogenic Neisseria: members of an abundant, multi-habitat, diverse genus. Microbiology. 2015 161:1297-312.

104.Tan F.Y., Wörmann M.E., Loh E., Tang C.M., Exley R.M. Characterization of a novel antisense RNA in the major pilin locus of Neisseria meningitidis influencing antigenic variation. J. Bacteriol. 2015 197: 1757-68.

105.McDowell M.A., Marcoux J., McVicker G., Johnson S., Fong Y.H., Stevens R., Bowman L.A., Degiacomi M.T., Yan J., Wise A., Friede M.E., Benesch J.L., Deane J.E., Tang C.M., Robinson C.V., Lea S.M. Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS. Mol. Microbiol. 2016 99: 749-66.

106.Wörmann M.E., Horien C.L., Johnson E., Liu G., Aho E., Tang C.M., Exley R.M. Neisseria cinerea isolates can adhere to human epithelial cells by type IV pilus-independent mechanisms. Microbiology2016 162: 487-502.

*107.Loh E., Lavender H., Tan F., Tracy A., Tang C.M. Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame. PLoS Pathog. 2016 12: e1005794.

*108.Barnwal R.P., Loh E., Godin K.S., Yip J., Lavender H., Tang C.M.,† Varani G. Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis.Nucleic Acids Res. 2016 pii: gkw584. †joint corresponding author

109.MacVicker G. Tang C.M. Deletion of toxin-antitoxin systems in the evolution of Shigella sonnei as a host-adapted pathogen. Nature Microbiol. 2016 2:16204.

110. Lavender H., Poncin K., Tang C.M.Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines.Infect. Immun. 2017 pii: IAI.00305-17

111.Pilla G., MacVicker G. Tang C.M.Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. PLoS Genet. (in press)

Patents since 2005 as main inventor

1. WO2005060995 - 2005-07-07

Genetic screening for immunogens

2.WO2006067518 - 2006-06-29

Meningococcal antigens

3.WO2010046715 - 2010-04-29

Vaccine compositions comprising mutated factor H binding protein

4. WO2014030003 - 2014-02-27

Neisseria meningitidis fHbp variant and its use for vaccination

5. WO2014140562 - 2014-09-18

Immunogenic composition to Neisseria

6. PCT/GB2017/052535 filed 31 August 2017

Factor H binding protein as a molecular scaffold

1