Online Appendix for the following JACC article
TITLE: Effect of Serelaxin on Cardiac, Renal and Hepatic Biomarkers in the RELAX-AHF Development Program: Correlation With Outcome
AUTHORS:
Marco Metra, M.D.
Gad Cotter, M.D.
Beth A. Davison, Ph.D.
G. Michael Felker, M.D., M.H.S.
Gerasimos Filippatos, M.D.
Barry H. Greenberg, M.D.
Piotr Ponikowski, M.D., Ph.D.
Elaine Unemori, Ph.D.
Adriaan A. Voors, M.D., Ph.D.
Kirkwood F. Adams, Jr., M.D.
Maria Dorobantu, M.D.
Liliana Grinfeld, M.D.
Guillaume Jondeau, M.D.
Alon Marmor, M.D.
Josep Masip, M.D.
Peter S. Pang, M.D.
Karl Werdan, M.D.
Margaret F. Prescott, Ph.D.
Christopher Edwards
Samuel L. Teichman, M.D.
Angelo Trapani, Ph.D.
Christopher A. Bush, Ph.D.
Rajnish Saini, M.D.
Christoph Schumacher, Ph.D.
Thomas Severin, M.D.
John R. Teerlink, M.D.
for the RELAXin in Acute Heart Failure (RELAX-AHF) Investigators
Supplemental Material:
Study Personnel
Executive Committee: Marco Metra, M.D. (Co-Chairperson; University of Brescia, Brescia, Italy); John R. Teerlink, M.D. (Co-Chairperson; University of California at San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA);
Gad Cotter, M.D. (Momentum Research Inc., Durham, NC, USA); Beth A. Davison, Ph.D. (Momentum Research Inc., Durham, NC, USA); G. Michael Felker, M.D., M.H.S. (Duke University School of Medicine and Duke Heart Center, Durham, NC, USA); Gerasimos Filippatos, M.D. (Athens University Hospital, Attikon, Athens, Greece); Barry H. Greenberg, M.D. (University of California at San Diego, San Diego, CA, USA); Piotr Ponikowski, M.D., Ph.D. (Medical University, Clinical Military Hospital, Wroclaw, Poland); Thomas Severin, M.D. (Novartis Pharma AG, Basel, Switzerland); Sam L. Teichman, M.D. (Corthera, Inc., San Carlos, CA, USA); Elaine Unemori, Ph.D. (Corthera, Inc., San Carlos, CA, USA); Adriaan A. Voors, M.D., Ph.D. (University of Groningen, Groningen, the Netherlands).
Steering Committee: Kirkwood F. Adams, Jr., M.D. (University of North Carolina, Chapel Hill, NC, USA); Maria Dorobantu, M.D. ("Floreasca" Emergency Clinical Hospital, Bucharest, Romania); Liliana Grinfeld, M.D., Ph.D. (University of Buenos Aires, , Buenos Aires, Argentina); Guillaume Jondeau, M.D. (Hôpital Bichat, Paris, France); Alon Marmor, M.D. (Ziv Medical Center, Safed, Israel); Josep Masip, M.D. (Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain); Peter S. Pang, M.D. (Northwestern University, Chicago, IL, USA); Karl Werdan, M.D. (Martin-Luther-Universität Halle-Wittenberg, Halle, Germany).
Data and Safety Monitoring Board:Barry M. Massie (Chairperson; University of California at San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA); Michael Böhm, M.D. (Klinik fur Innere Medizin III Kardiologie, Hamburg, Germany); Sidney Goldstein, M.D. (Henry Ford Hospital, Detroit, MI, USA); Gary Francis, M.D. (University of Minnesota, Minneapolis, MN, USA).
Clinical Events Committee: G. Michael Felker, M.D., M.H.S. (Chairperson; Duke Clinical Research Institute, Durham, NC, USA); Javed Butler, M.D. (Emory University Hospital Center for Heart, Atlanta, GA, USA); Adrian F. Hernandez, M.D. (Duke Clinical Research Institute, Durham, NC, USA); Alan B. Miller, M.D. (University of Florida Health Sciences Center, Jacksonville, FL, USA).
Statistical analysis: Beth A. Davison, Ph.D. (Momentum Research Inc., Durham, NC, USA); Christopher A. Bush, Ph.D. (Novartis Pharmaceuticals Corp., East Hanover, NJ, USA); Corinne Miede (Accovion GmBH, Marburg, Germany); Christopher Edwards (Momentum Research Inc., Durham, NC, USA)
Data management: Leslie Quinn (Momentum Research Inc., Durham, NC, USA); Margaret Prescott (Functional Biomarkers Group - Critical Care Franchise Global Clinical Development Novartis Pharmaceuticals Corporation One Health Plaza East Hanover, NJ 07936-1080 USA
); Kim New (Pharm-Olam International, Durham, NC, USA); Kristie Barnes (Pharm-Olam International, Durham, NC, USA); Jason Pottratz (Clinical Reference Laboratory Corp., Lenexa, KS, USA); Sandra Malynn, Ph.D. (ICON Central Laboratories, Farmingdale, NY, USA)
Investigative sites by Country (alphabetical order): Investigators in descending order of patients enrolled (affiliation, city):
Argentina (71):Gustavo Maria Ferrari, M.D. (Hospital Britanico de Buenos Aires, Buenos Aires); Ariel Quiroga, M.D. (Hospital Español, Rosario); Alberto Fernandez, M.D. (Sanatorio Modelo de Quilmes, Quilmes); Eduardo Perna, M.D. (Instituto de Cardiologia de Corrientes "J. F. Cabral", Corrientes); María Silvina Ramos, M.D. (Clinica Constituyentes, Moron); Luis Guzman, M.D. (Sanatorio Allende, Cordoba); Guillermo Cursack, M.D. (Instituto Cardiovascular de Rosario, Rosario - Santa Fe); Oscar Allall, M.D. (Hospital Cordoba, Cordoba); Marcelo Gustavo Masuelli, M.D. (Complejo Medico de la Policia Dederal Argentina Churruca Visca, Buenos Aires); Carlos Rapallo, M.D. (Sanatorio Itoiz S.A., Avellaneda).
France (21): Alain Cohen-Solal, M.D., Ph.D. (Hopital Lariboisiere, Paris); Michel Galinier, M.D. (CHU de Rangueil, Toulouse); Guillaume Jondeau, M.D., Ph.D. (Hôpital Bichat, Paris); Richard Isnard, M.D., Ph.D. (Hopital Pitie-Salpêtrière, Paris).
Germany (78):Hans-Georg Olbrich, M.D. (Asklepios Klinik Langen, Langen); Veselin Mitrovic, M.D. (Kerckhoff-Klinik GmbH, Bad Nauheim); Karl Werdan, M.D. (Martin-Luther-Universität Halle-Wittenberg, Halle); Stephan Felix, M.D. (Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald); Thomas Heitzer, M.D. (Klinikum Dortmund); Gerhard Cieslinski, M.D. (Krankenhaus Nordwest GmbH, Frankfurt am Main); Karl Stangl, M.D. (Charité - Universitätsmedizin Berlin, Berlin).
Hungary (151):János Tomcsányi, M.D., Ph.D. (Budai Irgalmasrendi Korhaz, Budapest); Dezso Apró, M.D. (Allami Szivkorhaz, Balatonfured); Kálmán Tóth, M.D., Ph.D., Sc.D., F.E.S.C. (Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs); András Vértes, M.D. (Egyesített Szent István és Szent László Kórház-Rendelőintézet, Budapest); Géza Lupkovics, M.D., Ph.D. (Zala Megyei Korhaz, Zalaegerszeg); Zoltán László, M.D., Ph.D. (Fővárosi Önkormányzat Szent János Kórháza, Budapest); Attila Cziraki, M.D., Ph.D. (Pécsi Tudományegyetem, Szívgyógyászati Klinika, Pécs).
Israel (210): Alon Marmor, M.D. (Ziv Medical Center, Safed); Sorel Goland, M.D. (Kaplan Medical Center, Rehovot); Amos Katz, M.D. (Barzilai Medical Center, Ashkelon); Reuven Zimlichman, M.D. (Wolfson Medical Center, Holon); Doron Aronson, M.D. (Rambam Health Care Campus, Haifa); Adi Butnaru, M.D. (Shaare-Zedek Medical Center, Jerusalem); Muhamad Omary, M.D. (Nazareth Hospital EMMS, Nazareth); Xavier Alejandro Piltz, M.D. (Bikur Cholim Hospital, Jerusalem); Doron Zahger, M.D. (Soroka University Medical Center, Beer-Sheva).
Italy (77):Marco Metra, M.D. (Azienda Ospedaliera Spedali Civili di Brescia, Brescia); Andrea Mortara, M.D. (Policlinico di Monza, Monza); Manrico Balbi, M.D. (Azienda Ospedaliera Universitaria "San Martino", Genova); Franco Cosmi, M.D. (Ospedale Valdichiana Santa Margherita, Cortona); Salvatore DiSomma, M.D., (Azienda Ospedaliera S. Andrea, Roma); Maria Cristiana Brunazzi, M.D. (Ospedale Civile “Destra Secchia”, Pieve di Coriano Mantova).
Netherlands (10):Adriaan A. Voors, M.D., Ph.D. (University Medical Center Groningen, Groningen); Peter E.F. Bendermacher, M.D. (Elkerliek,Helmond); Gert-Jan Milhous, M.D. (Beatrix Ziekenhuis, Banneweg); Paul L. van Haelst, M.D., Ph.D. (Antonius Ziekenhuis, Hanzeplein); Peter Dunselman, M.D. (Amphia Ziekenhuis, Breda).
Poland (258):Piotr Ponikowski, M.D., Ph.D. (Osrodek Chrob Serca, 4 Wojskowy Szpital Kliniczny, Wroclaw); Piotr Jankowski, M.D. (Sadmodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, Krakow); Andrzej Wysokinski, M.D., Ph.D. (Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin); Miroslaw Dluzniewski, M.D., Ph.D. (Wojewodzki Szpital Brodnowski, Warszawa); Janina Stepinska, M.D., Ph.D. (Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa); Wieslawa Tracz, M.D., Ph.D. (Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow); Maria Krzeminska-Pakula, M.D., Ph.D. (Wojewodzki Specjalistyczny Szpital im. WI. Bieganskiego, Lodz); Jacek Grzybowski, M.D., Ph.D. (Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa); Krystyna Loboz-Grudzien, M.D., Ph.D. (Dolnoslaski Szpital Specjalistyczny im. T. Marciniaka, Wroclaw).
Romania (153):Dan-Domenic Ionescu, M.D., Ph.D. (Craiova Cardiology Centre, Craiova); Costel Sorin Stamate, M.D., Ph.D. ("Sf. Pantelimon" Emergency Clinical Hospital, Bucharest); Maria Dorobantu, M.D., Ph.D. ("Floreasca" Emergency Clinical Hospital, Bucharest); Calin Pop, M.D., Ph.D. ("Dr. Constantin Opris" Emergency Clinical County Hospital, Baia Mare); Adrian Matei, M.D., Ph.D. (Cardiovascular Diseases and Transplant Institute, Targu Mures); Tiberiu Nanea, M.D., Ph.D. (Caritas Clinical Hospital, Bucharest); Mariana Radoi, M.D., Ph.D. (Brasov Emergency Clinical County Hospital, Brasov); Adriana Salajan, M.D., Ph.D. (Oradea Emergency Clinical County Hospital, Oradea).
Spain (18): Josep Masip, M.D., Ph.D. (Hospital Sant Joan Despí Moises Broggi. Consorci Sanitari Integral. Barcelona); Domingo Pascual, M.D., Ph.D. (Hospital Universitario Virgen de la Arrixaca, El Palmar – Murcia); Manuel Gomez Bueno, M.D., Ph.D. (H. Puerta de Hierrro de Majadahonda, Majadahonda); Roberto Muñoz, M.D., Ph.D. (Hospital Infanta Leonor, Madrid).
United States of America (114):Sheba Meymandi, M.D. (Olive View-UCLA Medical Center, Sylmar, CA); Philip Levy, M.D., M.P.H. (Wayne State University/ Detroit Receiving Hospital, Detroit, MI); Peter Pang, M.D. (Northwestern University, Chicago, IL); Craig Clark, D.O. (Iowa Health Cardiology, Des Moines, IA); Gregory Fermann, M.D. (University of Cincinnati University Hospital, Cincinnati, OH); Kirkwood Adams, Jr., M.D. (University of North Carolina, Chapel Hill, NC); Biykem Bozkurt, M.D., Ph.D. (Baylor College of Medicine/ Michael E DeBakey VA Medical Center, Houston, TX); James Fulmer, M.D. (River City Clinical Research, Jacksonville, FL); Donna Mancini, M.D. (New York Presbyterian Hospital - Columbia University Medical Center, New York, NY); Timothy Vittorio, M.S., M.D. (Mount Sinai Medical Center, New York, NY); Ronald Zolty, M.D., Ph.D. (Albert Einstein College of Medicine, Bronx, NY); Barry Greenberg, M.D., (University of California San Diego Medical Center, La Jolla, CA); Eugene Chung, M.D. (The Lindner Research Center, Cincinnati, OH); Viorel Florea, M.D., Ph.D., Sc.D. (Minneapolis VA Medical Center, Minneapolis, MN); John Heilman, III, M.D. (Black Hills Cardiovascular Research, Rapid City, SD); Alan Storrow, M.D. (Vanderbilt University Medical Center, Nashville, TN); Maria Rosa Costanzo, M.D. (Midwest Heart Foundation, Oakbrook Terrace, IL); Gervasio Lamas, M.D. (Mount Sinai Medical Center, Miami Beach, FL); Mitchell Greenspan, M.D. (Grand View - Lehigh Valley Health Services, Sellersville, PA); Marc Klapholz, M.D. (University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ); Joaquin Martinez-Arraras, M.D. (Amarillo Heart Clinical Research Institute Inc., Amarillo, TX); Wm. Frank Peacock, M.D. (The Cleveland Clinic, Cleveland, OH); Nizar Saleh, M.D. (St. Mary's Duluth Clinic Health System, Duluth, MN); Roy Small, M.D. (Lancaster Heart & Stroke Foundation, Lancaster, PA); John R. Teerlink, M.D. (San Francisco Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, CA); Benjamin Trichon, M.D. (Asheville Cardiology Associates, Asheville, NC); Detlef Wencker, M.D. (Hartford Hospital University of Connecticut, Hartford, CT).
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