OMRF Microarray Research Facility Projects and Publications

OMRF Microarray Research Facility Projects and Publications

Scientists at the Oklahoma Medical Research Foundation's Microarray Research Facility are involved in research projects in a number of diseases including arthritis, cancer, bladder diseases, liver diseases, sexually-transmitted diseases, and opthalmic diseases, as well as advances in bioinformatics. Some of these projects are directed at a basic understanding of the disease process, while others are designed to monitor the progression of the disease and response to therapy in particular patients.

Peer-Reviewed Microarray Publications from the OMRF Microarray Research Facility

2003

Dozmorov, I., Saban, M. R., Gerard, N. P., Lu, B., Nguyen, N-B., Centola, M., and Saban, S. Neurokinin 1 recept ors and neprilysin modulation of mouse bladder gene-regulation.Physiol. Genomics 12:239-250, 2003. (Published online December 19, 2002 10.1152/physiolgenomics.00141.2002)

Dozmorov, I., and Centola, M. An associative analysis of gene expression array data.Bioinformatics 19:204-211, 2003.

Tucker, A.E., Salles, I.I., Voth D.E., Ortiz-Leduc, W., Wang, H., Dozmorov, I., Centola, M., Ballard, J.D. Decreased glycogen synthasekinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cellular Microbiology 5(8):523-532, 2003.

Dozmorov, I., Saban, M. R., Knowlton, N., Centola, M., and Saban, R. Connective Molecular Pathways of Experimental Bladder Inflammation.Physiol. Genomics 209-222, 2003. (Published online September 9, 2003. 10.1152/physiolgenomics.00130.2003 )

2004

Jarvis, J. N., Dozmorov, I., Jiang, K., Frank, M. B., Szodoray, P., Alex, P., Centola, M. Novel Approaches to Gene Expression Analysis of Active Juvenile Rheumatoid Arthritis. Arthritis Research and Therapy 6:15-32, 2004. (Published online November 6, 2003)

Jarvis, J. N., Dozmorov, I., Jiang, K., Chen, Y., Frank, M. B., Cadwell, C., Turner, S. and Centola, M. Gene Expression Arrays Reveal Rapid Return to Normal Homeostasis in Immunologically-Challenged Trophoblast-Like JAR Cells. J. Reproductive Immunol. 61:99-113, 2004.

Nunlist, E., Dozmorov, I., Tang, Y., Cowan, R., Centola, M., and Lin, H.-K. Partitioning of 5-Dihydrotestosterone and 5-Androstane-3,17-diol Activated Pathways for Stimulating Human Prostrate Cancer LNCaP Cell Proliferation. Journal of Steroid Metabolism and Molecular Biology. 91:157-170. 2004.

Dozmorov, I., Knowlton, N., Tang, Y.G., Centola, M. Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays. BMC Bioinformatics 5:53-61 Art. No. 53, 2004.

Knowlton, N., Dozmorov, I. M., Centola, M. Micraoarray Data Analysis Toolbox (MDAT): for Normalization, Adjustment, and Analysis of Gene Expression Data. Bioniformatics (Bioinformatics Advance Access published online July 22, 2004 10.1093/bioinformatics/bth424 2004.)

Zimmerman, R. A., Dozmorov, I., Nunlist, E., Tang, Y., Cowan, R., Centola, M., Frank, M. B., and Lin, H.-K. 5-Androstane-3-diol Activates Pathway that Resembles the Epidermal Growth Factor Responsive Pathways in Stimulating Human Prostrate Cancer LNCaP Cell Proliferation. Prostate Cancer and Prostatic Diseases. 7:364-374, 2004.

Jorgensen, E. D., Dozmorov, I., Frank, M. B., Centola, M., and Albino, A. P. Global Gene Expression Analysis of Human Epithelial Cells T reated with Tobacco Condensates.Cell Cycle 3(9):1154-1168, 2004.

Frank, M. B., Cadwell, R. C., Kane, M. D., and Centola, M. Optimizing Oligonucleotide Microarray Printing Parameters. Genomics and Proteomics.E-published November 18, 2004.

Dozmorov, I., Knowlton, N., Tang, Y., Shields, A., Pathipvanich, P., Jarvis, J. N., and Centola, M. Hypervariable Genes - Experimental Error or Hidden Dynamics.Nucleic Acids Research 32:e147.

2005

Huang, H., Frank, M. B., Dozmorov, I., Cao, W., Cadwell, C., Knowlton, N., Centola, M., and Anderson, R. Identification of Mouse Retinal Genes Differentially Regulated by Dim and Bright Cyclic Light Rearing. Experimental Eye Research. 80:727-739, 2005.

Yu, X., Tang, Y., Li, F., Frank, M. B., Huang, H., Dozmorov, I., Zhu, Y., Centola, M., and Cao, W. Protection Against Hydrogen Perozide-Induced Cell Death in Cultured Human Retinal Pigment Epithelial Cells by 17-Estradiol: A Differ ential Gene Expression Profile. Mech. Ageing and Development.126(11)1135-1145, 2005.

Kurella, S., Dozmorov, I., Frank, M. B., Centola, M., and Farris, A. D. Transcriptional Modulation of TCR, Notch, and Wnt Signaling Pathways in SEB-Anergized CD4+ T Cells. Genes and Immunity. 6(7):596-608.

Dozmorov, I., Centola, M., Knowlton, N., and Tang, Y. Mobile Classification in Microarray Experiments.Scand J. Immunol. 62 Suppl 1:84-91, 2005.

Jarvis, J. and Centola, M. Gene-Expression Profiling: Time for Clinical Application? Lancet. Jan 15-21;365(9455):199-200, 2005. Erratum in: Lancet. 2005 Jan 22;365(9456):294, 2005.

Szodoray, P., Alex, P., Jonsson, M. V., Knowlton, N., Dozmorov, I., Nakken, B., Delaleu, N., Jonsson, R., and Centola, M. Distinct profiles of Sjogren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. ClinImmunol. 117(2):168-76, 2005.

2006

Knowlton, N., Dozmorov, I., Kyker, K. D., Saban, R., Cadwell, C., Centola, M. B., and Hurst, R. E. Template-Driven Gene Selection Procedure. IEE Proc. Syst. Biol. 153(1):4-12, 2006.

Li, C., Tang, Y., Li, F., Turner, S., Li, K., Zhou, X., Centola, M., Yan, X., Cao. W. 17 -estradiol ( E2) protects human retinal Muller cell against oxidative stress in vitro: evaluation of its effects on gene expression by cDNA microarray. Glia. 53(4):392-400, 2006.

Dozmorov, M.G., Kyker, K.D., Saban, R., Knowlton, N., Dozmorov, I., Centola, M.B., Hurst, R.E. Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells. BMC Cancer 6:12, 2006.

Saban, M.R., Hellmich, H.L., Turner, M., Nguyen, N.B., Vadigepalli, R., Dyer, D.W., Hurst, R.E., Centola, M., Saban, R.The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa.BMC Physiol. 6(1):1, 2006.

Szodoray, P., Alex, P., Frank, M. B., Turner, M., Turner, S., Knowlton, N., Cadwell, C., Dozmorov, I., Tang, Y., Wilson, P. C., Jonsson, R., Centola, M.A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis.Rheumatology (Oxford). 45(12):1466-76, 2006.

Centola, M., Frank, M. B., Alex, P., Zeher, M., Jonsson, R., Nakken, B., Szegedi, G., Szodoray, P. A Genome Scale Assessment of Molecular Pathology in Systemic Autoimmune Diseases Using Microarray Technology: A Breakthrough Diagnostic and Individualized Therapy-Design Tool. Scand. J. Immunol. 64(3):236-42, 2006.

Jarvis, J. N., Petty, H. R., Tang, Y., Frank, M. B., Tessier, P. A., Dozmorov, I., Jiang, K., Kindzelski, A., Chen, Y., Cadwell, C., Turner, M., McGhee, J. L., and Centola M. Evidence for Chronic, Peripheral Activation of Neutrophils in Polyarticular Juvenile Rheumatoid Arthritis. Arthritis Research and Therapy. 8(5):R154, 2006.

Knowlton, N., Dozmorov, I., Kyker, K.D., Saban, R., Cadwell, C., Centola, M.B., Hurst, R.E. Template-driven gene selection procedure. SystBiol (Stevenage). 153(1):4-12, 2006.

2007

Lawrence, S., Tang, Y., Frank, M.B., Dozmorov, I., Jiang, K., Chen, Y., Cadwell, C., Turner, S., Centola, M., Jarvis, J.N. A dynamic model of gene expression in monocytes reveals differences in immediate/early genes between adult and neonatal cells. J. Inflamm (Lond). 16;4:4, 2007.

Zhu, H., Tang, Y., Ivanciu, L., Centola, M., Lupu, C., Taylor, F.B. Jr, Lupu, F. Temporal dynamics of gene expression in the lung in a babbon model of E. coli sepsis. BMC Genomics. 8:58, 2007.

Saban, M.R., Simpson, C., Davis, C., Wallis, G., Knowlton, N., Frank, M.B., Centola, M., Gallucci, R.M., Saban, R. Discriminator of mouse bladder response to intracesical Bacillus Calmette-Guerin (BCG).BMC Immunol. 8:6, 2007.

Dozmorov, M.G., Kyker, K.D., Saban, R., Shankar, N., Baghdayan, A.S., Centola, M.B., Hurst, R.E.Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcusfaecalis. BMC Bioinformatics. 8(Suppl 7):S2, 2007.

2008

Wang, H., Kesinger, J.W., Zhou, Q., Wren, J.D., Martin, G., Turner, S., Tang, Y., Frank, M.B., Centola, M. Identification and characterization of zebrafish ocular formation genes.Genome. 51(3):222-35, 2008.

Dozmorov, M.G., Kyker, K.D., Hauser, P.J., Saban, R., Buethe, D.D., Dozmorov, I., Centola, M.B., Culkin, D.J., Hurst, R.E. From microarray to biology: an integraged experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells. BMC Bioinformatics. 9(Suppl 9):S4, 2008.

Myers, T., Chengedza, S., Lightfoot, S., Pan, Y., Dedmond, D., Cole, L., Tang, Y., Benbrook, D.M. Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo. Invest. New Drugs. Sep 18, 2008.

Nakou, M., Knowlton, N., Frank, M.B., Bertsias, G., Osban, J., Sandel, C.E., Papadaki, H., Raptopoulou, A., Sidiropoulos, P., Kritikos, I., Tassiulas, I., Centola, M., Boumpas, D.T. Gene expression in systemic lupus erythematosus: bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesus signatures. Arthritis Rheum. 58(11):3541-3549, 2008.

2009

Knowlton, N., Jiang, K., Frank, M. B., Aggarwal, A., Wallace, C., McKee, R., Chaser, B., Tung, C., Smith, L., McGhee, J. L., Chen, Y., Centola, M., O'Neil, K., and Jarvis J. N. The Meaning of Remission on Polyarticular Juvenile Idiopathic Arthritis: Gene Expression Profiling in Peripheral Blood Mononuclear Cells and Neutrophils Identifies Distinct Disease States. Arthritis and Rheumatism, 60:892-900, 2009. NIHMSID: 87494

Frank, M. B., Wang, S., Aggarwal, A., Knowlton, N., Jiang, K., Chen, Y., McKee, R., Chaser, B., McGhee, T., Osban, J., and Jarvis, J. N. Disease-Associated Pathophysiologic Structures in Pediatric Rheumatic Diseases Show Characteristics of Scale-Free Networks Seen in Physiologic Systems: Implications for Pathogenesis and Treatment. BMC Medical Genomics, 2:9, 2009.PMCID: PMC2649160

Webb, R., Wren, D. D., Jeffries, M., Kelly, J. A., Kaufman, K. M., Tang, Y., Frank, M. B., Merrill, J., PROFILE study group, Alarcón-Riquelme, M. E., James, J. A., Vyse, T. J., Moser, K. L., Gilkeson, G. S., Harley, J. B., and Sawalha, A. H. Variants within MECP2, a key transcriptional regulator, are associated with increased susceptibility to lupus and differential gene expression in lupus patients. Arthritis and Rheumatism, 60:1076-1084, 2009. NIHMSID: 87799

Frank, M. B., Yang, Q., Osban, J., Azzarello, J. T., Saban, M. S., Saban, R., Ashley, R. A., Welter, J. C., Fung, K-M., and Lin, H-K. Frankincense Oil derived from Boswelliacarteri Induces Tumor Cell Specific Cytotoxicity. BMC Complementary and Alternative Medicine, 9:6, 2009. PMCID: PMC2664784

Jarvis, J. N., Jiang, K., Frank, M. B., Knowlton, N., Aggarwal, A., Wallace, C., McKee, R., Chaser, B., Tung, C., Smith, L. B., McGhee, J. L., Chen, Y., Osban, J., O'Neil, K. N., and Centola, M. Gene Expression Profiling in Neutrophils of Children with Polyarticular Juvenile Idiopathic Arthritis. Arthritis and Rheumatism, 60:1488-1495, 2009. PMID: 19404961

Torgerson, T. R., Genin, A., Chen, C., Zhang, M., Zhou, B., Añover-Sombke, S., Frank, M. B., Dozmorov, I., Ocheltree, E., Kulmala, P., Centola, M., Ochs, H. D., Wells, A. D., Cron, R. Q. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol. 183:907-15, 2009.

Dozmorov, M. G., Hurst, R. E., Culkin, D. J., Kropp, B. P., Frank, M. B., Osban, J., Penning, T. M., and Lin, H.-K.: Unique Pattern of Molecular Profiling between Human Prostate Cancer LNCaP and PC-3 Cells. The Prostate, 69:1077-1090, 2009.

Jiang, K., Krous, L. C., Knowlton, K., Chen, Y., Frank, M. B., Cadwell, C., Centola, M., and Jarvis, J. N. Ablation of Stat3 by siRNA Alters Gene Expression Profiles in Jeg-3 Cells: A Systems Biology Approach. Placenta. 30: 806-815, 2009.

Gu, J., Wei, Y. L., Wei, J. C., Huang, F., Jan, M. S., Centola, M., Frank, M. B., and Yu, D. Identification of RGS1 as a Candidate Biomarker for Undifferentiated Spondyloarthritis by Genome-Wide Expression Profiling and Real-Time Polymerase Chain Reaction. Arthritis and Rheumatism 60:3269-3279, 2009.

2010

Carreras, E., Turner, S., Frank, M. B., Knowlton, K., Osban, J., Centola, M., Park, C. G., Simmons, A., Alberola-Ila, J., and Kovats, S. Estrogen Receptor Signaling Promotes Dendritic Cell Differentiation by Increasing Expression of the Transcription Factor IRF4. Blood 115:238-46, 2010.

Jarvis, J. N., and Frank, M. B. Functional Genomics and Rheumatoid Arthritis: Where Have We Been and Where Should We Go? Genome Med. 2:44, 2010.(Invited review).

Microarray Abstracts and Meeting Presentations from the Microarray Research Facility

2002

Dozmorov, I., Jarvis, J. N., Frank, M. B., Jiang, K., Cadwell, C., and Centola, M. Novel Mathematical Modeling Identifies Leukocyte Gene Expression Patterns That Are Disrupted in Polyarticular JRA. Arthritis and Rheumatism. 46: S474, 2002.

Jarvis, J. N., Frank, M. B., Dozmorov, I., Jiang, K., Cadwell, C., McGhee, J. L., and Centola, M. Gene Expression Analysis of Children With Active Polyarticular JRA. Arthritis and Rheumatism. 46: S474, 2002.

2003

Dozmorov, I., Saban, M.R., Nguyen, N.B., Centola, M., Saban, R. Neurokinin 1 receptors and neprilysin modulate mouse bladder gene-expression. Journal of Urology 169(4):8 No. 32, 2003.

Huang, H., Frank, M. B., Dozmorov, I., Centola, M., and Anderson, R. E. Microarray Analysis of Retinas from Mice Raised in Dim- and Bright-Cyclic Light: Identification of Differentially Expressed Genes in A Mouse Adaptive Neuroprotective Model. Association for Research in Vision and Opthalmology.Abstract 5135, 2003.

Szodoray, P., Frank, M. B., Tang, Y., Nakken, B., Turner, S., Cadwell, C., Dozmorov, I., Wilson, P. C., Jonsson, R., Centola, M. Gene Expression Profile of Peripheral Blood B Cells in Rheumatoid Arthritis. Arthritis and Rheumatism.S344, 2003.

Jarvis, J. N, Jiang, K., Chen, Y., Dozmorov, I., Frank, M. B., Centola, M. Cocultivation of trophoblast-like Jar cells results in transcriptional activation of multiple genes: further evidence for matern al-fetal immunologic cross-talk. Pediatric Research 53:57A-58A, 2003.

Gran, C. D., Feloney, M. P., Slobodov. G., Frank. M. B., Dozmorov, I., Cadwell, R., Turner, S., Lin, H. K., Centola, M., and Culkin, D. J. Microarray analysis of differential gene expression from bladder biopsy and whole blood total RNA in interstitial cystitis versus patients without bladder disease. Poster presentation at International Bladder Symposium, Arlington, VA. Mar. 6-9, 2003.

Dozmorov, I ., Kyker, K. D., Cadwell, C., Centola, M. B., and Hurst, R.E. Dissecting Complex Interactions Regulating The Phenotype Of Bladder Cancer Cells With Supervised Learning With Biological Models. International Bladder Symposium, Arlington, VA, Mar. 6-9, 2003.

Graham, D.R., Dozmorov, I., Frank, M.B., Cadwell, C., Centola, M., Ash, J.D. Retinal gene expression changes mediated by leukemia inhibitory factor (LIF).Investigative Opthalmology & Visual Science 44:U389 1663 Suppl. 1, 2003.

2004

Lawrence, S.M., Tang, Y., Dozmorov, I., Frank, M.B., Centola, M., Jarvis, J.N. Gene expression arrays reveal distinct patterns of activation that differ between adult and neonatal monocytes. Journal of Investigative Medicine 52(1):S297-S298, 2004.

Kurella, S., Yaciuk, J.C., Dozmorov, I., Centola, M., Farris, A.D. Novel gene expression changes in SEB-anergized CD4+V beta 8+ T cells. FASEB Journal 18(5):A807-A808, 2004.

Lawrence, S., Tang, Y.H,, Jiang, K.Y., Dozmorov, L., Frank, M.B., Centola, M., Jarvis, J.N. Gene expression arrays reveal distinct patterns of activation that differ between adult and neonatal monocytes. Pediatric Research 55(4):18A 100 Part 2, S, 2004.

Jarvis, J.N., Dozmorov, I., Jiang, K.Y., Chen, Y.M., Frank, M.B., Centola, M. Using a gene microarray to dissect immunologic responses in a trophoblast model: Evidence that immunologic challenge enhances trophoblast growth and differentiation. Pediatric R esearch 55(4):468A 2657 Part 2, 2004.

Dervieux, T., Tang, Y.H., Cadwell, C., Levy, V., Dozmorov, I., Philippe, M., Sutton, C., Richerson, R., Centola, M.A multi-tissue analysis of Crohn's disease (CD) and ulcerative colitis (UC) etiopathology using microarrays.Gastroenterology 126(4): A209 Suppl. 2, 2004.

Alex, P., Dozmorov, I., Chappell, C., Szodoray, P., Cockrum, K., Cadwell, C., Turner, M., Levy, V., Frank, B., Centola, M. Novel Approachs to Identify Distinct Immunopathogenic Biomarkers in Patients with Rheumatoid Arthritis.Arthritis and Rheumatism 50:S351, 2004. Poster presentation at the American College of Rheumatology Annual Meeting, San Antonio, TX, October 16-21, 2004.

Jarvis, J.N., Zospah, R., Tang, Y., Dozmorov, I., Jiang, K., Chen, Y., Frank, M. B., Centola, M. Gene Expression Arrays Exclude Immune Complex Accumulation as a Critical Factor in the Leukocyte Activation in Polyarticular JRA. Arthritis and Rheumatism 50:S363, 2004. Pos ter presentation at the American College of Rheumatology Annual Meeting, San Antonio, TX, October 16-21, 2004.

Jarvis, J. N., Tang, Y., Dozmorov, I., Jiang, K., Frank, M. B., Chen, Y., McGhee, J. L., and Centola, M. Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children With Polyarticular JRA. Is JRA a Primarily a Neutrophil Disorder? Arthritis and Rheumatism 50:S443, 2004. Poster presentation at the American College of Rheumatology Annual Meeting, San Antonio, TX, October 16-21, 2004.

Alex, P., Szodoray, P., Weng, H., Tang, Y., Dozmorov, I., Chappell, C., Cadwell, C., Turner, S., Knowlton, N., Levy, V., Onnoonay, J., Frank, B., Ayoubi, P., Centola, M. An Extensive Microarray Analysis to Identify Therapeutic Response Biomarkers to Methotrexate in Patients with Rheumatoid Arthritis.Presented at the Third International Meeting on Gene Therapy in Rheumatology and Orthopedics, Boston. 2004.

Alex, P., Szodoray, P., Dozmorov, I., Chappell , C., Cadwell, C., Turner, S., Levy, V., Tang, Y., Turner, M., Onnoonay, J., Frank, B., and Centola, M. A Novel Approach to Identify Therapeutic Response Biomarkers to Methotrexate in Patients with Rheumatoid Arthritis.Accepted for presentation at the 10th Annual Meeting of the Association of Molecular Pathology.Journal of Molecular Diagnostics. 2004.

Wang, H.,.Kesinger, J. W., Tang, Y., Zhang, Y., Zhao, T., Abatiell, A., Vasquez, S., Frank, B., and Centola, M. 2004. Microarray Analysi s of Zebrafish Embryonic Circadian Rhythmicity.Presented at the 6th International Conference on Zebrafish Genetics and Development, July 29-August 2, Madison, Wisconsin.

Kesinger, J. W., Tang, Y., Frank, B., Centola, M., and Wang, H. 2004. Identification of putative target genes in the zebrafishmbl/axin1 mutant by microarray analysis.Presented at the 6th International Conference on Zebrafish Genetics and Development, July 29-August 2, Madison, Wisconsin.

2005

Alex, P., Szodoray, P., Dozmorov, I., Sagar, Y., Turner, M., Frank, M. B., Levy, V., Chappell, C., Flinn, D., Willis, L., Hynd, R., Arthur, E., Centola, M. Identification of Regulatory Models from Gene Expression Profiles in Patients with Rheumatoid Arthritis. Presented at Systems Biology 2005 Meeting, March 17 – 20, 2005, Cold Spring Harbor, NY.

Alex, P., Szodoray, P., Frank, M. B., Cadwell, C., Turner, S. Levy, V., Arthur, E., Willis, L., Hynd, R., Flinn, D., and Centola, M. Novel Targets I dentified in Gene Expression Profiles of Neutrophils and Peripheal Blood Mononuclear Cells from Patients with Rheumatoid Arthrits. Presented at the American College of Rheumatology 2005 Annual Meeting, San Diego, CA. November 12-17, 2005. Arthritis and Rheumatism 52:S153.

Knowlton, N. Improving Microarray Normalization. Presented at Microarays in Transcriptional Profiling - A Joint FDA/Johns Hopkins University/PhRMA Workshop, Rockville Maryland, July 20-21, 2005.

Drewe, E., Frank, M. B., Dozmorov, I., Centola, M., Powell, R. J., and Tighe, P. J. Investigation of TNF Receptor Signalling in Peripheral Blood Mononuclear Cells in TNF-Receptor 1 Associated Periodic Syndrome (TRAPS). The Fourth International Congress on Systemic Autoinflammatory Diseases.National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda MD. November 6-10, 2005.

Kesinger, J. W., Tang, Y., Frank, M. B., Centola, M., and Wang, H. Effects of Zebrafishmbl/axin1 on Circadian Rhythmicity. OKBIOS 2005: Life Sciences in the Information Age, Oklahoma City, October 28, 2005.

2006

Torgerson, T., Genin, A., Anover, S., Ocheltree, E., Frank, B., Dozmorov, I., Ochs, H., and Cron, R. FOXP3 inhibits inducible NFAT2 gene expression. Presented at the FOCIS 2006 Annual Meeting, San Francisco, CA, June 1-5, 2006.Clinical Immunology 119: Supplement S7-S8, 2006.

Aggarwal, A., Dozmorov, I., Frank, M. B., Jiang, K., Chen, Y., Centola, M., and Jarvis, J. N. Neutrophils from Children with Polyarticular and Pauciarticular Juvenile Rheumatoid Arthritis (JRA) Show Distinct Gene Expression Profiles. Presented at the 2006 Annual Scientific Meeting of the American College of Rheumatology, Washington, D.C., November 10-15, 2006. Arthritis & Rheumatism 54(9) Supplement:S694, 2006.

O'Neil, K. M., Neff, J., Frank, M. B., Dozmorov, I., Cadwell, C., Centola, M. Characterization of Transcriptionally Regulated Inflammatory Networks in Peripheral Blood Mononuclear Cells (PBMC) of Children with Systemic Lupus Erythematosus. Presented at the 2006 Annual Scientific Meeting of the American College of Rheumatology, Washington, D.C., November 10-15, 2006. Arthritis & Rheumatism 54(9) Supplement:S696, 2006.

O'Neil, K. M., Neff, J., Dozmorov, I., Frank, M. B., Cadwell, C., Nguyen, T., Centola, M. Pathway Analysis if Genes Differentially Expressed in Peripheral Blood Mononuclear Cells of Children with Systemic Lupus Erythematosus and Controls. Presented at the 2006 Annual Scientific Meeting of the American College of Rheumatology, Washington, D.C., November 10-15, 2006. Arthritis & Rheumatism 54(9) Supplement:S830, 2006.

Mudd, P. A., Teague, B. N., Frank, M. B., Dozmorov, I. M., Cadwell, C., Centola, M., and Farris, D. The Yaa Gene Mediates Defective T Cell Responsiveness in vitro and Is Associated with Enhanced Innate Immune Sensing and Up-Regulation of B7-H1. Presented at the 2006 Annual Scientific Meeting of the American College of Rheumatology, Washington, D.C., November 10-15, 2006. Arthritis & Rheumatism 54(9) Supplement:S449-450, 2006.

Alex, P., Turner, M., Codding, C., Carson, C., Kumar, P., Willis, L., Arthur, E., Hynd, R., Nguyen, T., Knowlton, N., Frank, B., Centola, M. Disease Activity and Therapeutic Response Assessment in RA using Multiplex Cytokine Profiling. Presented at the 2006 Annual Scientific Meeting of the American College of Rheumatology, Washington, D.C., November 10-15, 2006. Arthritis & Rheumatism 54(9) Supplement: S698-699, 2006.

2007

Alex, P. Frank, M. B., Sutton, S., Cadwell, C., Dozmorov, I., Levy, V., Miner, P., Li, X., Centola, M. Distinct Th1/Th2/Th17 Profiles Identified in Gene and Cytokine Expression Signatures from Patients with Inflammatory Bowel Disease. Presented at the AGA Institute, Digestive Disease Week, Washington Convention Center, Washington, DC, May 19-24, 2007.Gastroenterology Supplement April, 2007.

O'Neil, K. O., Frank, M. B., Nguyen, A. B. Cadwell, C., Centola, M., and Dozmorov, I. Abnormal Expression of Apoptosis-Related Genes in Neutrophils of Children with Systemic Lupus Erythematosus. Presented at the Pediatric Academic Societies Meeting, Toronto, Canada, May 5-8, 2007.

Frank, M. B. Utilization of Microarrays for Research and Teaching in Primarily Undergraduate Institutions. Invited Speaker, INBRE Undergraduate Faculty Retreat, Presbyterian Health Foundation Conference Center, Oklahoma City, October 12, 2007.

Alex, P., Frank, M. B., Cadwell, R. C., Osban, J., Miner Jr., P., Arthur, E., Willis, L., Hynd, R., Flinn, D., Li, X., and Centola, M. Common and Disease-Specific Biomarkers Identified from Peripheral Blood Gene Expression Profiling of Rheumatoid Arthritis and Inflammatory Bowel Disease. Presented at the 2007 Annual Scientific Meeting of the American College of Rheumatology, Boston, MA, November 6-11, 2007. Arthritis & Rheumatism 56(9):S241, 2007.

Jarvis, J. N., Knowlton, N., Frank, M. B., Aggarwal, A., Jiang, K., Chen, Y., McKee, R., McGhee, J. L., O’Neil, K. M., Chaser, B., and Centola, M. A Systems Biology Approach to JIA: Gene Expression Profiling Detects Only Small Differences Between Children With Pauciarticular and Polyarticular Disease. Presented at the 2007 Annual Scientific Meeting of the American College of Rheumatology, Boston, MA, November 6-11, 2007. Arthritis & Rheumatism 56(9):S670, 2007.