Nanobodies in Creative Biolabs
A nanobody is an antibody fragment,which contains of a single monomeric variable antibody domain. It is similar to a whole antibody and is able to bind selectively to a specific antigen. The first nanobody wasgenerated from heavy-chain antibodies found in camelids.
Camel's immune system is very different from that of human and other mammals, but it is very effective. Compared with those antibodies generated by human body, the antibodies generated by camel’s body are smaller, which means that they can deeply penetrate into the interior of the cells. Moreover, camel antibodies are particularly effective for some viruses as well.In this way, with those particular advantages, camelid antibodies are so special that they can be used to make nanobodies easily.
Although nanobodies are similar to human antibodies’variable regions, entering people’s bloodstream still needs some changes,for the purpose of ensuring that nanobodieswill not be regarded as the external substances to elicit immune response.Nanobody is much simpler than those conventional antibodies. In addition,they can be used in the plants as well.
Creative Biolabsis the recognized leader in nanobody production, as well as single domain antibody library fields. They are professional in generatingnanobodiesagainst any targets. Additionally, Creative Biolabs also provide a wide range of services, such as the construction of immunized single domain antibody libraries by using camel, large-scale production of recombinant single domain antibodies, and so on. Furthermore, together with Creative Biomart and some other biological companies, Creative Biolabs provide users with a large list of nanobodies. They are also professional in conducting affinity maturation of nanobodies. Massive library sorting by phage display or yeast surface display has been used for the aim of improving the affinity of singledomain antibodies.
To be brief, the nanobody technology was originally developed by following the related biological discovery in camel. Together with some featured services like bispecific nanobody production, nanobodies in Creative Biolabs are equipped with various advantages, such as high production yield, great stability, reversible refolding, and so on. As for nanobodies’ prospects, scientists in this research field have pointed out that nanobodies will change the future medical treatment to a large degree.
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Creative Biolabs is a leading provider in nanobody construction. It is backed up by a great team of antibody experts and advanced techniques. Visit creative-biolabs.com to learn more detailed information about nanobody services and Creative Biolabs.
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Editor: Elaine
Company: Creative Biolabs
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