CURRICULUM VITAE

Mahmoud Mohamed Sheha

  1. Contact Data

  1. Name: MAHMOUD MOHAMED SHEHA

Home Address: / Business Address:
  1. P.O. Box: 71526
/
  1. P.O. Box: 51399

  1. City: ASSIUT
/
  1. City: Jeddah

  1. Postal Code:
/
  1. Postal Code:21543

  1. Country: EGYPT
/
  1. Country:Saudi Arabia

  1. Telephone:Fax:Pager:Mobile Phone:Telex:E-mail Address:Cable: 0020123971632
/
  1. Telephone:Fax:Pager:Mobile Phone:Telex:E-mail Address:Cable: 00966509964032

  1. Personal Data

  1. Sex: MALE
/
  1. Citizenship:EGYPTIAN

  1. Date of Birth: May 18th 1962
/
  1. Religion: MUSLIM

  1. Native Language: ARABIC
/
  1. Marital Status: MARRIED

III. Educational Data
Academic History
Degree / Year / Name of Institute / Major Field of study / Country
Ph.D / 1996 / KyotoPharmaceuticalUniversity / Medicinal Chemistry / Japan
M.Sci / 1990 / AssiutUniversity / Medicinal Chemistry / Egypt
B.Pharm. / 1985 / AssiutUniversity / Pharmaceutical Sciences / Egypt
Current Specialization: Pharmaceutical Chemistry
Special skills/interests:
Prodrug, site-specific drug targeting, Drug Design, CADD
Professional and Organization Memberships:
Egyptian Pharmacy Syndicate, American Association of Pharmaceutical Sciences (AAPS)
Recent Published Papers: 14 Scientific papers published in international pharmaceutical journals (J. Med. Chem. & Pharm. Sci. & Die Pharmazie & Bioorg. Med. Chem. & Archive die Pharmazie & chromatograpgy) and 3 papers (Alzheimer Disease) published recently in join-work with international scientific team (French and Americans).
D. Employment History
Present Employer: College of Health Sciences, Jeddah
Title: Assistant Professor / Head of Pharmacy Department
Date of Employment:
MONTH /
EAR / MONTH / Y
AR
From: / 10 / 2003 / To: / Present / Present
Previous Employer: AssiutUniversity, Faculty of Pharmacy
Title: Associate Professor
Date of Employment:
MONTH / YEAR / MONTH / YEAR
From: / 9 / 2003 / To: / Present / Present
Previous Employer: AssiutUniversity, Faculty of Pharmacy
Title: Lecturer
Date of Employment:
MONTH / YEAR / MONTH / YEAR
From: / 6 / 1996 / To: / 8 / 2003
Previous Employer: T3A Pharma
roup
Title:
Quality Control Manager
Date of Employment:
MONTH / YEAR / MONTH / YEAR
From: / 9 / 1999 / To: / 10 / 2001

RECENT Publications LIST

1. Journal of Chromatography B, 2008, in print

Stress degradation studies on betahistine and development of a validated stability-indicating assay method. Alaa Khedr, Mahmoud M. Sheha

2. Australian Journal of chemistry, 2007, 60(2), 128-132

Thiazolamide-ascorbic acid conjugate: a γ-secretase inhibitor with enhanced distribution into the brain through the Blood Brain Barrier

Younes Laras, Mahmoud Sheha, Nicolas Pietrancosta and Jean-Louis Kraus

3. Journal of Chromatography B, 2007, 856, 337–342

Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate

Alaa Khedr, Mahmoud M. Sheha, Ibrahim A. Darwish

4.Organic Biomolecular Chemistry, 2005, 3, 2450 – 2457

Enhanced delivery of -secretase inhibitor DAPT into the brain via an ascorbic acid mediated strategy

Gilles Qu´el´ever, Philippe Kachidian, Christophe Melon, C´edrik Garino, Younes Laras, Nicolas Pietrancosta, Mahmoud Sheha and Jean Louis Kraus

5. Medicinal Chemistry, Indian Journal, 2005, 1, 7-13

Synthesis, Analgesic and Anti-Inflammatory Activities of
4-Oxo-4-(4-(Pyrimidin-2-yl)Piperazin-1-yl)Butanoic Acid Derivatives

Hamdy M.Abdel-Rahman, Mahmoud M.Sheha

6. Organic Biomolecular Chemistry, 2005 , 3, 612–618

Substituted Thiazolamide Coupled to a Redox Delivery System: A New -Secretase Inhibitor with Enhanced Pharmacokinetic Profile

Y. Laras,G. Qu´el´ever, C.Garino, N. Pietrancosta, M. Sheha, F. Bihel, M. S. Wolfe and J. L. Kraus

7. Patent Application in Egypt2005 (in progress)

New Carriers For Specific Delivery Of Drugs To The Brain

M. Sheha and H.H. Farag

8. Arch. Pharm. Pharm. Med. Chem. 2003, 336, 47-52

Brain Chemical delivery of HIV PR inhibitor containing APNS.

M. Sheha, N. El-Koussi, H. Farag.

9. Bioorganic Medicinal Chemistry 2003, 11:8:1865-1872

AAPS 2001 Proceeding, October 23, Control number; 01-A-13091-AAPS 2001 entitled "New Carriers For Specific Delivery Of Drugs To The Brain".

Mahmoud Sheha, Aly El-Tayeb, Hosny El-Sherif, and Hassan Farag.

10. Arch. De Pharmazie 2003, 336, 258-263

1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New Carriers for Brain Specific Delivery II: Delivery of Phenethylamine as Model Drug

Sahar Mahmoud, Mahmoud Sheha, Tarek Aboul-Fadl, Hassan Farag.

11. J.Chromatographic Sci. 2003, 41(1); 10-16

Quantitative Thin Layer Chromatographic Method of Analysis of Azithromycin in Pure and Dosage Forms

Alaa Khedr and Mahmoud Sheha

12. Arch. de Pharmazie 2003,41(9); 823-826

1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New Carriers for Brain Specific Delivery I: Synthesis and Estimation of Oxidation Kinetics Using Multivariate Calibration Method.

Sahar Mahmoud, Mahmoud Sheha, Tarek Aboul-Fadl, Hassan Farag.

13. Eur. J. Pharm. Sci. 2002, 17, 121-130

AAPS 2001 Proceeding, October 23, Control number; 01-A-13468-AAPS entitled "Biological and Metabolic Study of Naproxen-Propyphenazone Hybrid Drug".

Mahmoud Sheha, ALAA Khedr, Hosny El-Sherief.

14. Eur J Med Chem 2000 Oct;35(10):887-894

Synthesis of di- and tripeptide analogues containing alpha-ketoamide as a new core

structure for inhibitionof HIV-1 protease.

Sheha MM, Mahfouz NM, Hassan HY, Youssef AF, Mimoto T, Kiso Y.

15. Pharmazie 2000 Jul;55(7):513-517

In vitro and in vivo evaluation of an amylobarbitone/hydroxy-propyl-beta-cyclodextrin

complex prepared bya freeze-drying method.

Fathy M, Sheha M.

OTHER ACTIVITIES

1.Three M.SC and Two Ph.D thesis supervision:

- Med. Chem. Dept., Faculty of Pharmacy, Assiut University, Egypt. (Chemical delivery system).

-Med. Chem. Dept., Faculty of Pharmacy, Al-Azhar University, Egypt. (Drug-Brain delivery).

-Med. Chem. Dept., Faculty of Pharmacy, Assiut University, Egypt. (Prodrug for site-specific drug delivery).

-Food Manufacturing Dept., Faculty of Agriculture, Assiut University, Egypt. (Effect of manufacturing processes

on Isoflavone content in commercial Soybean foods).

  1. Bioequivalence study, analytical method development and consultancy for some pharmaceutical companies.
  2. Join-research projects with FrenchUniversity (Université de la Meditérranée) and Inserm Institute (France) and patent applications about drug targeting to the brain.

INTERNATIONAL CONFERENCES

[1] Achema 2000, International Meeting on Chemical Engineering, Environmental Protection and Biotechnology, Frankfurt, Germany, May 22-27, 2000.

[2] American Association of Pharmaceutical Sciences, Indianapolis, 21 - 25 October 2000.

[3] American Association of Pharmaceutical Sciences, Denver, 21 - 25 October 2001 (Two papers; Oral and poster presentations).

[4] NODCAR Conference, Cairo, 23-25 March 2002 (Poster presentation).

[5] Egyptian Pharmaceutical Conference, Cairo, December 23, 2002 (Poster Presentation).