Jianhua Yu, PhD Updated: 05/31/2016
Jianhua Yu, PhD
General Information
The Ohio State University
Biomedical Research Tower
Room 816, 460 West 12th Avenue
Columbus, OH 43210
614-293-1471(office)
614-688-7594 (Lab)
Education
2003Ph.D.Molecular Biology, Purdue University, West Lafayette, Indiana
2005PostdocImmunology and Cancer Biology, College of Medicine, Comprehensive Cancer Center, James Cancer Hospital, Columbus, Ohio
Current Position
2015-presentAssociate Professor with Tenure, Division of Hematology, Department of Internal Medicine, College ofMedicine, The Ohio State University.
Research Areas
NK cell biology, chimeric antigen receptor (CAR) NK and CAR T cells, oncolytic virus, gene regulation and cell signaling in immune response and malignant transformation, blood and marrow stem cell transplantation,immuno-cellular therapy or oncolytic virotherapy for acute myeloid leukemia, multiple myeloma, glioblastoma, etc.
Professional Experience and Academic Appointments
2011-2015Assistant Professor, Division of Hematology, Department of Internal Medicine, College of
Medicine, The Ohio State University.
2007-2011Research Scientist, Division of Hematology, Department of Internal Medicine, College of
Medicine, The Ohio State University.
2005-2006Research Associate, Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University.
2003-2005Postdoctoral Researcher, The Ohio State University Comprehensive Cancer Center.
2001-2003Research Assistant, Purdue University.
Honors and Awards
National
2015Jack Latham Memorial Award for Innovative Research, the National Blood Foundation
2015Research Scholar, the American Cancer Society
2015Gabrielle's Angel Foundation Medical Award
2012Scientific Research Grant Recipient, the National Blood Foundation
2004ASH Travel Award, the American Society of Hematology
Institutional
2015FAME Faculty of the Year Award for Researchers, College of Medicine, The Ohio State University
2012Institutional Research Grantee, the American CancerSociety
2003-2004Up on the Roof Postdoctoral Fellowship, the James Cancer Hospital, The Ohio State
University
Professional Memberships and Activities
2015-Member, The International Society for Natural Immunity
2014-Member, The Asia-Pacific Blood and Marrow Transplantation Organization (APBMT)
2012-Member, The International Association of Comparative Research on Leukemia
and Related Diseases (IACRLRD)
2011-Member, The American Association of Blood Banks (AABB)
2011- Member, The Ohio State University Comprehensive Cancer Center (OSUCCC)
2005-Member, The American Association for Cancer Research (AACR)
2005-Member, The American Society of Hematology (ASH)
Educational Activities
Teaching at The Ohio State University
2016Biomedical Sciences Graduate Program (BSGP) 8800: Cancer Biology and Therapeutics
2016The Integrated Biomedical Science Graduate Program (IBGP) 7040: Research Problem Solving in Biomedical Science
2016Pathology/Veterinary Biosciences 6640: Fundamentals of Oncology
2015Adoptive Cell Transfer, Basic Science Lecture for Fellows
2015The Integrated Biomedical Science Graduate Program (IBGP) 7040: Research Problem Solving in Biomedical Science
2015The immunology part of Biomedical Engineering 5310 – Advanced Biomaterials
2014MVIMG (Molecular Virology, Immunology & Medical Genetics) 8010: Cancer Immunology
2014The Integrated Biomedical Science Graduate Program (IBGP) 7040: Research Problem Solving in Biomedical Science
2014The immunology part of Biomedical Engineering 5310 – Advanced Biomaterials
2014Biology 4998: Undergraduate Research
2014Pathology 850: Seminar in Pathology and Clinical Pathology (Immunology)
2013The Integrated Biomedical Science Graduate Program (IBGP) 7040: Research Problem Solving in Biomedical Science
2013Pathology 850: Seminars in Pathology
2013IBGP 7930: Individual Studies in Integrated Biomedical Science (Laboratory Rotations)
2013MCDB 7780: Molecular, Cellular, and Developmental Biology (MCDB) Interdisciplinary Graduate Program Laboratory Rotations
2012The immunology part of Biomedical Engineering (BME) 5310 – Advanced Biomaterials
2012IBGP 7060: Faculty Research in Biomedical Science
2012Pathology 850: Seminars in Pathology
2011Biology 4998: Undergraduate Research
Editorial Board Services
2015-Member,Journal of Cancer Biology and Treatment
2014-Member, Journal of Cellular Immunotherapy
2013-Academic Editor, PLOS ONE
2012-Member, American Journal of Translational Research
2012-Member, Scientifica-Hematology
Ad HocJournal Referee
2016-presentReviewer, Nature Reviews Immunology
2016-presentReviewer, Science Translational Medicine
2016-presentReviewer, Clinical Cancer Research
2016-presentReviewer, Current Medicinal Chemistry
2016-presentReviewer, Journal of Video Experiments
2016-presentReviewer, Journal of Hematology and Oncology
2016-presentReviewer, Molecular and Cellular Biochemistry
2015-presentReviewer, Scientific Reports (Nature Publisher)
2015-presentReviewer, Oncotarget
2015-presentReviewer, Oncoimmunology
2015-presentReviewer, Cancer Immunology Research
2015-presentReviewer, Innate Immunity
2014-presentReviewer, Haematologica
2014-presentReviewer, Blood and Marrow Transplantation
2014-presentReviewer, BMC Cancer
2014-presentReviewer, Immunity
2013-presentReviewer, International Immunopharmacology
2013-presentReviewer, Scientifica-Hematology
2013-presentReviewer, World Journal of Pediatrics
2013-presentReviewer, PLoS One
2013-presentReviewer, Stem Cells
2012-presentReviewer, Leukemia Research
2011-presentReviewer, Apoptosis
2010-presentReviewer, Cancer Immunology and Immunotherapy
2010-presentReviewer, Immunotherapy (Future Medicine)
2009-presentReviewer, European Journal of Immunology
2005-presentReviewer, Blood
2005-presentReviewer,Journal of Leukocyte Biology
Contributions to National/International Professional Organizations
2015Abstract reviewer and session moderator, The 57th Annual Meeting of the American Society of Hematology, the session of Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections II
2014 Co-chair, Translational Research Cancer Center Consortium (TRC3), Symposium II,
Seven Springs, Pennsylvania, United States
2013Abstract review coordinator, The 55th Annual Meeting of the American Society of Hematology
2013Meeting session moderator, The 55th Annual Meeting ofAmerican Society of Hematology
2013Abstract reviewer, The 55th Annual Meeting of the American Society of Hematology, the session of Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections II
2012Meeting session moderator, The 54th Annual Meeting of American Society of Hematology
2012Abstract reviewer, The 54th Annual Meeting of the American Society of Hematology, the session of Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections II
Journal Article Publications
1.Yu J, Marshall K, Yamaguchi M, et al. Microhomology-dependent end-joining and repair of transposon-induced DNA hairpin by host factors in Saccharomyces cerevisiae.Molecular and Cellular Biology.2004 Feb;24(3):1351-64.Highlighted in Faculty of 1000 Biology. PMCID: PMC321453.
2.Liu S, Shen T, Huynh L, Klisovic MI, Rush LJ, Ford JL, Yu J, Becknell B, Yu L, Liu C, Vukosavljevic T, Whitman SP, Chang KS, Byrd JC, Perrotti D, Plass C, Marcucci G. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Research. 2005 Feb;65(4):1277-84. PMID:15735013.
3.Trotta R, Parihar R, Yu J, Becknell B, Allard J, Wen J, Ding W, Mao H, Tridandapani S, Carson WE 3rd, Caligiuri MA.Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine co-stimulation. Blood. 2005 Apr 15;105(8):3011-8. PMID:15604218.
4.Becknell B*, Trotta R*, Yu J*, Ding W, Mao HC, Hughes T, Marburger T, and Caligiuri MA. Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector. Journal of Immunological Methods. 2005 Jan;296(1-2):115-23.*These authors equally contributed to this paper. PMID:15680156.
5.Fulci G, Breymann L, Gianni D, Rhee SS, Brat DJ, Stemmer-Rachamimov A, Yu J, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proceedings of the National Academy of Sciences of the United States of America.2006 Feb 15;103(34):12873-78.PMCID: PMC1568940.
6.Yu J, Wei M, Becknell B, Trotta R, Liu S, Boyd Z, Jaung MS, Blaser BW, Sun J, Benson DM, Mao H, Yokohama A, Bhatt D, Shen L, Davuluri R, Weinstein W, Marcucci G, Caligiuri MA. Pro- and anti-inflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity. 2006 May;24(5):575-90. PMID:16713975.
Note: Commentary in Immunity by Dr. Howard A. Young, 2006, 24(5): 506-7.In news. Highlighted in Faculty of 1000 Biology.
7.Becknell B, Hughes T, Freud AG, Blaser BW, Yu J, Trotta R, Mao HC, Caligiuri de Jesús ML. Alghothani M, Benson Jr DM, Lehman A, Jarjoura D, Perrotti D, Bates MD, Caligiuri MA. Hlx homeobox transcription factor negatively regulates interferon- production in monokine-activated natural killer cells. Blood. 2007 Mar;109(6): 2481-7. PMCID: PMC1852195.
8.Liu S, Klisovic RB, Vukosavljevic T, Yu J, Paschka P, Huynh L, Pang J, Neviani P, Liu Z, Blum W, Chan KK, Perrotti D, Marcucci G. Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells. Journal of Pharmacology and Experimental Therapeutics. 2007 Jun;321(3):953-60. PMID:17389244.
9.Caligiuri MA, Briesewitz R,Yu J, Wang L, Wei M, Arnoczky KJ, Marburger T, Wen J, Perrotti D, Bloomfield CD, Whitman SP. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.Blood. 2007 Aug;110(3):1022-4.PMCID: PMC1924768.
10.Trotta R, Col JD, Allard J II, Neviani P, Santhanam R, Mao H, Becknell B, Yu J, Ferketich AK, Modi A, Blaser BW, Perrotti D, Caligiuri MA. The PP2A inhibitor SET regulates natural killer cell IFN- gene expression. Journal of Experimental Medicine. 2007 Oct;204(10):2397-405. PMCID: PMC2118465.
11.Yu J*, Wei M, Boyd Z, Lehmann EB, Trotta R, Mao H, Becknell B, Jaung MS, Jarjoura D, Wu LC, Caligiuri MA*. Transcriptional control of human T-BET expression: the role of Sp1. European Journal of Immunology. 2007 Sept;37(9):2549-61. PMID:17705132.*Co-corresponding author.
12.Liu S, Liu Z, Xie Z, Pang J, Yu J, Lehmann E, Huynh L, Vukosavljevic T, Klisovic RB, Baiocchi R, Blum W, Porcu P, Garzon R, Byrd JC, Perrotti D, Caligiuri MA, Chan KK, Wu LC, and Marcucci G. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood. 2008 Feb 15;111(4):2364-73.PMCID: PMC2234064.
13.Kondadasula VS,Roda JM, Parihar R,Yu J, Caligiuri MA, Tridandapani S, Carson W 3rd. Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of Erk and enhanced production of IFN-gamma.Blood. 2008 Apr;111(8):4173-83. PMCID: PMC2288725.
14.Trotta R, Col JD, Yu J, Ciarlariello D, Thomas B, Zhang X, Allard J 2nd, Wei M, Mao H, Byrd JC, Perrotti D, Caligiuri MA. TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells. The Journal of Immunology. 2008 Sept;81(6):3784-92.PMCID: PMC2924753.
15.Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G. MicroRNA -29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. 2009 Jan;113(17):4008-10.PMCID: PMC2710934.
16.Park IK, Giovenzana C, Hughes TL, Yu J, Trotta R, Caligiuri MA.The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.Blood. 2009 Mar;113(11):2470-7.PMCID: PMC2656272.
17.Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Curcumin is a potent DNA hypomethylation agent. Bioorganic & Medicinal Chemistry Letters. 2009 Feb;19(3):706-9. PMID:19112019.
18.Benson DM Jr, Yu J, Becknell B, Wei M, Freud AG, Ferketich AK, Trotta R, Perrotti D, Briesewitz R, Caligiuri MA. Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells. Blood. 2009 Mar;113(12):2706-14.PMCID: PMC2661858.
19.Yu J*, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM Jr, Caligiuri MA*. CD94 defines phenotypically and functionally distinct mouse NK cell subsets. The Journal of Immunology. 2009 Oct;183(8):4968-74.PMCID: PMC2924742.*Co-corresponding author.
20.Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, Mao H, Nuovo G, Yu J, Caligiuri MA. Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. Blood. 2009 Apr; 113(17):4008-10.PMCID: PMC2673127.
21.Yu J*, Ershler M, Yu L, Wei M, Hackanson B, Yokohama A, Mitsui T, Liu C, Mao H, Liu S, Liu Z, Trotta R, Liu CG, Liu X, Huang K, Visser J, Marcucci G, Plass C, Belyavsky AV, Caligiuri MA*. TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Blood. 2009 May;113(22):5558-67.PMCID: PMC2689053.*Co-corresponding author.
22.Yokohama A, Mishra A, Mitsui T, Becknell B, Johns J, Curphey D, Blaser BW, Vandeusen JB, Mao H, Yu J, Caligiuri MA. A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.Leukemia Research. 2010 Feb;4(2):203-9.PMCID: PMC2814907.
23.Schwartzbaum JA, Huang K, Lawler S, Ding B, Yu J, Chiocca EA. Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma. Neuro-Oncology. 2010 Apr;12(4):320-7.PMCID: PMC2940608.
24.Yu J*, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA*. CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK cell subsets. Blood. 2010 Jan;115(2):274-81. PMCID: PMC2808153. *Co-corresponding author. Highlighted in Faculty of 1000 Biology.
25.Guimond M, Freud AG, Mao HC, Yu J, Blaser BW, Leong JW, Vandeusen JB, Dorrance A, Zhang J, Mackall CL, Caligiuri MA. In vivo role of Flt3 ligand and dendritic cells in natural killer cell homeostasis. The Journal of Immunology. 2010 Mar;184(6):2769-75. PMCID: PMC2924750.
26.Zhang X, Yu J. Target recognition-induced NK cell responses. Blood. 2010 Mar;115(11):2119-20. PMID:20299516.
27.Benson DM Jr, Bakan CE, Mishra A, Hofmeister CC, Efebera Y, Becknell B, Baiocchi RA, Zhang J, Yu J, Smith MK, Greenfield CN, Porcu P, Devine SM, Rotem-Yehudar R, Lozanski G, Byrd JC, Caligiuri MA. The PD-1 / PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel, monoclonal anti-PD-1 antibody. Blood. 2010 Sept; 116(13):2286-94. PMCID: PMC3490105.
28.Hughes TL, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA. Interleukin-1beta selectively expands and sustains IL-22(+) immature human natural killer cells in secondary lymphoid tissue. Immunity. 2010 Jun; 25:32(6):803-14. PMCID: PMC3742307.
29.Liu S, Wu LC, Pang J, Santhanam R, Schwind S, Wu YZ, Hickey CJ, Yu J, Becker H, Maharry K, Radmacher MD, Li C, Whitman SP, Mishra A, Stauffer N, Eiring AM, Briesewitz R, Baiocchi RA, Chan KK, Paschka P, Caligiuri MA, Byrd JC, Croce CM, Bloomfield CD, Perrotti D, Garzon R, Marcucci G. Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell. 2010 Apr;17(4):333-47.PMCID: PMC2917066.
30.Smith MA, Maurin M, Cho HI, Becknell B, Freud AG, Yu J, Wei S, Djeu J, Celis E, Caligiuri MA, Wright KL. PRDM1/Blimp-1 controls effector cytokine production in human NK cells. The Journal of Immunology. 2010 Nov;185(10):6058-67. PMCID: PMC3864810.
31.Trotta R, Ciarlariello D, Dal Col J, Mao C, Chen L, Briercheck E, Yu J, Zhang J, Perrotti D, Caligiuri MA. The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells. Blood. 2011 Feb;117(8):2378-84. PMCID: PMC3062407.
32.Liu S, Madiai F, Hackshaw KV, Allen CE, Carl J, Huschart E, Karanfilov C, Litsky A, Hickey CJ, Marcucci G, Huja S, Agarwal S, Yu J, Caligiuri MA, Wu L-C. The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis. PLoS ONE. 2011 Mar;6(3):e17161.PMCID: PMC3048431.
33.Kannan Y, Yu J, Raices RM, Seshadri S, Wei M, Caligiuri MA, and Wewers MD. IB augments IL-12- and IL-18-mediated IFN- production in human NK cells. Blood.2011 Mar;117(10):2855–63. PMCID: PMC3062297.
34.Yu J*, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson DM Jr, Loughran TP Jr, Tridandapani S, Caligiuri MA*. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. TheJournal of Clinical Investigation. 2011 Apr;121(4):1456–70.PMCID: PMC3069763.Note: *Co-corresponding author.In news. Highlighted in Faculty of 1000 Biology.
35.Yang X, Peng Y, Yu B, Yu J, Zhou C, Mao Y, Lee LJ, Lee RJ. A covalently stabilized lipid-polycation-DNA (sLPD) vector for antisense oligonucleotide delivery.Mol Pharm. 2011 Jun 6;8(3):709-15. PMCID: PMC3599967.
36.McClory S and Yu J. CD25 and IFN- expression in the diagnosis of primary immunodeficiency’s. Journal of Pediatric Biochemistry. 2011;2(1):1-2.
37.Mehta P, Wavreille AS, Justiniano SE, Marsh RL, Yu J, Burry RW, Jarjoura D, Eubank T, Caligiuri MA, Butchar JP, Tridandapani S. LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis.PLoS ONE. 2011;6(6):e21175. PMCID: PMC3114867.
38.Yu J. Zoledronate activates NK cells.Blood.2011 Sept;118(10):2642-3. PMID: 21903898.
39.Alvarez-Breckenridge CA*, Yu J*, Price R, Wei M, Min Wei, Wang Y, Nowicki O, Ha YP, Bergin S, Hwang C, Fernandez SA, Kaur B, Caligiuri MA, Chiocca EA. The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells with inhibition of STAT5/T-BET signaling and IFN- generation. Journal of Virology. 2012 Apr;86(8):4566-77. PMCID: PMC3318659. *These authors equally contributed to this paper.
40.Alvarez-Breckenridge CA, Yu J, Kaur Balveen, Caligiuri MA, Chiocca, EA. Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. Advances in Virology. 2012:702839. Epub 2011 Dec 11. PMCID: PMC3263705.
41.McClory S, Hughes T, Freud AG, Briercheck E, Chelsea M, Trimboli A, Yu J, Zhang X, Leone G, Nuovo G, Caligiuri MA. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. TheJournal of Clinical Investigation. 2012 Apr;122(4):1403–1415. PMCID: PMC3314444.
42.Haseley A, Boone S, Wojton J, Yu L, Yoo JY , Yu J, Kurozumi K, Glorioso JC, Caligiuri MA, and Balveen Kaur. Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Research. 2012 Mar;72:1353–62.PMCID: PMC3366191.
43.Hsu S-H, Wang B, Kota J, Yu J*, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, and Ghoshal K. Essential metabolic, anti-inflammatory and anti-tumorigenic functions for miR-122 in mouse liver. TheJournal of Clinical Investigation. 2012 Aug;122(8):2871-83. PMCID: PMC3408748. *Co-first author.
44.Ren Y, Wei M, Still PC, Yuan S, Deng Y, Chen XZ, Himmeldirk K, Kinghorn AD, Yu J. Synthesis and antitumor activity of ellagic acid peracetate. ACS Med. Chem. Lett..2012;3(8)631–36. PMCID: PMC3505040.
45.Alvarez-Brackenridge CA*, Yu J*, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez S, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EA. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nature Medicine. 2012;18(12):1827-34. PMCID: PMC3668784. *Co-first author.
46.Alvarez-Brackenridge CA, Yu J, Caligiuri MA, Chiocca EA. Uncovering a novel mechanism of NK cell suppression of glioblastoma virotherapy. Oncoimmunology. 2013 Apr 1;2(4):e23658. PMCID: PMC3654589.
47.Zhang W, Zhao S, Rao W, Snyder J, Choi JK, Wang J, Khan IA, Saleh NB, Mohler PJ, Yu J, Hund TJ, Tang C and He X. A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells. Journal of Materials Chemistry B.2013;(7):1002-9. Epub 2012 Nov 23. PMCID: PMC3596163.
48.Park IK, Trotta R, Yu J, Caligiuri MA. The Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development. European Journal of Immunology. 2013 Oct;43(10):2750-5. PMCID: PMC3829002.
49.Yu J*, Peng Y, Wu L-C, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, Liu S, Grever MR, Chan KK, Liu Z. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.PLoS ONE. 2013;8(2):e55934. PMCID: PMC3572185.
*Communicating author.
50.Li Y, Mao W, Fan Z, Li J, Fang Z, Ji X, Hua X, Zong G, Li F, Liu C, Yu J. Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives. Chin. Chem. Lett. 2013, 24(12),1134–36.
51.Peng Y, Dai Y, Hitchcock C, Yang X, Liu L, Sun H-L, Cui R, Wei H, Kim T, Lee TJ, Jeon Y-J, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM. Insulin growth factor signaling is regulated by miR-486, an underexpressed microRNA in lung cancer. Proceedings of the National Academy of Sciences of the United States of America.2013 Sept;110(37):15043-48.PMCID: PMC3773758.
52.Yu J*, Freud AG, Caligiuri MA*. Location and cellular stages of NK cell development. Trends in Immunology. 2013 Sep; (13)00112-9. PMCID: PMC3852183.*Communicating author.
53.Wang B, Hsu S, Wang X, Kutay H, Bid H, Yu J, Ganju R, Jacob S, Yuneva M, and Ghoshal K.Reciprocal Regulation of miR-122 and c-Myc in Hepatocellular Cancer: Role of E2F1 and TFDP2. Hepatology.2014 Feb;59(2):555-66. doi: 10.1002/hep.26712. Epub 2013 Dec 20. PMCID: PMC4199239
54.Liu Z, Yu J, Carson WE 3rd, Bai XF. The role of IL-27 in the induction of anti-tumor cytotoxic T lymphocyte response. American Journal of Translational Research. 2013 Aug;5(5):470-480. PMCID: PMC3745435.
55.Agarwal P, Zhao S, Bielecki P, Rao W, Choi JK, Zhao Y, Yu J, Zhang W, and He X. One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells. Lab Chip. 2013Dec;13(23):4525-33. PMCID: PMC3848340.
56.Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner GD, Huang YW. Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. Carcinogenesis. 2013 Dec;34(12):2842-50. PMCID: PMC3845896.
57.Zhao R, Han C, Eisenhauer E, Kroger J, Zhao W, Yu J, Selvendiran K, Liu X, Wani AA, Wang Q. DNA DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells. Molecular Cancer Research. 2014 May;12(3):370-80. Epub 2013Nov 18. PMCID: PMC3962721.
58.Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YW. Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. Cancer Prevention Research. 2013 Dec;6(12);1317-27. PMCID: PMC3902171.
59.Wei R, Zhang W, Fuentes IP, Lei Y, Agarwal P, Weekes B, Li C, Lu X, Yu J, He X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomater. 2014 Feb;10(2):831-42. PubMed PMID: 24516867; PubMed Central PMCID: PMC4136765.
60.Rao W, Bellotti A, Littrup PJ, Yu J, Lu X, and He X. Nanoparticle-encapsulated doxorubicin enhances cryoablation of cancer stem-like cells. Technology.02, 28 (2014). DOI: 10.1142/S2339547814500022.