Name ______Date______Period______Pre AP

Mutations Worksheet

The following is the original DNA sequence. Determine the mRNA sequence and the corresponding amino acids. Compare each of the mutations below to the original to determine the change that occured. Answer the questions for each mutated sequence.

Original DNA Sequence: T A C A C G T T G G C G A C G A C T
mRNA Sequence: ______
Amino Acid Sequence: ______
Mutated DNA Sequence #1: T A C A C G T G T G G C G A C G A C T
mRNA Sequence: ______
Amino Acid Sequence: ______
Circle the mutation on the DNA sequence.
Explain the effect this had on the polypeptide chain:
Mutated DNA Sequence #2: T A C A C C T T G G C G A C G A C T
mRNA Sequence: ______
Amino Acid Sequence: ______
Circle the mutation on the DNA sequence.
Explain the effect this had on the amino acid sequence:
Mutated DNA Sequence #3: T A C A C G T T A G C G A C G A C T
mRNA Sequence: ______
Amino Acid Sequence: ______
Circle the mutation on the DNA sequence.
Explain the effect this had on the polypeptide chain:
Mutated DNA Sequence #4: T A C A C G T T G G G A C G A C T
mRNA Sequence: ______
Amino Acid Sequence: ______
Circle the mutation on the DNA sequence.
Explain the effect this had on the polypeptide chain:

DNA: T A C C G A T A G C C G A C T

mRNA: ______

AA Sequence: ______

5. Determine a single mutation that would alter more than one amino acid in the DNA strand above.

-Record the new DNA sequence. ______

-Circle the mutation.

-A frameshift mutation is more likely to have a greater effect on an organism than a point mutation. Explain the reason for this.

6. A geneticist found that a particular mutation had no effect on the protein coded by a gene. What do you think is the most likely type of mutation in this gene? Why?