Msc Molecular Neuroscience

MSc Molecular Neuroscience

MSc Biomedical Sciences Research

MSc Biophysics and Molecular Life Sciences

PhD Neural Dynamics

2017/2018

UNIT 1 – Foundations of Neuroscience

Reading List

Please note: The literature listed below is partly background literature to be used to look up things that you may not have understood readily from the lectures and partly literature to further deepen your knowledge.

As a further guidance:

Reading labelled ‘essential’ will help you to understand the core material; ‘recommended’ readings will provide you with a more comprehensive understanding of the subject but it should be read selectively; ‘further’ readings contain background (reference) material or more specialised material, which you may want to use to look up specific topics or to obtain further insight.

I. MSc Molecular Neuroscience

Lecture 1: Gross functional anatomy and cellular anatomy (25.09.17) [Daniel Whitcomb]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 1, The brain and behavior [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 2, Nerve cells, neural circuitry and behavior [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 15, The organization of the central nervous system [recommended]

Lecture 2: CNS development (25.09.17) [Elek Molnar]

·  Sanes DH, Reh TA, Harris WA – Development of the nervous system, Academic Press ISBN 13: 978-0-12-618621-5 [recommended]

Lecture 3: Perception (26.09.17) [James Uney]

·  Olivers Sacks. The man who mistook his wife for a hat. [recommended]

·  Principles of Neural Science, Fourth or Fifth Edition Kandel ER et al. Chapter 22. The bodily senses [essential]

·  Principles of Neural Science, Fourth or Fifth Edition Kandel ER et al. Chapter 21; Coding of sensory information, Chapter 23, Touch; [further]

·  Gili et al 2013 J Neurosci 33(9): 4024-4031 Systems/Circuits The Thalamus and Brainstem Act As Key Hubs in Alterations of Human Brain Network Connectivity Induced by Mild Propofol Sedation. [further]

Lecture 4: Neurotransmission (27.09.17) [Daniel Whitcomb]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 8, Overview of synaptic transmission [essential]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 13, Neurotransmitters [essential]

·  Haines DE, Fundamental neuroscience for basic and clinical applications. Chapter 4, the chemical basis for neuronal communication. [recommended]

·  Rang and Dale’s Pharmacology 7th Edition – section 4 – the nervous system [recommended]

Lecture 5: Sleep (28.09.17) [Claire Durant]

·  Principles and practice of sleep medicine [edited by] Meir H. Kryger, Thomas Roth, William C. Dement. [further]

·  Sleep Disorders. S. Wilson & D Nutt. Oxford Psychiatry Library 2013, S Wilson, D Nutt. (Chapters 1,2 &9) [further]

·  Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005 Oct 27;437(7063):1257-63 [recommended]

·  Paterson LM, Nutt DJ, Wilson SJ Sleep and its disorders in translational medicine. J Psychopharmacol (2011) 25:1226-1234 [recommended]

·  Steiger A. Sleep and endocrinology. J Intern Med. 2003 Jul;254(1):13-22 [further]

·  McCarley, R. W. "Neurobiology of REM and NREM sleep." Sleep Med. 8.4 (2007): 302-30 [further]

Lecture 6: Electrophysiology (28.09.17) [Mascia Amici]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 5, Ion channels [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 6, Membrane potential and the passive electrical properties of the neuron [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 7, Propagated signaling: the action potential [recommended]

Lecture 7: Introduction to Neuroendocrinology (02.10.17) [Craig McArdle]

·  Greenspan's Basic & Clinical Endocrinology 8th Edition. D. Gardner and D. Shoback (electronic edition UofB library) [further]

·  Basic & clinical pharmacology 11th ed. Edited By B.G. Katzung, S.B. Masters, A.J. Trevor (electronic edition UofB library) [further]

·  Human Physiology (5th edition). Fox S.I. Wm. C. Brown Publishers. [further]

·  Pharmacology (6th Edition). Rang H.P. et al. Churchill Livingstone [further]

Lecture 8: Autonomic nervous system (02.09.17) [Sergey Kasparov]

·  Vander's Human Physiology, (Wildmaier et al 11ed, 2008; new edition due Nov 2010), chapter 6 [further]

·  WJ Germann and CL Stanfeld "Principles of Human Physiology" [further]

·  Boron and Boulpaep "Medical Physiology" [further]

Lecture 9: Introduction to Genetics (04.10.17) [Mike Greenwood]

·  Molecular Biology of the Cell (5th Edition). Alberts B. et al. Part II, Basic Genetic Mechanisms. [essential]

·  An Introduction to Genetic Analysis (7th Edition). Griffiths A.J.F. et al. Chapter 8, The Structure and Replication of DNA. [essential]

·  Murgatroyd C, Wu Y, Bockmühl Y, Spengler D (2010) Genes learn from stress. Epigenetics 5: 194-199. [recommended]

·  Robertson KD (2005) DNA methylation and human disease. Nature Reviews Genetics 6: 597-610. [recommended]

Lecture 10: Stem cells and the brain (05.10.17) [Lucy Crompton]

·  Arvidsson et al., Nature Med. (2002) 8:963-970 [essential]

·  Daadi et al., PLOS ONE (2008) 3:e1644 [essential]

•  Kelly et al., PNAS (2004) 101:11839-44 [essential]

•  Ebert et al., Nature (2009) 457:277-281 [essential]

•  Takahashi et al., Cell, (2007) 131:861-72 [essential]

•  Caldwell, M. A. et al. Nat. Biotechnol. 19, 475–479 (2001) [essential]

·  Liu, H. & Zhang, S. C. Cell. Mol. Life Sci. (2011) 68:3995–4008 [further]

·  Takahashi, K. & Yamanaka, S. Development 140, 2457–2461 (2013) [further]

·  Takahashi & Yamanaka, Cell (2006) 126:663-676 [further]

·  Ormerod, B. K., Palmer, T. D. & Caldwell, M. A. Philos Trans R Soc Lond B Biol Sci 363, 153–170 (2008) [further]

•  Thomson et al., Science (1998) 282:1145-7 [further]

•  http://www.explorestemcells.co.uk/ClassifyingStemCellsCategory.html [further]

Lecture 11: Neuroplasticity (05.10.17) [Hans Reul]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 65, Learning and memory [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 66, Cellular mechanisms of implicit memoy storage and the biological basis of individuality [further]

·  James L. McGaugh (2000) Memory -- a century of consolidation. Science 287:248-251 [further]

·  Ming G-L, Song H (2011) Adult neurogenesis in the mammalian brain: Significant answers and significant questions. Neuron 70:687-702 [recommended]

Lecture 12: Pain (06.10.17) [Fiona Holmes]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 24, Pain [essential]

·  Basbaum AI, Bautista, DM, Scherrer, G & Julius, D (2009) Cellular and molecular mechanisms of pain. Cell 139: 267-284. [recommended]

·  Woolf & Ma (2007) Nociceptors - noxious stimulus detectors. Neuron 55:353-364 [further]

·  Campbell & Meyer (2006) Mechanisms of neuropathic pain. Neuron 52:77-92 [recommended]

·  Scholz & Woolf (2002) Can we conquer pain? Nature Neuroscience 5:1062-1067 [recommended]

Lecture 13: Use of Animals in Research; An Overview (09.10.17) [Nicola Watts]

None.

Lecture 14: Animal models (09.10.17) [Astrid Linthorst]

·  Crawley JN (2008) Behavioral phenotyping strategies for mutant mice. Neuron 57:809-818. [recommended]

·  Nestler Eric J, Hyman Steven E (2010) Animal models of neuropsychiatric disorders. Nature Neuroscience 13:1161-1169. [essential]

·  Wong AH, Josselyn SA (2016) Caution when diagnosing your mouse with schizophrenia: the use and misuse of model animals for understanding psychiatric disorders. Biological Psychiatry 79: 32-38. [further]

·  Toth I, Neumann ID (2013) Animal models of social avoidance and social fear. Cell Tissue Research 354:107-118. [further]

Lecture 15: Information processing in neural networks (09.10.17) [Matt Jones]

·  Moser EI, Kropff E, Moser MB (2008) Place cells, grid cells and the brain's spatial representation system. Annu Rev Neurosci 31: 69-89 [essential]

·  Varela F, Lachaux JP, Rodriguez E & Martinerie J (2001) The brainweb: phase synchronization and large-scale integration. Nature Reviews Neuroscience 2: 229-239 [recommended]

·  Buzsaki G, Moser EI (2013) Memory, navigation and theta rhythm in the hippocampal-entorhinal system. Nature Neuroscience 16:130-138 [recommended]

·  Jones MW, Wilson MA (2005) Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task. PloS Biol 3(12):e402 [further]

·  Seger CA, Miller EK (2010) Category learning in the brain. Annu Rev Neurosci 33:203-219 [further]

Workshop: In Vivo Imaging of the CNS (10.10.17) [Risto Kauppinen]

·  McRobbie D.W., Moore E.A., Graves M & Prince M.R. (2006) From Picture to Protons. Cambridge University Press. Part A. [essential]

·  Abraham T & Feng J. Evolution of brain imaging instrumentation. Semin Nucl Med 2011 41: 202-219. [recommended]

·  Politis M & Piccini P. Positron emission tomography imaging in neurological disorders J Neurol 2012, 259: 1769-80. [essential]

Tutorial: Neuroanatomy (29.09.17) [Zuner Bortolotto]

·  Book: Neuroanatomy by AR Crossman & D Neary - 3rd edition [further]

·  Any recent book or atlas on Human neuroanatomy [further]

II. MSc Biomedical Sciences Research and MSc Biophysics and Molecular Life Sciences

A. Lectures 1-12 and 15-16 of MSc Molecular Neuroscience as above.

B. Additional Lectures:

FBS-LT1: Neurodegenerative disorders [Elek Molnar]

·  Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med 8:595-608. [recommended]

·  Walsh DM, Selkoe DJ (2016) A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci 17:251-260. [recommended]

·  Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R (2017) Protein misfolding in neurodegenerative diseases: implications and strategies. Translational Neurodeg 6:6. [recommended]

·  Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148:1204-1222. [recommended]

FBS-LT2: Demyelinating disorders [Elek Molnar]

·  Cole KLH, Early JJ, Lyons DA (2017) Drug discovery for remyelination and treatment of MS. Glia 65:1565-89. [recommended]

·  Dominigues HS, Portugal CC, Socodato R, Relvas JB (2016) Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair. Frontiers in Cell Dev Biol 4:71. [recommended]

·  Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F (2016) Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol 15:1089-1102. [recommended]

·  Salmaso N, Jablonska B, Scafidi J, Vaccarino FM, Gallo V (2014) Neurobiology of premature brain injury. Nat Neurosci 17:341-346. [recommended]

·  Volpe JJ (2010) Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol 8:110-24. [recommended]

FBS-LT3: Psychiatric Disorders [Andreas Papadopoulos]

·  Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Kapur S. Am J Psychiatry. 2003;160(1):13-23. [essential]

·  Major depressive disorder: new clinical, neurobiological, and treatment perspectives. David J Kupfer, MD, Ellen Frank, PhD, and Mary L Phillips, MD, Lancet. 2012; 379(9820): 1045–1055. [essential]

·  How antidepressants work. New perspectives on the pathophysiology of depressive disorder. Reid IC, Stewart CA The British Journal of Psychiatry 2001; 178: 299-303 [recommended]

·  Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate – serotonin interactions for pharmacotherapy Carlsson ML. Journal of Neural Transmission 1998; 105: 525-535 [recommended]

FBS-LT4: Epilepsy [Zuner Bortolotto]

·  Avanzini G, Franceschetti S (2003) Cellular biology of epileptogenesis. Lancet Neurol 2:33-42. [recommended]

·  DeLorenzo RJ, Sun DA, Deshpande LS (2005) Cellular mechanisms underlying acquired epilepsy: The calcium hypothesis of the induction and maintenance of epilepsy. Pharmacol Therapeutics 105:229-66. [further]

·  Pitkänen A, Lukasiuk K (2009) Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy & Behavior 14: 16-25 [recommended]

·  Principles of Neural Science, Fifth Edition, Edited by Kandel ER et al., Chapter 50, Seizures and Epilepsy. [essential]

·  Berg AT & Scheffer YE. (2011) New concepts in classification of the epilepsies: Entering the 21st century. Epilepsia, 52(6):1058–1062. [recommended]

FBS-LT5: Glutamate receptors in health and disease [Elek Molnar]

·  Collingridge et al. (2013) The NMDA receptor as a target for cognitive enhancement. Neuropharmacology 64:13-26. [recommended]

·  Molnár E (2017) Glutamate receptors. In: Encyclopedia of Signaling Molecules, Second Edition (ed: Choi S), Springer Reference, ISBN: 978-1-4939-6799-5 (print), 978-1-4939-6801-5 (eReference), 978-1-4939-6800-8 (print and eBook) (in press; Oct 2017) [recommended]

·  Niciu MJ, Kelmendi B, Sanacora G (2012) Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behavior 100:656-664 [recommended]

·  Nicoletti et al. (2011) Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology 60:1017-41. [recommended]

·  Traynelis et al. (2010) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62:405-96. [recommended]

FBS-LT6: Discovering new therapies for neurological and psychiatric diseases [Elek Molnar]

·  Pankevich DE, Altevog BM, Dunlop J, Gage FH, Hyman SE (2014) Improving and accelerating drug development for nervous system disorders. Neuron 84:546-53. [recommended]

·  Duyckaerts C, Potier M-C, Delatour B (2008) Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropath 115:5-38 [recommended]

·  Mullane K, Williams M (2013) Alzheimer’s therapeutics: Continued clinical failures question the validity of the amyloid hypothesis – but what lies beyond? Biochem Pharmacol 85:289-305 [recommended]

·  Musardo S, Saraceno C, Pelucchi S, Marcello E (2013) Trafficking in neurons: Searching for new targets for Alzheimer’s disease future therapies. Eur J Pharmacol 719:84-106 [recommended]

PhD Neural Dynamics

A. Lectures 1-16 MSc Molecular Neuroscience as above.

B. Lectures FBS-LT1-6 MSc Biomedical Sciences Research as above.

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