Mohamed Ali Shafie

PERSONAL DATA:

First name: / Mohamed / Middle name: / Ali
Last name: / Attia Shafie
Address: / Faculty of Pharmacy – Assiut University
Phone: / 088/2335156 / Mobile: / 0112727999
Email: /
Date of birth: / Sept. 4, 1946
Nationality: / Egyptian
Marital Status: / Married

Academic Degrees:

Bachelor

University: / Assuit / Year: / 1969
Major: / Pharmacy and Pharmaceutical Chemistry

Master

University: / Assiut / Year: / 1972
Major: / Pharmaceutics

PHD

University: / First Medical Institute-Mosco- USSR / Year: / 1978
Major: / Formulation of Ophthalmic Preparations

Habilitation

University: / Year:
Major:

Teaching Experience:

Name of Institution / AssiutUniversity
From – To / 2002 - 2006
Job Title / Professor and Head of Pharmaceutics
Department .
Courses taught / Biopharmaceutics – Dosage form design .
Name of Institution / MisrInternationalUniversity
From – To / 2004 – 2006
Job Title / Part time position
Courses taught / Technology of Dosage forms and Dosage
Form design .
Name of Institution / AssiutUniversity
From – To / 1986 – 1990
Job Title / Professor of Pharmaceutics
Courses taught / Post-graduate students in field of
Pharmaceutics .

Professional Experience:(non-academic)

Company/ Institution / Liptis Pharmaceutcals
From – To / 2004 – 2006
Job Title/Department / Consultant
Job description / Share in design of the company building.
Formulation of new products.
Follow-up the production of market
Products .
Company/ Institution / Cid – Pharmaceutical company
From – To / 1994 – 2005
Job Title/Department / Cosultant
Job description / Propose new products .
Follow- up the production of some products .
Solve problems raised during production .
Company/ Institution / T3A pharmaceutical company
From – To / 1999 – 2000
Job Title/Department / Production Manager
Job description / Manage the production of different
Pharmaceutical dosage forms .

Research Experience:

Name of Institution / Assiut University
From – To / 1994 – 2006
Job Title / Prof. of Pharmaceutics
Research field / Ophthalmic preparations .
Buccal Delivery .
Oral delivery of Protein and Peptide .
Name of Institution / Pharmedic Company – USA
From – To / 1990 – 1991
Job Title / Scientist
Research field / Development of some Dosage
Preparations .
Improve the stability and release of some
Drugs from different forms .
Name of Institution / Applied Analytical Industries - USA
From – To / 1991 – 1994
Job Title / Senior Scientist .
Research field / Developing many products in different
Dosage forms .

Areas of Research Interest:

Design of Ophthalmic preparations .

Oral delivery of protein and peptide .

Transdermal delivery .

Conferences:

  • Controlled release of bioactive materials conference, basel, switzerland, August, 1988.
  • Controlled release conference, Illinois, U.S.A., 1989.
  • A.A.P.S. conference, Las Vagus, U.S.A., 1990.
  • A.A.P.S. conference, WashingtonD.C., 1992.
  • Egyptian pharmaceutical sciences, Cairo, Egypt, 1995.
  • AssiutUniversity 1st Pharmaceutical sciences conference, 1998.
  • AssiutUniversity 2nd Pharmaceutical science, conference, 2000.
  • Round table discussion and about "Environmental pollution health problems-Diagnosis, prevention and treatment from 18 to 23 May, 1996. AssiutUniversity.
  • Egyptian pharmmaceutical Sciences conference, Cairo, Egypt, 2004 .

Publications:

  1. Mohamed Ali Attia Shafie1 and Mai Ahmed Hassan Rady: In vitro and In vivo Evaluation of Timolol Maleate Ocular Inserts UsingDifferent Polymers. Journal of Clinical and Experimental Ophthalmology. 3(8), 1-9, 2012
  2. Mohamed Attia , Mohamed El Azizi, Mohamed S. Hashish : Design and Evaluation of Ciprofloxacin hydrochloride Ocular Inserts . J. Pharmacyand Pharmacology. InternationaL Journal of PharmTech Research. 3(3): 1750-1763, 2011.
  3. Mohamed Attia, Heba Y. El Badawy : Film forming gel for treatment of oral mucositis : In-Vitro studies . International J. of Drug Delivery 2, 314 – 2, 2010.
  4. Mohamed Attia, Heba Y. El Badawy : Film forming gel for treatment of oral mucositis : In-Vitro studies . International J. of Drug Delivery 2, 314 – 21, 2010
  5. Gihan Fetih, Habib Fawsia, Naoki Okada, Takuya Fujita,Mohamed Attia and Akira Yamamoto : Colon-Specific delivery and enhanced colonic absorption of [ Asu ]- eel Calcitonin using Chitosan Capsules containing Various Additives in Rats . J. Drug Target,14(3): 165 – 72, 2006 .
  6. Gihan Fetih, Fawsia Habib, Hidmasa Katsum, Naoki Okada,TakuyaFujita, Mohamed Attia, and Akira Yamamoto : Excellent Absorption Enhancing Characteristics of NO Donors forimproving the Intestinal Absorption of Poorly Absorbable Compound Compared with Conventional Absorption Enhancers .Drug Metab. Pharmacokinet. Vol. 21, No. 3, 2006 .
  7. Attia, M. A. et.al. Nitric oxide donors can enhance the intestinal transport and absorptionof insulin and [ Asu1,7] -eel calcitonin in rats . J. Control. Release 106, 287 – 297, 2005 .
  8. Attia, M. A. et. al. Improvement of absorption enhancing effects of n-dodecyl- B - D -maltopyranoside by its colon-specific delivery using chitosan capsules Int. J. Pharmaceutics 293, 127 – 135, 2005 .
  9. Attia, M.A. et. al. Transbuccal permeation, anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels .Int. J. Pharmaceutics 267, 11 – 28, 2004 .
  10. Attia, M.A. et. al.Ocular Bioavailability of Prednisolone Multiple Emulsion Delivery Systems .Bull. Pharm. Sci. Assiut Univ., Vol. 17, Part 2, 1995
  11. Abd-Elmageed, A.; Attia, M.A.; Masoud A.A.; Abd-Elotaleb, M.E.: Performance of propranolol hydrochloride ophthalmic preparations in the eye of human patients. Mans. J. Pharm. Sci., 14(1): 129-142, 1998.
  12. Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro and in-vivo studies on propranolol hydrochloride ophthalmic solutions. Int. Conf. Pharm. Ind., Abs. Book 30, May , Alexandria-Egypt, 1990.
  13. Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro release and in-vivo performance of propranolol hydrochloride from ophthalmic gels. Int. Conf. Pharm. Ind., Abs. Book 30, May, Alexandria-Egypt, 1990.
  14. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: The formulation-performance relationship of multiple emulsions and ocular activity. J. of controlled release. 32, 259 - 268, 1994.
  15. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: Preparation and evaluation of Hydrocortisone Multiple emulsions in rabbits eye. J. die Pharm. Ind. 56(6), 584 - 588, 1994.
  16. Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: Influence of the phase volume ratio of multiple emulsions on the ocular activity of prednisolone. J.S.T.P. Pharma Sciences. 5(4) 309-315, 1995.
  17. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Refinement of Current Theories Underlying the mechanisms of action of viscolizers in ophthalmic preparations. 16th inter. Symposium on controlled release of Bioactive Materials, Chicago, Illinois, U.S.A., 1989.
  18. Attia, M.A.; Kassem, M.A.; Safwat, M.S.: In-vitro and In-vitro release of C-Mofebutazone from ocular polymeric inerts. 16th Inter. Symposium on controlled Release of Bioactive Materials, Chicago, Illinois, U.S.A., 1989.
  19. Attia, M.A.; Kassem, M.A.; Schulte, Karl E.: Patent DE 35 33 635 C2 West Germany, 1988.
  20. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect of phenylephrine hydrochloride on betamethasone side effect in relation to viscosity of ophthalmic preparations. II. Gel. State. Drug Development and Industrial Pharmacy, 15(2), 1989.
  21. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect of phenylephrine hydrochloride on betamethasone side effect in relation to viscosity of ophthalmic preparations. I. Viscous Solutions. Drug Development and Industrial Pharmacy, 15(2), 1989.
  22. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Influence of phenylephrine hydrochloride on the anti-inflmmatory effect of betamethasone in the eye of rabbit. 15th inter. Symp. on Controlled Release of Bioactive Materials. Basel-Switzerland, August, 1988.
  23. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vivo performance of H-dexamethasone ophthalmic film delivery system in rabbit eye. Inter. J. of Pharmaceutics, 47, 21 – 30, 1988.
  24. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Impact of formulation factors on Pharmacokinetics of H-dexamethasone in ocular tissues. 15th Inter. Symp. On controlled release of bioactive materials. Basel-Switzerland, August, 1988.
  25. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of opththalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye. II. Effect of methylhydroxyethylcellulose. Drug Development and Industrial Pharmacy, 13(8), 1987.
  26. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of ophthalmic solutions of betamethasone and phenylephrine hydrochloride in the eye of rabbit. I. Effect of Methylcellulose. J. Drug Development and Industrial Pharmacy, 13(8), 1987.
  27. Attia, M.A.; Habib, F.S.: Permeability of phenylephrine hydrochloride through the cornea of rabbits. J. de Pharmazeutische Industrie, 48(11), 1986.
  28. Attia, M.A.; Habib, F.S.: In-vitro study of physostigmine salicylate and pilocarpine hydrochloride release from different gel formulations. J. Die Pharmazie, 41. H. 2, 1986.
  29. Attia, M.A.; Habib, F.S.: Effect of polyol type on the In-vitro release of prednisolone from oil-in-water type ointment. J. Pharm. Ind., 48(11), 1986.
  30. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Release and rheological characteristics of chloramphenicol ophthalmic ointments. J. Pharm. Ind., 48(10), 1986.
  31. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation variables on the permeation of dexamethasone through different polymeric films. I. Effect of different polymer type and plasticizers. J.S.T.P. Pharma, 2(12), 1986.
  32. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation variables on the permeation of dexamethasone through different polymeric films. II. Effect of different surfactants. J.S.T.P. Pharma, 2(13), 1986.
  33. Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vitro release of dexamethasone from polymeric inserts. J. Pharm. Belg. 41(2), 1986.
  34. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcohol. Pharmaceutical Research. 3(4), 1986.
  35. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vitro release study of betamethasone and phenylephrine hydrochloride from ophthalmic preparations. Intern. J. of Pharmaceutics, 29, 1986.
  36. Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Activity of ophthalmic gels of betamethasone and phenylephrine hydrochloride in the rabbits eye. Intern. J. Pharmaceutics, 32, 1986.
  37. Attia, M.A.; Habib, F.S.: Pilocarpine delivery from multiple emulsions. J. S.T.P. Pharma, 2(18), 1986.
  38. Attia, M.A.; Habib, F.S.: Ocular delivery of pilocarpine hydrochloride from water soluble polymeric inserts. Acta Pharm. Technol. 32(3), 1986.
  39. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Vehicle influence on ocular disposition of chlortetracycline hydrochloride and chloramphenicol in albino rabbit. Acta Pharmaceutica Technologica, 31(2), 1985.
  40. Attia, M.A.; Habib, F.S.; El-Shanawany, S.M.: Ocular bioavailability of pilocarpine hydrochloride in combination with physostigmine salicylate from different gel formulations. Arch. Pharm. Chem. Sci. Ed., 13, 1985.
  41. Attia, M.A.; Habib, F.S.; El-Shanawany, S.M.: Effect of different ointment bases on ocular disposition of ethylphenylephrine in rabbit eyes. Inter. J. Pharmaceutics 26, 1985.
  42. Attia, M.A.; Habib, F.S.: Dissolution rates of carbamazepine and nitrazepam utilizing sugar solid dispersion system. Drug Development and Industrial Pharmacy, 11(11), 1985.
  43. Attia, M.A.; Habib, F.S.: Effect of particle size on dissolution rate of monophenyl-butazone solid dispersion in presence of certain additives. Drug Development and Industrial Pharmacy, 11(11), 1985.
  44. Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Stability of chlortetracycline hydrochloride and chloramphenicol in some ophthalmic ointment bases. J. Die. Pharmazie, 40, H. 9, 1985.
  45. Attia, M.A.; Habib, F.S.: Comparative study of the ocular activity in rabbit eyes of adrenaline bitartrate formulated in carbopol and poloxamer gels. Arch. Pharm. Chem. Sci. Ed., 12, 1984.
  46. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of different disintegrants on the avalilability of directly compressed sulphadimidine tablets. J. Die Pharmazie, 38, H. 7, 1983.
  47. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.:Effect of certain organic and inorganic additives on the flocculation of suspensions containing different sulphonamides. Bull. of Pharm. Sci., Assiut, Vol. 6, Part 1, 1983.
  48. A Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Study on the dissolution of diazepam from its solid dispersion and coprecipitates in the presence of various concentrations of non-ionic surfactants. J. die. Pharmazie, 37, H. 4, 1982.
  49. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Dissolution study on sulfisoxazle, sulphapyridine and sulphamerazine from their solid dispersions and coprecipitates. Bull. of Pharm. Sci. Assiut, Vol. 5, 1982.
  50. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of directly compressible vehicles on uniformity of contents of oxytetracycline hydrochloride tablets. Bull. Of Pharm. Sci., Assiut, Vol. 5, 1982.
  51. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain ophthalmic preparations containing pilocarpine hydrochloride and dexamethasone on the intraocular pressure of rabbits eye. Bull. Of Pharm. Sci., Assiut, Vol. 5, 1982.
  52. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: A study on the release of prednisone from new ointment bases containing various additives. J. Die. Pharmazie, 36(1), 1981.
  53. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of micellar structure on the solubility of prednisone and prednisolone. Indian. J. of Pharmacy, 43(1), 1981.
  54. Attia, M.,A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain additives on the solubilization of dexamethasone. J. Drug Research, Egypt, 13(1-2), 1981.
  55. Attia, M.A.; El-Sourady, A.; El-Shanawany, S.M.: Release and rheological characteristics of chlortetracycline hydrochloride ophthalmic ointments. Bull. Pharm. Sci., Assiut, Vol. 4, 1981.
  56. Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of surfactant structure on the release of dexamethasone from different ointment bases. Bull. Of Pharm. Sci. Assiut (3), 1980.
  57. Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Effect of Sorption and Leaches of Plastic Granules on the stability of antimicrobial agents and antioxidants. Indian, J. Pharmacy, 35(2), 1973.
  58. Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Leaches and Water Sorption of Polyethylene and Polyvinyl chloride. Indian, J. Pharmacy, 34(4), 1972.

Titles Of Thesis Performed Under My Supervision

MSc. Thesis

  1. Formulation and Evaluation studies on Topical Emulgel Containing Meloxicam, 2012. (German University)
  2. Formulation and Evaluation of Metochlopramide-loaded Solid Lipid Nanoparticles for Rectal Delivery, 2012. (German University)
  3. Design and Evaluation of Ocular Inserts Containing Timolol Maleate, 2011. (German University)
  4. Design and Evaluation of Ciprofloxacin Hydrochloride Ocular Inserts, 2011. (German University)
  5. Film Forming Gel Containing Diclofenac Sodium, Ofloxacin and Their Combination for Treatment of Oral Mucositis, 2010. (German University)
  6. Formulation and Evalauation Studies on Buccal Gels Containing Piroxicam, 2000. (Assiut University)
  7. Pharmaceutical Study of Certain Corticosteroids in Multiple Emulsion, 1992. (Assiut University)
  8. Performance of Propranolol Hydrochloride in Certain Ophthalmic Preparations, 1991. (Assiut University)

Doctor Philosophy Degree:

  1. Oral Delivery of Certain Peptide Derivatives, 2005 (Assiut University
    )
  2. Biopharmaceutical Studies of Certain Corticosteroids and Phenylehrine Hydrochloride in Ophthalmic Preparations, 1985. (Assiuy University)
  3. Design and Evaluation of Polymer-based Films as Ophthalmic Dru Delivery Systems, 1984. (Assiut University)
  4. Formulation and availability Studies of Some Antibiotics From Eye Ointment Bases, 1993. (Assiut University)

Thesis Reviewed by myself

  1. Preparation and Evaluation of Controlled Release Ketoprofen Oral Formulations, 2012. (Assiut University)
  2. A Niosomal Encapsulation of Amikacin Sulfate for Increasing its Efficacy and Safety, 2012. (Al Azhar University)
  3. Incorporation of Chemotherapeutic Agents into Nano or Micro Particles to be Administered by Routes Other than I.V. Systems, 2011. (Beni-Suef University)
  4. Unfractionated Heparin Versus Low Molecular weight Heparine in the Treatment of Deep Venous Thrombosis: Impact of Pharmaceutical Care, 2008. (Helwan University)
  5. Formuation and Evaluation of Some Tinidazole Preparations Containing Certain Bioadhesives, 2004. (Mansoura University)