This bulletin covers aspects of head and neck cancers and should be of interest to multidisciplinary teams working in this area.

Sections can include:

·  Combined Modality Therapies

·  Drug Therapy

·  Pathology, Staging, Polymorphisms & Biomarkers

·  Prognosis, Survival & Risk Factors

·  Radiotherapy & Imaging

·  Supportive Care & Symptom Management

·  Surgery

Many of the following articles are available online via the NHS Scotland Knowledge Network. Please use the links where provided and your ATHENS password. A complete list of available online journals and registration for ATHENS can be found at www.knowledge.scot.nhs.uk/

If the article you require is not available via the NHS Scotland Knowledge Network and you would like to request a print copy, please submit your request online at www.quest.scot.nhs.uk

This bulletin contains a selection of material gathered from a search of the evidence base, and is not intended to be comprehensive. Professional judgment should be exercised when appraising the material. The Library takes no responsibility for the wording, content and accuracy of the information supplied, which has been extracted in good faith from reputable sources. NHSGGC is not responsible for the content of external internet sites.

Compiled by:

Kirsty Coltart

Subject Librarian

Beatson West of Scotland Cancer Centre

0141 301 7285,

General

Iorio, M.L., Ter Louw, R.P., Kauffman, C.L., et al. (2013). Evidence-based medicine: facial skin malignancy. Plastic & Reconstructive Surgery 132,6:1631-1643.

Jenckel, F. and Knecht, R. (2013). State of the art in the treatment of laryngeal cancer. Anticancer Research 33,11:4701-4710.

Lee, S.Y., Shin, H.A., Rho, K.J., et al. (2013). Characteristics, management of the neck, and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions. British Journal of Oral & Maxillofacial Surgery 51,7:e142-7.

Pfister, D.G., Ang, K.K., Brizel, D.M., et al. (2013). Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network 11,8:917-923.

Stoker, S.D., van Diessen, J.N., de Boer, J.P., et al. (2013). Current treatment options for local residual nasopharyngeal carcinoma. Current Treatment Options in Oncology 14,4:475-491.

Combined Modality Therapies

Chitapanarux, I., Tharavichitkul, E., Kamnerdsupaphon, P., et al. (2013). Randomized phase III trial of concurrent chemoradiotherapy vs accelerated hyperfractionation radiotherapy in locally advanced head and neck cancer. Journal of radiation research 54,6:1110-1117.

Ghadjar P. Sun H. Zimmermann F. Bodis S. Bernier J. Studer G. Aebersold DM. Swiss Group for Clinical Cancer Research (SAKK). (2013). Physical examination during chemoradiation predicts outcome of locally advanced head and neck cancer. Secondary results of a randomized phase III trial (SAKK 10/94). Oral oncology 49,10:1006-1009.

Kong, L., Hu, C., Niu, X., et al. (2013). Neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: Interim results from 2 prospective phase 2 clinical trials. Cancer 119,23:4111-4118..

Mittal, B.B., Wang, E., Sejpal, S., et al. (2013). Effect of recombinant human deoxyribonuclease on oropharyngeal secretions in patients with head-and-neck cancers treated with radiochemotherapy. International journal of radiation oncology, biology, physics 87,2:282-289.

Nijkamp, M.M., Span, P.N., Terhaard, C.H., et al. (2013). Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. European journal of cancer 49,15:3202-3209.

Strom, T., Trotti, A.M., Kish, J., et al. (2013). Risk factors for percutaneous endoscopic gastrostomy tube placement during chemoradiotherapy for oropharyngeal cancer. JAMA Otolaryngology-- Head & Neck Surgery 139,11:1242-1246.

Wu, X., Huang, P.Y., Peng, P.J., et al. (2013). Long-term follow-up of a phase III study comparing radiotherapy with or without weekly oxaliplatin for locoregionally advanced nasopharyngeal carcinoma. Annals of Oncology 24,8:2131-2136.

Drug & Targeted Therapies

Argiris, A. (2013). Current status and future directions in induction chemotherapy for head and neck cancer. Critical Reviews in Oncology-Hematology 88,1:57-74.

Bossi, P., Locati, L. and Licitra, L. (2013). Emerging tyrosine kinase inhibitors for head and neck cancer. Expert Opinion on Emerging Drugs 18,4:445-459.

OuYang, P.Y., Xie, C., Mao, Y.P., et al. (2013). Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials. Annals of Oncology 24,8:2136-2146.

Patel, K., Foster, N.R., Farrell, A., et al. (2013). Oral cancer chemotherapy adherence and adherence assessment tools: a report from north central cancer group trial n0747 and a systematic review of the literature. Journal of Cancer Education 28,4:770-776.

Pathology, Staging, Polymorphisms & Biomarkers

Bauman, J.E., Austin, M.C., Schmidt, R., et al. (2013). ERCC1 is a prognostic biomarker in locally advanced head and neck cancer: results from a randomised, phase II trial. British journal of cancer 109,8:2096-2105.

Lassen, P., Overgaard, J. and Eriksen, J.G. (2013). Expression of EGFR and HPV-associated p16 in oropharyngeal carcinoma: Correlation and influence on prognosis after radiotherapy in the randomized DAHANCA 5 and 7 trials. Radiotherapy & Oncology 108,3:489-494.

Mehra, R., Serebriiskii, I.G., Burtness, B., et al. (2013). Aurora kinases in head and neck cancer. Lancet Oncology 14,10:e425-35.

Shuman, A.G., McKiernan, J.T., Thomas, D., et al. (2013). Outcomes of a head and neck cancer screening clinic. Oral oncology 49,12:1136-1140.

Prognosis, Survival & Risk Factors

Cao, C.N., Luo, J.W., Gao, L., et al. (2013). Recurrence of nasopharyngeal carcinoma in the parotid region after definitive intensity-modulated radiotherapy. Journal of Oral & Maxillofacial Surgery 71,11:1993-1997.

Chang, H., Gao, J., Xu, B.Q., et al. (2013). Haemoglobin, neutrophil to lymphocyte ratio and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3,237 patients from a single institution. Clinical Oncology (Royal College of Radiologists) 25,11:639-646.

Rademakers, S.E., Hoogsteen, I.J., Rijken, P.F., et al. (2013). Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial. Radiotherapy & Oncology 108,3:517-522.

Zang, J., Li, C., Zhao, L.N., et al. (2013). Prognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta-analysis. Head & neck 35,10:1507-1514.

Yasumatsu, R., Nakashima, T., Toh, S., et al. (2013). Salvage of recurrent hypopharyngeal carcinoma after primary curative treatment. Acta Oto-Laryngologica 133,10:1110-1116.

Radiotherapy & Imaging

Al-Saleh, M.A., Jaremko, J.L., Saltaji, H., et al. (2013). MRI findings of radiation-induced changes of masticatory muscles: a systematic review. Journal of Otolaryngology: Head and Neck Surgery 42,26.

Bhatnagar, P., Subesinghe, M., Patel, C., et al. (2013). Functional imaging for radiation treatment planning, response assessment, and adaptive therapy in head and neck cancer. Radiographics 33,7:1909-1929.

Fairchild, A., Straube, W., Laurie, F., et al. (2013). Does quality of radiation therapy predict outcomes of multicenter cooperative group trials? A literature review. International journal of radiation oncology, biology, physics 87,2:246-260.

Gunn, G.B., Debnam, J.M., Fuller, C.D., et al. (2013). The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Cancer 119,17:3162-3169.

Hoeben, B.A., Bussink, J., Troost, E.G., et al. (2013). Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer. Acta Oncologica 52,7:1257-1271.

Li, J.G., Yuan, X., Zhang, L.L., et al. (2013). A randomized clinical trial comparing prophylactic upper versus whole-neck irradiation in the treatment of patients with node-negative nasopharyngeal carcinoma. Cancer 119,17:3170-3176.

May, J.T., Rao, N., Sabater, R.D., et al. (2013). Intensity-modulated radiation therapy as primary treatment for oropharyngeal squamous cell carcinoma. Head & neck 35,12:1796-1800.

Monnier, L., Touboul, E., Durdux, C., et al. (2013). Hypofractionated palliative radiotherapy for advanced head and neck cancer: The IHF2SQ regimen. Head & neck 35,12:1683-1688.

Nooh, N. (2013). Dental implant survival in irradiated oral cancer patients: a systematic review of the literature. International Journal of Oral & Maxillofacial Implants 28,5:1233-1242.

Patel, M., Al-Momani, Z., Hodson, N., et al. (2013). Computerized tomography, stereolithography and dental implants in the rehabilitation of oral cancer patients. Dental update 40,7:564-566.

Sreeraman, R., Vijayakumar, S. and Chen, A.M. (2013). Correlation of radiation treatment interruptions with psychiatric disease and performance status in head and neck cancer patients. Supportive Care in Cancer 21,12:3301-3306.

Takacsi-Nagy, Z., Oberna, F., Koltai, P., et al. (2013). Long-term outcomes with high-dose-rate brachytherapy for the management of base of tongue cancer. Brachytherapy 12,6:535-541.

Teo, P.T., Tan, N.C. and Khoo, J.B. (2013). Imaging appearances for recurrent nasopharyngeal carcinoma and post-salvage nasopharyngectomy. Clinical radiology 68,11:e629-38.

Supportive Care & Symptom Management

Alshadwi, A., Nadershah, M., Carlson, E.R., et al. (2013). Nutritional considerations for head and neck cancer patients: a review of the literature. Journal of Oral & Maxillofacial Surgery 71,11:1853-1860.

Bhayani, M.K., Hutcheson, K.A., Barringer, D.A., et al. (2013). Gastrostomy tube placement in patients with oropharyngeal carcinoma treated with radiotherapy or chemoradiotherapy: Factors affecting placement and dependence. Head & neck 35,11:1634-1640.

Bhayani, M.K., Hutcheson, K.A., Barringer, D.A., et al. (2013). Gastrostomy tube placement in patients with hypopharyngeal cancer treated with radiotherapy or chemoradiotherapy: Factors affecting placement and dependence. Head & neck 35,11:1641-1646.

Bradley, P.J., Counter, P., Hurren, A., et al. (2013). Provision of surgical voice restoration in England: questionnaire survey of speech and language therapists. Journal of Laryngology & Otology 127,8:760-767.

Cartmill, B., Cornwell, P., Ward, E., et al. (2013). Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer. Head & neck 35,8:1211-1219.

Dechaphunkul, T., Martin, L., Alberda, C., et al. (2013). Malnutrition assessment in patients with cancers of the head and neck: A call to action and consensus. Critical Reviews in Oncology-Hematology 88,2:459-476.

Duarte, V.M., Chhetri, D.K., Liu, Y.F., et al. (2013). Swallow Preservation Exercises during Chemoradiation Therapy Maintains Swallow Function. Otolaryngology - Head & Neck Surgery 149,6:878-884.

Hsin, C.H., Chen, T.H., Liang, K.L., et al. (2013). Postirradiation otitis media with effusion in nasopharyngeal carcinoma patients treated by intensity-modulated radiotherapy. Laryngoscope 123,9:2148-2153.

Jensen SB. Jarvis V. Zadik Y. Barasch A. Ariyawardana A. Hovan A. Yarom N. Lalla RV. Bowen J. Elad S. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). (2013). Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Supportive Care in Cancer 21,11:3223-3232.

Lambrecht, M., Mercier, C., Geussens, Y., et al. (2013). The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation: a single-center, randomized, prospective study of a calcium phosphate mouth rinse+standard of care versus standard of care. Supportive Care in Cancer 21,10:2663-2670.

Langius, J.A., Zandbergen, M.C., Eerenstein, S.E., et al. (2013). Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo)radiotherapy: a systematic review. Clinical Nutrition 32,5:671-678.

Lonbro, S., Dalgas, U., Primdahl, H., et al. (2013). Progressive resistance training rebuilds lean body mass in head and neck cancer patients after radiotherapy--results from the randomized DAHANCA 25B trial. Radiotherapy & Oncology 108,2:314-319.

Lonbro, S., Dalgas, U., Primdahl, H., et al. (2013). Lean body mass and muscle function in head and neck cancer patients and healthy individuals--results from the DAHANCA 25 study. Acta Oncologica 52,7:1543-1551.

Mason, H., Derubeis, M.B., Foster, J.C., et al. (2013). Outcomes evaluation of a weekly nurse practitioner-managed symptom management clinic for patients with head and neck cancer treated with chemoradiotherapy. Oncology nursing forum 40,6:581-586.

McAllister, P., Maciver, C., Wales, C., et al. (2013). Gastrostomy insertion in head and neck cancer patients: a 3 year review of insertion method and complication rates. British Journal of Oral & Maxillofacial Surgery 51,8:714-718.

McGuire DB. Fulton JS. Park J. Brown CG. Correa ME. Eilers J. Elad S. Gibson F. Oberle-Edwards LK. Bowen J. Lalla RV. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). (2013). Systematic review of basic oral care for the management of oral mucositis in cancer patients. Supportive Care in Cancer 21,11:3165-3177.

Meade, S., McConkey, C., Sanghera, P., et al. (2013). Revised radiobiological modelling of the contribution of synchronous chemotherapy to the rate of grades 3-4 mucositis in head and neck cancer. Journal of Medical Imaging & Radiation Oncology 57,6:733-738.

Milbury, K., Rosenthal, D.I., El-Naggar, A., et al. (2013). An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral oncology 49,11:1067-1071.

Mortensen, H.R., Overgaard, J., Jensen, K., et al. (2013). Factors associated with acute and late dysphagia in the DAHANCA 6 & 7 randomized trial with accelerated radiotherapy for head and neck cancer. Acta Oncologica 52,7:1535-1542.

Mujica-Mota, M., Waissbluth, S. and Daniel, S.J. (2013). Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: A systematic review. Head & neck 35,11:1662-1668.

Nicolatou-Galitis O. Sarri T. Bowen J. Di Palma M. Kouloulias VE. Niscola P. Riesenbeck D. Stokman M. Tissing W. Yeoh E. Elad S. Lalla RV. Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). (2013). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients. Supportive Care in Cancer 21,11:3179-3189.

Pauloski, B.R., Logemann, J.A., Rademaker, A.W., et al. (2013). Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer. Head & neck 35,8:1124-1131.

Platek, M.E., Myrick, E., McCloskey, S.A., et al. (2013). Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: implications for nutrition integrated treatment pathways. Supportive Care in Cancer 21,10:2825-2833.

Rogers, L.Q., Anton, P.M., Fogleman, A., et al. (2013). Pilot, randomized trial of resistance exercise during radiation therapy for head and neck cancer. Head & neck 35,8:1178-1188.

Semple, C., Parahoo, K., Norman, A., et al. (2013). Psychosocial interventions for patients with head and neck cancer. Cochrane Database of Systematic Reviews 7,009441.

So, W.K., Choi, K.C., Chan, C.W., et al. (2013). Perceived unmet supportive care needs and determinants of quality of life among head and neck cancer survivors: a research protocol. Journal of advanced nursing 69,12:2750-2758.

Sopka, D.M., Li, T., Lango, M.N., et al. (2013). Dysplasia at the margin? Investigating the case for subsequent therapy in 'low-risk' squamous cell carcinoma of the oral tongue. Oral oncology 49,11:1083-1087.