Supplemental data

Table S1.Workup after the aborted Sudden Cardiac Arrest

Diagnostic test / Proportion of patients undergoing the test / Result of the test
when performed
Coronary angiogram / 89.2% / Normal 64.1%
1 vessel 15.2%
2 vessels 3.6%
3 vessels 16.6%
Abnormal anatomy 0.5%
Acute occlusion 0.0%
CT coronarography / 6% / Normal 80%
Non-significant stenosis 13.3%
Abnormal anatomy 6.7%
Ergotamine test / 14.8% / Negative 94.6%
Positive 5.4%
Right ventricle angiography / 1.6% / No ARVC/D 85.7
ARVC/D 14.3%
Right Ventricle isotopic angiography / 5.6% / Normal 85.7%
ARVC/D 14.3%
Cardiac Magnetic Resonance Imaging / 51.6% / Normal 36.4%
Abnormal 63.6%
Programmed
ventricular
stimulation / 22.0% / Negative 81.8%
Sustained VT 12.7%
VF 5.5%
Ajmaline / flecainide test / 18.0% / Negative 95.6%
Positive 4.4%
Holter ECG recording / 36.0% / Short coupled VPB 4.1%
Long QT interval 5.9%
Exercise stress test / 8.8% / Normal 100%
High Amplification ECG / 12.8% / Negative 71.9%
Positive 28.1%
Genetic testing / 18.4% / Negative 82.6%
Positive 17.4%

Table S2. Final diagnosis after workup

Etiology / N (%)
Structural
Heart
Disease
64% / Ischemic cardiomyopathy / 70 (28.0%)
Dilated cardiomyopathy / 40 (16.0%) (footnote 1)
Hypertrophic cardiomyopathy / 6(2.4%)
Hypertensive cardiomyopathy / 5(2.0%)
Infiltrative cardiomyopathy / 4 (1.6%) (footnote 2)
Valvular cardiomyopathy / 9 (3.6%)
Arrhythmogenic Right Ventricular Cardioomyopathy / 9(3.6%)
Myocarditis scar / 6(2.4%)
Congenital cardiomyopathy / 2(0.8%)
Coronary Artery Disease / 9 (3.6%)
Structurally
Normal
Heart
36% / Idiopathic Ventricular Fibrillation / 48 (19.2%)
Short coupled VPB / 14 (5.6%)
Long QT Syndrome / 9 (3.6%)
Early Repolarization Syndrome / 8 (3.2%)
Brugada syndrome / 7 (2.8%)
Short QT syndrome / 1 (0.4%)
Catecholergic Polymorphic
Ventricular Tachycardia / 1 (0.4%)
Coronary spasm / 2 (0.8%)

(1) Including 2 Left Ventricular noncompaction

(2) 1 sarcoidosis, 1 Fabry disease, 1 sclerodermia, 1 lymphoma

1