Table S2. Trends in characteristics and mortality for ICU admissions following out-of-hospital cardiac arrest. Data from the 116 ICUs contributing data throughout the study period.

2004 / 2005 / 2006 / 2007 / 2008 / 2009 / 2010 / 2011 / 2012 / 2013 / 2014 / p value for trend
Number of admissions after cardiac arrest, n (%) / 1,186 (2.1) / 1,236 (2.1) / 1,207 (2.0) / 1,434 (2.4) / 1,649 (2.6) / 1,629 (2.5) / 1,752 (2.5) / 1,914 (2.6) / 2,083 (2.6) / 2,282 (2.8) / 2,271 (2.7) / <0.001
Age, mean (sd) / 60 (17.6) / 62 (17.4) / 61 (16.8) / 59 (18.6) / 60 (17.6) / 60 (17.3) / 61 (17.2) / 61 (17.2) / 61 (17.4) / 60 (17.6) / 60 (17.7) / 0.809
Gender, males n (%) / 708 (60.1) / 768 (62.3) / 753 (62.6) / 906 (63.1) / 1,050 (64.3) / 1,034 (64.0) / 1,119 (64.9) / 1,207 (63.8) / 1,357 (65.4) / 1,463 (64.8) / 1,399 (63.1) / 0.015
ICNARC Physiology Score, mean (sd) / 28 (10.1) / 28 (10.1) / 28 (10.1) / 28 (10.0) / 28 (10.0) / 28 (9.9) / 28 (9.5) / 29 (9.6) / 29 (9.5) / 29 (9.7) / 29 (10.4) / <0.001
Critical care unit length of stay, mean (sd) / 4 (6.5) / 4 (5.9) / 4 (5.7) / 5 (7.0) / 4 (6.2) / 5 (6.3) / 5 (7.1) / 5 (7.9) / 5 (8.2) / 5 (7.8) / 5 (8.4) / <0.001*
Critical care unit length of stay, median (IQR) / 1.9 (0.8 4.1) / 1.9 (0.8 3.9) / 2.1 (0.9 4.5) / 2.3 (1.0 4.8) / 2.3 (1.0 4.7) / 2.6 (1.1 4.9) / 2.6 (1.1 5.2) / 2.8 (1.2 5.8) / 2.8 (1.2 5.5) / 3.0 (1.2 5.9) / 2.7 (1.0 5.9) / <0.001*
Hospital length of stay, mean (sd) / 12 (27.1) / 14 (26.6) / 14 (24.0) / 14 (24.2) / 14 (27.9) / 15 (30.4) / 14 (30.3) / 13 (25.4) / 13 (22.8) / 13 (23.1) / 13 (25.2) / <0.001*
Hospital length of stay, median (IQR) / 3.0 (1.0 12.0) / 4.0 (1.0 15.0) / 4.0 (1.0 16.0) / 4.0 (1.0 16.0) / 4.0 (1.0 16.0) / 5.0 (1.0 15.0) / 4.0 (1.0 15.0) / 5.0 (2.0 15.0) / 5.0 (2.0 16.5) / 5.0 (1.0 14.5) / 5.0 (1.0 14.0) / <0.001*
lowest temperature of ≤ 34 oC 24h n (%) / 153 (13.3) / 213 (17.8) / 292 (24.8) / 511 (36.5) / 689 (42.8) / 770 (48.1) / 894 (52.4) / 1,052 (56.4) / 1,248 (60.7) / 1,374 (61.4) / 842 (38.4) / <0.001
Treatment withdrawn n (%) / 375 (31.8) / 378 (30.7) / 383 (31.9) / 426 (29.7) / 522 (32.0) / 527 (32.6) / 589 (34.2) / 689 (36.4) / 715 (34.5) / 821 (36.4) / 774 (34.9) / <0.001
Time to treatment withdrawn (days) mean (sd) / 3 (3.2) / 3 (3.3) / 4 (3.3) / 4 (3.6) / 3 (2.8) / 4 (3.3) / 4 (2.8) / 4 (5.0) / 4 (3.3) / 5 (4.2) / 4 (3.7) / <0.001*
Time to treatment withdrawn (days) median (IQR) / 2.4 (1.7 4.1) / 2.5 (1.9 3.6) / 2.5 (1.9 4.1) / 2.6 (1.8 4.2) / 2.9 (1.9 4.3) / 2.9 (2.0 4.5) / 3.3 (2.0 4.8) / 3.4 (2.1 5.3) / 3.2 (2.0 4.8) / 3.4 (2.1 5.6) / 3.3 (2.0 5.4) / <0.001*
Solid organ donor n (%)** / 24 (2.9) / 18 (2.2) / 27 (3.5) / 35 (3.8) / 47 (4.6) / 58 (5.7) / 75 (6.6) / 97 (8.1) / 124 (9.7) / 123 (8.3) / 146 (10.1) / <0.001
ICU mortality, n (%) / 692 (58.7) / 654 (53.0) / 619 (51.5) / 740 (51.5) / 844 (51.7) / 852 (52.7) / 945 (54.8) / 1,034 (54.7) / 1,105 (53.3) / 1,288 (57.1) / 1,252 (56.5) / 0.024
Hospital Mortality, n (%) / 822 (70.5) / 816 (67.0) / 782 (65.7) / 922 (64.9) / 1,030 (63.7) / 1,021 (63.7) / 1,129 (65.9) / 1,202 (64.0) / 1,284 (62.1) / 1,487 (66.1) / 1,452 (65.9) / 0.024
Survivors discharged home,
n (%)*** / 261 (75.9) / 298 (74.1) / 289 (70.8) / 330 (66.1) / 392 (66.9) / 391 (67.2) / 387 (66.2) / 457 (67.7) / 499 (63.8) / 503 (65.9) / 483 (64.1) / <0.001

* Jonckheere-Terpstra test ** percentage of hospital deaths***percentage of hospital survivors

Table S3. Trends in characteristics and mortality for ICU admissions following in-hospital cardiac arrest.Data from the 116 ICUs contributing data throughout the study period.

2004 / 2005 / 2006 / 2007 / 2008 / 2009 / 2010 / 2011 / 2012 / 2013 / 2014 / p valuefor trend
Number of admissions after cardiac arrest, n (%) / 1,759 (3.1) / 1,833 (3.1) / 1,813 (3.1) / 1,734 (2.9) / 1,629 (2.6) / 1,712 (2.7) / 1,855 (2.6) / 1,839 (2.5) / 2,132 (2.7) / 2,193 (2.7) / 2,340 (2.8) / <0.001
Age, mean (sd) / 64 (16.2) / 63 (16.7) / 65 (15.8) / 64 (16.4) / 63 (16.5) / 64 (16.1) / 64 (16.2) / 64 (15.6) / 65 (15.2) / 65 (15.6) / 65 (15.1) / <0.001
Gender, males n (%) / 1,003 (57.2) / 1,052 (57.4) / 1,092 (60.6) / 1,029 (58.9) / 1,018 (61.1) / 1,038 (60.1) / 1,125 (60.1) / 1,093 (59.8) / 1,321 (62.2) / 1,357 (62.4) / 1,471 (64.0) / <0.001
ICNARC Physiology Score, mean (sd) / 29 (11.3) / 29 (10.8) / 30 (11.0) / 29 (10.9) / 29 (10.6) / 29 (10.4) / 29 (10.3) / 29 (10.1) / 29 (9.7) / 29 (10.2) / 28 (10.2) / 0.001
Critical care unit length of stay, mean (sd) / 5 (8.7) / 6 (10.0) / 5 (8.5) / 5 (9.4) / 6 (9.2) / 6 (10.2) / 6 (9.7) / 6 (12.5) / 6 (9.0) / 6 (9.5) / 6 (8.7) / <0.001*
Critical care unit length of stay, median (IQR) / 1.9 (0.6 5.6) / 2.1 (0.7 6.1) / 1.9 (0.6 5.5) / 2.1 (0.8 5.9) / 2.5 (0.8 7.0) / 2.7 (0.8 7.0) / 2.6 (0.9 6.2) / 2.9 (1.0 6.7) / 3.3 (1.1 7.4) / 3.0 (1.0 7.0) / 3.1 (1.2 6.9) / <0.001*
Hospital length of stay, mean (sd) / 22 (36.1) / 23 (38.3) / 20 (33.0) / 22 (33.7) / 23 (33.8) / 21 (32.7) / 22 (44.7) / 22 (35.8) / 22 (31.9) / 21 (33.5) / 20 (30.9) / 0.2309*
Hospital length of stay, median (IQR) / 11.0 (3.0 27.0) / 12.0 (4.0 28.0) / 10.0 (3.0 26.0) / 11.5 (4.0 27.0) / 12.0 (4.0 28.0) / 11.0 (4.0 27.0) / 10.0 (4.0 25.0) / 11.0 (4.0 27.0) / 12.0 (5.0 28.0) / 10.0 (4.0 25.0) / 10.0 (4.0 24.0) / 0.2309*
lowest temperature of ≤ 34 oC 24h n (%) / 151 (9.0) / 186 (10.7) / 245 (14.2) / 262 (15.5) / 326 (20.1) / 368 (21.7) / 486 (26.6) / 542 (30.2) / 737 (35.3) / 770 (35.8) / 499 (22.0) / <0.001
Treatment withdrawn n (%) / 504 (28.7) / 513 (28.0) / 482 (26.7) / 471 (27.0) / 477 (28.6) / 543 (31.4) / 582 (31.1) / 551 (30.1) / 614 (28.9) / 672 (30.9) / 708 (30.8) / 0.001
Time to treatment withdrawn (days) mean (sd) / 4 (6.5) / 4 (5.3) / 4 (5.5) / 4 (5.6) / 5 (6.7) / 5 (8.1) / 5 (6.4) / 5 (6.2) / 5 (7.3) / 5 (5.7) / 5 (5.6) / <0.001*
Time to treatment withdrawn (days) median (IQR) / 2.3 (1.4 4.3) / 2.4 (1.4 4.4) / 2.4 (1.6 4.5) / 2.4 (1.5 4.3) / 2.5 (1.5 5.4) / 2.8 (1.7 5.3) / 2.9 (1.7 5.2) / 3.3 (1.9 5.5) / 3.5 (1.9 6.1) / 3.1 (1.8 5.7) / 3.4 (2.0 6.1) / <0.001*
Solid organ donor n (%)** / 20 (1.6) / 15 (1.2) / 15 (1.2) / 16 (1.4) / 15 (1.4) / 29 (2.6) / 22 (1.9) / 28 (2.6) / 44 (3.5) / 56 (4.3) / 60 (4.3) / <0.001
ICU mortality, n (%) / 1,025 (58.4) / 1,012 (55.2) / 1,012 (56.2) / 903 (51.7) / 873 (52.4) / 928 (53.8) / 981 (52.4) / 920 (50.3) / 1,033 (48.6) / 1,087 (50.0) / 1,150 (50.0) / <0.001
Hospital mortality, n (%) / 1,218 (70.6) / 1,224 (67.7) / 1,239 (69.6) / 1,108 (64.6) / 1,050 (64.1) / 1,108 (65.0) / 1,186 (64.2) / 1,089 (60.5) / 1,241 (59.0) / 1,309 (60.7) / 1,385 (61.1) / <0.001
Survivors discharged home, n (%)*** / 370 (73.0) / 426 (72.9) / 400 (73.8) / 446 (73.4) / 437 (74.3) / 435 (72.9) / 476 (72.0) / 524 (73.6) / 646 (74.9) / 629 (74.3) / 649 (73.8) / 0.518

* Jonckheere-Terpstra test ** percentage of hospital deaths***percentage of hospital survivors