Research Workshop of Legacy Heritage-ISF Biomedical Science Partnership on
MITOCHONDRIA: FUNCTION AND DYSFUNCTION
November21-24, 2010, Kibbutz Ein Gedi, Dead Sea, Israel

SCIENTIFIC PROGRAM

Sunday, November21, 2010

12:00-13:00Registration and Distribution of Meeting Material

13:00- Welcome and opening remarks: Abdussalam Azem, Tel Aviv

Keynote lecture

Chair: Ophry Pines, Jerusalem

13:00-13:40Walter Neupert, Munich

Cooperation between different pathways of protein import into mitochondria.

13:40-14:40Light Lunch

Protein targeting

14:40- 15:05Doron Rapaport,Tuebingen

Multiple pathways in the biogenesis of mitochondrial outer membrane proteins.

15:05- 15:30Maya Schuldiner, Rehovot.

The tale of tail-anchored proteins - using high throughput microscopy to understand protein insertion

15:30- 15:55Dejana Mokranjac,Munich

The mitochondrial Tim23 preprotein translocase

15:55- 16:20Johannes Herrmann,Kaiserslautern

The mitochondrial disulfide relay

16:20- 16:45Kai Hell, Munich

Redox-regulated import of proteins into the intermembrane space of mitochondria?

16:45- 17:10Coffee Break

Translation, transcription and degradation

Chair: Abdussalam Azem, Tel Aviv

17:10- 17:35Thomas Langer,Cologne

Mitochondrial quality control and membrane dynamics

17:35- 18:00Tom Fox,Ithaca

Assembly of the Cox2 subunit of cytochrome c oxidase in the intermembrane space

18:00- 18:25Joseph Orly,Jerusalem

Mitochondrial Protein Stress Response and Regulation of the Organelle Proteases

18:25-18:50Nils-Goran Larsson,Cologne

Regulation of mammalian mtDNA transcription

19: 00DinNer

Monday, November22, 2010

8:00-9:00Breakfast

Morphology, inheritance and nucleic acids

Chair: Ioav Cabantchik, Jerusalem

09:00-09:25Benedict Westermann, Bayreuth

Mitochondrial dynamics in yeast

09:25-09:50Michael Glickman, Haifa

Mitochondria and the ubiquitin-proteasome - mutual regulation ship

09:50-10:15Joseph Shlomai,Jerusalem

Regulation of mitochondrial DNA replication: Functions of the replication initiator protein

10:15-10:40Coffee break

Chair: Varda Shoshan-Barmatz, Beer-Sheva.

10:40-11:05Yoav Arava, Haifa

cis elements and trans factors involved in mRNA localization to the mitochondria

11:05-11:30Gadi Schuster,Haifa

Polyadenylation and degradation in human mitochondria.

11:30-11:45Inge Kühl, Gif-sur-Yvette cedex

Mitochondrial translation factors in the yeast S. pombe.

11:45-12:00Martin Ott, Kaiserslautern

Mitochondrial ribosomes are platforms to organize the biogenesis of the respiratory chain.

12:00- 14:00Poster session and light lunch in the poster area

Disorders in human

Chair: Orly Elpeleg, Jerusalem

14:00- 14:25Eric Schon, New York

Mitochondrial connections in Alzheimer disease

14:25- 14:50Haya Lorberboum-Galski, Jerusalem

Enzyme replacement therapy for mitochondrial disorders-new hopes for un-curable diseases?

14:50- 15:15Massimo Zeviani,Milano

New mechanisms of disease in mitochondrial medicine

15:15- 15:40Ann Saada-Reisch, Jerusalem

The complex, complex I.

15:40-16:10Coffee break

Chair: Hanna Mandel, Haifa

16:10-16:35Dan Mishmar, Beer-Sheva

Evolutionary principles govern disease susceptibility - the maternal side of the story

16:35- 17:00Agnes Rotig,Paris

Translation deficiencies in mitochondrial diseases

17:00-17:25Ivan Tarassov, Strasbourg

Mitochondrial import of RNA as a therapeutic tool?

17:25-17:40Raffaella Magnoni, Aarhus

Heterozygous Hsp60 knock-out mice represent a model of hereditary spastic paraplegia type13

17:40-17:55Grzegorz Ciesielski, Gdansk

The role of Hsp40, Mdj1 in maintenance of mitochondrial DNA

19:15MIDDLE ESTERN DINNER at Metzoke Dragot

(departure from the hotel lobby)

Tuesday, November23, 2010

7:00-8:55Breakfast

Chair: Haim Breitbart, Ramat Gan

08:55- 09:25Nikolaus Pfanner,Freiburg

Import and assembly of mitochondrial proteins

Stress and Metabolism

09:25- 09:50Roland Lill,Marburg

The role of mitochondria for the iron and sulfur metabolism

09:50- 10:15Ophry Pines,Jerusalem

Fumarase: A journey from yeast mitochondria to tumor suppression

10:15- 10:40Coffee break

10:40- 11:05Christian Ungermann, Osnabrueck

Exploring membrane contact zones between mitochondria and the endomembrane system

11:05- 11:30Lily Vardimon, Tel Aviv

Tissue specific targeting of mitochondrial glutamine synthetase

11:30-11:45Jan Dudek, Goettingen

Sap4 is involved in the organization of respiratory chain complexes

11:45-12:10David A. Ferrick, Billerica

Advanced bioenergetic tools drive new discoveries in age-related diseases.

12:10- 14:00Poster session and LIGHT LUNCH IN THE POSTER AREA

14:00-17:00EIN GEDI SPRINGS (departure from the hotel lobby at 14:00)

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