Invasive Cutaneous Squamous Cell Carcinoma Incidence in US Health Care Workers

Invasive Cutaneous Squamous Cell Carcinoma Incidence in US Health Care Workers

Archives of Dermatological Research

Khang D. Nguyen, MD 1; Jiali Han, PhD 1,2,3; Tricia Li, MS 2; Abrar A. Qureshi, MD, MPH 1,2

Author Affiliations: 1 Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; 2 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; 3 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

Corresponding author: Abrar A. Qureshi, MD, MPH, Associate Professor, Harvard Medical School, Department of Dermatology, Brigham and Women’s Hospital, BWH Alumni Hall, 41 Ave Louis Pasteur, Boston, MA 02115. E-mail: .

Abbreviations: HPFS, Health Professionals Follow-Up Study; NHS, Nurses’ Health Study; NHS II, Nurses’ Health Study II; SCC, squamous cell carcinoma

Supplementary Table 1. Characteristics of US Women and Men With In Situ Squamous Cell Carcinoma in the Nurses’ Health Study (1976-2008), Nurses’ Health Study II (1989-2009), and Health Professionals Follow-Up Study (1986-2008)
NHS
n=829 / NHS II
n=317 / HPFS
n=379
Incidence rate for total follow-up period, per
100 000 persons in cohort / 681 / 272 / 736
Age, mean(SD)a, years / 66.4(7.8) / 48.8(5.8) / 66.2(8.7)
Family history of malignant melanomab, % / 7 / 10 / 6
≥6 moles on an extremityc,d, % / 4 / 25 / 7
History of ≥6 sunburnsc,% / 11 / 17 / 43
Painful or blistering reaction to the sun as child/adolescente, % / 21 / 37 / 28
Natural red or blonde hairf, % / 20 / 29 / 14

Abbreviations: HPFS, Health Professionals Follow-Up Study; NHS, Nurses’ Health Study; NHS II, Nurses’ Health Study II; SD, standard deviation

a Mean age, in years, at the time of diagnosis of in situ SCC

b Family history of malignant melanoma at the time of diagnosis of in situ SCC

c ≥5 for NHS II

d Defined as moles ≥3 mm on the left arm in NHS, bilateral lower legs in NHS II, and bilateral forearms in HPFS

e Skin reaction to 2 or more hours of bright sun exposure as a child/adolescent

f Natural hair color at age 21 years

Supplementary Figure 1. Plot of in situ SCC incidence rates for US women and men aged 35-45 at baseline; Nurses’ Health Study (NHS, 1976-1994), Nurses’ Health Study II (NHS II, 1989-2007), and Health Professionals Follow-Up Study (HPFS, 1986-2004). NHS: dark line, NHS II: dotted line, HPFS: dashed line.

Supplementary Figure 2. Body site distributions of in situ SCC lesions in US women and men; Nurses’ Health Study (NHS, 1976-2008), Nurses’ Health Study II (NHS II, 1989-2009), and Health Professionals Follow-Up Study (HPFS, 1986-2008). NHS: white bar, NHS II: dark bar, HPFS: striped bar