Intense Thz Pulses Down-Regulate Genes Associated with Skin Cancer and Psoriasis: a New

Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?

Lyubov V. Titova,1* Ayesheshim K. Ayesheshim,1 Andrey Golubov,2 Rocio Rodriguez-Juarez,2 Rafal Woycicki,2 Frank A. Hegmann,1*and Olga Kovalchuk2*

1Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada

2Department of Biology, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada

*e-mail:, ,

Supplementary Table S1. Genes differentially expressed following exposure to 1.0 μJ THz pulses.

Gene symbol / Log 2 fold change / p-value / Entrez gene ID / Definition
LOC728454 / -4.029 / 1.1E-06 / 728454 / PREDICTED: Homo sapiens similar to Beta-defensin 2 precursor (BD-2)
DEFB4 / -3.975 / 5.3E-32 / 1673 / Homo sapiens defensin
DDIT4 / -3.353 / 4.8E-35 / 54541 / Homo sapiens DNA-damage-inducible transcript 4 (DDIT4)
SPRR3 / -2.467 / 4.8E-35 / 6707 / Homo sapiens small proline-rich protein 3 (SPRR3)
SPRR2A / -2.461 / 4.8E-35 / 6700 / Homo sapiens small proline-rich protein 2A (SPRR2A)
LCN2 / -2.136 / 6.1E-09 / 3934 / Homo sapiens lipocalin 2 (LCN2)
LCE3E / -1.835 / 2.6E-11 / 353145 / Homo sapiens late cornified envelope 3E (LCE3E)
MMP3 / -1.830 / 6.2E-04 / 4314 / Homo sapiens matrix metallopeptidase 3 (stromelysin 1
IL1A / -1.765 / 6.4E-15 / 3552 / Homo sapiens interleukin 1
S100A7A / -1.763 / 4.6E-32 / 338324 / Homo sapiens S100 calcium binding protein A7A (S100A7A)
SIAE / -1.706 / 2.6E-11 / 54414 / Homo sapiens sialic acid acetylesterase (SIAE)
DHRS9 / -1.673 / 1.8E-05 / 10170 / Homo sapiens dehydrogenase/reductase (SDR family) member 9 (DHRS9)
DEFB103A / -1.641 / 6.3E-04 / 55894 / Homo sapiens defensin
PLA2G4D / -1.606 / 2.0E-17 / 283748 / Homo sapiens phospholipase A2
LCE3D / -1.498 / 8.7E-06 / 84648 / Homo sapiens late cornified envelope 3D (LCE3D)
TRIB3 / -1.497 / 1.8E-09 / 57761 / Homo sapiens tribbles homolog 3 (Drosophila) (TRIB3)
SLPI / -1.457 / 3.2E-27 / 6590 / Homo sapiens secretory leukocyte peptidase inhibitor (SLPI)
IER3 / -1.420 / 2.0E-10 / 8870 / Homo sapiens immediate early response 3 (IER3)
IVL / -1.416 / 4.4E-19 / 3713 / Homo sapiens involucrin (IVL)
STC1 / -1.410 / 4.3E-29 / 6781 / Homo sapiens stanniocalcin 1 (STC1)
S100A12 / -1.408 / 4.0E-06 / 6283 / Homo sapiens S100 calcium binding protein A12 (S100A12)
SPRR2B / -1.405 / 1.4E-18 / 6701 / Homo sapiens small proline-rich protein 2B (SPRR2B)
CNFN / -1.405 / 7.6E-08 / 84518 / Homo sapiens cornifelin (CNFN)
ATP12A / -1.363 / 2.6E-26 / 479 / Homo sapiens ATPase
BHLHB2 / -1.355 / 1.7E-15 / 8553 / Homo sapiens basic helix-loop-helix domain containing
LY6G6C / -1.316 / 2.6E-06 / 80740 / Homo sapiens lymphocyte antigen 6 complex
AAK1 / -1.288 / 7.2E-18 / 22848 / Homo sapiens AP2 associated kinase 1 (AAK1)
LCE3A / -1.281 / 2.8E-03 / 353142 / Homo sapiens late cornified envelope 3A (LCE3A)
CLIC3 / -1.274 / 1.1E-18 / 9022 / Homo sapiens chloride intracellular channel 3 (CLIC3)
SPRR2D / -1.274 / 4.6E-24 / 6703 / Homo sapiens small proline-rich protein 2D (SPRR2D)
SPRR1B / -1.255 / 1.1E-23 / 6699 / Homo sapiens small proline-rich protein 1B (cornifin) (SPRR1B)
MTHFD2 / -1.253 / 1.8E-14 / 10797 / Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2
ERRFI1 / -1.249 / 2.2E-08 / 54206 / Homo sapiens ERBB receptor feedback inhibitor 1 (ERRFI1)
KRT78 / -1.235 / 4.9E-04 / 196374 / Homo sapiens keratin 78 (KRT78)
LYAR / -1.226 / 5.6E-06 / 55646 / Homo sapiens Ly1 antibody reactive homolog (mouse) (LYAR)
DUSP1 / -1.223 / 1.9E-24 / 1843 / Homo sapiens dual specificity phosphatase 1 (DUSP1)
KIAA1199 / -1.215 / 2.0E-12 / 57214 / Homo sapiens KIAA1199 (KIAA1199)
SPRR2C / -1.196 / 6.3E-19 / 6702 / Homo sapiens small proline-rich protein 2C (pseudogene) (SPRR2C)
ZFP36 / -1.192 / 2.9E-11 / 7538 / Homo sapiens zinc finger protein 36
KLK10 / -1.188 / 3.0E-03 / 5655 / Homo sapiens kallikrein-related peptidase 10 (KLK10)
ARHGEF2 / -1.179 / 1.2E-12 / 9181 / Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2)
PRSS27 / -1.174 / 2.3E-06 / 83886 / Homo sapiens protease
DDIT3 / -1.167 / 4.0E-19 / 1649 / Homo sapiens DNA-damage-inducible transcript 3 (DDIT3)
ALOX12B / -1.166 / 1.9E-02 / 242 / Homo sapiens arachidonate 12-lipoxygenase
CRYAB / -1.155 / 2.2E-04 / 1410 / Homo sapiens crystallin
CD207 / -1.111 / 8.7E-04 / 50489 / Homo sapiens CD207 molecule
TUBB4Q / -1.103 / 1.0E-15 / 56604 / Homo sapiens tubulin
TUBB3 / -1.101 / 2.6E-03 / 10381 / Homo sapiens tubulin
PNO1 / -1.095 / 2.1E-18 / 56902 / Homo sapiens partner of NOB1 homolog (S. cerevisiae) (PNO1)
TUBA4A / -1.090 / 1.1E-08 / 7277 / Homo sapiens tubulin
CDSN / -1.087 / 2.1E-06 / 1041 / Homo sapiens corneodesmosin (CDSN)
MXD1 / -1.086 / 2.7E-07 / 4084 / Homo sapiens MAX dimerization protein 1 (MXD1)
KRT34 / -1.086 / 2.8E-05 / 3885 / Homo sapiens keratin 34 (KRT34)
HERPUD1 / -1.086 / 2.9E-09 / 9709 / Homo sapiens homocysteine-inducible
PPP1R3C / -1.083 / 3.8E-04 / 5507 / Homo sapiens protein phosphatase 1
HSPC159 / -1.083 / 9.4E-12 / 29094 / Homo sapiens galectin-related protein (HSPC159)
GSTT2 / -1.080 / 1.5E-05 / 653689 / Homo sapiens glutathione S-transferase theta 2 (GSTT2)
SH2B3 / -1.076 / 3.5E-07 / 10019 / Homo sapiens SH2B adaptor protein 3 (SH2B3)
PLA2G4B / -1.076 / 2.1E-03 / 8681 / Homo sapiens phospholipase A2
GSTT2B / -1.068 / 1.6E-16 / 653689 / Homo sapiens glutathione S-transferase theta 2B (gene/pseudogene) (GSTT2B)
C1orf63 / -1.054 / 1.4E-14 / 57035 / Homo sapiens chromosome 1 open reading frame 63 (C1orf63)
ADAP2 / -1.035 / 4.6E-06 / 55803 / Homo sapiens ArfGAP with dual PH domains 2 (ADAP2)
PRSS3 / -1.034 / 3.9E-04 / 5646 / Homo sapiens protease
CALB2 / -1.012 / 1.7E-07 / 794 / Homo sapiens calbindin 2 (CALB2)
CDA / -1.011 / 1.7E-04 / 978 / Homo sapiens cytidine deaminase (CDA)
CD24 / -1.010 / 1.7E-10 / 100133941 / Homo sapiens CD24 molecule (CD24)
PI3 / -1.007 / 2.0E-17 / 5266 / Homo sapiens peptidase inhibitor 3
DUSP5 / -1.003 / 3.0E-06 / 1847 / Homo sapiens dual specificity phosphatase 5 (DUSP5)
SERPINB13 / -0.996 / 3.1E-05 / 5275 / Homo sapiens serpin peptidase inhibitor
APOB / -0.996 / 8.4E-03 / 338 / Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB)
TGM3 / -0.979 / 4.0E-04 / 7053 / Homo sapiens transglutaminase 3 (E polypeptide
NAB2 / -0.965 / 5.2E-12 / 4665 / Homo sapiens NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2)
CD55 / -0.963 / 1.7E-04 / 1604 / Homo sapiens CD55 molecule
HIST1H1C / -0.950 / 6.8E-05 / 3006 / Homo sapiens histone cluster 1
SBSN / -0.948 / 7.0E-04 / 374897 / Homo sapiens suprabasin (SBSN)
POLR3B / -0.942 / 8.7E-13 / 55703 / Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B)
ZFP36L1 / -0.936 / 7.5E-05 / 677 / Homo sapiens zinc finger protein 36
FAM25G / -0.929 / 9.2E-09 / 100133093 / Homo sapiens family with sequence similarity 25
CRNN / -0.922 / 3.3E-03 / 49860 / Homo sapiens cornulin (CRNN)
CLK1 / -0.921 / 1.3E-06 / 1195 / Homo sapiens CDC-like kinase 1 (CLK1)
DNAJB9 / -0.916 / 6.2E-09 / 4189 / Homo sapiens DnaJ (Hsp40) homolog
RHOD / -0.911 / 8.3E-06 / 29984 / Homo sapiens ras homolog gene family
NOP16 / -0.907 / 3.1E-14 / 51491 / Homo sapiens NOP16 nucleolar protein homolog (yeast) (NOP16)
NP / -0.904 / 9.4E-04 / 4860 / Homo sapiens nucleoside phosphorylase (NP)
SLURP1 / -0.904 / 1.9E-15 / 57152 / Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1)
SERPINB4 / -0.902 / 2.1E-12 / 6318 / Homo sapiens serpin peptidase inhibitor
SPINK6 / -0.899 / 6.1E-06 / 404203 / Homo sapiens serine peptidase inhibitor
DKC1 / -0.898 / 4.5E-12 / 1736 / Homo sapiens dyskeratosis congenita 1
ABCE1 / -0.896 / 1.7E-12 / 6059 / Homo sapiens ATP-binding cassette
MT1G / -0.895 / 1.4E-10 / 4495 / Homo sapiens metallothionein 1G (MT1G)
KIAA0020 / -0.893 / 4.1E-14 / 9933 / Homo sapiens KIAA0020 (KIAA0020)
BTG2 / -0.893 / 3.0E-04 / 7832 / Homo sapiens BTG family
SPRR4 / -0.892 / 3.9E-05 / 163778 / Homo sapiens small proline-rich protein 4 (SPRR4)
HSPC111 / -0.887 / 1.1E-12 / 51491 / Homo sapiens hypothetical protein HSPC111 (HSPC111)
LYPD5 / -0.883 / 1.5E-06 / 284348 / Homo sapiens LY6/PLAUR domain containing 5 (LYPD5)
CCDC86 / -0.867 / 6.5E-05 / 79080 / Homo sapiens coiled-coil domain containing 86 (CCDC86)
SPRR2F / -0.862 / 6.2E-11 / 6705 / Homo sapiens small proline-rich protein 2F (SPRR2F)
KRT80 / -0.857 / 1.1E-05 / 144501 / Homo sapiens keratin 80 (KRT80)
SIPA1L2 / -0.857 / 5.6E-07 / 57568 / Homo sapiens signal-induced proliferation-associated 1 like 2 (SIPA1L2)
TUBB2A / -0.854 / 1.6E-10 / 7280 / Homo sapiens tubulin
SERPINB7 / -0.853 / 1.6E-13 / 8710 / Homo sapiens serpin peptidase inhibitor
PRSS2 / -0.846 / 6.6E-06 / 5645 / Homo sapiens protease
FAM43A / -0.846 / 2.3E-12 / 131583 / Homo sapiens family with sequence similarity 43
CHST7 / -0.845 / 4.5E-08 / 56548 / Homo sapiens carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
ISG20 / -0.843 / 3.7E-10 / 3669 / Homo sapiens interferon stimulated exonuclease gene 20kDa (ISG20)
ALOXE3 / -0.842 / 5.8E-04 / 59344 / Homo sapiens arachidonate lipoxygenase 3 (ALOXE3)
PFKFB3 / -0.840 / 5.7E-13 / 5209 / Homo sapiens 6-phosphofructo-2-kinase/fructose-2
TUBB2C / -0.839 / 1.2E-02 / 10383 / Homo sapiens tubulin
GPX3 / -0.839 / 1.1E-03 / 2878 / Homo sapiens glutathione peroxidase 3 (plasma) (GPX3)
C16orf56 / -0.837 / 4.5E-02 / 80152 / Homo sapiens chromosome 16 open reading frame 56 (C16orf56)
CYP4F22 / -0.836 / 5.2E-04 / 126410 / Homo sapiens cytochrome P450
CARS / -0.827 / 9.8E-06 / 833 / Homo sapiens cysteinyl-tRNA synthetase (CARS)
PSMD12 / -0.826 / 5.4E-09 / 5718 / Homo sapiens proteasome (prosome
PPP1R15A / -0.826 / 6.1E-11 / 23645 / Homo sapiens protein phosphatase 1
C6orf66 / -0.822 / 3.6E-07 / 29078 / Homo sapiens chromosome 6 open reading frame 66 (C6orf66)
FUT3 / -0.818 / 1.4E-02 / 2525 / Homo sapiens fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase
SCNN1B / -0.817 / 6.5E-07 / 6338 / Homo sapiens sodium channel
CLOCK / -0.816 / 2.2E-03 / 9575 / Homo sapiens clock homolog (mouse) (CLOCK)
SPRR2E / -0.815 / 1.3E-12 / 6704 / Homo sapiens small proline-rich protein 2E (SPRR2E)
SLC5A1 / -0.814 / 1.8E-04 / 6523 / Homo sapiens solute carrier family 5 (sodium/glucose cotransporter)
TM7SF2 / -0.810 / 7.4E-04 / 7108 / Homo sapiens transmembrane 7 superfamily member 2 (TM7SF2)
SRM / -0.804 / 3.1E-10 / 6723 / Homo sapiens spermidine synthase (SRM)
FOXQ1 / -0.803 / 6.2E-05 / 94234 / Homo sapiens forkhead box Q1 (FOXQ1)
SIAH2 / -0.796 / 3.5E-10 / 6478 / Homo sapiens seven in absentia homolog 2 (Drosophila) (SIAH2)
UGCG / -0.796 / 5.2E-03 / 7357 / Homo sapiens UDP-glucose ceramide glucosyltransferase (UGCG)
TMEM79 / -0.794 / 7.1E-03 / 84283 / Homo sapiens transmembrane protein 79 (TMEM79)
DDX21 / -0.792 / 3.0E-09 / 9188 / Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 (DDX21)
FOS / -0.789 / 8.3E-06 / 2353 / Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)
MTAP / -0.787 / 2.3E-09 / 4507 / Homo sapiens methylthioadenosine phosphorylase (MTAP)
PI15 / -0.786 / 1.7E-02 / 51050 / Homo sapiens peptidase inhibitor 15 (PI15)
S100P / -0.781 / 7.4E-03 / 6286 / Homo sapiens S100 calcium binding protein P (S100P)
TMEM222 / -0.778 / 1.4E-04 / 84065 / Homo sapiens transmembrane protein 222 (TMEM222)
CENPT / -0.777 / 1.2E-02 / 80152 / Homo sapiens centromere protein T (CENPT)
CCL20 / -0.774 / 1.1E-02 / 6364 / Homo sapiens chemokine (C-C motif) ligand 20 (CCL20)
FAM25C / -0.768 / 6.1E-05 / 644054 / Homo sapiens family with sequence similarity 25
C9orf169 / -0.768 / 2.5E-03 / 375791 / Homo sapiens chromosome 9 open reading frame 169 (C9orf169)
DUOXA1 / -0.767 / 1.7E-04 / 90527 / Homo sapiens dual oxidase maturation factor 1 (DUOXA1)
IER5L / -0.766 / 2.5E-06 / 389792 / Homo sapiens immediate early response 5-like (IER5L)
SPNS2 / -0.765 / 2.9E-09 / 124976 / Homo sapiens spinster homolog 2 (Drosophila) (SPNS2)
IL1F9 / -0.765 / 2.3E-07 / 56300 / Homo sapiens interleukin 1 family
RHCG / -0.757 / 3.9E-03 / 51458 / Homo sapiens Rh family
LOC100128288 / -0.748 / 1.0E-06 / 100128288 / Homo sapiens hypothetical protein LOC100128288 (LOC100128288)
SIK1 / -0.746 / 3.2E-03 / 150094 / Homo sapiens salt-inducible kinase 1 (SIK1)
WFDC5 / -0.746 / 2.0E-03 / 149708 / Homo sapiens WAP four-disulfide core domain 5 (WFDC5)
DDX10 / -0.746 / 2.4E-07 / 1662 / Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10)
CDKN1B / -0.745 / 4.6E-04 / 1027 / Homo sapiens cyclin-dependent kinase inhibitor 1B (p27
LYPD3 / -0.744 / 9.1E-03 / 27076 / Homo sapiens LY6/PLAUR domain containing 3 (LYPD3)
LIPG / -0.742 / 1.0E-02 / 9388 / Homo sapiens lipase
C1orf116 / -0.741 / 2.4E-02 / 79098 / Homo sapiens chromosome 1 open reading frame 116 (C1orf116)
TFRC / -0.741 / 7.0E-05 / 7037 / Homo sapiens transferrin receptor (p90
TARS / -0.737 / 7.0E-09 / 6897 / Homo sapiens threonyl-tRNA synthetase (TARS)
SEPW1 / -0.733 / 5.6E-03 / 6415 / Homo sapiens selenoprotein W
Magmas / -0.733 / 3.8E-05 / 51025 / Homo sapiens mitochondria-associated protein involved in granulocyte
-macrophage colony-stimulating factor signal transduction (Magmas)
HIST2H2AC / -0.726 / 6.7E-07 / 8338 / Homo sapiens histone cluster 2
IL1F10 / -0.725 / 3.2E-02 / 84639 / Homo sapiens interleukin 1 family
MAK16 / -0.719 / 2.2E-04 / 84549 / Homo sapiens MAK16 homolog (S. cerevisiae) (MAK16)
NSUN2 / -0.719 / 1.3E-03 / 54888 / Homo sapiens NOP2/Sun domain family
HIST2H2AA3 / -0.719 / 1.5E-09 / 8337 / Homo sapiens histone cluster 2
RNASE7 / -0.717 / 3.7E-03 / 84659 / Homo sapiens ribonuclease
AVPI1 / -0.715 / 4.5E-03 / 60370 / Homo sapiens arginine vasopressin-induced 1 (AVPI1)
GTPBP4 / -0.714 / 1.3E-05 / 23560 / Homo sapiens GTP binding protein 4 (GTPBP4)
BYSL / -0.712 / 7.4E-03 / 705 / Homo sapiens bystin-like (BYSL)
KLK7 / -0.704 / 1.1E-02 / 5650 / Homo sapiens kallikrein-related peptidase 7 (KLK7)
RRP15 / -0.703 / 2.9E-06 / 51018 / Homo sapiens ribosomal RNA processing 15 homolog (S. cerevisiae) (RRP15)
RNF39 / -0.697 / 6.4E-06 / 80352 / Homo sapiens ring finger protein 39 (RNF39)
GRWD1 / -0.697 / 4.7E-03 / 83743 / Homo sapiens glutamate-rich WD repeat containing 1 (GRWD1)
BNIPL / -0.694 / 3.2E-02 / 149428 / Homo sapiens BCL2/adenovirus E1B 19kD interacting protein like (BNIPL)
SH3BGRL3 / -0.691 / 2.4E-08 / 83442 / Homo sapiens SH3 domain binding glutamic acid-rich protein like 3 (SH3BGRL3)
DIMT1L / -0.687 / 3.7E-07 / 27292 / Homo sapiens DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) (DIMT1L)
RUNDC3A / -0.686 / 3.5E-03 / 10900 / Homo sapiens RUN domain containing 3A (RUNDC3A)
NICE-1 / -0.685 / 1.2E-02 / 54544 / Homo sapiens cysteine-rich C-terminal 1 (CRCT1)
YWHAE / -0.685 / 2.5E-07 / 7531 / Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
activation protein
C10orf137 / -0.684 / 1.3E-05 / 26098 / Homo sapiens chromosome 10 open reading frame 137 (C10orf137)
PDZK1IP1 / -0.683 / 2.4E-03 / 10158 / Homo sapiens PDZK1 interacting protein 1 (PDZK1IP1)
MRPL12 / -0.682 / 5.7E-03 / 6182 / Homo sapiens mitochondrial ribosomal protein L12 (MRPL12)
DUSP6 / -0.679 / 5.9E-03 / 1848 / Homo sapiens dual specificity phosphatase 6 (DUSP6)
SERPINB3 / -0.675 / 5.9E-09 / 6317 / Homo sapiens serpin peptidase inhibitor
SMPD3 / -0.673 / 1.0E-05 / 55512 / Homo sapiens sphingomyelin phosphodiesterase 3
DEFB1 / -0.672 / 3.9E-05 / 1672 / Homo sapiens defensin
RASD1 / -0.671 / 1.6E-04 / 51655 / Homo sapiens RAS
SLC15A1 / -0.669 / 8.9E-03 / 6564 / Homo sapiens solute carrier family 15 (oligopeptide transporter)
SERTAD2 / -0.664 / 5.7E-09 / 9792 / Homo sapiens SERTA domain containing 2 (SERTAD2)
SLC20A1 / -0.664 / 1.7E-04 / 6574 / Homo sapiens solute carrier family 20 (phosphate transporter)
S100A11 / -0.663 / 1.9E-04 / 6282 / Homo sapiens S100 calcium binding protein A11 (S100A11)
TERF2IP / -0.662 / 1.4E-07 / 54386 / Homo sapiens telomeric repeat binding factor 2
C16orf30 / -0.657 / 8.7E-04 / 79652 / Homo sapiens chromosome 16 open reading frame 30 (C16orf30)
SDAD1 / -0.657 / 1.7E-04 / 55153 / Homo sapiens SDA1 domain containing 1 (SDAD1)
GPATCH4 / -0.656 / 4.5E-02 / 54865 / Homo sapiens G patch domain containing 4 (GPATCH4)
TMEM166 / -0.655 / 6.1E-05 / 84141 / Homo sapiens transmembrane protein 166 (TMEM166)
KIF13B / -0.655 / 1.5E-02 / 23303 / Homo sapiens kinesin family member 13B (KIF13B)
JUN / -0.654 / 5.1E-06 / 3725 / Homo sapiens jun oncogene (JUN)
TFPI2 / -0.652 / 1.9E-02 / 7980 / Homo sapiens tissue factor pathway inhibitor 2 (TFPI2)
ANXA3 / -0.652 / 4.6E-02 / 306 / Homo sapiens annexin A3 (ANXA3)
KAT2B / -0.651 / 4.6E-03 / 8850 / Homo sapiens K(lysine) acetyltransferase 2B (KAT2B)
PMM2 / -0.651 / 6.1E-03 / 5373 / Homo sapiens phosphomannomutase 2 (PMM2)
NOL11 / -0.651 / 9.8E-08 / 25926 / Homo sapiens nucleolar protein 11 (NOL11)
CAMSAP1L1 / -0.651 / 1.7E-08 / 23271 / Homo sapiens calmodulin regulated spectrin-associated protein 1-like 1
PA2G4 / -0.650 / 4.6E-03 / 5036 / Homo sapiens proliferation-associated 2G4
LTV1 / -0.650 / 1.9E-08 / 84946 / Homo sapiens LTV1 homolog (S. cerevisiae) (LTV1)
DNASE1L2 / -0.648 / 2.7E-06 / 1775 / Homo sapiens deoxyribonuclease I-like 2 (DNASE1L2)
CTSL2 / -0.648 / 2.3E-06 / 1515 / Homo sapiens cathepsin L2 (CTSL2)
TMEM106A / -0.647 / 1.4E-02 / 113277 / Homo sapiens transmembrane protein 106A (TMEM106A)
EXOSC6 / -0.647 / 1.4E-04 / 118460 / Homo sapiens exosome component 6 (EXOSC6)
NARG1 / -0.646 / 5.1E-04 / 80155 / Homo sapiens NMDA receptor regulated 1 (NARG1)
RBM25 / -0.645 / 5.5E-08 / 58517 / Homo sapiens RNA binding motif protein 25 (RBM25)
SPINK5 / -0.643 / 9.5E-03 / 11005 / Homo sapiens serine peptidase inhibitor
FAM62C / -0.643 / 3.7E-02 / 83850 / Homo sapiens family with sequence similarity 62 (C2 domain containing)
IFFO2 / -0.642 / 2.4E-02 / 126917 / Homo sapiens intermediate filament family orphan 2 (IFFO2)
PTGR2 / -0.642 / 8.7E-07 / 145482 / Homo sapiens prostaglandin reductase 2 (PTGR2)
TREX2 / -0.642 / 2.7E-03 / 11219 / Homo sapiens three prime repair exonuclease 2 (TREX2)
IGFL2 / -0.639 / 2.1E-06 / 147920 / Homo sapiens IGF-like family member 2 (IGFL2)
MRTO4 / -0.639 / 1.5E-02 / 51154 / Homo sapiens mRNA turnover 4 homolog (S. cerevisiae) (MRTO4)
FABP5 / -0.638 / 1.9E-04 / 2171 / Homo sapiens fatty acid binding protein 5 (psoriasis-associated) (FABP5)
PPAT / -0.638 / 1.7E-04 / 5471 / Homo sapiens phosphoribosyl pyrophosphate amidotransferase (PPAT)
KPNA4 / -0.638 / 2.0E-04 / 3840 / Homo sapiens karyopherin alpha 4 (importin alpha 3) (KPNA4)
TRMT6 / -0.637 / 4.0E-03 / 51605 / Homo sapiens tRNA methyltransferase 6 homolog (S. cerevisiae) (TRMT6)
NFXL1 / -0.635 / 1.5E-02 / 152518 / Homo sapiens nuclear transcription factor
NCCRP1 / -0.635 / 5.9E-04 / 342897 / Homo sapiens non-specific cytotoxic cell receptor protein 1 homolog
KLK5 / -0.634 / 1.1E-02 / 25818 / Homo sapiens kallikrein-related peptidase 5 (KLK5)
NFE2L3 / -0.634 / 7.2E-03 / 9603 / Homo sapiens nuclear factor (erythroid-derived 2)-like 3 (NFE2L3)
EXOSC9 / -0.632 / 7.0E-03 / 5393 / Homo sapiens exosome component 9 (EXOSC9)
NEFH / -0.631 / 4.0E-02 / 4744 / Homo sapiens neurofilament
LDLR / -0.625 / 5.6E-03 / 3949 / Homo sapiens low density lipoprotein receptor (familial hypercholesterolemia)
INO80C / -0.625 / 1.6E-02 / 125476 / Homo sapiens INO80 complex subunit C (INO80C)
FLVCR2 / -0.625 / 3.2E-04 / 55640 / Homo sapiens feline leukemia virus subgroup C cellular receptor family
POF1B / -0.624 / 1.3E-02 / 79983 / Homo sapiens premature ovarian failure
BCLAF1 / -0.623 / 1.7E-04 / 9774 / Homo sapiens BCL2-associated transcription factor 1 (BCLAF1)
CEBPG / -0.622 / 1.6E-07 / 1054 / Homo sapiens CCAAT/enhancer binding protein (C/EBP)
C12orf5 / -0.621 / 6.8E-03 / 57103 / Homo sapiens chromosome 12 open reading frame 5 (C12orf5)
TDP1 / -0.619 / 2.5E-02 / 55775 / Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1)
SFN / -0.618 / 3.9E-02 / 2810 / Homo sapiens stratifin (SFN)
PTGS2 / -0.618 / 1.3E-05 / 5743 / Homo sapiens prostaglandin-endoperoxide synthase 2
MTERFD1 / -0.616 / 8.5E-06 / 51001 / Homo sapiens MTERF domain containing 1 (MTERFD1)
ARG1 / -0.616 / 9.0E-03 / 383 / Homo sapiens arginase
RABGGTB / -0.616 / 2.6E-06 / 5876 / Homo sapiens Rab geranylgeranyltransferase
MGC4677 / -0.613 / 3.9E-02 / 112597 / Homo sapiens hypothetical protein MGC4677 (MGC4677)
TRIM25 / -0.612 / 3.8E-03 / 7706 / Homo sapiens tripartite motif-containing 25 (TRIM25)
IDS / -0.608 / 2.6E-05 / 3423 / Homo sapiens iduronate 2-sulfatase (Hunter syndrome) (IDS)
WDR12 / -0.606 / 4.1E-04 / 55759 / Homo sapiens WD repeat domain 12 (WDR12)
WDSOF1 / -0.603 / 1.4E-04 / 25879 / Homo sapiens WD repeats and SOF1 domain containing (WDSOF1)
WWC1 / -0.602 / 1.2E-02 / 23286 / Homo sapiens WW and C2 domain containing 1 (WWC1)
MKNK2 / 0.600 / 2.2E-02 / 2872 / Homo sapiens MAP kinase interacting serine/threonine kinase 2 (MKNK2)
SFRP2 / 0.602 / 8.3E-04 / 6423 / Homo sapiens secreted frizzled-related protein 2 (SFRP2)
AKR1B15 / 0.602 / 2.6E-05 / 441282 / Homo sapiens aldo-keto reductase family 1
PCOLCE / 0.602 / 1.5E-02 / 5118 / Homo sapiens procollagen C-endopeptidase enhancer (PCOLCE)
GPR68 / 0.605 / 1.4E-04 / 8111 / Homo sapiens G protein-coupled receptor 68 (GPR68)
LAMA4 / 0.610 / 4.4E-22 / 3910 / Homo sapiens laminin
MBP / 0.610 / 2.9E-02 / 4155 / Homo sapiens myelin basic protein (MBP)
ACYP1 / 0.610 / 6.1E-04 / 97 / Homo sapiens acylphosphatase 1
OLFML1 / 0.610 / 3.6E-05 / 283298 / Homo sapiens olfactomedin-like 1 (OLFML1)
MGC16169 / 0.610 / 8.0E-04 / 93627 / Homo sapiens hypothetical protein MGC16169 (MGC16169)
ETS2 / 0.612 / 1.5E-06 / 2114 / Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2
PAQR4 / 0.618 / 1.3E-02 / 124222 / Homo sapiens progestin and adipoQ receptor family member IV (PAQR4)
ZNF627 / 0.619 / 3.9E-08 / 199692 / Homo sapiens zinc finger protein 627 (ZNF627)
PDGFC / 0.619 / 4.7E-06 / 56034 / Homo sapiens platelet derived growth factor C (PDGFC)
SKAP2 / 0.620 / 3.8E-03 / 8935 / Homo sapiens src kinase associated phosphoprotein 2 (SKAP2)
COL12A1 / 0.620 / 4.8E-07 / 1303 / Homo sapiens collagen
ZBTB20 / 0.621 / 6.4E-03 / 26137 / Homo sapiens zinc finger and BTB domain containing 20 (ZBTB20)
ZNF433 / 0.622 / 3.6E-03 / 163059 / Homo sapiens zinc finger protein 433 (ZNF433)
HS1BP3 / 0.622 / 4.3E-06 / 64342 / Homo sapiens HCLS1 binding protein 3 (HS1BP3)
IFNGR2 / 0.623 / 2.4E-08 / 3460 / Homo sapiens interferon gamma receptor 2 (interferon gamma transducer 1)
TMEM119 / 0.624 / 1.7E-10 / 338773 / Homo sapiens transmembrane protein 119 (TMEM119)
PODN / 0.624 / 1.0E-03 / 127435 / Homo sapiens podocan (PODN)
CAPN5 / 0.624 / 4.4E-02 / 726 / Homo sapiens calpain 5 (CAPN5)
TGFB3 / 0.625 / 1.0E-02 / 7043 / Homo sapiens transforming growth factor
ODZ3 / 0.626 / 2.4E-03 / 55714 / Homo sapiens odz
MN1 / 0.627 / 4.0E-04 / 4330 / Homo sapiens meningioma (disrupted in balanced translocation) 1 (MN1)
TAP1 / 0.629 / 9.8E-08 / 6890 / Homo sapiens transporter 1
BST2 / 0.630 / 1.2E-04 / 684 / Homo sapiens bone marrow stromal cell antigen 2 (BST2)
ZDHHC14 / 0.630 / 7.3E-04 / 79683 / Homo sapiens zinc finger
INHBB / 0.631 / 1.5E-04 / 3625 / Homo sapiens inhibin
FAM46A / 0.637 / 2.1E-07 / 55603 / Homo sapiens family with sequence similarity 46
COL3A1 / 0.637 / 1.7E-13 / 1281 / Homo sapiens collagen
TCF12 / 0.637 / 2.6E-05 / 6938 / Homo sapiens transcription factor 12 (TCF12)
TBL1XR1 / 0.637 / 4.4E-04 / 79718 / Homo sapiens transducin (beta)-like 1X-linked receptor 1 (TBL1XR1)
NGLY1 / 0.638 / 1.5E-03 / 55768 / Homo sapiens N-glycanase 1 (NGLY1)
ANKDD1A / 0.638 / 2.2E-06 / 348094 / Homo sapiens ankyrin repeat and death domain containing 1A (ANKDD1A)
C2orf64 / 0.639 / 1.7E-04 / 493753 / Homo sapiens chromosome 2 open reading frame 64 (C2orf64)
KLHDC8B / 0.639 / 6.0E-03 / 200942 / Homo sapiens kelch domain containing 8B (KLHDC8B)
AXIN2 / 0.640 / 3.9E-04 / 8313 / Homo sapiens axin 2 (conductin
MYLIP / 0.643 / 6.7E-04 / 29116 / Homo sapiens myosin regulatory light chain interacting protein (MYLIP)
CACNB3 / 0.644 / 4.0E-04 / 784 / Homo sapiens calcium channel
SULF1 / 0.645 / 1.8E-05 / 23213 / Homo sapiens sulfatase 1 (SULF1)
OSR2 / 0.645 / 2.2E-04 / 116039 / PREDICTED: Homo sapiens odd-skipped related 2 (Drosophila) (OSR2)
VCAN / 0.645 / 3.9E-05 / 1462 / Homo sapiens versican (VCAN)
SLC40A1 / 0.646 / 1.5E-04 / 30061 / Homo sapiens solute carrier family 40 (iron-regulated transporter)
AKR1C2 / 0.650 / 8.3E-12 / 1646 / Homo sapiens aldo-keto reductase family 1
KRT9 / 0.654 / 1.2E-03 / 3857 / Homo sapiens keratin 9 (epidermolytic palmoplantar keratoderma) (KRT9)
LCE1E / 0.655 / 3.7E-02 / 353135 / Homo sapiens late cornified envelope 1E (LCE1E)
ZBTB4 / 0.655 / 7.6E-06 / 57659 / Homo sapiens zinc finger and BTB domain containing 4 (ZBTB4)
BNC1 / 0.658 / 1.3E-02 / 646 / Homo sapiens basonuclin 1 (BNC1)
CXCL10 / 0.659 / 6.2E-03 / 3627 / Homo sapiens chemokine (C-X-C motif) ligand 10 (CXCL10)
CGNL1 / 0.660 / 4.1E-04 / 84952 / Homo sapiens cingulin-like 1 (CGNL1)
HMGB2 / 0.663 / 2.0E-04 / 3148 / Homo sapiens high-mobility group box 2 (HMGB2)
LOC728661 / 0.663 / 1.9E-06 / 728661 / Homo sapiens similar to solute carrier family 35
SNX25 / 0.666 / 2.3E-04 / 83891 / Homo sapiens sorting nexin 25 (SNX25)
EGFL6 / 0.666 / 3.3E-06 / 25975 / Homo sapiens EGF-like-domain
LUM / 0.666 / 5.5E-06 / 4060 / Homo sapiens lumican (LUM)
HELZ / 0.668 / 8.9E-06 / 9931 / Homo sapiens helicase with zinc finger (HELZ)
RASL12 / 0.669 / 2.8E-07 / 51285 / Homo sapiens RAS-like
HAS2 / 0.669 / 2.1E-06 / 3037 / Homo sapiens hyaluronan synthase 2 (HAS2)
FAM134B / 0.671 / 5.3E-03 / 54463 / Homo sapiens family with sequence similarity 134
ANGPTL2 / 0.672 / 2.5E-04 / 23452 / Homo sapiens angiopoietin-like 2 (ANGPTL2)
CYP2S1 / 0.672 / 1.2E-04 / 29785 / Homo sapiens cytochrome P450
MEGF6 / 0.674 / 4.6E-03 / 1953 / Homo sapiens multiple EGF-like-domains 6 (MEGF6)
ERAP2 / 0.674 / 2.0E-08 / 64167 / Homo sapiens endoplasmic reticulum aminopeptidase 2 (ERAP2)
INA / 0.675 / 1.4E-04 / 9118 / Homo sapiens internexin neuronal intermediate filament protein
ARL4A / 0.680 / 7.1E-09 / 10124 / Homo sapiens ADP-ribosylation factor-like 4A (ARL4A)
SSPN / 0.682 / 3.6E-05 / 8082 / Homo sapiens sarcospan (Kras oncogene-associated gene) (SSPN)
NYNRIN / 0.685 / 4.3E-09 / 57523 / Homo sapiens NYN domain and retroviral integrase containing (NYNRIN)
IRF1 / 0.685 / 1.6E-05 / 3659 / Homo sapiens interferon regulatory factor 1 (IRF1)
A2M / 0.685 / 4.8E-03 / 2 / Homo sapiens alpha-2-macroglobulin (A2M)
ATXN1 / 0.687 / 4.1E-09 / 6310 / Homo sapiens ataxin 1 (ATXN1)
GALNTL4 / 0.688 / 5.9E-04 / 374378 / Homo sapiens UDP-N-acetyl-alpha-D-galactosamine
TNFRSF6B / 0.689 / 4.7E-13 / 8771 / Homo sapiens tumor necrosis factor receptor superfamily
AKR1C3 / 0.690 / 3.7E-07 / 8644 / Homo sapiens aldo-keto reductase family 1
COL5A1 / 0.691 / 6.2E-06 / 1289 / Homo sapiens collagen
ZNF827 / 0.692 / 1.6E-04 / 152485 / Homo sapiens zinc finger protein 827 (ZNF827)
GPRC5C / 0.693 / 2.9E-12 / 55890 / Homo sapiens G protein-coupled receptor
MXRA5 / 0.693 / 1.4E-08 / 25878 / Homo sapiens matrix-remodelling associated 5 (MXRA5)
TNFSF10 / 0.696 / 4.1E-03 / 8743 / Homo sapiens tumor necrosis factor (ligand) superfamily
FBLN2 / 0.696 / 5.1E-06 / 2199 / Homo sapiens fibulin 2 (FBLN2)
RGS4 / 0.696 / 4.3E-05 / 5999 / Homo sapiens regulator of G-protein signalling 4 (RGS4)
COL16A1 / 0.699 / 4.4E-12 / 1307 / Homo sapiens collagen
DPT / 0.701 / 1.0E-03 / 1805 / Homo sapiens dermatopontin (DPT)
GPX2 / 0.703 / 2.7E-04 / 2877 / Homo sapiens glutathione peroxidase 2 (gastrointestinal) (GPX2)
KCNS3 / 0.704 / 8.2E-04 / 3790 / Homo sapiens potassium voltage-gated channel
PTGER4 / 0.704 / 1.9E-03 / 5734 / Homo sapiens prostaglandin E receptor 4 (subtype EP4) (PTGER4)
SCARF2 / 0.705 / 4.9E-18 / 91179 / Homo sapiens scavenger receptor class F
ADH1A / 0.708 / 1.6E-04 / 124 / Homo sapiens alcohol dehydrogenase 1A (class I)
APBB3 / 0.709 / 3.8E-07 / 10307 / Homo sapiens amyloid beta (A4) precursor protein-binding
CD248 / 0.709 / 8.5E-14 / 57124 / Homo sapiens CD248 molecule
ACPL2 / 0.717 / 9.6E-07 / 92370 / Homo sapiens acid phosphatase-like 2 (ACPL2)
FLJ35258 / 0.718 / 3.1E-07 / 284297 / Homo sapiens hypothetical protein 284297 (FLJ35258)
RNF150 / 0.719 / 6.2E-07 / 57484 / Homo sapiens ring finger protein 150 (RNF150)
OLFML2A / 0.720 / 6.2E-05 / 169611 / Homo sapiens olfactomedin-like 2A (OLFML2A)
KBTBD11 / 0.721 / 1.3E-06 / 9920 / Homo sapiens kelch repeat and BTB (POZ) domain containing 11 (KBTBD11)
ARHGAP20 / 0.722 / 5.0E-04 / 57569 / Homo sapiens Rho GTPase activating protein 20 (ARHGAP20)
FGF11 / 0.722 / 2.8E-07 / 2256 / Homo sapiens fibroblast growth factor 11 (FGF11)
KIAA0182 / 0.727 / 4.8E-05 / 23199 / Homo sapiens KIAA0182 (KIAA0182)
REV3L / 0.727 / 4.8E-05 / 5980 / Homo sapiens REV3-like
SAP30 / 0.734 / 4.6E-03 / 8819 / Homo sapiens Sin3A-associated protein
BBX / 0.734 / 1.6E-12 / 56987 / Homo sapiens bobby sox homolog (Drosophila) (BBX)
ADAMTS1 / 0.736 / 6.2E-05 / 9510 / Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif
SLC25A42 / 0.737 / 9.0E-07 / 284439 / Homo sapiens solute carrier family 25
RCOR2 / 0.737 / 8.3E-04 / 283248 / Homo sapiens REST corepressor 2 (RCOR2)
PPFIA4 / 0.738 / 9.3E-04 / 8497 / Homo sapiens protein tyrosine phosphatase
AKR1B10 / 0.739 / 1.8E-05 / 57016 / Homo sapiens aldo-keto reductase family 1
COL7A1 / 0.740 / 9.1E-09 / 1294 / Homo sapiens collagen
LCE1D / 0.740 / 6.1E-03 / 353134 / Homo sapiens late cornified envelope 1D (LCE1D)
DHRS13 / 0.743 / 8.3E-05 / 147015 / Homo sapiens dehydrogenase/reductase (SDR family) member 13 (DHRS13)
TMEM100 / 0.744 / 2.0E-05 / 55273 / Homo sapiens transmembrane protein 100 (TMEM100)
CLDN23 / 0.745 / 4.5E-09 / 137075 / Homo sapiens claudin 23 (CLDN23)
COL15A1 / 0.747 / 1.0E-03 / 1306 / Homo sapiens collagen
SH3PXD2A / 0.759 / 2.7E-35 / 9644 / Homo sapiens SH3 and PX domains 2A (SH3PXD2A)
PTGFR / 0.760 / 1.7E-05 / 5737 / Homo sapiens prostaglandin F receptor (FP) (PTGFR)
EGLN1 / 0.764 / 1.0E-06 / 54583 / Homo sapiens egl nine homolog 1 (C. elegans) (EGLN1)
ELN / 0.767 / 6.1E-05 / 2006 / Homo sapiens elastin (ELN)
ABR / 0.775 / 5.2E-03 / 29 / Homo sapiens active BCR-related gene (ABR)
DHRS3 / 0.776 / 1.1E-12 / 9249 / Homo sapiens dehydrogenase/reductase (SDR family) member 3 (DHRS3)
SNX33 / 0.777 / 8.3E-09 / 257364 / Homo sapiens sorting nexin 33 (SNX33)
CD276 / 0.777 / 9.0E-04 / 80381 / Homo sapiens CD276 molecule (CD276)
LPPR4 / 0.778 / 9.8E-08 / 9890 / Homo sapiens plasticity related gene 1 (LPPR4)
ARHGEF16 / 0.778 / 8.0E-06 / 27237 / Homo sapiens Rho guanine exchange factor (GEF) 16 (ARHGEF16)
ASCL2 / 0.780 / 4.5E-05 / 430 / Homo sapiens achaete-scute complex homolog 2 (Drosophila) (ASCL2)
LAMA5 / 0.795 / 2.9E-03 / 3911 / Homo sapiens laminin
PDGFRB / 0.795 / 5.5E-11 / 5159 / Homo sapiens platelet-derived growth factor receptor
INTS3 / 0.801 / 2.5E-05 / 65123 / Homo sapiens integrator complex subunit 3 (INTS3)
SPRY1 / 0.805 / 2.8E-06 / 10252 / Homo sapiens sprouty homolog 1
POSTN / 0.810 / 1.1E-18 / 10631 / Homo sapiens periostin
DTX2 / 0.812 / 3.1E-03 / 113878 / Homo sapiens deltex homolog 2 (Drosophila) (DTX2)
LRRC32 / 0.814 / 3.8E-06 / 2615 / Homo sapiens leucine rich repeat containing 32 (LRRC32)
FAM83B / 0.814 / 4.7E-07 / 222584 / Homo sapiens family with sequence similarity 83
PTPRK / 0.817 / 2.8E-07 / 5796 / Homo sapiens protein tyrosine phosphatase
FBLN1 / 0.819 / 2.3E-06 / 2192 / Homo sapiens fibulin 1 (FBLN1)
NAV1 / 0.822 / 3.5E-10 / 89796 / Homo sapiens neuron navigator 1 (NAV1)
PHLDB2 / 0.826 / 2.6E-10 / 90102 / Homo sapiens pleckstrin homology-like domain
LAMA2 / 0.829 / 4.8E-07 / 3908 / Homo sapiens laminin
MEG3 / 0.844 / 1.7E-06 / 55384 / Homo sapiens maternally expressed 3 (non-protein coding) (MEG3)
CYR61 / 0.845 / 1.2E-09 / 3491 / Homo sapiens cysteine-rich
VANGL2 / 0.854 / 1.3E-08 / 57216 / Homo sapiens vang-like 2 (van gogh
LDB2 / 0.860 / 3.4E-07 / 9079 / Homo sapiens LIM domain binding 2 (LDB2)
XPO1 / 0.861 / 2.3E-10 / 7514 / Homo sapiens exportin 1 (CRM1 homolog
PTK7 / 0.863 / 3.0E-10 / 5754 / Homo sapiens PTK7 protein tyrosine kinase 7 (PTK7)
PHF21A / 0.863 / 2.7E-35 / 51317 / Homo sapiens PHD finger protein 21A (PHF21A)
PENK / 0.865 / 4.7E-05 / 5179 / Homo sapiens proenkephalin (PENK)
TIMP3 / 0.867 / 1.8E-07 / 7078 / Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3)
TRAM2 / 0.874 / 2.7E-35 / 9697 / Homo sapiens translocation associated membrane protein 2 (TRAM2)
THBS2 / 0.878 / 2.7E-35 / 7058 / Homo sapiens thrombospondin 2 (THBS2)
KLHL22 / 0.878 / 4.2E-12 / 84861 / Homo sapiens kelch-like 22 (Drosophila) (KLHL22)
UAP1L1 / 0.880 / 4.2E-05 / 91373 / Homo sapiens UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (UAP1L1)
HCP5 / 0.883 / 1.6E-06 / 10866 / Homo sapiens HLA complex P5 (HCP5)
TRIM47 / 0.890 / 6.2E-08 / 91107 / Homo sapiens tripartite motif-containing 47 (TRIM47)
CDC2L6 / 0.893 / 1.6E-04 / 23097 / Homo sapiens cell division cycle 2-like 6 (CDK8-like) (CDC2L6)
CFB / 0.895 / 2.4E-05 / 629 / Homo sapiens complement factor B (CFB)
IGFL1 / 0.897 / 1.3E-08 / 374918 / Homo sapiens IGF-like family member 1 (IGFL1)
CH25H / 0.900 / 1.8E-07 / 9023 / Homo sapiens cholesterol 25-hydroxylase (CH25H)
OSR1 / 0.905 / 1.2E-11 / 130497 / Homo sapiens odd-skipped related 1 (Drosophila) (OSR1)
FGFR3 / 0.909 / 4.4E-02 / 2261 / Homo sapiens fibroblast growth factor receptor 3 (achondroplasia
LCE1B / 0.914 / 3.8E-07 / 353132 / Homo sapiens late cornified envelope 1B (LCE1B)
MUC1 / 0.917 / 1.5E-14 / 4582 / Homo sapiens mucin 1
RHOU / 0.921 / 2.7E-35 / 58480 / Homo sapiens ras homolog gene family
APCDD1 / 0.931 / 2.7E-35 / 147495 / Homo sapiens adenomatosis polyposis coli down-regulated 1 (APCDD1)
GRAMD4 / 0.943 / 7.6E-10 / 23151 / Homo sapiens GRAM domain containing 4 (GRAMD4)
LCE1A / 0.946 / 1.9E-04 / 353131 / Homo sapiens late cornified envelope 1A (LCE1A)
CXXC5 / 0.957 / 2.2E-23 / 51523 / Homo sapiens CXXC finger 5 (CXXC5)
SPRY2 / 0.960 / 3.0E-08 / 10253 / Homo sapiens sprouty homolog 2 (Drosophila) (SPRY2)
FZD2 / 0.960 / 2.7E-35 / 2535 / Homo sapiens frizzled homolog 2 (Drosophila) (FZD2)
NFKBIA / 0.963 / 8.5E-14 / 4792 / Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in
B-cells inhibitor
ITGA2 / 0.967 / 1.2E-12 / 3673 / Homo sapiens integrin
FAM13A / 0.985 / 6.1E-15 / 10144 / Homo sapiens family with sequence similarity 13
MAFB / 1.002 / 2.8E-07 / 9935 / Homo sapiens v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
COMP / 1.013 / 8.2E-09 / 1311 / Homo sapiens cartilage oligomeric matrix protein (COMP)
CXADR / 1.014 / 2.5E-10 / 1525 / Homo sapiens coxsackie virus and adenovirus receptor (CXADR)
PBX3 / 1.016 / 2.1E-11 / 5090 / Homo sapiens pre-B-cell leukemia homeobox 3 (PBX3)
CXCL2 / 1.038 / 1.8E-04 / 2920 / Homo sapiens chemokine (C-X-C motif) ligand 2 (CXCL2)
CCL2 / 1.044 / 8.6E-12 / 6347 / Homo sapiens chemokine (C-C motif) ligand 2 (CCL2)
SEMA6A / 1.051 / 9.8E-13 / 57556 / Homo sapiens sema domain
LFNG / 1.057 / 2.9E-12 / 3955 / Homo sapiens LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGP / 1.064 / 1.0E-09 / 4256 / Homo sapiens matrix Gla protein (MGP)
ALDH2 / 1.113 / 2.7E-35 / 217 / Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2)
MIR1978 / 1.116 / 2.7E-35 / 100302173 / Homo sapiens microRNA 1978 (MIR1978)
ID1 / 1.121 / 5.0E-18 / 3397 / Homo sapiens inhibitor of DNA binding 1
MMP11 / 1.129 / 1.0E-12 / 4320 / Homo sapiens matrix metallopeptidase 11 (stromelysin 3) (MMP11)
ZNF395 / 1.155 / 2.7E-35 / 55893 / Homo sapiens zinc finger protein 395 (ZNF395)
CDC25B / 1.184 / 2.7E-35 / 994 / Homo sapiens cell division cycle 25 homolog B (S. pombe) (CDC25B)
PLAU / 1.190 / 2.7E-35 / 5328 / Homo sapiens plasminogen activator
MSMB / 1.211 / 2.0E-10 / 4477 / Homo sapiens microseminoprotein
SGK / 1.250 / 2.7E-35 / 6446 / Homo sapiens serum/glucocorticoid regulated kinase (SGK)
ID3 / 1.271 / 6.6E-08 / 3399 / Homo sapiens inhibitor of DNA binding 3
CXCL1 / 1.313 / 2.3E-05 / 2919 / Homo sapiens chemokine (C-X-C motif) ligand 1
ZMIZ1 / 1.322 / 2.7E-35 / 57178 / Homo sapiens zinc finger
MGC42105 / 1.331 / 2.7E-35 / 167359 / Homo sapiens serine/threonine-protein kinase NIM1 (MGC42105)
ID2 / 1.358 / 2.7E-35 / 3398 / Homo sapiens inhibitor of DNA binding 2
SLC2A1 / 1.375 / 4.4E-10 / 6513 / Homo sapiens solute carrier family 2 (facilitated glucose transporter)
SGK1 / 1.384 / 2.7E-35 / 6446 / Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1)
CDKN1C / 1.479 / 2.7E-35 / 1028 / Homo sapiens cyclin-dependent kinase inhibitor 1C (p57
ENO2 / 1.671 / 2.7E-35 / 2026 / Homo sapiens enolase 2 (gamma
NDRG1 / 1.691 / 2.7E-35 / 10397 / Homo sapiens N-myc downstream regulated gene 1 (NDRG1)
RASL11B / 1.769 / 2.7E-35 / 65997 / Homo sapiens RAS-like
LCE5A / 2.030 / 2.7E-35 / 254910 / Homo sapiens late cornified envelope 5A (LCE5A)
PFKFB4 / 2.492 / 2.7E-35 / 5210 / Homo sapiens 6-phosphofructo-2-kinase/fructose-2

Supplementary Table S2. Genes differentially expressed following exposure to 0.1 μJ THz pulses.