EUROPRISE SCIENCE UPDATE 09-40
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EUROPRISE SCIENCE UPDATE N° 09-40
28 September 2009
WEEK 09-40
Main Headings
Microbicides
Diagnosis
Epidemiology
Health economics
Health strategies
Immunology
Pathology
Therapy
Vaccines, clinical
Vaccines, research
Virology
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CONTENTS
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Microbicides
Acceptability of the Microbicide UC781 When Administered Rectally Among HIV Negative Women and Men
Experiences With Decision-Making for Microbicide Clinical Trial Enrollment Among Women in Lusaka, Zambia
Diagnosis
New HIV Testing Strategies: Supply Chain Implications
Use of a Rapid HIV Home Test to Screen Sexual Partners: An Evaluation of Its Possible Use and Relative Risk Among Men Who Have Sex With Men
The Howard University Hospital Experience With Routineized HIV Screening: A Progress Report*
Saliva As a Diagnostic Medium
Dried Blood Spots Can Expand Access to Virological Monitoring of HIV Treatment in Resource-Limited Settings
Heterophilic Antibody Interference Causing False-Positive Rapid Human Immunodeficiency Virus Antibody Testing
Epidemiology
[The State Faces Risks of Pandemics]
Challenges and Statistical Issues in Estimating HIV Incidence
Time Gaps Between HIV Infection, Testing, and Treatment Among Racial/Ethnic Minority Drug Users: Opportunities for Enhanced Prevention
Projection of HIV/AIDS Cases in Children and Adolescents
An Innovative Documentation of AIDS Mortality: Demographic and Mortality Surveillance in Ethiopia-Butajira, 2008
Long-Term Trends in HIV Risk Behaviors Among Gay Men
Perinatal Acquisition of Drug-Resistant HIV-1 Infection: Mechanisms and Long-Term Outcome
Injection Drug Use Among Street-Involved Youth in a Canadian Setting
Occupational Transmission of Bloodborne Diseases to Healthcare Workers in Developing Countries: Meeting the Challenges
Diagnosis and Monitoring of HIV-1 Group O-Infected Patients in Cameroun
[HIV Infection in Women]
[Epidemiology of the HIV Infection]
Concurrent Sexual Partnerships and Racial Disparities in HIV Infection Among Men Who Have Sex With Men
HIV Epidemics Among Men Who Have Sex With Men in Central and Eastern Europe
Young People: Not As Healthy As They Seem
Mother-to-Child HIV and HHV-8 Transmission in Neonates at Saint Camille Medical Centre in Burkina Faso
Health economics
A Study Examining the United States' General Population Attitudes Toward Spending of Healthcare Dollars on Critical Public and Personal Health Services
Determining a Cost Effective Intervention Response to HIV/AIDS in Peru
Health strategies
Influence of Health Knowledge in Shaping Political Priorities: Exploring HIV/AIDS Knowledge, Global Health, and Domestic Concerns
A School-Based Educational Intervention to Increase Knowledge About HIV Among Teenage Students in Rural Western Kenya
Overview of the First National Population-Based HIV Testing Survey in Nigeria
Effectiveness of Media Interventions to Prevent HIV, 1986-2006: A Meta-Analysis
Let's Do It: Measuring the Effect of Using an Integrated HIV Testing Approach
Efficacy of HIV Interventions in Developing Countries in Asia and the Pacific Region, 1995-2006: A Meta-Analysis
Waves of the Future: Utilizing Technology for HIV/AIDS Prevention and Healthy Living Via the Global HELP- Health Education Leadership Program
A School-Based Teenage Education Program Focusing on Alcohol and HIV Prevention
Pilot Testing an Intervention to Help Black Girls Avoid Behaviors That Put Them at Risk for Contracting HIV
To Cut or Not to Cut: Willingness to Change the Maasai Male Circumcision Procedure
Adolescent Girls: The Missing Link in Child Survival and Maternal Health Programs
AIDS Policy Development in Kenya: A Historical Institutionalist Analysis
Native American Youth Empowerment Project: Using Creative Expression As a Prevention Modality
State Regulations in Health Information Disclosure: Examining the Interoperability of Health Information Exchange Across States
Looking Backward, Moving Forward: The Future of Sex Education
It Is Not About Whether They Are at Risk: Examining Communication Between Mothers and 9-15 Year Old Daughters About Sex
Examining Intention to Use Condoms Among Adolescents in Ghana
Lessons Learned From UNICEF International Experience on Communicating With Children
Preparing for a Career in Global Health: The Development of an Educational Track for Postgraduate Medical Trainees
Communicating With Children As a Key Public Health Strategy: Introduction to the Session
Systematic Review of HIV Prevention and Intervention Programs for Black Men Who Have Sex With Men
Prediction of Condom Use in Ethnically Diverse Adolescents
Degrees of Disclosure: A Study of Women's Covert Use of the Diaphragm in an HIV Prevention Trial in Sub-Saharan Africa
Filling a Gap in Transfusion Medicine Education and Research
Immigrants With HIV May Face Death If Deported From UK
Research Participant Recruitment in Hispanic Communities: Lessons Learned
Successes, Challenges, and Limitations of Current Antiretroviral Therapy in Low-Income and Middle-Income Countries
Preventing Mother-to-Child Transmission of HIV
Immunology
HIV-1 Infection Impairs the Bronchoalveolar Immune Response to Mycobacteria
Restriction of HIV-1 Replication in Monocytes Is Abolished by Vpx of SIVsmmPBj
Active Site Remodeling Switches HIV Specificity of Antiretroviral TRIMCyp
Regulatory T Cells Reinforce Intestinal Homeostasis
Genetic Determinants of HIV-1 Infection and Progression to AIDS: Immune Response Genes
Differential Modulation of Mitochondrial OXPHOS System During HIV-1 Induced T-Cell Apoptosis: Up Regulation of Complex-IV Subunit COX-II and Its Possible Implications
Compartmentalization of HIV-1 Within the Female Genital Tract Is Due to Monotypic and Low-Diversity Variants Not Distinct Viral Populations
Highly Active Antiretroviral Therapy Drugs Inhibit in Vitro Cholesterol Efflux From Human Macrophage-Derived Foam Cells
Prevalence of Cross-Reactive HIV-1-Neutralizing Activity in HIV-1-Infected Patients With Rapid or Slow Disease Progression
Toll-Like Receptor and Chemokine Receptor Expression in HIV Infected T-Lymphocyte Subsets
Correlation Between HIV-1 Seropositivity and Prevalence of a Gamma-Secretase Polymorphism in Two Distinct Ethnic Populations
DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides That Mimick the Carbohydrate Epitope of HIV
Altered Immune Responses in Rhesus Macaques Co-Infected With SIV and Plasmodium Cynomolgi: an Animal Model for Coincident AIDS and Relapsing Malaria
Kupffer Cells Are Depleted With HIV Immunodeficiency and Partially Recovered With Antiretroviral Immune Reconstitution
Disease Progression in HIV-1-Infected Patients Heterozygous for the Sickle Hemoglobin Gene
Platelet Factor 4 (CXCL4) Facilitates Human Macrophage Infection With HIV-1 and Potentiates Virus Replication
Identification of Novel MHC Class I Sequences in Pig-Tailed Macaques by Amplicon Pyrosequencing and Full-Length CDNA Cloning and Sequencing
HLA-C Is Necessary for Optimal HIV-1 Infection of Human Peripheral Blood CD4 Lymphocytes
Functional Analysis and Structural Modeling of Human APOBEC3G Reveals the Role of Evolutionarily Conserved Elements in HIV-1 and Alu Inhibition
ANALYSIS OF HIV-1 MATRIX BINDING TO MEMBRANES AND NUCLEIC ACIDS
No Evidence for Competition Between Cytotoxic T-Lymphocyte Responses in HIV-1 Infection
Impact of Human Immunodeficiency Virus 1 Infection and Inflammation on the Composition and Yield of Cervical Mononuclear Cells in the Female Genital Tract
Astrocyte Elevated Gene-1 (AEG-1) Is Induced by Lipopolysaccharide As Toll-Like Receptor 4 (TLR4) Ligand and Regulates TLR4 Signalling
Oral Cyclosporin A Inhibits CD4 T Cell P-Glycoprotein Activity in HIV-Infected Adults Initiating Treatment With Nucleoside Reverse Transcriptase Inhibitors
Ion-Abrasion Scanning Electron Microscopy Reveals Surface-Connected Tubular Conduits in HIV-Infected Macrophages
Prognosis of Patients Treated With CART From 36 Months After Initiation, According to Current and Previous CD4 Cell Count and Plasma HIV-1 RNA Measurements
Orally Exposed Uninfected Individuals Have Systemic Anti-HIV Responses Associating With Partners' Viral Load
RNA Interference Directed Against Axin1 Upregulates Human Immunodeficiency Virus Type 1 Gene Expression by Activating the Wnt Signaling Pathway in HeLa-Derived J111 Cells
Pathology
Malignancy in Hiv-Positive South African Children
Mutual Impact of HIV Infection on HIV/Tuberculosis Co-Infection
Tuberculosis in HIV Infected Patients in a Large Industrial Center
Tuberculous Meningitis (Tm) of HIV-Infected Patients
CNS Inflammation and Macrophage/Microglial Biology Associated With HIV-1 Infection
Neurosyphilis in the Age of AIDS: Clinical and Laboratory Features
Aetiology Of Bacteraemia Among Adult Aids Patients Attending Lagos University Teaching Hospital (LUTH), Lagos, Nigeria
Intestinal Parasitic Infections in Relation to HIV/AIDS Status, Diarrhea and CD4 T-Cell Count
Prevalence of HIV Seropositivity in Patients With Lymphoid Malignancies in a Tertiary Centre in Southern Nigeria
Neuromuscular Diseases Associated With HIV-1 Infection
A Meta-Analysis of the Incidence of Non-AIDS Cancers in HIV-Infected Individuals
HIV-Associated Pulmonary Arterial Hypertension: Survival and Prognostic Factors in the Modern Therapeutic Era
Tuberculosis Among People With HIV Infection in the United Kingdom: Opportunities for Prevention?
[Causes of Death in HIV Patients]
HIV and Kidney Disease in Sub-Saharan Africa
Controversies in the Pathogenesis of HIV-Associated Renal Diseases
The Renal Complications of HIV
Oral Manifestations Among People Living With HIV/AIDS in Tanzania
Viral Hepatitis Is Associated With Reduced Bone Mineral Density in HIV-Infected Women but Not Men
Detectable HIV Viral Load Is Associated With Metabolic Syndrome
Mucocutaneous Manifestations in 150 HIV-Infected Indian Patients and Their Relationship With CD4 Lymphocyte Counts
Progressive Multifocal Leukoencephalopathy in HIV-1 Infection
Therapy
[Dietary Intake and Dyslipidemia Arising From Combination Antiretroviral Therapy for HIV Infection: a Systematic Review.]
Significant Publications on Infectious Diseases Pharmacotherapy in 2008
Efavirenz: a Decade of Clinical Experience in the Treatment of HIV
Early Mortality and Cause of Deaths in Patients Using HAART in Brazil and the United States
The Effect of Combined Antiretroviral Therapy on the Overall Mortality of HIV-Infected Individuals
[New Antiretroviral Drug Classes in HIV Therapy]
Impact of Hepatitis B Virus Infection on Human Immunodeficiency Virus Response to Antiretroviral Therapy in Nigeria
[Advance on Targets and Drugs for Anti-HIV]
The Nephrotoxic Effects of HAART
Adult Clinical and Immunologic Outcomes of the National Antiretroviral Treatment Program in Rwanda During 2004-2005
CD4+ Response and Subsequent Risk of Death Among Patients on Antiretroviral Therapy in Lusaka, Zambia
Genetic and Functional Mitochondrial Assessment of HIV-Infected Patients Developing HAART-Related Hyperlactatemia
Activity, Pharmacokinetics and Safety of Lersivirine (UK-453,061), a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor, During 7-Day Monotherapy in HIV-1-Infected Patients
CYP2B6, CYP2A6 and UGT2B7 Genetic Polymorphisms Are Predictors of Efavirenz Mid-Dose Concentration in HIV-Infected Patients
Response to Nonnucleoside Reverse Transcriptase Inhibitor-Based Therapy in HIV-Infected Children With Perinatal Exposure to Single-Dose Nevirapine
Vaccines, clinical
Process and Outcome Evaluation of Project EAST: An Intervention to Increase Minority Participation in HIV/AIDS Clinical Trials
Vaccines, research
Increasing Support for HIV Vaccine Research: Findings From Qualitative Research With HIV/AIDS Stakeholders in the United States
Genetically-Modified Dendritic Cells Expressing IL-15, Its Receptor and Tumor Antigen Enhanced Tumor-Specific Humoral Immunity in CD4+ T Cell Depleted Mice
Rejuvenation of the Thymus Combined With Gene Manipulation of Stem Cells: A Novel Approach to Treating Autoimmunity and Aids
Phase Ii Safety and Efficacy of Oz1: Retroviral Vector Anti-Tat/Vpr Ribozyme for Hiv-1
HIV-1 Derived Peptides Fused to HBsAg Affect Its Immunogenicity
Interleukin-10 Responses to Therapeutic Vaccination During Highly Active Antiretroviral Therapy and After Analytical Therapy Interruption
[Protective Mucosal Immunity and HIV-1 Mucosal Vaccine Strategy]
Glycoprotein 96 Mediated Presentation of HIV-1 Specific HLA Class I Restricted Peptide and Humoral Immune Responses to HIV-1 P24
Co-Immunization With an Optimized Plasmid-Encoded Immune Stimulatory Interleukin, High-Mobility Group Box 1 Protein, Results in Enhanced Interferon-Gamma Secretion by Antigen-Specific CD8 T Cells
Tonsillar Application of AT-2 SIV Affords Partial Protection Against Rectal Challenge With SIVmac239
Heterologous Prime-Boost Vaccination
Virology
Molecular Epidemiology of HIV-1 in Central Taiwan During 2007-2008
The Effect of Intrinsic Stochasticity on Transmitted HIV Drug Resistance Patterns
Visualizing Fusion of Pseudotyped HIV-1 Particles in Real Time by Live Cell Microscopy
Brazilian Network for HIV Drug Resistance Surveillance: a Survey of Individuals Recently Diagnosed With HIV
Signature Nucleotide Polymorphisms at Positions 64 and 65 in Reverse Transcriptase Favor the Selection of the K65R Resistance Mutation in HIV-1 Subtype C
The HIV-1 Integrase Genotype Strongly Predicts Raltegravir Susceptibility but Not Viral Fitness of Primary Virus Isolates
Evolution and Molecular Epidemiology of Subtype C HIV-1 in Zimbabwe
Role of HIV-1 Nef Protein for Virus Replication in Vitro
[The Impact of the HIV-1 Envelope (Env) Mutation on Its Assembly of Functional Pseudovirus]
Prevalence of Persistent and Latent Viruses in Untreated Patients Infected With HIV-1 From Ghana, West Africa
Emergence and Diversity of Different HIV-1 Subtypes in South Africa, 2000-2001
Molecular Characterization of the Env Gene of Two CCR5/CXCR4-Independent Human Immunodeficiency 2 Primary Isolates
Structure-Function Analysis of HIV-1 Gp120 Amino Acid Mutations Associated With Resistance to the CCR5 Co-Receptor Antagonist Vicriviroc
Molecular Phylodynamics of the Heterosexual HIV Epidemic in the United Kingdom
Protease Inhibitor Resistance in South African Children With Virologic Failure
Association of Oncogenic and Nononcogenic Human Papillomavirus With HIV Incidence
PREFERRED SEQUENCES WITHIN A DEFINED CLEAVAGE WINDOW SPECIFY DNA 3' END-DIRECTED CLEAVAGES BY RETROVIRAL RNASES H
A HIV-1 Heterosexual Transmission Chain in Guangzhou, China: a Molecular Epidemiological Study
Pairwise and Higher-Order Correlations Among Drug-Resistance Mutations in HIV-1 Subtype B Protease
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Microbicides
Acceptability of the Microbicide UC781 When Administered Rectally Among HIV Negative Women and Men
VENTUNEAC A., Carballo-Dieguez, A., Dennis, R., McGowan, I., Adler, A., Khanukhova, E., Price, C., Saunders, T., Siboliban, C., and Anton, P.
137th Annual Meeting and Exposition of the American Public Health Association (APHA) ,Philadelphia, PA; USA, 207497 ,2009
1) HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University, New York, NY; 2) Center for HIV Prevention Research, David Geffen School of Medicine at UCLA, Los Angeles, CA; 3) Magee Womens Research Institute, University of Pittsburg Medical Center, Pittsburgh, PA; 4) Lemon Tree Tours, Mill Valley, CA
Source: MIS
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Microbicides
Experiences With Decision-Making for Microbicide Clinical Trial Enrollment Among Women in Lusaka, Zambia
WILLIAMS N., Akers, A., Reid, C., Kapina, M., Stringer, J., and Hillier, S.
137th Annual Meeting and Exposition of the American Public Health Association (APHA) ,Philadelphia, PA; USA, 204229 ,2009
1) School of Medicine, University of Pittsburgh, Pittsburgh, PA; 2) Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Hospital, Pittsburgh, PA; 3) Microbicide Trials Network, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; 4) Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
Source: MIS
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Diagnosis
New HIV Testing Strategies: Supply Chain Implications
ALLERS C., Keddem, C., and Ombeva, A.
137th Annual Meeting and Exposition of the American Public Health Association (APHA) ,Philadelphia, PA; USA, 206324 ,2009
1) Usaid | Deliver Project, John Snow, Inc., Arlington, VA; 2) JSI/Global Fund Consortium, Nairobi, Kenya
Source: MIS
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Diagnosis
Use of a Rapid HIV Home Test to Screen Sexual Partners: An Evaluation of Its Possible Use and Relative Risk Among Men Who Have Sex With Men
VENTUNEAC A., Carballo-Diéguez, A., Cheng Shiun, Leu P., Levin, B., Bauermeister, J., Woodman-Maynard, E., and Giguere, R.
137th Annual Meeting and Exposition of the American Public Health Association (APHA) ,Philadelphia, PA; USA, 209534 ,2009
1) Center for Clinical and Behavioral Studies at New York State Psychiatric Institute and Columbia University, New York, NY; 2) Mailman School of Public Health, Biostatistics, Columbia University, New York, NY; 3) Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI
Source: MIS
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Diagnosis
The HowardUniversityHospital Experience With Routineized HIV Screening: A Progress Report*
SCOTT V. F., Sitapati, A., Martin, S., Summers, P., Washington, M., Daniels, F., Mouton, C., Bonney, G., Apprey, V., Webster, V., Smith, A., Mountvarner, G., Daftary, M., and Maxwell, C. J.
Trans.Am.Clin.Climatol.Assoc. 120:429-34., 429-434 ,2009
AD - Potomac, Maryland-eng
BACKGROUND: HowardUniversityHospital (HUH) is the first hospital in the nation to have instituted a hospital-wide routine rapid HIV screening campaign as recommended by the CDC for healthcare settings. METHODS: HUH developed a protocol and implemented a hospital-wide routine HIV screening in October 2006. Rapid oral fluid-based HIV testing was conducted throughout the hospital using the OraSure OraQuick Advance Rapid HIV-1/2 Antibody Test. Patients with a preliminarily reactive test result were either referred for confirmatory testing or offered a Western Blot confirmatory test on-site and referred for follow-up care. This is a report on the progress of this program for the first eight months. RESULTS: Of the 9,817 patients offered HIV testing, 5,642 consented. The mean age of the screened population was 40.7 years. Ninety percent of the patients screened were black and 55% were female. A preliminarily reactive test result was identified in 139 patients for a seroprevalence rate of 2.46%. Of these patients, 136, or 98% were black; 63% were male and 37% were female. HIV prevalence in the overall sample, among blacks, and among both black males and females peaked in the 40-54 year old age group. Challenges were experienced initially in securing confirmatory tests. CONCLUSIONS: Hospital-wide routine HIV screening is both possible and productive. The routine HIV screening campaign instituted at HowardUniversityHospital has identified a significant number of previously unidentified HIV positive persons. Success in assuring confirmatory testing and transition to care improved as time progressed
Link :
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Diagnosis
Saliva As a Diagnostic Medium
PINK R., Simek, J., Vondrakova, J., Faber, E., Michl, P., Pazdera, J., and Indrak, K.