A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors. Author: Cynthia D Nevison
Institute for Arctic and Alpine Research, University of Colorado, Boulder,
Boulder, CO 80309-0450, USA
Cytochrome P450 2D6, the major detox pathway for humans and plants as it relates to Autism by Eileen Dannemann, director, National Coalition of Organized Women and founder of
The Cynthia Nevision study regarding Autism trends documents thatthe prevalence of diagnosed autism has increased rapidly over the last several decades amongst U.S. children. Environmental factors are thought to be driving this increase and a list of the top ten suspected environmental toxins was published recently which includes vaccines and agricultural pesticides and herbicides such as Monsanto’s Round-UP used as the companion for genetically engineered seeds.
My article in response to this brave new study focuses on an uninvestigated commonality-Cytochrome P450 in layman’s terms.
What is Cytochrome P450?According to WikipediaHuman CYPs are primarily membrane-associated proteins[13] located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. Some CYPs metabolize only one (or a very few) substrates, such as CYP19 (aromatase), while others may metabolize multiple substrates. (like 2D6) Both of these characteristics account for their central importance in medicine. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver.The Human Genome Project has identified 57 human genes coding for the various cytochrome P450 enzymes.[14]CYPs are the major enzymes involved in drug metabolism, accounting for about 75% of the total metabolism.[16] Most drugs undergo deactivation by CYPs, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYPs to form their active compounds.
Drug interaction
Many drugs may increase or decrease the activity of various CYP isozymes either by inducing the biosynthesis of an isozyme (enzyme induction) or by directly inhibiting the activity of the CYP (enzyme inhibition). This is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs.
Let us begin a layman’s humble attempt to explain: Aside from the mercury, aluminum and agricultural chemicals, Ms. Nevsion’s study also mentions that high fructose corn syrup (HFCS), which is found in many food products, is another source of dietary mercury. It is to be noted that the corn that HFCS is derived from is genetically engineered corn grown with glysophate (Round Up), which interferes in Cytochrome P450 2D6 metabolism. Patents will show that the dual program of Round Up and GMO seeds has much to do with Cytochrome P450 in plants. Hence, the study’s implication that glysophate is a contributor to Autism.
Mercury also inhibits the activity of this major detox mechanism. Both aluminum and mercury inhibit the activity of the most major detox pathway of both the plant and human body.
Mercury modulates the cytochrome P450 1a1, 1a2 and 1b1 ...
National Center for Biotechnology Information
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ResearchGate
ABSTRACT Aluminum (Al) is a low toxicological metal and can accumulate in the liver. The hepatic microsomal cytochrome P450 enzyme system (CYPS) plays...
Vaccines containing high concentrations of neurotoxic aluminum were added to the child immunization schedule when several vaccines containing mercury were removed. Two-month old babies now receive 1,225 mcg of aluminum from their vaccines -- 50 times higher than safety levels!
Glutathione
Very interesting to note is that Cytochrome P450 also regulates glutathione - found depleted in Autism cases.
Cytochrome P450 Immature In infants and Children
Another thing to consider is that cytochrome P450 is “maturing”. That is this major gene and detox pathway of the human body is not “mature” in the infant or child. Hence, every child that is vaccinated has a variation in their ability to clear out the toxins whether it is mercury, aluminum or other toxic elements of the vaccines. For example, 10 % of Caucasians are non-metabolizers due to simple genetic variation. It is not a defect. They have no (emphasis added) activity of the most major Detox pathway Cytochrome P450 2D6. Given this, it can be theorized that the extreme cases such as Autism on the Autism Spectrum are amongst children who may be poor or non-metabolizers by their Cytochrome P450 genetic nature. (remember it is not a defect) And that the lesser range of Autism Spectrum or neurological injuries are due to the variations in a child’s individual maturity of the cytochrome functioning which controls their ability to detoxify the intense children’s vaccine schedule. So some children are harmed more than other and some recover more quickly. I have noted that children who are on gluten and casein free organic diets (known as the GAP diet) recover more easily since the immune system is present in the gut.
As another way of explaining this in layman’s terms-Tanzanian Africans, for example are ultra rapid metabolizers. Over generations, they have multiplied their cytochrome detoxing function due to ingesting medicinal weeds in place of good food because of poor soil conditions of their country and poverty. So, it stands to reason that people in the USA where soil conditions (prior to 1930s and before the introduction of toxic agriculture) were organic, may have initiated a “dormant” cytochrome P450 2D6 cycle function as toxicity was not an issue.
At that time food was primarily organic and the pharmaceuticals had not yet developed the enormous range of drugs we have today such as the SSRIs (Prozac, Zoloft, Wellbutin, etc). Hence the cytochrome function may have become dormant in the generational demographics that ate organic foods and had little or no exposure to toxins. Of course there was some insanity going on at that time in history but there was also over the counter drugs such as cough medicine, codeine, etc. that persons without the metabolizing ability were taking on a daily basis.
Suddenly, in the last decade mankind finds themselves in a toxic soup with a high need for a functioning detox mechanism. It is to be noted regarding the toxic soup we live in is that once the child is diagnosed on the autism spectrum, or mental illness, which in reality is a toxic assault from vaccination, they are given the modern SSRI drugs. 10,000 toddlers between the ages of 1 and 3 are on medication. 25% of American children are on psyche meds due to this misdiagnosis of mental illness or Autism Spectrum. of these drugs, as per the newer package inserts such as found in Respirdal, are detoxed through the Cytochrome P450 2D6 pathway. Ritalin and Adderall the most generously prescribed medication for school aged children need Cytochrome P450 2D6 to metabolize. Having injected children from the 1980s to 2001 (the relative date when the CDC was forced to take the mercury out of 15 of the recommended children’s vaccines) with 25 mcgs of mercury with each vaccine, despite identifying the maturity factor or the presence of a functioning Cytochrome P450 2D6, the mercury and aluminum remains lodged in the body depending on ones ability to metabolize. Mercury and aluminum inhibits Cytochrome P450 2D6. Hence, when the psyche drugs are then given to kids, they are harmed even more because their cytochrome P450 is inhibited due to the presence of the heavy metals and they have adverse reactions to the psyche meds, which are usually downplayed.
School Shooters and Cytochrome P450
James Holmes, Adam Lanza, Jerod Loughner are just a few names of young men involved in the modern epidemic of mass shootings. All of which were vaccinated and were put on psyche drugs. Are these examples of people who are non-or poor metabolizers? Dr. Yolande Lucire, Australian psychiatrist has done a study on homicides and Cytochrome P450 2D6.
Those who are non-or poor metabolizers and are on psyche drugs have a penchant to commit heinous homicides or suicides. List of the drugs that need 2D6 pathway to metabolize. Because of their low cytochrome function they are virtually INVOLUNTARILY INTOXICATED by psyche ward hospitals and private physicians. Many of the psyche meds have black box warnings of suicidal ideations.
These SSRI and more are the drugs that must have a highly functioning Cytochrome P450 2d6 to detoxify the drugs from the body. However, it is not standard of care to test for the functioning prior to the prescribing or the injecting of vaccines into little infants and children. If one is a non-or poor metabolizer, or has mercury or aluminum lodged in the body interfering in the cytochrome functioning, then that person can become psychotic very easily. It appears that the heinous (emphasis added) homicidal ideations and the suicidal ideations come when they quit the medications suddenly.
Disabling Humanity-The pattern
First the pregnant woman is injected with 4 vaccine doses, (in-utero vaccination to a fetus the size of a thumb) a CDC recommendation that has no scientific basis. On the contrary, there was a 4,250% increase in fetal deaths during the 2009/10 H1N1 pandemic year when they double dosed pregnant women with the seasonal flu shot and the untested H1N1 strain both containing 25 mcgs of mercury and yet due to a successful and fraudulent cover up the CDC successfully recommends that a pregnant woman get the TDaP vaccines and the flu shot without consideration of the mercury content.
multidose flu vaccine is usually given to the poor people and the uninformed in the United States and all over the world. It contains mercury. The single dose vial does not. Therefore, not only are the USA clinic/Medicaid patients (children, adults and the elderly) receiving a shot from the cheaper cost multidose vial containing mercury but the poor all over the world are receiving 25mcgs of mercury in every yearly flu shot, as if they haven’t got enough problems.
Then children are injected with 49 vaccine doses by the time they are six years old starting on the day of birth with the Hepatitis B vaccine which at one time contained mercury. We could also mention the Rhogam shots to pregnant women, which at one time also contain mercury. Furthermore Vaccines containing high concentrations of neurotoxic aluminum were added to the child immunization schedule when several vaccines containing mercury were removed. Two-month old babies now receive 1,225 mcg of aluminum from their vaccines -- 50 times higher than safety levels!
They are then misdiagnosed as mentally ill rather than physiologically neurologically injured and are given psyche medications (see links above).
And all the while the CDC is not only continuing to recommend and mandate vaccines for children in order to go to school but the State’s due to the funding programs from the Federal government take no oversight position to determine for themselves whether a vaccine is effective for the child or cost effective for the state.
Meanwhile, there is a healthcare crisis and a Medicaid crises. Government assistant programs such as Medicaid and special needs education at both Federal and state levels are unsustainable as the vaccination program is considered by researchers and parent alike as the cause of life long chronic illnesses. The governments are attempting to sustain programs for every chronically ill individual’s lifetime. Illnesses such as obesity, asthma, allergies, autism, adhd, ocd, bipolar, precocious puberty, juvenile diabetes, neurodevelopmental problems, educational problems, angelman’s syndrome, etc. are just some of the lifelong problems. Besides its damaging effect to the individual and the happiness of the families who are burdened with life long illnesses, vaccinations are not cost-effective and their cost effectiveness should be analyzed in light of the preponderance of independent research that point to vaccines as the 1000 lb gorilla in the room.
Comprehensive Article by Brandon Turberville
Dr. Mercola on Cytochrome P450 2D6