Supplement
In our study, cardiac computed tomography was performed at the 3rd month after the repeat procedure to evaluatepulmonary veinstenosis. We have considered the effect of contrast-enhanced cardiac computed tomography onrenal function in acute phase. Once the patient underwent cardiac computed tomography, blood samples were collected at the appointed time, including1 day after the examination, 3 days after the examination and 1 week after the examination, to determine if the contrast-induced nephropathy (CIN) occurred. CIN is defined as an acute renal failure that occurs within 24-72 hours of exposure to intravenous or intraarterial iodinated contrast media that cannot be attributed to other causes. Because the rise in serum creatinine is peaking on the third to fifth day after expoding toiodinated contrast media, returning to baseline within 10-14 days, we calculated enrolled patients’eGFR at 1 day, 3 days and 1 week after the performance of cardiac computed tomography.We define baseline eGFR as the eGFR before the repeat procedure.ΔeGFR (1 day) was calculated as the eGFR at 1 day after the performance of cardiac computed tomography minus baseline eGFR. Likewise, ΔeGFR (3 days) was calculated as the eGFR at 3 days after the performance of cardiac computed tomography minus baseline eGFR. ΔeGFR (1 week) was calculated as the eGFR at 1 week after the performance of cardiac computed tomography minus baseline eGFR.None of enrolled patients suffered from CIN inthe period of 1 week after the examination. For patients in Group I and Group II, differences ofΔeGFR (1 day)、ΔeGFR (3 days) andΔeGFR (1 week) were determined by analysis of t test (Supplement 1). There were no significant differences inΔeGFR (1 day)、ΔeGFR (3 days) andΔeGFR (1 week) between Group I and Group II.
In our study, we analyze the effect of performance of cardiac computed tomography on renal function in acute phase, which refers to the period of 1 week after the examination, and potential eGFR changes in acute phase due to computed tomography have no impact on group categorization. But we no longer assess renal function of patients after more than one week until at 12-month and 24-month follow-up. So we can not analyze the delayed effect of performance of cardiac computed tomography on renal function and its impact on group categorization.
Supplement. Changes of renal function inthe period of 1 weekafter the performance of cardiac computed tomography for patients in Group I and Group II
Group I / Group II / P valueΔeGFR (1 day) / 0.22±0.56 / 0.24±0.64 / 0.595
ΔeGFR (3 days) / 0.35±0.72 / 0.33±0.96 / 0.636
ΔeGFR (1 week) / 0.32±0.65 / 0.29±0.94 / 0.604
Baseline eGFR, the eGFR before the repeat procedure;ΔeGFR (1 day), the eGFR at 1 day after the performance of cardiac computed tomography minus baseline eGFR; ΔeGFR (3 days), the eGFR at 3 days after the performance of cardiac computed tomography minus baseline eGFR; ΔeGFR (1 week), the eGFR at 1 week after the performance of cardiac computed tomography minus baseline eGFR.