Alignment of Zfh-1 family members. Below this is an alignment of the zinc finger regions of these proteins.
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
5 15 25 35 45 55
Human_Nil2 -----MADGP RCKRRKQANP RRNNVTNYNT VVETNSDSDD EDKLHIVEEE SVTDA---AD
Human_O60315 MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD GIANP---LD
Dros_Zfh1 ---MLSCLAP SSSRFGQEDT IIQQSMPSTS PFAMQFPSLA STLLHHNQSP KHSNPGSSGI
Celeg_F28F9.1 ------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
65 75 85 95 105 115
Human_Nil2 CEGVP------EDDLPTDQT VLPGRSSE-- -REGNAKNCW ED------DRKEGQ
Human_O60315 QETSPASVPN HESSPHVSQA LLPREEEEDE IREGGVEHPW HNNEILQASV DGPEEMKEDY
Dros_Zfh1 QDAHPNQPGA AADAFLVKCT QCHKRFPEYQ SLSEHIASEH PHDKLNCGAA QPESDAEDEQ
Celeg_F28F9.1 ------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
125 135 145 155 165 175
Human_Nil2 EILG------PEAQADEAG- -CTVKDDECE SDAEN------EQN-HDP NVEEFLQQQ-
Human_O60315 DTMG------PEATIQTAIN NGTVKNANCT SDFEEYFAKR KLEERDGHAV SIEEYLQRS-
Dros_Zfh1 SNMSGSSRRY AKSPLASNNN SSTANANNNS TSSQS--MNN NSELAKNHNS ANKMSPMCSP
Celeg_F28F9.1 ------MV-
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
185 195 205 215 225 235
Human_Nil2 ------DTAV IFPEAPEEDQ RQGTPEASGH DEN----GTP DAFS------QLLTCPYCDR
Human_O60315 ------DTAI IYPEAPEELS RLGTPEANGQ EENDLPPGTP DAFA------QLLTCPYCDR
Dros_Zfh1 GSLTPGDLFA QLQHPPPQLP PHLHAQFMAA AASLAMQSAR TASSPSQQQQ QQLQQQQQLQ
Celeg_F28F9.1 ------DIAE AMPTTASSLP ------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
245 255 265 275 285 295
Human_Nil2 GYKRFTSLKE HIKYRHEKNE DNFS------
Human_O60315 GYKRLTSLKE HIKYRHEKNE ENFS------
Dros_Zfh1 QQQQMQQQQQ HQMAMQQLLP PQLPGSNSSV GSNSAYDLDL SAPRSTSSPG STTGDLSGAY
Celeg_F28F9.1 ------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
305 315 325 335 345 355
Human_Nil2 -CSLCSYTFA YRTQLERHMT SHKSG------RD Q-RHV--TQS
Human_O60315 -CPLCSYTFA YRTQLERHMV THKPG------TD QHQML--TQG
Dros_Zfh1 PCMQCTASFA SREQLEQHEQ LHSPCGPAAV SNVSQTCRIC HKAFANVYRL QRHMISHDES
Celeg_F28F9.1 ------SD E------A-
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
365 375 385 395 405 415
Human_Nil2 GCNRKFKCTE CGKAFKYKHH LKEHLRIHSG EKPYECPNCK KRFSHSGSYS SHISSKKCIS
Human_O60315 AGNRKFKCTE CGKAFKYKHH LKEHLRIHSG EKPYECPNCK KRFSHSGSYS SHISSKKCIG
Dros_Zfh1 ALLRKFKCKE CDKAFKFKHH LKEHVRIHSG EKPFGCDNCG KRFSHSGSFS SHMTSKKCIS
Celeg_F28F9.1 --LRKFKCPE CTKAFKFKHH LKEHIRIHSG EKPFECQQCH KRFSHSGSYS SHMSSKKCVQ
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
425 435 445 455 465 475
Human_Nil2 LIPVNGRPRT GLKTSQCSSP SLSASPGSPT RPQIRQKIEN -K--PLQEQL SVNQIKTEPV
Human_O60315 LISVNGRMRN NIKTGSSPN- SVSSSPTNSA ITQLRNKLEN GKPLSMSEQT GLLKIKTEPL
Dros_Zfh1 MGLKLNNNRA LLKR------LEKSPGSAS SASRRSPSDH GKG-KLPEQP SLPGLPHPMS
Celeg_F28F9.1 QASPS------MVTPFN-- -PYQLMMYRN -----IMLQL QTPQVSFLPS
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
485 495 505 515 525 535
Human_Nil2 DY-EFKPIVV ASGINCSTPL QNGVFTGGGP LQATS---SP QGMVQAVVLP TVGLVSPISI
Human_O60315 DFNDYKVLMA THGFSGTSPF MNGGLGATSP LGVHPSAQSP MQHLGVGMEA PLLGFPTMNS
Dros_Zfh1 YFASDAQVQG GSAAPAPFPP FHPNYMNAAL LAFPHNFMAA AAGLDPRVHP YSIQRLLQLS
Celeg_F28F9.1 TAANNMDYMS LLQANLFQSL ENGTSP--TP TQEPSAPASP EPKIEVVDEP -----EVSSE
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
545 555 565 575 585 595
Human_Nil2 NLSDIQNVLK VAVDGNVIRQ VLE---NNQA NLASKEQETI NASPIQQGGH S-VISAISLP
Human_O60315 NLSEVQKVLQ IVDN-TVSRQ KMDCKAEEIS KLKGYHMKDP CSQPEEQGVT SPNIPPVGLP
Dros_Zfh1 AAGQQQREEE REEQ--QKQQ QHD---EEET PDEPKLVMDI EEPETKEMAP TPEATEAATP
Celeg_F28F9.1 VKTEVKTEVK TEDS------VPE---ESIT PAVS---MSL SPAPEQNGNE S--MNNGGS-
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
605 615 625 635 645 655
Human_Nil2 LVDQDGTTKI IINYSLEQPS QLQVVPQNLK KENPVATNSC KSEKLPEDLT VKSEKDKSFE
Human_O60315 VVSHNGATKS IIDYTLEKVN EAKACLQSLT TDSRRQISNI KKEKLRTLID LVTD-DKMIE
Dros_Zfh1 IKREESR-EA SPDPESYRSS S-----QAIK QEQEPLNVAE ERQ------TPVEEHAPVE
Celeg_F28F9.1 --GSDG--KS SPDWRPLRS------RSFL NDSQVAVLQN ------HFK
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
665 675 685 695 705 715
Human_Nil2 GG--VNDSTC LLCDD-CPGD INALPELKHY DLKQPTQPPP LPAAEAEKPE SS------
Human_O60315 NHNISTPFSC QFCKESFPGP IPLHQHERYL CKMNEEIKAV LQPHENIVPN KAGVFVDNKA
Dros_Zfh1 H---SADLRC SRCSKQFNHP TELVQHEKVL CGLIKEELEQ HFQ-QQQATS FA------
Celeg_F28F9.1 ----RNPFPS KYELSAVAEQ IGVNKRVVQV WFQNTRAKER RSNRLPSMPR GS------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
725 735 745 755 765 775
Human_Nil2 --VSSATGDG NLSPSQPPLK NLLSLLKAYY ALNAQPSAEE LSKIADSVNL PLDVVKKWFE
Human_O60315 LLLSSVLSEK GMTSPINPYK DHMSVLKAYY AMNMEPNSDE LLKISIAVGL PQEFVKEWFE
Dros_Zfh1 --LASASEED EEDEE------MDVEEE PRQESGERKV
Celeg_F28F9.1 --VASAAAAA ATSPT------VWQT PVQLMAAWAS
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
785 795 805 815 825 835
Human_Nil2 KMQAGQISVQ SS---EPSS- PEPGKVNIPA KNNDQPQS------AN ANEPQDSTVN
Human_O60315 QRKVYQYSNS RSPSLERSSK PLAPNSNPPT KDSLLPRSPV KPMDSITSPS IAELHNSVTN
Dros_Zfh1 RVRTAINEEQ QQ------QLKQHYS------LN ARPSRDEFRM
Celeg_F28F9.1 QFSNGNNSLT AS------QDER------N N-ENTDEVMD
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
845 855 865 875 885 895
Human_Nil2 LQSPLKMTN- ---SPVLPVG STTNGSRSST PSPSPLNLSS SRNTQGYLYT AEGAQ-EEPQ
Human_O60315 CDPPLRLTKP SHFTNIKPVE KLDHS-RSNT PSPLNLSSTS SKNSHSSSYT PNSFSSEELQ
Dros_Zfh1 IAARLQLDP- ----RVVQVW FQNNRSRERK MQSFQNNQAA GAAPPMPIDS QASLT---RE
Celeg_F28F9.1 HDGLKDGKE- ---TPLDLTL STDDTEPEWS PEKLIGFLDQ TGGVIQELLR QAGNG--FVT
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
905 915 925 935 945 955
Human_Nil2 VEPLDLSLPK QQGE------LLERSTIT SVYQNSVYSV QE---EPLNL SCAKKEPQKD
Human_O60315 AEPLDLSLPK QMKEPKSIIA TKNKTKASSI SLDHNSVSSS SENSDEPLNL TFIKKEFSNS
Dros_Zfh1 DQPLDLSVKR DPLTP------KSESSPP YIAPPSGEAL NP---EAINL SRKFSTSASM
Celeg_F28F9.1 NQEDEEEKPI KAEE------SPVSSGSS SIWPSFIGQY PS---ILDSA SLSVLEKALD
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
965 975 985 995 1005 1015
Human_Nil2 SCVTD--SEP VVNVIPPSAN PINIAIPTVT AQLPTIVAIA DQNSVPCLRA LAANKQTILI
Human_O60315 NNLDNKSTNP VFSMNPFSAK PLYTALPPQS AFPPATFMPP VQTSIPGLRP YPGLDQMSFL
Dros_Zfh1 SPASIS--PS SAAALYFGAA PPPSPPNSQL DSTPRSGQAF PGLPPYMLPM SLPMEALFKM
Celeg_F28F9.1 VSFID---FS ECFAIQFLML HVLNSVVSWK EQKTFLAYLS GKN----FFD SLGFREDIRA
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1025 1035 1045 1055 1065 1075
Human_Nil2 PQVAYTYSTT -VSPAVQEPP LKVIQ-PNGN QDERQDTSSE GVSNVEDQND SDSTPPKKKM
Human_O60315 PHMAYTYPTG -AATFADMQQ RRKYQRKQGF QGELLDGAQD YMSGLDDMTD SDSCLSRKKI
Dros_Zfh1 RPGGDFASNH ALMNSIKLPD YRGTSLSPGG SEKRSWRDDD SRISHEDEFG AGVLMPPKPR
Celeg_F28F9.1 VRYVIIYSNK QIFEKLYYPP RYALT--NNF QDMQQKSSED DASSLCS-NE SKLLKFPTTP
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1085 1095 1105 1115 1125 1135
Human_Nil2 RK-----TEN G----MYACD LCDKIFQKSS SLLRHKYEHT GKRPHECGIC KKAFKHKHHL
Human_O60315 KK-----TES G----MYACD LCDKTFQKSS SLLRHKYEHT GKRPHQCQIC KKAFKHKHHL
Dros_Zfh1 RGKVETHGHA GDPDLPYVCD QCDKAFAKQS SLARHKYEHS GQRPYQCIEC PKAFKHKHHL
Celeg_F28F9.1 LK-----EEE G----LFSCD QCDKVFGKQS SLARHKYEHS GQRPYKCDIC EKAFKHKHHL
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1145 1155 1165 1175 1185 1195
Human_Nil2 IEHMRLHSGE KPYQCDKCGK RFSHSGSYSQ HMNHRYSYCK REAEERDSTE QEE------A
Human_O60315 IEHSRLHSGE KPYQCDKCGK RFSHSGSYSQ HMNHRYSYCK REAEEREAAE REAREKGHLE
Dros_Zfh1 TEHKRLHSGE KPFQCSKCLK RFSHSGSYSQ HMNHRYSYCK PYRE------
Celeg_F28F9.1 TEHKRLHSGE KPFQCDKCLK RFSHSGSYSQ HMNHRYSYCK PYRE------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1205 1215 1225 1235 1245 1255
Human_Nil2 GPEILSNEHV GARASPS-QG DSDERESLTR EEDEDSEKEE EEEDKEMEEL QEEKECEKPQ
Human_O60315 PTELLMNRAY LQSITPQGYS DSEERESMPR --DGESEKEH E---KEGEDG --YGKLGRQD
Dros_Zfh1 ------
Celeg_F28F9.1 ------QPASPS--- DVLNGGSVTV S------PS ------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1265 1275 1285 1295 1305 1315
Human_Nil2 GDEEEEEEEE EVEEEEVEEA ENEGEEAKTE GLMKDDRAES QASSLGQKVG ESSEQVSEEK
Human_O60315 GDEEFEEEEE ESENK---SM DTDPETIRDE EETGDHSMDD SSEDGKMETK SDHEEDNMED
Dros_Zfh1 ------
Celeg_F28F9.1 ------SS NTPPPST------
....
Human_Nil2 TNEA
Human_O60315 GM--
Dros_Zfh1 ----
Celeg_F28F9.1 ----
Alignment of the zinc finger regions of the above proteins.
NIL2_HUMAN CNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCI
O60315 GNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCI
F28F9.1 ALRKFKCPECTKAFKFKHHLKEHIRIHSGEKPFECQQCHKRFSHSGSYSSHMSSKKCV
zfh-1 LLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCI
***** ** ****:*******:********: * :* ********:***::****:
NIL2_HUMAN MYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHL
O60315 MYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHL
F28F9.1 LFSCDQCDKVFGKQSSLARHKYEHSGQRPYKCDICEKAFKHKHHL
zfh-1 PYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIECPKAFKHKHHL
: ** *** * *.*** ******:*:**::* * *********
NIL2_HUMAN IEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAE
O60315 IEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAE
F28F9.1 TEHKRLHSGEKPFQCDKCLKRFSHSGSYSQHMNHRYSYCKPYRE
zfh-1 TEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE
** ********:**.** ********************* *