Alignment of vertebrate ADHs included in the phylogenetic tree. Only full-length sequences have been included. ADH sequences from Xenopus laevis, Xenopus tropicalis,Anoliscarolinensis(anole lizard) and Pelodiscus sinensis(turtle) are those described in this manuscript and their accession numbers are provided in Tables3 and 4. Accession numbers of other ADH sequences are compiled in Table 2.
10 20 30 40 50 60 70 80 90 100
....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
Human 3 ---ANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTKLKA--GDTVIPLYIP
Rat 3 ---ANQVIRCKAAVAWEAGKPLSIEEIEVAPPQAHEVRIKIIATAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTKLKA--GDTVIPLYIP
Mouse 3 ---ANQVIRCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKILATAVCHTDAYTLSGRDPEGC-FPVILGHEGAGIVESVGEGVTKLKA--GDTVIPLYIP
Rabbit 3 ---ANKVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIFATAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTNLKA--GDTVIPLYIP
Chicken 3 ---ASGVIKCKAAVAWEAGKPLSIEEVEVAPPKAHEVRIKIVATALCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTKVKP--GDTVIPLYIP
Turtle 3 ---ASGVIKCKAAVAWEAGKPLSIEEVEVAPPKVHEVRIKVVATAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTKVKP--GDTVIPLYVP
Uromastyx 3 ---ASGVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRVKIIATAVCHTDAYTLSGADPEGS-FPVILGHEGAGIVESVGEGVTKFKP--GDTVIPLYIP
X.tropicalis 3 -ETAGKVVKCKAAVAWEAGKPLSIEEVEVAPPKAHEVRIKIVSTAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTRVKP--GDKVIPLYIP
X.laevis 3 -ETAGKVIKCKAAVAWEAGKPLSMEEVEVAPPKAHEVRIKIVSTAVCHTDAYTLSGADPEGC-FPVILGHEGAGIVESVGEGVTRVKP--GDKVIPLYIP
Anole 3 ------VIKCKAAVAWESGKPLSIEEVEVAPPKAHEVRIRIIATAVCHTDAYTLSGADPERE-FPCHPGHERAGIVESVGEGVTKFKA--GDTVIPLYIP
Marmoset 2 -STKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEIRIQIIATSLCHTDATVIDSKFEGLA-FPVIVGHEAAGIVESIGPEVTNFKP--GDKVIPLYAP
Bovine 2 -GTKGKIIKCKAAIAWEANKPLSNEEVEVAPPKDHEVRIQIIATALCHSDAHILHPQFEGGV-FPVILGHEAAGIVESIGPGVTNFKP--CDKVIPLHAP
Human 2 -GTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDASVIDSKFEGLA-FPVIVGHEAAGIVESIGPGVTNVKP--GDKVIPLYAP
Rat 2 -GTQGKVITCKAAIAWKTDSPLCIEEIEVSPPKAHEVRIKVIATCVCPTDINATNPKKK-AL-FPVVLGHECAGIVESVGPGVTNFKP--GDKVIPFFAP
Mouse 2 -GTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKK-AL-FPVVLGHECAGIVESVGPGVTNFKP--GDKVIPFFAP
Rabbit 2A -GTKGKVIKCKAAIAWEAGKPLSIEEVEVAPPKAHEVRVQINAAGLCRSDTHVINPKFEGAF-LPVILGHEGAGIVESVGPGVTNVKP--GDKVIPLYIP
Rabbit 2B -STKGKVIKCKAAIAWEAGKPLSIEEVEVAPPKAHEVRVQIIAASVCRSDTYVINPAFKEGL-LPVILGHECAGIVESVGPGVNNFKP--GDKVIPLYVP
Ostrich 2 -TTEGKVIKCKAAIAWEAGKPLSVEEIEVSPPKDHEVRVKIVATGVCRTDEHAINPSFKEGV-FPVILGHEGAGIVESIGQGVSKFKP--GDKVIPLYMP
Turtle 2 -STVGKVIKCKAAIAWEAGSLFSIEEVEVAPPKEHEIRVKIVATGVCRSDAHAISPSFKEGL-FPVILGHEGAGIVESTGPGVTKFKP--GDKVIPLYMP
X.tropicalis 2 -STARKVIKCKAAVAWEAGKPFSIEEIEVAPPRDHEVRVKIVATGVCRTDAHAVSTHFKEGL-FPVILGHEGAGIVESVGPGVTRVKP--GDKVIPLYIP
Human 4 -GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVS-K-FPVIVGHEATGIVESIGEGVTTVKP--GDKVIPLFLP
Rat 4 -DTAGKVIKCKAAVLWGTNQPFSIEDIEVAPPKAKEVRVKILATGICGTDDHVIKGTMVS-K-FPVIVGHEAVGIVESVGEEVTTVRP--GDKVIPLFLP
Mouse 4 -GTAGKVIKCKAAVLWGVNQPFSIEEIEVAPPKAKEVRVKILATGICRTDDHIIKGSMVS-K-FPVIVGHEAVGVVESVGEGVTTVRP--GDKVIPLFLP
Human 1B1 -STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT-P-LPVILGHEAAGIVESVGEGVTTVKP--GDKVIPLFTP
Rat 1 -STAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFT-P-LPAVLGHEGAGIVESIGEGVTCVKP--GDKVIPLFSP
Mouse 1 -STAGKVIKCKAAVLWELHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGTLVT-P-LPAVLGHEGAGIVESVGEGVTCVKP--GDKVIPLFSP
Rabbit 1 ---AGKVIKCKAAVLWQLNKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHAVTGSIAV-P-LPVILGHEAAGIVESIGEGVTTVKP--GDKVIPLFTP
Ostrich 1 -STAGKVIKCKAAVLWEPKKPFSIEEVEVAPPKAHEVRVKIIATGICRSDDHVISGVLVM-P-FPIILGHEAAGVVESVGEGVTSVKP--GDKVIPLFVP
Quail 1 -STAGKVIKCKAAVLWEANKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGALAM-P-FPVILGHEAAGVVESVGEKVTLLKP--GDAVIPLFVP
Chicken 1 -STVGKVIKCKAAVLWEANKPFSLEEVEVAPPKAHEVRIKIVATGICRSDDHVVTGALAM-P-FPIILGHEAAGVIESVGEKVTSLKP--GDAVIPLFVP
Alligator 1 -STAGKVIKCKAAITWEIKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVTAGLLTM-P-LPMILGHEAAGVVESTGEGVTSLKP--GDKVIPLFVP
Turtle 1 -STSGKIIKCKAAIAWELKKSLSIEEVEVAPPKAHEVRIKIFATGICRSDEHVMSGALAQ-P-FPIILGHESAGVVESVGEGVTSVKP--GDKVIPLFVP
Cobra 1 -STAGKVIKCKAAIAWELNKPLSIEQIEVAPPKAHEVRIKILATGVCRSDEHVISGAFRM-P-LPMVLGHEAAGVVESVGEGVTCVKP--GDKVIPLFAP
Uromastyx 1A -GTAGKVIKCKAAIAWEIKKPLSIEQIEVAPPKAHEVRIKILATGICRSDDHVISGAFKM-P-LPMVLGHEAAGVVESVGEGVTCVKP--GDKVIPLFVP
Uromastyx 1B -STAGKVIKCKAAVVWEPKKPFSIVEIEVAPPKAHEVRIKILASGICRSDDHVLSGALKV-N-FPIILGHEAAGVVESVGEGVTSMKP--GDKVIPIFLP
Anole 1A -STAGKVIKCKAAIAWEIKKPLSIEQIEVSPPKAHEVRIKILATGICRSDDHVISGAFAM-P-LPMVLGHEAAGVVESVGEGVTCVKP--GDKVIPLFVP
Anole 1B -STAGKVIKCKAAVVWEPKKPFSIVEIEVAPPKAHEVRIKILASGICRSDDHVLSGALIV-N-FPIILGHEAMGVVESVGEGVTSVKP--GDKVIPLFLP
Anole1C -STVGKVIKCKAAIVFEAKGPFKIVEIEVAPPKAHEVRIKILGTGICRTDEHVQAGAIKV-N-YPVIPGHEAVGIVESIGEGVTCVKP--GDKVIPLCLP
Anole 1D -STAGKVIKCKAAIVFEAKGPLKVVEIEVAPPKAHEVRIKILATGICRTDDHVLNGTIKV-N-YPVIPGHEAVGAVESIGEGVTCVKP--GDKIIPLCLP
Anole 1E -CTAGKVIKCKAAVLFEVKQPLHIVEIEVAPPKAHEVRVKILASGICRSDDHVLNGTLKV-K-FPIIPGHEALGVVESIGEGVTYVKP--GDKVIPLFLP
Anole1F -STAGKVIKCKAAIVFEPKKPFSIVEIEVAPPKAHEARIKILATGICRTDDHILSGSIKT-T-YPVIPGHEAVAVVESIGEGVTCVKP--GDKVIPLFLP
Anole 1G ------VIRCKAAVVWEPKKPFSIVEIEVAPPKAHEVRIKILAAGICHSDEHVLSDDLKA-T-FPVILGHEAVGVVESVGEGVTSVKP--GDKVIPLFIP
Anole 1H -STAGKVIKCKAAVIWEPKTPFSIVEIEVAPPKAHEVRIKILASGICRSDDHVLSGALKV-T-FPIILGHEAAGVVESVGEGVTSVKT--GDKVIPTFVP
Rana 1 -ATAGKVIKCKAAVCWGPKQPLSIEEIEVAPPKRHEVRVKIVATGICRSDDHVISGALSDMK-FPVILGHEAAGVVESVGEGVTKFKP--GDKVIPLFVP
X.tropicalis 1B -ATAGKVIKCKAAVAWGPKQPLTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGAISDMK-FPAILGHEGAGIVESVGEGVKNIKP--GDKVIPLFVP
X.laevis 1B -ATAGKVIKCKAAIAWGPKQPLTIEDIEVAPPKAHEVRVKIVATGICRSDDHVLSGAISDMK-FPAILGHEGAGIVESVGEGVKNIKP--GDKVIPLFVP
X.tropicalis 1A -AAAGKVIKCKAAVAWAAKQPFSIEDIEVAPPKAHEVRVKMVATGICRSDDHVLNGSMSFPN-FPVILGHEGAGIVESIGPGVKNIKP--GDKVITLFNP
X.laevis 1A2 -TTAGNVIKCKAAVAWAPKQPLSIEDIEVAPPKAHEIRVKMVATGICGSDDTVLSGSFSSIK-FPVILGHEGAGIVESVGTGVKNVKP--GDKVIALFQP
X.tropicalis 1C -STAGKVIKCTAAVVWEPGQPFSIEDIEVAPPKAHEVRVKIVASGVCHTDYHVMSGSVDNIK-YPLILGHEGAGIVESVGEGVKKVKP--GDKVIPLSLP
X.laevis 1C -STAGKTIECKAAVVWGPDQPFSVETIQVAPPKAHEVRVKIVASGVCHTDYHIMVGAVANVK-YPLILGHEGAGIVESVGEGVKKVKP--GDKVIPLSLP
Rana 8 -CTAGKDITCKAAVAWEPHKPLSLETITVAPPKAHEVRIKILASGICGSDSSVLKEII-PSK-FPVILGHEAVGVVESIGAGVTCVKP--GDKVIPLFVP
X.tropicalis 8B -DTAGQVIKCKAAIAWGDHKPLTIEEIEVAPPKANEVRIKILASGICGTDTAALKGKL-GTK-FPAILGHEAIGIVESIGNGVTTVQP--GDKVIPLCMP
X.laevis 8B ------IKCKAAIAWEEHKPLTIEEIEVAPPKDHEVRIKILASGVCGTDSAALKGKL-GTK-FPAILGHEAIGVVESIGKGVTTVKP--GDKVIPLCLP
X.laevis 8A -DTTGKVIKCKAAIAWELHKPLKIEXIEVAPPKAHEVRIKILASGVCGSDLSVLNDKLGGVK-FPNILGHEAIGVVESIGEGVTVVQP--GDKVIPLFVP
X.tropicalis 8A -DTTGKVIKCKAAIAWGLHKPLTIEEIEVAPPKAHEVRIKILASGICGSDLSVLKDKLSGVK-FPTILGHEAIGIVESIGKDVTVVKP--GDKAIPLFVP
X.tropicalis 9 -STVGKVIHCKAAVALEAKKPLVIQQIEVAPPKAKEVRIKIYHSGICHTDDHALGGFMAGIT-FPVILGHEGAGVVESVGEGVTTVKP--GDHVIAICSP
X.laevis9 -STVGKVIHCKAAVALEAKKPLVIQQIEVAPPKAKEIRIKIYHSGICHTDDHALGGFMAGIK-FPIILGHEGAGVVESVGEGVTSVEP--GDHVIAICSP
X.tropicalis 10B -ESAGQVIKCKAAVTWEKDAPFSIEEIEVAPPKAHEVRIKLIATGICRSDDHSLEGKFAAVK-FPVILGHEGVGIVESIGDGVKDIKP--GDKVIPLVAP
X.laevis 10B -ESAGQVIKCKAAVTWGKNAPFSIEEIEVAPPKAHEVRIKMIATGICRSDHHSIEGKFSSVK-FPVIVGHEGVGIVESIGEGVKDIKP--GDKVIPLVTP
X.tropicalis 10A -DTAGKVIKCKAAVIWEKSAPFSIEEVEVAPPKANEVRIKIVATGICRSDDHAIEGKLSTVK-FPVILGHEGVGIVESTGESVKHIKP--GDRVIPLFVP
X.laevis 10A -DTAGKVIKCKAAVTWEKGAPFSIEEVEVAPPKAQEVRIKIIATGICRSDDHAVEGKLSQVK-FPIILGHEAVGIVESTGESVKNLKP--GDRVIPLFAP
Human 5 -STTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLDLL-YPTILGHEGAGIVESIGEGVSTVKP--GDKVITLFLP
Bovine 5 -STTGKVIRCKAAIVWKPGGSFSIEEVEVAPPKAKEVRIKMVATALCGTEMKMLKDKNLQHQHYPIIMGHEGAGIVESVGEGVSTVKA--GDKVIALFLP
Rabbit 5 -STAGKVIRCRAAVLWKSGAPFSIEEVEVAPPKEKEVRIKIVATGLCGTEMKMLARTDLPGL-YPIILGHEGAGIVESVGGGVNTVKP-VGDKVIILFLP
Rat 5 -GTQGKVIRCKATVLWKPGAPLAIEEIEVAPPKAKEVRIKMVATGVCGTDIKHLDTQELSKF-CPMIMGHEGVGIVESVGEGVSSVRT--GDKVILLCIP
Deermouse 5 -STAGKVIRCKAAVLWKPGAPLTMEEIDVAPPKGKEVRVKMVAAGICGTDIKSLDNKKLAPF-CPIIMGHEGTGIVESVGEGVSTVKT--GDKVIILCLP
X.tropicalis 7 -DTAGKIVKCKAAVAWEIGKPLTIEEIEVEVPKASEVRIKMVATGICRTDDHVLKGALKGID-FPVILGHEGAGIIESVGEGVTGLKP--GDKVIPLCIP
Turtle 7 -GTAGKVIKCKAAIAWEANKPVSVEEVEVAPPKAREVRVKIVATGICRTDDHVLKGSLPNIN-YPVIPGHEGAGIVESIGEGVTCVKP--GDKVIPLCLP
Chicken 7 -ATSGKVIRCRAAVAWAAGKSLSVEEIEVAPPKAREVRVKMVATGICHTDEHVLEGNFPDVD-FPVILGHEGAGIVESIGEGVTSVKP--GDKVILFPLP
Zebra finch 7 -ATAGKVIRCRAAVAWAPGKPLSVEEVEVAPPKAGEVRIKIVATSICHTDDHVLKGSLQKVE-FPVIPGHEGAGIVESIGQGVTSVKP--GDKVIPLCLP
Pigeon 7 -ATSGKVIRCRAAVAWAVGKPLSVEEVEVAPPKAGEVRIKIVATGICRTDDHVVKGCIANVE-FPVIPGHEGAGIVESIGEGVTSVKP--GDKVIPLCIP
Anole 7A -ATVGKVIKCKAAIIWEVGKTPSIEEVEVAPPKSHEVRVKIVATGICRTDYHVLKGFFPKLD-YPVIAGHEGAGIVESIGPGVTCVKP--GDKVIPLCLP
Anole 7B -ETTGKIIKCKAAVAWEIGKPLSIEEIEVAPPKSHEVRVKIIATGICGTDDHVLSGSFPKVN-YPVIPGHEGAGIVESVGEGVTGLNP--GDKVIPLCLP
Anole7C -ATAGKVIKCKAAIIWEVGKMPSIEEVEVAPPKNHEIRIKIVATSICRTDDNVLKGIFPDLE-YPVIAGHEGAGIVESVGPGVTYVKP--GDKVIPLCVP
Rat 6A -DTLGKTITCRAAIAWAENSPLSIEEVQVEPPKSGEVRIKMISSGICGSDDHMLKGELLA-N-FPLIPGHEGAGIVESVGDGVCSVKP--GDKVLTLIIP
Mouse 6A -NTLGKTLTCRAAIAWAKNSPLSIEEVQVEPPKSGEVRIKMISSGICGSDDHVLKGELVV-N-FPLIPGHEGAGIVESVGDGVCSMKP--GDKVLILIIP
Rat 6B ------VITCRAAVAWTTNAPLSVEEVTVDPPKACEVRVKIISSGICGTDNHILEGKMET-P-FPVILGHEGAGIVESIGQGVTTVKP--GDKVLMFPLP
Mouse 6B ------VIRCRAAVAWTTNAPLSIEEVEVDPPKAGEVRVKIIASGICGTDNHTLEGKMKT-P-FPVILGHEGAGVVESVGPGVTTVKP--GDKVLMFPLP
Bovine 6 -DTLGKTITCLAAIAWKTNSSLSLEEVQVEPPKAGEVRIKMISTGICGSDDHAIKGIMPL-K-YPFIPGHEGAGLVESIGEGVSSVKP--GDKVLTLIVP
Dog 6 -SLCPQTITCRAAIAWAANSTLSIEEVQVEPPKAGEVRIKLASTGICGTDDHAIKGLLSA-I-FPFIPGHEGAGIVESIGKGVTSVKP--GDKVLTLIIP
Panda 6 LSLCQQTITCRAAVAWAANSTLSIEEVQVEPPKAGEVRIKLTSTGICGSDDHAIKGLLSA-V-FPYIPGHEGAGIVESIGKGVSSVKPDIGDKVLTLIIP
Horse 6 -----QVITCWAAIAWTANAPLSIEEVEVDPPKAGEVRIKILSSGLCGTDLHILEGKLRV-P-FPMILGHEGAGIVESTGDGVTSVKA--GDKVLMFPLP
110 120 130 140 150 160 170 180 190 200
....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
Human 3 QCGECKFCLNPKTNLCQKIR----VTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEP
Rat 3 QCGECKFCLNPKTNLCQKIR----VTQGKGLMPDGTSRFTCKGKPILHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEP
Mouse 3 QCGECKFCLNPKTNLCQKIR----VTQGKGLMPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEP
Rabbit 3 QCGECKFCLNPKTNLCQKIR----VTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAALNTAKVEP
Chicken 3 QCGECKYCKNPKTNLCQKIR----VTQGKGLMPDGTIRFTCKGKQIYHFMGTSTFSEYTVVADISVAKIDPAAPFDKVCLLGCGVSTGYGAAVNTAKVEP
Turtle 3 QCGECKFCLNPKTNLCQKIR----VTQGKGLMPDGTSRFTCKGKQIYHFMGTSTFSEYTVVADISLAKIDAAAPLDKVCLLGCGISTGYGAVINTAKVEP
Uromastyx 3 QCGECKFCLNPKTNLCQKIR----VTQGKGVMPDGTSRFTCKGKQVLHFMGTSTFSEYTVVADISLTKINASAPLDKVCLLGCGVSTGYGAALNTAKVEP
X.tropicalis 3 QCGECKFCLNPKTNLCQKIR----ITQGKGFMPDGSSRFTCKGQQIFHFMGTSTFSEYTVVADISVAKIDDSAPLDKVCLLGCGISTGYGAVINTAKVEP
X.laevis 3 QCGECKFCLNPKTNLCQKIR----ITQGKGFMPDGTSRFTCKGQQIFHFMGTSTFSEYTVVADISVAKIEDSAPLDKVCLLGCGISTGYGAVINTAKVEP
Anole 3 QCGECKFCLNPKTNLCQKIR----VTQGKGVMPDGTSCFTCKGKQVLHFMGTSTFSEYTVVADISLAKIDASAPLDKVCLLGCGVSTGYGAALNTAKVEP
Marmoset 2 HCRKCKFCLSPLTNFCGKISNLKNPATHQQLMEDKTSRFTCKGKPIYHFLGISTFSQYTVVSDINLVKIDDDANLERVCLLGCGFSTGYGAAINNAKVTP
Bovine 2 QCGKCKFCLSPRTNFCGKLKHFKNPMGDQKLMEDGTSRFTCKGKPIYHFMGTSTFSQYTVVSDVNLAKLEDDANLERVCLLGCAFSTGYGAVINNAKVTP
Human 2 LCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTP
Rat 2 QCKKCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTSKERSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFTSGYGAAINTAKVTP
Mouse 2 QCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTP
Rabbit 2A HCKKCKFCLSPLTNFCEKFCKGKNPLIEQELMEDKTSRFTCKGKSIYHFFGISAFSQYTVVKDVNLAKIDDDANLERVCLIGCGFSTGYGAAINTAKVTP
Rabbit 2B HCRKCKFCQSPLTNFCTKFSEHKNPIIEQELMDDKTSRFTCKGKSIYHFLGISAFSQYTVVKDINLAKIDDDANLKRVCLIGCGFSTGYGAAINDAKVTP
Ostrich 2 QCGHCKFCLNPKTNLCEKISKIKTPISDQEVMSDGTSRFTCKGKPIYHFMGTSTFSEYTVVSESSLAKIDAAAPLDKVCLIGCGFSTGYGAAINTAQVEP
Turtle 2 QCGQCKFCLSPKTNLCEKISKIKTAISDQDLMPDGTSRFTCKGKQIYHFMGTSTFSEYTVVAETSLVKIDDAAPLEKVCLIGCGFSTGYGAAINTAKVEP
X.tropicalis 2 QCGECKFCLNPKTNLCEKISKIKTAISDQDLMADNTSRFTCKGKQIYHFMGTSTFSEYTVCAETSVAKIDDAAPLEKVCLIGCGFSTGYGAAINTAKVEP
Human 4 QCRECNACRNPDGNLCIRSD----I-TGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKP
Rat 4 QCRECNPCRNPEGNLCIRSD----L-TGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKIDAEAPPEKACLIGCGFSTGYGAAVKTAKVSP
Mouse 4 QCRECNACLNPEGNLCIRSD----L-TGCGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKVDGAAPPEKACLIGCGFSTGYGAAVKTAKVTP
Human 1B1 QCGKCRVCKNPESNYCLKND----LGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTP
Rat 1 QCGKCRICKHPESNLCCQTK---NLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTP
Mouse 1 QCGECRICKHPESNFCSRSD----LLMPRGTLREGTSRFSCKGKQIHNFISTSTFSQYTVVDDIAVAKIDGASPLDKVCLIGCGFSTGYGSAVKVAKVTP
Rabbit 1 QCGKCRICKHPESNFCLIND----LGKPKGMLLDGTSRFTCKGKPIHHFIGTSTFSQYTVVDEIAVAKIDAAAPLEKVCLIGCGFSTGYGSAVKVAKVTP
Ostrich 1 QCGECSVCLSTKGNLCRKND----IGPASALMPDGTSRFTCKGKAIHHFAGTSTFTEYTVLHETAVAKIDAAAPLEKVCLIGCGFSTGYGAALQTAKVEP
Quail 1 QCGECRSCLSTKGNLCIKND---LSSSPTGLMADGTTRFTCKGKAIHHFIGTSTFTEYTVVHETAAAKIDSAAPLEKVCLIGCGFSTGYGAVLQTAKVEP
Chicken 1 QCGECRSCLSTKGNLCIKND---LSSSPTGLMADGTTRFTCKGKAIHHFVGTSTFTEYTVVHETAAAKIDSAAPLEKVCLIGCGFSTGYGAVLQTAKVEA
Alligator 1 QCGECMPCLKSNGNLCIRND----LGSPSGLMADGTSRFTCKGKDIHHFIGTSTFTEYTVVHETAVARIDAAAPLEKVCLIGCGFSTGYGAAVKDAKVEP
Turtle 1 QCGECSSCISPKGNLCTKSD----LTTSRGLMCDGTSRFTCKGKSIHHFIGTSTFTEYTVVHETAVAKIDELAPPEKVCLIGCGFSTGYGAAINTAKVEG
Cobra 1 QCGKCRACQSPKGNLCTSND----LNSGSGLMPDGTSRFTCKGKSIHHFISTSTFTEYTVVHENSVVKIDPSAPLEKVCLIGCGFSTGYGAAMQTAKVEP
Uromastyx 1A QCGKCSSCRSTRGNLCTSND----LSAATGLMPDGTSRFTCKGKSLHHFISTSSFTEYTVVHENSVVKIDAAAPLEKVCLIGCGFSTGYGAAVETAKVEP
Uromastyx 1B QCGECNSCRHPRGNVCKKSE----LGPFTGLLYDGTSRFTYQGKPVYHFVRTGTFTEYTVAPEDSVVKIDASAPLEKVCLIGCGFSTGYGAAINSAKVQP
Anole 1A QCGKCSSCQSTKGNLCTAND----LSSGQGLMPDGTCRFTCKGKSLHHFISTSTFTEYTVVHENAVVKIDDAAPLEKVCLVGCGFSTGYGAAVQTAKVEP
Anole 1B QCEKCSFCIHPKGNLCEKAD----FGIPTGLMYDGTSRFTYKGQPIYKFVSTGTFTEYTVVHEDAVAKIDAAAPPEKVCLIGCGFSTGYGAAVNSAKVEP
Anole1C QCGRCPPCKNPEGNMCQKSD----FLTAKGVMYDGTSRFSYKGKPVHNFVNTSTFTEYTVVHEDAVVKIDPAAPIEKACLMGCGFSTGYGAATKTAKVTP
Anole 1D QCGKCRPCKNPEGNLCEQSD----FFKNTGLMYDGTSRFSYKGKPIHHFANTSTFTEYTVVHEDSVAKIDPAAPPEKACLIGCGFSTGYGAATKTAKVTP
Anole 1E QCGKCRACKNPQRNLCEKSD----TFKGTGLMYDGTSRFSYKGKPVHHFANTSTFTEYTVVHEDAVAKVDPAAPPEKACLIGCGFSTGYGAATKTAKVTP
Anole1F QCGKCRTCKNPEGNLCEKND----LYEFKGLMYDGTTRFSYKGKPVHNFASTSTFTEYTVVHEDSLAKIDPAAPPEKACLIGCGFSTGYGAAIRSGKVTP
Anole 1G QCEECRPCIHPRGNLCKLNG----IETPLGLMPDGTSRFSYKGELVHNFVSTSTFTEYTVVHESSVAKIDASAPPEKACLIGCGFSTGYGAAINSAKVEP
Anole 1H QCGECSPCIHPRGNLCKLND----FGTFVGLLPDGTSRFSYKGELIHSFVSTSTFTEYTVVHESSVAKIDAAAPPEKVCLIGCGFSAGYGAAINSAKVEP
Rana 1 QCGECRCCKNPESNLCYKND----IGKYDGVLLDKTSRFTCKGKSIHNFISTSTFTEYTVLDEIAVAKIHEDAPLEKVCLIGCGFSTGYGSAVNTGKVKP
X.tropicalis 1B QCGECRCCTNVRSNLCDKHD----IGPYRGLMLDNTNRFTCKGNPVYTFLSTSTFTEYTVLDEICVAKIDDNAPLDKVCLIGCGFSTGYGSAVKIAKVEQ
X.laevis 1B QCGECRSCTNSRSNLCDKHD----IGPYIGLLLDKTSRITCKGKPVYNFLSTSTFTEYTVLDEICVAKIDDNAPLDKVCLIGCGFSTGYGSAVKTAKVEP
X.tropicalis 1A QCRECKNCLDPKSNVCIKSD----IGKLTGLMLDNTSRFTCKGKQIHHFVHTSTFTEYTVLDEMAVAKIHNDAPLDKVCLIACGFSTGYGSALNTAKVEP
X.laevis 1A2 QCGECQNCLNPKSNMCFKSD----LGKYTGMMLDNTSRFTCKGKLIHHFMHTSTFTEYTVLDEIAVAKIQDDAPLDKVCLISCGFSAGYGSVLNTAQVKQ
X.tropicalis 1C QCGKCLLCLNPKSNICEKSD----FGKYSGLMLDNTSRFTCKGKLIYHFVRTSTFTEYTVLDEISVAKIDDSAPLDKVCLISCGFSTGYGSAVKIAKVEP
X.laevis 1C QCGECQNCLNPKSNICEKSD----FGKFSGLMLDNTSRFTCKGKLIHNFVSTSTFTEYTVLDEICVAKIDDNAPLDKVCLIGCAFSTGYGSALNTAKVEP
Rana 8 QCGSCRACKSSNSNFCEKND----MGAKTGLMADMTSRFTCRGKPIYNLVGTSTFTEYTVVADIAVAKIDPKAPLE-SCLIGCGFATGYGAAVNTAKVTP
X.tropicalis 8B QCGQCRACKSPNANLCDKND----FTNNTGLMQDKTSRFTCKGKQVYHFVGTSTFTEYTVVSEISVAKVDPAAPLE-VCIVGCGFATGYGAAVN-SKIAP
X.laevis 8B QCRQCRACKNPNANLCVKND----FGSNSGLMHDNTSRFTCKGKQIYHFLFTSTFTEYSVIPEICIAKVNPAAPDE-VCIIGCGFATGYGAAVN-AKIPP
X.laevis 8A QCGQCRACKTPNCNLCDKND----FIAKTGLMQDNTSRFTCKGKQIYHYMCTSTFTEYTVVPDICVAKVDPAAPVE-GCLIGCGFATGYGAAVNTAKVTP
X.tropicalis 8A QCGQCRACKTPNCNVCEKND----FTTKKGLMQDNTSRFTCKGEQVYHFMSTSTFTEYTVVPDICVAKVDPAAPVE-GCLIGCGFATGYGAAVNTAKVTP
X.tropicalis 9 MCMKCPSCLHPDSNFCVKND----VGKHVGLMLDKTSRFSIKGKLIHNFMSTSTFCEYTVVDEFACVKIDPKAPLHEVCLIGCGFSTGYGSVLNTAKVQP
X.laevis9 MCMKCPSCLHPDSNFCVQND----VGKNVGMMLDKTSRFSINGKMIHNFMSTSTFCEYTVLDEFACVKIDCKAPLYEVCLIGCGFSTGYGSVLNTAKVQQ
X.tropicalis 10B QCGKCQCCKDPRTNRCLT-R----LKRQFGLMSDGTSRFTCRGKQIYHFMNTSTFTEYTVVEEMAVAKIDDNATMDSVCLIGCGFSTGYGSALNTAKVHP
X.laevis 10B QCGQCQCCKDPRANRCLTIK----LERQYGLMADGTSRFTCRGKQIYHFLNTSTFTEYTVVEEIAVAKIDDTATMDSVCLIGCAFSTGYGSVINTAKVHP
X.tropicalis 10A QCGQCICCKDPRSNMCIAGK----MKKAVGLMSDGTSRFTCKGKQIYHFMNTSTFTEYTVAEEMSVAKIDSGASLDNTCLIGCGFSTGYGSALNSAKVHP
X.laevis 10A QCEQCMCCKDPRSNICIATK----LTKSVGVMSDGTSRFTCKGKQIYHFLNTSTFTEYTVVDEMAVTKIDGGASLENTCLIGCGFSTGYGSALNTAKVHP
Human 5 QCGECTSCLNSEGNFCIQFK----QSKTQ-LMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFSTGFGAAINTAKVTP
Bovine 5 QCGECTSCLNSADNFCIKLK----QAETH-LMSDGTSRFTCKGKPVYHFGNTSTFSEYTVMDEISVAKIDAAAPLEKVFLVSCGFSTGYGGAINTAKVTP
Rabbit 5 QCGECSSCLNSGENYCIKLK----QSKTA-LMSDGTSRFTCKGKSVKQFAATSTFTEYTVVREDSIAKIDASAPLEKVCLISCGFSTGFGAAINTAKVTP
Rat 5 QCGECKTCLNSKNNICTEIR----LSKTH-LASEGTSRITCKGKLVHQYIALGSFSEYTVLKEISVAKIDEGAPLEKVCIIGCGFATGYGAAINSAKVTP
Deermouse 5 QCGECNTCLNSKNNICKEVR----LSGTH-LTSEGNSRITCKGKTTYQYITTGTFSEYIVIKEISVAKVDEDALLEKACIIGCGFATGFGAAINSAKVSP
X.tropicalis 7 QCGKCSSCLNPNTNCCLKTH----LSESQNVMPDKTSRFLCKGKAAYHFLWTSTFSEYTVVPVDAVAKIDDRVPMDKACLFGCGFPTGYGAVVNTAKVEP
Turtle 7 QCGECSSCLNPDTNCCLKTH----LYESQNLMPDNTSRFTCKGQRIYHFLWISTFSEYTVMPDSAIAKIDDDAPLDKVCLFGCGFSTGYGAAINTAKVKP
Chicken 7 QCGECSFCLNPDSNYCLKSH----LTEPQNLMPDKTTRFTCKGKQIQHFLWNSTFAEYTVVPEYTLAKIDAAAPLDKVCVFACGFSTGYGAAVNTAKVKL
Zebra finch 7 QCGECSFCQNPESNYCQKTH----FSEPQNLLPDKTSRFTCKGKQIHHYLWISTFAEYTVVPEYAVAKIDAAAPLDKVCLIACGFSTGYGAAINTAKVKP
Pigeon 7 NCGECTFCLNPEASYCVKSH----FSEPQNLMPDKTSRFTCKGKQIHHFMWVSTFAEYTVAPETAVAKIDSAAPLDKVCLLGCGFSTGYGAAINTAKVKP
Anole 7A QCGECSCCRSPKDNCCLKTH---FCERPQNLMPDQTSRFTCKGKRIHHLMWVSTFSEYTVMPDASIVKIDNNAPLDRVCLLGCGFPTGYGAAINTAEVAP
Anole 7B QCGECSSCLKSNTNCCLKTH----LNEPQNLMPDKTSRFTCKGKLIHHFLWISTFSEYTVMPDSTVVKIDAAAPLDKVCLFGCGFSTGYGAALNTAQVMP
Anole7C QCGECACCLSPKANCCLKSH---ICKPLQNLMPDKTSRFTCRGKQIHHFLWISTFSEYTVVPDVSIAKISNDAPLDKVCLFGCGFSTGYGAAINNAKVEP
Rat 6A QCRECDSCLHLKGNFCEKQD----VLPCSGVMLDGTSRFSCRGRKIYHSFRTSSFTEYTVVPEIAVVKIDDAAPMDKVCLISCGFPTGYGAAVNSAKVTP
Mouse 6A QCRECDACLHPKGNFCYKQD----VLPCSGVMLDGTSRFSCRGQKIYHSFRTSSFTEYTVVPEIAAVKIDDAAPMDKVCLISCGFPTGYGGAVNSAKVTP
Rat 6B ECRECIYCLHPKGNFCKKQN----ILSPTGLMLDGTSRFTCRGKKIYHLQGTSTFTEYTVVDEIAVAKINDRAPMDTVCIISCEVSTGFGAVFNTAQVTP
Mouse 6B ECRECFYCLYPKGNFCEKEN----ILSPTGLMLDGTSRFTCRGKKIYNIMGTSTFTEYTVVHEIAVAKIEAAAPMDTVCIMSCAVPTGFGAVFNTAQVTP
Bovine 6 QCRECSACLNPKGNFCEKQD----ILPSSGLMLDGTSRFTCKGEKIYHSFRTSTFSEYTVVPEISVVKIDAAAPMDKICVISCEVPTGYGAAVHSAKVTP
Dog 6 QCRECSSCLHPKGNFCEKQD----VLPSSGLMLDGTSRFTCKGKKIYHSFRTSTFTEYTVVPEIAVAKIDDAAPMDKVSLISCEVPTGYGAAVHSAKVTH
Panda 6 QCRECSSCLHPKGNFCEKQD----VLSSSGLMLDGTSRFTCKGKKIHHSFRTSTFTEYTVVLEIAVAKIDDAAPMDKVSAISCEVPTGYGAAVHSAKVTR
Horse 6 ECRECSSCLHPKGNLCLKEN----VLSPNGLMLDGTSRFTCRGKKIYHLYGTSTFAEYTVVHEIAVGKIDAAAPMDKVCIMSCEVPTGFGAVFNTAKVTP
210 220 230 240 250 260 270 280 290 300
....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
Human 3 GSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDG-GVDYSFECIGNVKVMRAALEACHKGWGVSV
Rat 3 GSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMTDG-GVDFSFECIGNVKVMRSALEAAHKGWGVSV
Mouse 3 GSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDG-GVDYSFECIGNVKVMRSALEAAHKGWGVSV
Rabbit 3 GSTCAVFGLGGVGLAAIMGCKAAGASRIIAVDINKDKFARAKEFGATECINPQDFSKPIQEVLVEKTDG-GVDYSFECIGNVKVMRAALEACHKGWGVSV
Chicken 3 GSTCAVFGLGGVGLATVMGCKAAGASRIIGIDINKNTYAKAKEFGAAECISPQDFEKPIQEVLVEMTDG-GVDYSFECIGNVGVMRAALEACHKGWGVSV
Turtle 3 GSTCAIFGLGGVGLAVIMGCKVAGASRIIGVDLNKDKFAKAKEFGATECINPQDFKKPIQEVLVELTEG- GVDYSFECIGNVGVMRAALEACHKGWGVSV
Uromastyx 3 GSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDLNKDKFAKAKEFGATECISPADFKKPIQEVLIEMTDG-GVDYSFECIGNVGVMRAALEACHKGWGVSV
X.tropicalis 3 GSTCAVFGLGGVGLAVIMGCKVAGATRIIGIDLNKDKFVKATEFGATDCLNPADFKKPIQDVLIEMTDG-GVDYSFECIGNVGVMRAALEACHKGWGTSV
X.laevis 3 GSTCAVFGLGGVGLAVIMGCKVAGATRIIGIDLNKDKFAKATEFGATECLNPADFNKPIQDVLIDMTDG-GVDYSFECIGNVRVMRSALEACHKGWGTSV
Anole 3 GSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDLNKDKFTKAKEFGATECISPEDSKKPIQEVLVEMTDG-GVDYSFECIGNVHVMRAALEACHKGWGVSV
Marmoset 2 GSTCAVFGLGGVGLSAVIGCKMAGASRIIGVDINSEKFAKAKALGATECLNPRDLHKPVQEVITELTKG-GVDFALDCAGGSESMKAALDCTTAGWGSCT
Bovine 2 GSTCAIFGLGGVGLSAVMGCKASGASRIIVVDINSEKFTKAKALGATDCLNPKDLDKPIQEVIVEMTNG-GVDFAFECVGGAKIMRAALDSVTVGWGVCT
Human 2 GSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKG-GVDFALDCAGGSETMKAALDCTTAGWGSCT
Rat 2 GSACAVFGLGCVGLSAVIGCKIAGASRIIAIDINSEKFPKAKALGATDCLNPRDLDKPVQDVITELTGG-GVDFSLDCAGTAQTLKAAVDCTVVGWGSCT
Mouse 2 GSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAG-GVDYSLDCAGTAQTLKAAVDCTVLGWGSCT
Rabbit 2A GSTCAVFGLGGVGLSAIMGCKTAGASRIIAIDINSDKFAKAKALGATDCLNPRELNKPVQDVIVEMTNG-GVDFAIDCAGGSEVMKATVDCATVGWGSCT
Rabbit 2B GSTCAVFGLGGVGLSAVIGCKTAGASRIIAVDINSDKFAKAKALGATDCLNPRELNKPVQDVIVEMTNG-GVDFAIDCAGGSEVMKATVDCTTVGWGSCT
Ostrich 2 GSTCAVFGLGGVGLSAVMGCKAAGASKIFGIDINKDKFPLAKKLGATDCLNPQDIRKPVQEIIAEMTNG-GVDFAIECIGNPDVMKAAFESTTVGWGTCV
Turtle 2 GSTCAVFGLGGVGLSAVMGCKVSGASRIFAIDINKDKFSLAKELGATDCLNPQDFKKPIQEVITEMNDG- GVDFAIECIGNIAVMNAALECTTVGWGTCV
X.tropicalis 2 GSSCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSDKFEKALELGATECINPKDYDKPIQQVISEMTGG-GVDFSIECIGIIDVMKAALECTTVGWGTCA
Human 4 GSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGN-NVGYTFEVIGHLETMIDALASCHMNYGTSV
Rat 4 GSTCAVFGLGGVGLSVVMGCKAAGASRIIGIDINKDKFQKALDVGATECINPRDFTKPISEVLSDMTGN-TVQYTFEVIGRLETMVDALSSCHMNYGTSV
Mouse 4 GSTCVVFGLGGVGLSVIMGCKAAGASRIIGIDINKDKFQKALAVGATECISPKDSTKPISEVLSDMTGN-TVQYTFEVIGRLETMVDALSSCHMNYGTSV
Human 1B1 GSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCHEACGTSV
Rat 1 GSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDG-GVDFSFEVIGRLDTMTSALLSCHSACGVSV
Mouse 1 GSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYSKPIQEVLQEMTDG-GVDFSFEVIGRLDTMTSALLSCHAACGVSV
Rabbit 1 GSTCAVFGLGGVGLSVIMGCKAAGASRIIAVDINKDKFPKAKEVGATECINPQDYKKPIQEVIQEISDG-GVDFSFEVIGRLDTVVAALLSCHGACGTSV
Ostrich 1 GSTCAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKELGATDCVNPKDFTKPIHEVLMEMTGL-GVDYSFEVIGHTETMAAALASCHFNYGVSV
Quail 1 GSTCAVFGLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKELGATECVNPKDFKKPIHEVLTEMTGK-GVDYSFEVIGRIETMTEALASCHYNYGVSV
Chicken 1 GSTCAVFGLGGVGLSVVMGCKAAGASRIIAVDINKDKFAKAKELGATECINPKDFKKPIHEVLTEMTGQ-GVDYSFEVIGRIETMTAALASCHNNYGVSV
Alligator 1 GSTCAVFGLGGVGLSTIMGCKAAGASRIIGIDINKDKFAKAKELGATECINPLDCKKPIQEVLSEMTGG-GVDYSFEVIGRIDTMTAALACCQDNYGTSV
Turtle 1 GSTCAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKELGATECINPQDFTKPIEDVLMELTGGDGVDYSFEVIGRIDTMKAAMASCHKNYGMSV
Cobra 1 GSICAVFGLGGVGLSVVMGCKAAGASRIIGVDINKDKFAKAKEMGATECINPLDFKKPINEVLFDLTGGEGVDYSFEVIGRTETMISAFTSCHQNLGTSV
Uromastyx 1A GSTCAVFGLGGVGLSAVMGCKAAGASRIIGVDINKDKFPKAKEMGATECVNPLDYKKPINEVLFDLTGGEGVDYSFEVIGRTDTMTAALASCHMDYGTSI
Uromastyx 1B GSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINKEKFPKAKELGATECVNPLDYKKPINEVLFDMTDGEGVEYSFEVIGRTDTMTAALASCHNNYGTSV
Anole 1A GSTCAVFGLGGVGLSAVMGCKAAGASRIIGVDINKDKFPKAKELGATECVNPLDFKKPINEVLFDLTGGEGVDYSFEVIGRIDTMTAALASCHNNYGTSV
Anole 1B GSTCAVFGLGGVGLSTVMGCKAAGASRIIGVDINKDKFPKAKQLGATECVNPLDFKKPINEVLFDMTDGKGVDYSFEVIGRTDTMMAAMTSCNINYGTSV
Anole1C GSTCAVFGLGGVGLPVIIGCKTSGASRIIGIDINKAKFPIAKELGATECISPLDFKKPINEVLLDMTDGEGVDYSFEVIGHTDTMAAALASCNLNYGVSV
Anole 1D GSSCAVFGLGGVGLAVVMGCKAAGASRIIGINRSKEKFPKAKEVGATECVSPLDFKKPIQEVLLDMTDGEGVDYSFEVVGSTETMIAALASCNMNYGTSV
Anole 1E GSSCAVFGLGGVGLPVVMGCKAAGASRIIGINRSKDKFPIAKELGATECVSPLDFKKPINEVLLEMTDGEGVDYSFEAIGRTDTMIAALASCNMNYGTSV
Anole1F DSSCAVFGLGGVGLSVVMGCKAAGASRIIGIDINKDKFPMAKELGATECISPLDFKKPINEVVLEMTEGEGVDYSFEVIGRTDTMVAALASCNMNYGVSV
Anole 1G GSTCAVFGLGGVGLSAVMGCKAAGASRIIGINRSKERFPKAKELGATECVSPLDFEKPINEVLFDMTDGDGVDYSFEATGCTDTMAAALASCNRNHGISV
Anole 1H GSTCAVFGLGGVGLSAVMGCKAAGASRIIGVDINKDKFPKAKEVGATECVNPLDFEKPINEVLHDMTEGDGVDYSFEVVGHTDTMIAALTSCNMNYGTSV
Rana 1 GSTCAVFGLGGVGLSVIIGCKVAGASRIIGVDLNSDKFTTAKECGATECINPKDYNIPIHEVLAKMTDD-GVDYAFEVIGNTTVMTSALSSSHFGCGKTV
X.tropicalis 1B GSSCAVFGLGGVGLSVLIGCKVAGASKIIGVDTNSDKFAKAKELGATECINPNDYNEPIHEVLAKISDG-GLDYTFECIGNTKVMESALKATHFGCGTSV
X.laevis 1B GSSCAVFGLGGVGLSVLIGCKVAGAAKIIGVDTNPDKFAKAKELGATECINPNDYKEPIHEVLAKMSNG-GLDYTFECIGNTKVMESALLATHFGCGTSV
X.tropicalis 1A GCTCAVFGLGGVGLSVIIGCKVAGAAKIIGVDTNSDKFAKAKEVGATECINPNDYKEPIHKVLEKMTDG-GLDYSFECIGNTRVMASALLSTKFACGTSV
X.laevis 1A2 GSTCAVFGLGGVGLSVVIGCRVAGAAKIIGVDTNSDKFPKAKEIGATECVNPNDYKEPIHKVLEKMTEG-GLDYSFECVGNTSVMASALLSTNYSYGTSV
X.tropicalis 1C GSTCAVFGLGGVGLSGIIGCKAAGASRIIGVDTNSKKFTAAKNVGATECINPNDYKEPVHEVLTKMTGL-GTDYSLEFVGDTNVMLSALLSTNFASGTTV
X.laevis 1C GSTCAVFGLGGVGLSGVIGCKAAGASKIIGVDTNSNKFTAAKKLGATECINPNDIKEPVHEVLTKMTGL-GVDYSFEFVGDTNVMLSALLSTNFASGTTV
Rana 8 GSTCAVFGLGGVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECLNPKDYDKPIYEVICEKTNG-GVDYAVECAGRIETMMNALQSTYCGSGVTV
X.tropicalis 8B GSTCAVFGLGGVGFSALIGCKISGAGRIIGVGSHKDKFPKAIELGATECLSPKDNDKPIQEVIRDMTNG-GVDFAFECSGNIETLKTAFESTYIGSGVTV
X.laevis 8B GSTCAVFGLGGVGFSAMIGCKIAGAGRIIGVGSHKDKFPKAIELGATECLSPKDYDKPIQEVIREKTNG-GVDFAFECSGNIDTMKAAFESTYIGNGVTV
X.laevis 8A GSTCAVFGLGGVGFSTIVGCKVAGAGRIIGVGSQKDKFEKAIELGATECLSPKDYDKPIQEVIRDMTNG-GVDFAFECTGYIETMKTAFESTYIGNGVTV
X.tropicalis 8A GSTCAVFGLGGVGFSALIGCKIAGAGRIIGVGSHKDKFPKAIELGATECLSPKDYDKPIQEVIRDMTNG-GVDFAFECTGYIETMKTAFDSTYLGNGVTV
X.tropicalis 9 GSACAVFGLGGIGMSVVMGCKVAGACRIIGVDINKGKFEIAKKLGCTECLDPNDYDKPIHEVIANMTDG-GVDYSFECVGNVDLMACVIQSCHYSYGCAT
X.laevis9 GSSCAVFGLGGIGMSAVMGCKVAGASRIIGVDINKGKFEIAKKLGCTECLDPNDYDKPIHEVIAEMTNG-GVDYSFECVGKVELMASVIQACHFSFGCAT
X.tropicalis 10B ESTCAIFGLGGIGLAVIMGCKIAGAARIIGVDINPDKFDIAKELGATECINPNDYDKPVAEMILEQTGG-GVDYAFECVGHAETMLAALHSSHFAFGTTV
X.laevis 10B GSTCVIFGLGGIGLAVIMGCKIAGAGRIIGVDVNPDKFDKAKELGATECINPKDYDKPVAQVIVEQTGG-GVDYAFECVGHAETMLAALHSSHFAYGTTV
X.tropicalis 10A GSTCAIFGLGGIGLAVIMGCKIAGAARIIGVDINPDKFNIAKELGATECINPKDYDKPVPQVILEQTGG-GVDYAFECVGHIETMLAALNSSHFAYGTTV
X.laevis 10A GSTCVIFGLGGIGLAVIMGCKIAGAGRIIGVDVNPDKFDKAKELGATECINPKDYDKPVAQVIVEQTGG-GVDYAFECVGHIETMLAALNSSHFAYGTTV
Human 5 GSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDA-GIDFCFEAIGNLDVLAAALASCNESYGVCV
Bovine 5 GSTCAVFGLGGVGLSVIMGCKAAGATRIIAVDINKDKFEKAKEVGATECINPQDYEKPIQEVLFDLTGD-GVDFSFEVIGNPETVAAALASCRESHGVCV
Rabbit 5 GSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFKKAEEVGATECISPQDFKKPIQEVLFDMTGA-GVEFCFEVIGNPDTVAAAVASCNESHGVCV
Rat 5 GSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDRFAKAKTVGATDCVDPRDFEKPIEEVLSDMIDG-GVDFCFEVTGNTEAVGAALGSCHKDHGVCV
Deermouse 5 GSTCAVFGLGGVGLSVIMGCKAAGAARIIAVDTNKDKFAKAKTVGATECIDPQDFEKPIQQVLFDMMND-GADFTFEVTGNPETVETALASCHKDHGVCV
X.tropicalis 7 GSTCAVFGLGGIGLSAVIGCKSAGAAIIIAVDINSAKFDIAKVFGATECINPLDYSKPIQEVITEMTNG-GVHYSFECIGNTDTMKAALECCHMGYGTSV
Turtle 7 GSTCAVFGLGGVGLSVVMGCKSAGAARIIGIDINKNKFVKAKELGATECIDPQDLKKPVQEVLVEMTDH-GVDYSFEVIGRVDTMTAALESCHMGSGTCV
Chicken 7 GSTCAVFGLGGVGLSVVMGCKAAGASRIIAIDINKDKFAKAKEMGATECINPQDFKKPIQQVLTEMTGH-GVDYSFEAIGTADTLIAALASCNMNTGVCV
Zebra finch 7 GSTCAIFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKARELGATDCINPRDFNKPTQEVLTEMTGQ-GVNYSFEAIGHVDTMIAALASCNASTGVCV
Pigeon 7 GSTCAVFGLGGVGLSVVMGCKVAGASRIIAIDINKDKFAKAKELGATDCINPQDFNKPIQEVVTEMTGH-EVDYSFEVIGRADTMIAALASCNMNTGVFV
Anole 7A GSSCAIFGLGGVGLSIIMGCKAAGASRIIGIDINKNKFAKAKELGATECLSPDDFKKPINEVLVEITGL-GVDYTFEAIGLVETTVAALASSHMAHGVCV
Anole 7B GSTCAIFGLGGVGLSVVMGCKAAGASRIIGIDINKDKFLKAKELGATECLNPQDYKKPIQELLVEMTGH-GVDYAFEVVGCLDTLTAALASCHLGCGVCV
Anole7C GSSCAIFGLGGVGLSVIMGCKAAGASRIIGVDINKDKFTKARELGATECISPEDFEKPINEVLMEMTGL-GVDYAFEVIGRVDIEAAALASCHLGHGVCV
Rat 6A GSTCVVFGLGGVGSAIVMGCKASGASRIIGVDINEQKFPRARALGVTDCLNPKKLEKPVQEVVKEMTGV-GVDFAFEAIGQVDTMAAAWNSCNHSYGVCL
Mouse 6A GSTCVVFGLGGVGSAIVMGCKASGASRIIGVDINEEKFPRARALGVTDCLNPNKLEKPVQEVVMEMTGV-GVDFAFEAIGLVDTMVAAWNSCNNSYGVCL
Rat 6B GSTCVVFGLGGIGSAIVMACKASGASRIIRVDTDEQKFPRARALGVTDCLNPKKLEKPVQKVVKEMTGV-GVDFAFEAIGLIETMVSALKSCNRSSGVCV
Mouse 6B GSSCVVFGLGGIGSAIVMACKASGACRIIGVDINEEKFPRARALGVTDCLNPNKLKKPVQEVVKEMTGV-GVDFAFEAIGLIETMVAALKSCNRSYGVCV
Bovine 6 GSTCVVFGLGGIGSAIVMGCKASGASRIIGVDINEEKFPRARALGVTDCLNPSNLKKPVQEAVKEMTGT-GVDFAFEAIGLAETMVAAWDSCHVSHGVCI
Dog 6 GSTCVVFGLGGIGSAIVMGCKASGASRIIGVDINEEKFPRARALGVTDCLNPQKFKKPVQQVVMEMTGV-GADFAFEAIGLSDTMLAAWDSCHRSYGVCL
Panda 6 GSTCVVYGLGGIGSAIVMGCKASGAARIIGVDINEEKFPRARALGVTDCLNPRKLKKPVQQVVMEMTGV-GADFAFEAIGLPDVMLAAWDSCHLSHGVCL
Horse 6 GSTCVVFGLGGIGSAVVMACKASGASRIIGVDINEEKFPRARALGVTDCLNPQKLKKPVQQVVVEMTGF-GVDFAFEAVGLIDTMVASLESCHLSYGVCV
310 320 330 340 350 360 370 380
....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....
Human 3 VVGVAAS-GEEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI----
Rat 3 VVGVAAS-GEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIRTVLKL----
Mouse 3 VVGVAAS-GEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM----
Rabbit 3 VVGVAGA-GEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKINVDEFVTNTLSFDQINEAFELMHSGKSIRTVVKI----
Chicken 3 IVGVAAA-GQEISTRPFQLVTGRTWKGTAFGGWKSVDSVPKLVNDYMAKKIKVDEFVTHTLPFDKINEAFDLLHKGKSIRTVLKF----
Turtle 3 IVGVAAA-GQEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVTEYMSKKIKVDEFVTHTLPFDRINEAFELMHAGKSIRSVLKF----
Uromastyx 3 IVGVAAA-GQEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVDEYMSKKMKVDEFVTHTLPFEQINEAFELMHAGKSIRSVLKF----
X.tropicalis 3 IVGVAAS-GQEIATRPFQLVTGRVWKGTAFGGWKSVDSVPKLVSEYMAKKIKVDEFVTHTLPFNSINEAFELMHAGKSIRGVLNY----
X.laevis 3 IVGVAAS-GQEIATRPFQLVTGRVWKGTAFGGWKSVDSVPKLVSEYMAKKIKVDEFVTHTLPFDSINEAFELMHAGKSIRSVLNY----
Anole 3 IVGVAAA-GQEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVAEYMSKKMKVDEFVTQNLPFEKINEAFELMHAGKSIRTVLKF----
Marmoset 2 FVGVAPG-NKGLTLFPETLIIGRTINGTFFGGWKS-DSIPKLVTDYKNKKFDLDALVTHTLPFDKLSEAFDLMNQGKSIRTILIF----
Bovine 2 IIGVNVG-DNGLNVSAMELLMGRTLTGTSFGGWKGVTSVPKLAADYKNKKLDLDALVTHTLPFDKVNEAFDLMYQGKSIRTVLLF----
Human 2 FIGVAAG-SKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF----
Rat 2 VVGAKV---DEMNISTVDMILGRSVKGTFFGGWKSVDSVPNLVTDYKNKKFDLDLLVTHALPFDKINDAIDLMNQGKSIRTILTF----
Mouse 2 VVGAKV---DEMTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF----
Rabbit 2A FVGVNLA-DKGLTISPIELILGRTLKGTNFGGWD-AETVPKLVSDYKNGKFDLDALVTHTLPFDKINEALNLLDQGKSIRTVLIF----
Rabbit 2B FVGVNVN-DKGLTISPVELILGRTLRGSSFGGWD-VDTVPKLVSDYKNGKFNLEALVTHTLPFEKINEALDLLKQGKSIRTILIY----
Ostrich 2 IVGVAVG-EQSIPFSPMQLIMGRKIKATFFGGWKSVKSVPKLVSDYMAKKFDLDALVSHTLPLDKINDAFDLMNAGKSNRTILVF----
Turtle 2 IVGVAVG-GQTIAVSPMQLIMGKKINATFFGGWKSIDSVPKLVSDYMAKKFNLDALVTYTLPFEKINKAFDLMCEGKSTRTVLVF----
X.tropicalis 2 IVGVSLD-EHGLPVAPFHLLMGRTLKATFFGGWKSVDNVPKLVEDYLGNKFDLDSLVTFTLPFDKINEAFDLMRDGKSIRTVLVF----
Human 4 VVGVPPS-AKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF----
Rat 4 VVGAPPS-AKMLSYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLGQLITHTLPFHNISEGFELLYSGQSIRTVLTF----
Mouse 4 VVGAPPS-AKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLDQLITHTLPFNNINEGFELLYSGKSIRTVLTF----
Human 1B1 IVGVPPA-SQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF----
Rat 1 IVGVPPS-AQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLVADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF----
Mouse 1 VVGVPPN-AQNLSMNPMLLLLGRTWKGAIFGGFKSKDSVPKLVADFMAKKFPLDPLITHVLPFEKINEAFDLLRSGKSIRTVLTF----
Rabbit 1 IVGVPPD-SQSLTVNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFSLDPLITNVLPFEKINEGFDLLRSGKSIRTILTF----
Ostrich 1 IVGVPPA-AEKLSFDPMLLFSGRTWKGSVFGGWKSKDSVPKLVADYMEKKFVLDPLITHTLPFHKINEGFDLLRTGKSIRSVLLF----
Quail 1 IVGVPPA-AQKISFDPMLIFSGRTWKGSVFGGWKSKDAVPKLVADYMKKKFVLDPLITHTLPFTKINEGFDLLRTGKSIRTVLVL----
Chicken 1 IVGVPPA-AQKISFDPMLIFSGRTWKGSVFGGWKSKDAVPKLVADYMKKKFVLDPLITHTLPFTKINEGFDLLRTGKSIRSVLVL----
Alligator 1 IVGVPPA-SEKITFNPMMLFTGRTWKGSVFGGWKSKESVPKLVADYMEKKINLDGLITHTLPFDKINEGFELLRTGKSIRSVLTF----
Turtle 1 IVGVPPS-ASQISFNPMLLFSGRTWKGSVFGGWKSKDSVPKLVADYLGKKINLDALITHTLPFDKINEGFELLRTGKSIRTVLIF----
Cobra 1 VVGVPPN-ASMITYNPLMLFTGRTWKGCVFGGWKSKDSVPKLVSDFMQKKFVLDPLITHTLPFEKINEGFDLLRSGKSIRTVLIF----
Uromastyx 1A IVGLPPS-ASEITFSPGLIFTGRTWKGSVFGGWKSKDSVPRLVSDFMQKKFSLDPLITHTMPFDKINEGFELLRAGKSIRSVLLF----
Uromastyx 1B IVGVPPS-ASQIAFDPLLLFTGRTWKGSVFGGWKSKDAVPRLVSDFMGKKFILDPLITHTMPFEKINEGFELLRSGKSIRTVLTF----
Anole 1A IVGVPPS-AAQISLDPMLLFTGRTWKGSVFGGWKSKDSVPKLVSDFMGKKFILDPLITHTMPFEKINEGFELLRSGKSIRTVLTF----
Anole 1B IVGVPPS-ASEITFSPGLIFSGRNWKGSLFGGWKSKDSVPRLVSDFMQKKFVLDPLITHTMPFDKINEGFELLRSGKSIRTVLVF----
Anole1C MVGVPPS-AAEMTLSPRLIFTGRTWKGSVFGGLKSKDDIPKLVLAGMEKKFNLDPLVTHVLPFEKINEGFELLHKGQSIRTVLKM----
Anole 1D VVGAPPS-ASEMTLSPTLIFTGRTWKGSVLGGLKSKDDVPVLVSELMAKKFNLDPLITHVLPFDKINEGFELLRNGKCIRTVLKM----
Anole 1E MVGLPPS-EAEMTLSPTLIFTGRTWKGSLFGDMRGKEDVPKLVSELMAKKFNLDPIITHVLPFDKINEGFELLRNGKCIRTVLKM----
Anole1F IVGAAPS-ASEVTLSPTLIFTGRTWKGSVFGGLKSKDAVPKLVLELMSKKFILDPLITHVLPFDKINEGFELLHKGESIRTVLKM----
Anole 1G MLGFSPA-LSKISFSPALILTGRTWKGCLFGGWKSKDAVPKLVLDFMQKKFTLDPLITHTMPFDKINEGFELLREGKSIRSVLVF----
Anole 1H MVGAPAT-GSEITLPPGLIITGRVWKGTVFGGWKSRDSIPRLVSDFMQKKFTLDPLITHTMPFDKINEGFELLQAGKSIRSILIF----
Rana 1 IVGLAPS-SAVMSFDPLLILTGRILTGAVFGGWKSKDDVPKLVRDYLNKKFDFDPLITHYMPFEKINEGFELLRNGKSIRTILTF----
X.tropicalis 1B IVGLAPA-SARVSVDPMEMLTGRTLKGALFGGWKSRDEVPQLVADFLAKKFELDGLITHRSTLDKINEGFDLLRKGDSIRTILQISQ--
X.laevis 1B IVGLAPA-SARVLVDPMEMLTGRTLKGALFGGWKSRDDVPKLVADFMAKKFELDGLITHRSTLDKINEGFDLLRKGDSIRTILQISQ--
X.tropicalis 1A IVGVAPS-TAELNLDPMVILTGRTLKGSLFGGWKSKDCVPKLVADFMENKFELDGLISHKLPLQKINEGFDLLHKGTSLRTVLYF----
X.laevis 1A2 IVGVAPL-AAELNLNPMEILTGRTLKGTLFGGWKGRDCVPKLVADFMAKKFELDGLITHRLPLQNINEGFDLLHKGESLRTVLYFC---
X.tropicalis 1C IVGLAHY-TAKMNFNPMVLLTGRTLKGGLLGGCKSKD-IPKLVSDLMAKKFDLDGLITHKMPLAKINEAYDVLTKGESLRTILMMSSCE
X.laevis 1C IVGLAHA-TAKMSFDPMVLLTGRTLKGSLLGGFKSKD-IPKLVCDLMAKKFDLDGLISHKMPLAKINEAYDLLNKGESLRTILIM----
Rana 8 VLGLASP-NERLPLDPLLLLTGRSLKGSVFGGFKG-EEVSKLVDDYMKKKINVNFLVSTKLTLDQINKAFELLSSGQGVRSIMIY----
X.tropicalis 8B LLGVAGP-NDKLCFHPGEVMMGRTIKGLPYGGFKGRDDIPKLVGDYMANKFNLNFMVSERMPLEKINEAFELMASGKGLRNLIIF----
X.laevis 8B VLGVAGP-NDKLCFHPGEVMMGRTIKGLPYGGFKSRDDIPKLVCDYMAKKFNLEFMVSQRLPVEKINEAFELMASGKGLRNLIIF----
X.laevis 8A VLGVAGP-DDRLSFHPGELLLGRTMKGSAFGGFKGRDEVPMLVSDYMAKKYDIKFLVSEKMPLEKINEAFELMKMGKGVRNIIIY----
X.tropicalis 8A VLGVAGP-DDRLSFHPGELLFGRTMKGSAFGGFKSRDEVPMLVSDYMEKKFNLDFMVSERIPLEKINEAFELMQSGKGVRNIIIF----
X.tropicalis 9 IIGVPPS-TARLCLDLIWLLTGRTLKGAFLGDYKAKEAFPGLVKDAMNKKFDIGALVTHRVKFDKIMDGFELMRHGKCVRAVLDM----
X.laevis9 IIGVPPS-TARLSLDLMWLLTGRTVKGAFLGDWKAKEAFPRLVQDAMKKKFPLKALVTHRVKFDKIMDGFELMRQGKCVRAALDM----
X.tropicalis 10B IIGASA---STLSFDPMILLSGRTLKSSSFGGWKSRLEVPKLVSDYLAKKFDLEKLVTHRLPFQKISEGFDLLHSGKCIRTILKF----
X.laevis 10B IIGVSA---STLSFDPMILLSGRTLKSSMLGGWKSKDSVPKLVSDYLAKKFDLEKLVTHRLPFQKIDEGFDLLLSGKCIRTILTFKAVD
X.tropicalis 10A IVGVSAP-DSTISFDPMILLTGRTIKGSVFGGWKSKNSVPQLVSDSLAKKFDLEKLVTHRLPLNKINEGFDLLRSGKSIRTILLV----
X.laevis 10A IVGVSAK-EATITFDPMILLTGRTLKGSVFGGWKSKSSVPQLVLDSMAKKFDLEKLVTHRLPLDKINEGFDLLHSGKSIRTILLV----
Human 5 VVGVLPA-SVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHTLNLDKINEAVELMKTGKCIRCILLL----
Bovine 5 IIGLIIG--VQLNISGHLFFTGRSLKGSVYGGWKGRDGASKLVSDYMAKKINLDALITHSLNLDKINEAVELMKTGKCVRCVLLL----
Rabbit 5 IVGLMSA-TDQVRIHGNLFFSGRTLKGSVFGGWKSREHVPKLVSDYIEKKFNLEPLITHTLNLDKINEASELMKTGKCIRCVLLP----
Rat 5 TVGALASFTSTLSIRSHLFFSGRILKGSILGGWKTKEEIPKLVSDYMAKKFNIDPLITHTLTLSEANEAVQLMKSGQCIRCVLLL----
Deermouse 5 IVGSLAS-WIQLNINSHLFFSGRTLKGSVLGGWKTKEEIPKLVSDYTAKKFNLDPLITHTLTLDKVNEAIQLMKNGQCIRCVLLP----
X.tropicalis 7 IIGEAPS-AAQISFDPILLFTGRTWKGSIFGGWKSKESVPRLVDEFMANKFNLDGLVSHTLPFDQINEGFELLRSGNSIRTILMF----
Turtle 7 MVGTPPA-GSRISFDPMLLFTGRTWKGSFIGGWKTKDSIPKLVSGYMEKKFNPDVLITHTLPFEKISEGFELLCSGKSIRSILLF----
Chicken 7 MVGVLPA-GSTVPIDPFLLLSGRTCKGTLAGGWKMRDSIPKLVASYLEKKFNSDLLITHTLPFAKINEGFELLRAGKSIRTVMLF----
Zebra finch 7 MVGVL---NSEISIDPVLLLTGRTWKGTLLGGWKTRECIPKLVSSYLEGKFNSDLLITHTLPFAKVNEGFELLRAGKSIRTVLLF----
Pigeon 7 MVGVAPS-DAVISVDPLLLLTGRTHKGTLVGGSKGRNFIPRLVSSYLEKKFNSDLLITHTLPFAKVNEGFALLHAGKSIRTVLLF----
Anole 7A VVGEPPA-GSHLSVDPVLLITGRKLLGCCMGGFRLKDAIPKLVSEYMEKKFNLDALRSHVLPFEKIGEGFELLCSGKSIRSVLLY----
Anole 7B MVGVPPL-GSRLTFDPMLLFTGRTLKGCFIGGWKMKDSIPQLVSSYMEKKFNSDALISHTLPFSQISEGFNLLHSGKSIRIVLVF----
Anole7C LVGAPPA-GSQLCISPLQLLTGKKLIGSLIGGWKLKDALPKLVSDYMANKFNTDALITHVLPFEKIGEGFELLNSGKSIRCVLLF----
Rat 6A IVGLAPS-DTHLSLEASKILSGKTLKGVCLGDYKTRDCIPQIVTDYLQNKINIDPLVTHQLPFSQLHKALELYHSGKTIRCVLLF----
Mouse 6A IAGLAPS-DAQLSLEAPKILSGKTLKGVCLGDYKTRDCIPQIVTDYLQNKINIDPLVTYQLPFNQLHEALELFHSGKAIRCVLLF----
Rat 6B IMGVAPT-GSQLSFDPVLLLPGRTLKSSVLGGYKTRDDIPKLVTDYVQXK FNIEPLITHR LPFPEINEGF KLLREGKCIR CVLSMRP--
Mouse 6B IMGVAPT-GSQLSFDPLVLLPGRTLKSSVLGGYKTRDDIPKLVTDYVQKKINIDPLITHRLPFPKINEGFRLLQEGKCIRCVLSMRP--
Bovine 6 ITGVSPP-NSKFSLSAQTVSTGRTLKGVCLGDYKTKDCFPQLVTAYLQNKINIDPLITHQLPFDQLHKAFKLYHAGKTIRCVLLF----
Dog 6 IVGVAPL-NSKLSLDAPMIVSGRTMKGVCLGDYKTRDCIHHLVTDYLQNKINIDPLVTHQLPFDQLHKAFELYHAGKTIRCILLF----
Panda 6 IVGVAPL-NSKLSLDASVIFSGRTLKGVCLGDYKTRDCIPRLVTDYLQNKINIDPLVTHQLPFDQLHKAFELYRAGKTIHCLLLF----
Horse 6 IIGAAPS-ESQLSFDPMLILAGRTLKGGILGKYKTRDSIPKLVTDYLQKKINIDPLITHKLPFERINEAFELLQGGKCIRCVLSF----