Hsiang-fu Kung, Ph.D.

CURRICULUM VITAE

Name : Hsiang-fu Kung, Ph.D.

Education:

1963 B.S. - NationalChungHsiangUniversity, Department of Agricultural Chemistry, Taichung,

Taiwan

1969 Ph.D- VanderbiltUniversity, Department of Biochemistry, School of Medicine, Nashville,

Tennessee, USA

1969-1971-NIH, Postdoctoral Fellow, Bethesda, Maryland, USA

Previous Related Experience :

1982-1986 -Research Leader, Department of Molecular Genetics & Molecular Oncology Research Division, Hoffmann-La Roche Inc., Nutley, NJ

1986-Date -Adjunct Professor Department of Chemical Biology & Pharmacognosy, College of Pharmacy, Rutgers University, Piscataway, NJ 08854

1986-1999 -Chief, Laboratory of Biochemical Physiology, NIH, NCI, Frederick, MD

1999-2004 - Director, Chair Professor, Institute of Molecular Biology, HKU

Membership :ChineseAcademy of Sciences

Federation of American Societies for Experimental Biology

American Association for the Advancement of Science

Other Academic Activities :

1986-Date -Editorial Board, BioFactors

1991-1996 -Editorial Board, Cellular and Molecular Biology Research

Visiting Professorship & Lectures – Kyutsu University (Japan), Ben Gurion University (Israel), Academia Scinica (Taiwan), National Health Research Institute (Taiwan), National Taiwan University, Academy of Military Medical Sciences (Beijing), Hunan Medical University (Changsha), China Medical University (Shengyang), Fu-Dan University (Shanghai), Jiao-fung University (Shanghai), Tong-ji Medical University (Wuhan), Zhong Shan University Medical School (Guangzhou), Development Center of Biotechnology (Taiwan).

Adjunct Professorship: Rutgers University, New Jersey, USA

Current Positions :

Chair Professor of VirologyHonorary ProfessorAdjunct Professor

Centre for Emerging Infectious DiseasesPekingUnionMedicalCollegeDept of Chemical Biology

The ChineseUniversity of Hong KongBeijing, ChinaCollege of Pharmacy

RutgersUniversity

New Jersey, USA

Publications :

420Peer-reviewed papers

15 Book Chapters

14 Patents

Awards : 1998 NIH Merit Award

2000 HKU Outstanding Research Award

Peer-Reviewed Publications (Books/Book Chapters and Abstracts are not included) :

  1. Wagner, C., Lusty S.M., Kung, H.F., and Rogers, N.L.: Trimethyl-sulfonium-tetrahydrofolate methyltransferase: A novel enzyme in the utilization of one- carbon units. J. Biol. Chem. 241:1923-1925, 1966
  1. Wagner, C., Lusty, S.M., Kung, H.F., and Rogers, N.L.: Preparation and properties of trimethylsulfonium tetrahydrofolate methyltransferase. J. Biol. Chem. 242:1287-1293, 1967
  1. Kung, H.F. and Wagner, C.: -glutamylmethylamine: A new intermediate in the metabolism of methylamine. J. Biol. Chem. 244:4136-4140, 1969
  1. Kung, H.F. and Wagner, C.: Oxidation of one-carbon units by Pseudomonas MS. Biochem. J. 116:357-365, 1970
  1. Kung, H.F. and Wagner C.: The enzymatic synthesis of N-methylalanine by Pseudomonas MS. Biochim. Biophys. Acta. 201:513-516, 1970.
  1. Kung, H.F., Cederbaum, S., Tsai, L., and Stadtman, T.C.: V. nicotinic acid metabolism: A conbamide coenzyme dependent conversion of -methyl-eneglutaric acid to dimethylmaleic acid. Proc. Natl. Acad. Sci. USA 65:978-984, 1970.
  1. Kung, H.F. and Stadtman, T.C.: VI. Nicotinic acid metabolism: Purification and properties of -methyleneglutarate mutase (B12-dependent) and methylitaconate isomerate. J. Biol. Chem. 246:3378-3388, 1971.
  1. Kung, H.F. and Tsai, L.: VII. Nicotinic acid metabolism: Mechanism of action of clostridial -methyleneglutarate mutase (B12-dependent) and methylaitaconate isomerase. J. Biol. Chem. 246:6436-6443, 1971.
  1. Kung, H.F., Tsai, L., and Stadtman, T.C.: VIII. Nicotinic acid metabolism: Tracer studies on the intermediary roles of a-methyleneglutarate, methylitaconate, dimethylmatlate, and pyruvate. J. Biol. Chem. 246:6444-6451, 1971.
  1. Kung, H.F. and Henning, U.: Limiting availability of binding sites for dehydrogenases on the cell membrane of E. coli. Proc. Natl. Acad. Sci. USA 69:925-929, 1972.
  1. Kung, H.F., Spears, C., Greene, R.C., and Weissbach, H.: Regulation of the terminal reactions in methionine biosynthesis by vitamin B12 and methionine. Arch. Biochem. Biophys. 150:23-31, 1972.
  1. Greene, R.C., Williams, R., Kung, H.F., Spears, C., and Weissbach, H.: Effects of methionine and vitamin B12 on the activities of methionine biosynthesis enzymes in Met J Mutants of E. coli K-12. Arch. Biochem. Biophys. 158:249-256, 1973.
  1. Kung, H.F., Fox, J.E., Spears, C., Brot, N., and Weissbach, H.: Studies on the role of ribosomal proteins L7 and L12 in the in vitro synthesis of -galactosidase. J. Biol. Chem. 248:5012-5015, 1973.
  1. Kung, H.F., Brot, N., Spears, C., Chen, B., and Weissbach, H.: Studies on the in vitro transcription and translation of lac operon. Arch. Biochem. Biophys. 160:168-174, 1974.
  1. Kung, H.F., Spears, C., Schulz, T., and Weissbach, H.: Studies on the in vitro synthesis of -galactosidase: Necessary components in the ribosomal wash. Arch. Biochem. Biophys. 162:578-584, 1974.
  1. Kung, H.F., Spears, C., and Weissbach, H.: Purification and properties of a soluble factor required for the in vitro synthesis of -galactosidase. J. Biol. Chem. 250:1556-1562, 1975.
  1. Schuldiner, S., Kung, H.F., Kaback, H.R., and Weil, R.: Differentiation between binding and transport of dansylga-lactosides in E. coli. J. Biol. Chem. 250:3679-3682, 1975.
  1. Kung, H.F., Morrissey, J., Revel, M., Spears, C., and Weissbach, H.: Studies of the lactose operon: The control of DNA-directed in vitro protein synthesis by interference factor i-. J. Biol. Chem. 250:8780-8784, 1975.
  1. Kung, H.F., Spears, C., and Weisshach, H.: DNA-directed in vitro synthesis of -galactosidase: Dependencies on elonga-tion factor Tu and tRNA. Arch. Biochem. Biophys. 174:100-104, 1976.
  1. Chen, B., Kung, H.F., and Bates, R.R.: Significance of methylation of template DNA on its coded enzyme -galactosidase synthesis in vitro. Chem. Biol. Interact. 14:101-111, 1976.
  1. Treadwell, B.V., Kung, H.F., and Weissbach, H.: Stimulation by spermidine on the DNA-directed in vitro synthesis of -galactosidase. Arch. Biochem. Biophys. 176:799-800, 1976.
  1. Chu, F., Kung, H.F., Caldwell, P., Weissbach, H., and Brot, N.: DNA-directed in vitro synthesis of protein L7 L12 from E. coli ribosomes in vitro. Proc. Natl. Acad. Sci.USA 73:3156-3159, 1976.
  1. Kung, H.F., Treadwell, B., Spears, C., Tai, P.C., and Weissbach, H.: DNA-directed in vitro synthesis of -galactosidase: Requirement for a ribosome release factor. Proc. Natl. Acad. Sci.USA 74:3217-3221, 1977.
  1. Kung, H.F., Redfield, B., Treadwell, B., Spears, C., and Weissbach, H.: DNA-directed in vitro synthesis of -galactosidase: Studies with purified factors. J. Biol. Chem. 252:6889-6894, 1977.
  1. Kung, H.F., Chu, F., Caldwell, P., Spears, C., Treadwell, B., Eskin, B., Brot, N., and Weissbach, H.: The mRNA-directed synthesis of the -peptide of -galactosidase, ribosomal proteins, L12 and L10, and EF-Tu using purified translational factors. Arch. Biochem. Biophys. 187:457-463, 1978.
  1. Kung, H.F., and Weissbach, H.: DNA-directed synthesis of E. coli-isopropylmalate dehydrogenase in vitro. J. Biol. Chem. 253:2078-2080, 1978.
  1. Kung, H.F., Tainsky, M., and Weissbach, H.: Regulation of the in vitro synthesis of the -peptide of -galactosidase by a restriction fragment of the lactose operon. Biochem. Biophys. Res. Commun. 81:1000-1010, 1978.
  1. Eskin, B., Treadwell, B., Redfield, B., Spears, C., Kung, H.F., and Weissbach, H.: Activity of different forms of initiation factor 2 in the in vitro synthesis of -galactosidase. Arch. Biochem. Biophys. 195:396-400, 1979.
  1. Kung, H.F., Eskin, B., Redfield, B., and Weissbach, H.: DNA-directed in vitro synthesis of -galactosidase: Requirement for formylation of methionyl-tRNA. Arch. Biochem. Biophys. 195:396-400, 1979.
  1. Kung, H.F., Redfield, B., and Weissbach, H.: DNA-directed in vitro synthesis of -galactosidase: Purification and characterization of stimulatory factors in an asites extract. J. Biol. Chem. 254:8404-8408, 1979.
  1. Schulz, T., Jerez, C., Goldberg, G., Kung, H.F., Huang, K.H., Brot, N., and Weissbach, H.: DNA-directed in vitro synthesis of protein involved in bacterial transcription and translation. Proc. Natl. Acad. Sci. USA 76:6115-6119, 1979.
  1. Kung, H.F., and Weissbach, H.: Further characterization of L-factor, a protein required for -galactosidase synthesis. Arch. Biochem. Biophys. 201:544-550, 1980.
  1. Greenblatt, J., Li, J., Adhya, S., Friedmaan, D.I., Baron, L.S., Redfield, B., Kung, H.F., and Weissbach, H.: L factor required for -galactosidase synthesis is the nusA gene product that is involved in transcription termination. Proc. Natl. Acad. Sci.USA 77:1991-1994, 1980.
  1. Shen, V., Cynamon, M., Daugherty, B., Kung, H.F., and Schlessinger, D.: Functional inactivation of lac -peptide mRNA by a factor that purifies with E. coli RNase III. J. Biol. Chem. 256:1896-1902, 1981.
  1. Staehelin, T., Hobbs, D., Kung, H.F., Lai, C.Y., and Pestka, S.: Purification and characterization of recombinant human leukocyte interferon (IFL-r) with monoclonal antibodies. J. Biol. Chem. 256:9750-9754, 1981.
  1. Miller, D., Kung, H.F., and Pestka, S.: Crystallization of recombinant human leukocyte interferon A. Science 215:689-690, 1982.
  1. Staehelin, T., Durrer, B., Schmidt, J., Takacs, B., Stocker, J., Miggiano, V., Stahli, C., Kung, H.F., Hobbs, D.S., Levy, W.P., Moschera, J.A., and Pestka, S.: Monoclonal antibodies to human leukocyte interferon: Their use in assay and purification. Tex. Rep. Biol. Med. 41:43-58, 1982.
  1. Herberman, R.B., Ortaldo, J.R., Mantovani, A., Hobbs, D.S., Kung, H.F., and Pestka, S.: Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol. 67:160-167, 1982.
  1. Chanda, P.K. and Kung, H.F.: In vitro synthesis of biologically active human leukocyte interferon in a RNA-dependent system from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci.USA 80:2569-2573, 1983.
  1. Chang, N.T., Kung, H.F., and Pestka, S.: Synthesis of a human leukocyte interferon with a modified carboxy terminus in E. coli. Arch. Biochem. Biophys. 221:585-589, 1983.
  1. Kung, H.F., Bekesi, E., Guterman, S.K., Gray, J.E., Traub, L., and Calhoun, D.H.: Autoregulation of the rho gene E. coli K-12. Mol. Gen. Genet. 193:210-213, 1984.
  1. Stacey, D.W. and Kung, H.F.: Transformation of NIH 3T3 cells by microinjection of H-ras p21 protein. Nature 310:508-511, 1984.
  1. Lacal, J.C., Santos, E., Notario, V., Barbacid, M., Yamazaki, S., Kung, H.F., Seamans, C., McAndrew, S., and Crowl, R.: Expression of normal and transforming ras genes in E. coli and purification of their encoded p21 proteins. Proc. Natl. Acad. Sci.USA 81:5305-5309, 1984.
  1. Manne, V., Yamazaki, S., and Kung, H.F.: Guanosine nucleotide binding by highly purified H-ras p21 protein produced in E. coli. Proc. Natl. Acad. Sci.USA 81:6953-6957, 1984.
  1. Chanda, P., Ono, M., Kuwano, M., and Kung, H.F.: Cloning sequence analysis and expression of alteration of mRNA stability gene (Ams) of E. coli. J. Bacteriol. 161:446-449, 1985.
  1. Calhoun, D.H., Wallen, J.W., Traub, L., Gray, J.E., Ast, M., and Kung, H.F.: Internal promoter in the ilvGEDA transcription unit of E. coli K-12. J. Bacteriol. 161-128-132, 1985.
  1. Manne, V., Bekesi, E., and Kung, H.F.: H-ras proteins exhibit GTPase activity – point mutation that activate H-ras gene products result in decreased GTPase activity. Proc. Natl. Acad. Sci.USA 82:376-380, 1985.
  1. Rashidbaigi, A., Kung, H.F., and Pestka, S.: Characterization of receptors for immune interferon in U937 cell line with (32P)-labelled human recombinant immune interferon. J. Biol. Chem. 260:8514-8519, 1985.
  1. Manne, V. and Kung, H.F.: Effect of divalent metal ions and glycerol on the GTPase activity of H-ras proteins. Biochem. Biophys. Res. Commun. 128:1440-1446, 1985.
  1. Tasi, S.C., Adamik, R., Moss, J., Vaughan, M., Manne, V., and Kung, H.F.: Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by E. coli. H-ras p21. Proc. Natl. Acad. Sci. USA 82:8310-8314, 1985.
  1. Willumsen, B.W., Papageorge, A.G., Hubbert, N., Bekesi, E., Kung, H.F., and Lowy, D.: Transforming p21 ras protein: Flexibility in the major variable region linking the catalytic and membrane anchoring domains. EMBO. J. 4:2893-2896, 1985.
  1. Petska, S., Jung, V., Rashidbaigi, A., Langer, J.A., and Kung, H.F.: Interferon and their receptors. Proc. on the Ares Serono International Symposium on the Interferon System 24:213-220, 1985.
  1. Rashidbaigi, A., Kung, H.F., and Petska, S.: Binding of 32P-Labeled Human Recombinant Immune Interferon to U937 Cells. Methods Enzymol. 119:315-321, 1986.
  1. Rashidbaigi, A., Langer, J.A., Jung, V., Jones, C., Morse, H.G., Tischfield, J.A., Trill, J.J., Kung, H.F., and Pestka, S.: The gene for the human immune interferon receptor is located on chromosome 6. Proc. Natl. Acad. Sci.USA 83:384-388, 1986.
  1. Kung, H.F., Smith, M.R., Bekesi, E., Manne, V., and Stacey, D.W.: Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins. Exp. Cell Res. 162:363-371, 1986.
  1. Papageorge, A.G., Willumsen, B.M., Johnson, M., Kung, H.F., Stacey, D.W., Vass, W.C., and Lowy, D.: A transforming ras gene can provide an essential function ordinarily specified by endogenous ras. Mol. Cell. Biol. 6:1843-1846, 1986.
  1. Halpern, J.L., Tsai, S.C., Adamik, R., Kanaho, Y., Bekesi, E., Kung, H.F., Moss, J., and Vaughan, M.: Structural and functional characterizations of guanyl nucleotide-binding proteins using monoclonal antibodies to the -subunit of transducin. Mol. Pharmacol. 29:515-519, 1986.
  1. Willumsen, B.M., Papageorge, A.G., Kung, H.F., Bekesi, E., Robins, T., Johnsen, M., Vass, W.C., and Lowy, D.R.: Mutational analysis of a ras catalytic domain. Mol. Cell. Biol. 6:2646-2654, 1986.
  1. Angus, C.W., Van Meurs, K.P., Tsai, S.C., Adamik, R., Chang-Miedel, M., Pan, Y.C.E., Kung, H.F., Moss, J., and Vaughan, M.: Identification of the probable site of choleragen-catalyzed ADP-ribosylation in a Go -like protein based on cDNA sequence. Proc. Natl. Acad. Sci. USA 83:5813-5816, 1986.
  1. Manne, V. and Kung, H.F.: Characterization of phosphatidylinositol specific phospholipase C from human platelets. Biochem. J. 243:763-771, 1987.
  1. Stacey, D.W., Watson, T., Kung, H.F., and Curran, T.: Microinjection of transforming ras protein induces c-fos expression. Mol. Cell. Biol. 7:523-527, 1987.
  1. Deshpande, A.K. and Kung, H.F.: Insulin induction of Xenopus oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins. Mol. Cell. Biol. 7:1285-1288, 1987.
  1. Van Meurs, K.P., Angus, C.W., Lavu, S., Kung, H.F., Czarnecki, S.K., Moss, J., and Vaughan, M.: Deduced amino acid sequence of bovine retina Go-: Similarities to other guanyl nucleotide-binding proteins. Proc. Natl. Acad. Sci.USA 84:3107-3111, 1987.
  1. Honda, S., Asano, T., Kajio, T., Nakagawa, S., Ikeyama, S., Ichimori, Y., Sugino, H., Nara, K., Kakinuma, A., and Kung, H.F.: Differential purification by immunoaffinity chromatography of two carboxy-terminal portion-deleted derivatives of recombinant human interferon- from E. coli. J. Interferon Res. 7:145-154, 1987.
  1. Willumsen, B.M., Kung, H.F., Johnsen, M., and Lowy, D.R.: A mutation analysis of ras function. Viral Carcinogenesis 24:385-400, 1987.
  1. Schultz, A.M., Tsai, S.C., Kung, H.F., Oroszlan, S., Moss, J., and Vaughan, M.: Hydroxylamine-stable covalent linkage of myristic acid in Go-, a guanine nucleotide-binding protein of bovine brain. Biochem. Biophys. Res. Commun. 146:1234-1239, 1987.
  1. Lavu, S., Clark, J., Swarup, R., Matsushima, K., Paturu, K., Moss, J., and Kung, H.F.: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go-. Biochem. Biophys. Res. Commun. 150:811-815, 1988.
  1. Matsushima, K., Kung, H.F., and Copeland, T.: Purification and characterization of a cytosolic 65 KDa phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin-1. Biochemistry 27:3765-3770, 1988.
  1. Kamata, T. and Kung, H.F.: Effects of ras proteins and PDGF on phospholipid turnover in NRK cells. Proc. Natl. Acad. Sci.USA 85:5799-5803, 1988.
  1. Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H.F., Leonard, E., and Oppenheim, J.J.: Molecular cloning of a human monocyte derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin-1 and tumor necrosis factor. J. Exp. Med. 167:1833, 1988.
  1. Faltynek, C. and Kung, H.F.: The biochemical mechanisms of action of the interferons. Biofactors 1:227-235, 1988.
  1. Longo, P.A., Broido, M.S., Chen, J., Kung, H.F., and Pincus, M.R.: The structure of the amino terminal transforming segment of the p21 protein, Tyr4-Thr20 (with Asp12), by two-dimensional NMR. Biochem. Biophys. Res. Commun. 157:776-782, 1988.
  1. Hseih, J.H., Shih, K.Y., Kung, H.F. et al.: Controlled fed-batch fermentation of recombinant Saccharomyces cerevisiae to produce hepatitis B surface antigen. Biotechnol. Bioeng. 32:334-340, 1988.
  1. Smith, M.R., Ryu, S.H., Suh, P.G., Rhee, S.G., and Kung, H.F.: S-phase induction and transformation of quiescent NIH/3T3 cells by micro-injection of phospholipase C. Proc. Natl. Acad. Sci.USA 86:3659-3663, 1989.

75.Brandt-Rauf, P., Pincus, M., Carty, R., Lubowsky, J., Avitable, M., Kung, H.F., and Maizel, J.: Conformational effects of amino acid substitutions at position 10, 12 and 13 in the p21 protein. J. Prot. Chem. 8:79-86, 1989.

76.Kock, A., Schwarz, T., Urbanski, A., Peng, Z., Vetterlein, M., Micksche, M., Ansel, J.C., Kung, H.F., and Luger, T.A.: Expression and release of interleukin 1 by different human melanoma cell lines. JNCI 81:36-41, 1989.

77.Brown, D., Yu, Z., Miller, P., Blake, K., Wei, C., Kung, H. F., Black, R.J., Tsao, P.O.P., and Chang, E.H.: Modulation of ras expression by anti-sense, nonionic-deoxyoligonucleotide analogs. Onocogene Res. 4:243-252, 1989.

78.Peng, Z., Calvert, I., Clark, J., Helman, L., Kahn, R., and Kung, H.F.: Molecular cloning, sequence analysis, and mRNA expression of human ADP-ribosylation factor. Biofactors 2:45-49, 1989.

79.Kung, H.F., Calvert, I., Bekesi, E., Khan, F.R. Huang, K.P., Oroszlan, S., Henderson, L.E., Copeland, T.D., Sowder, R.C., and Wei, S.J.: Phosphorylation of human interleukin-2 (IL-2). Mol. Cell. Biochem. 89:29-35, 1989.

80.Carucci, J.E., Carty, R.P., Chung, D.L., Randall, B.M., Chen, J., Kung, H.F., Nishimura, S., Brandt-Rauf, P.W., and Pincus, M.R.: Blocking of the nucleotide exchange of the p21 protein with the 2', 3'-dialdehyde of guanosine diphosphate, an active site affinity label. Medical Science Res. 17:559, 1989.

81.Chen, K., Peng, Z., Lavu, S., and Kung H.F.: Molecular cloning and sequence analysis of two distinct types of Xenopus laevis protein kinase C. Second Messengers and Phosphoproteins 12: (No. 5&6), 1989.

82.Boubik, M., Moschera, J.A., Wei, C., and Kung, H.F.: Conformation and activity of recombinant human fibroblast interferon. J Interferon Res. 10:213-219, 1990.

83.Tsai, W.P., Nara, P.L., Kung, H.F., and Oroszlan, S.: Inhibition of human immunodeficiency virus infectivity by chloroquine. AIDS Res. Hum. Retroviruses 6:481-489, 1990.

84.Smith, M.R., Munger, W.E., Kung, H.F., Takacs, L., and Durum, S.K.: Direct evidence for an intracellular role for tumor necrosis factor-(TNF): Microinjection of TNF kills target cells. J. Immunol. 144:162-169, 1990.

85.Kamata, T. and Kung, H.F.: Modulation of maturation and ribosomal protein S6 phosphorylation in Xenopus oocytes by microinjection of oncogenic ras protein and protein kinase C. Mol. Cell. Biol. 10:880-886, 1990.

86.Smith, M.R., Muegge, K., Keller, J.R., Kung, H.F., Young, H.A., and Durum, S.K.: Direct evidence for an intracellular role for interferon-: Microinjection of human interferon- induces Ia expression on murine macrophages. J. Immunol. 144:1777-1782, 1990.

87.Smith, M.R., Liu, Y.L., Kim H., Rhee, S.G., and Kung, H.F.: Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C. Science 247:1074-1077, 1990.

88.West, M., Kung, H.F., and Kamata, T.: A novel membrane factor stimulates guanine nuelcotide exchange reaction of ras proteins. FEBS Lett. 259:245-248, 1990.

89.Smith, M.R., Heidecker, G., Rapp, U.R., and Kung, H.F.: Induction of transformation and mitogenesis by oncogenic raf proteins. Mol. Cell. Biol. 10:3828-3833, 1990.

90.Mikovits, J., Raziuddin, Gonda, M., Ruta, M., Lohrey, N., Kung, H.F., and Ruscetti, F.: Negative regulation of HIV replication in monocytes: Distinctions between restricted and latent expression in THP-1 cells. J Exp. Med. 171:1705-1720, 1990.

91.Smith, M.R., Jaramillo, M., Liu, Y., Dever, T.E., Merrick, W.C., Kung, H.F., and Sonenberg, N.: Translation initiation factors induce DNA synthesis and transform NIH/3T3 cells. New Biologist 2:648-654, 1990.

92.Huang, Y.K., Kung, H.F., and Kamata, T.: Purification of a novel factor capable of stimulating guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular weight G-proteins. Proc. Natl. Acad. Sci. USA87:8008-8012, 1990.

93.Lee-Huang, S., Huang, P.L., Nara, P., Chen, H.C., Kung, H.F., Huang, P.H., Huang, H.I., and Huang, P.L.: MAP 30: A new inhibitor of HIV infection and replication. FEBS Lett. 272:12-18, 1990.

94.Kovacs,G. and Kung, H.F.: Site-specific, non-homologous chromatide exchange in hereditary and sporadic renal cell carcinomas. Proc. Natl. Acad. Sci. USA88:194-198, 1991.

95.Manne, V., Roberts, D., Tobin, A., O'Rourke, E., De Virgilio, M., Meyers, C., Ahmed, N., Kurz, B., Resh, M., Kung, H.F., and Barbacid, M.: Identification and preliminary characterization of farnesyl-protein transferase. Proc. Natl. Acad. Sci. USA87:7541-7545, 1991.

96.Calvert, I., Kung, H.F., and Raziuddin: Cloning and characterization of a novel sequence specific DNA-binding protein recognizing the negative regulatory region element (NRE) of HIV-l long terminal repeat. Gene 101:171-176, 1991.

97.Kovacs, G., Fuzesi, L., Emanuel, A., and Kung, H.F.: Cytogeneties of papillary renal cell tumors. Genes, Chromosomes and Cancer 3:249-235, 1991.

98.Kovacs, G., Emanuel, A., Neumann, H.P.H., and Kung, H.F.: Cytogenetics of renal cell carcinomas associated with Von Hippel Lindau disease. Genes, Chromosomes and Cancer 3:256-262, 1991.

99.Lee-Huang, S., Huang, P.L., Kung, H.F., Li, B.Q., Huang, P.L., Huang, P., Huang, H.I., and Chen, H.C.: TAP 29: An anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells. Proc. Nati. Acad. Sci. USA88:6570-6574, 1991.

100. Ono, M., Kuwano, M., and Kung, H.F.: Malignant transformation of mouse Balb/3T3 cells by polyoma middle T antigen requires epidermal growth factor receptor expression. Cell Growth & Differentiation 2:317-322, 1991.

101. Smith, M.R., Jaramillo, M., Tuazon, P.T., Traugh, J.A., Liu, Y.L., Sonenberg, N., and Kung, H.F.: Modulation of the mitogenic activity of eukaryotic translational initiation factor 4E by protein kinase C. New Biologist 3:601-607, 1991.

102. Raziuddin, Mikovits, J., Calvert, I., Ghosh, S., Kung, H.F., andRuscetti, F.: Negative regulation of chronic low-level HIV-l expression in monocytes: Involvement of the 65 + 50 kDa NF-B heterotetramer. Proc. Natl. Acad. Sci. USA88:9426-9430, 1991.

103. Lee-Huang, S., Kung, H.F., Huang, P.L., Huang, P.L., Li, B.Q., Huang, P., Huang, H.I., and Chen, H.C.: A new class of anti-HIV agents: GAP 31, DAPs 30 and 32. FEBS Lett. 291:139-144, 1991.

104. Chuang, L.F., Kung, H.F., Israel, M., and Chuang, R.Y.: Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluroacetyl-adriamycin -14- valerate (AD32). Biochem. Pharmacol. 43:865-872, 1992.

105.Kovacs, G., Kiechle-Schwarz, M., Scherer, G., and Kung, H.F.: Molecular analysis of the chromosome 1lp region in renal cell carcinoma. Cell. Mol. Biol. 38:59-62, 1992.

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