Haythem Saadeh, PhD


Addresses

Biography

Date of Birth: July 15, 1966

Place of Birth: Amman, Jordan

Citizenship: Jordanian

Education

09/2004- current Assistant Professor at the University of Jordan

09/2003-09/2003 Lecturer at the Hashemite University

04/2000- 06/2003 Senior chemist at Transphotonics L.L.C.

10/94-03/2000 Ph.D. candidate in organic andpolymeric chemistry.

The Universityof Chicago.

Advisor: Professor Luping Yu.

09/91-4/94 Ph.D. candidate in organic and

medicinal chemistry. LoyolaUniversity of Chicago.

Advisor: Professor Charles Thompson.

01/88-05/90 M.Sc. in organic chemistry. The

University of Jordan. Amman,Jordan.

09/84-12/87 B.Sc. in chemistry. Yarmouk

University, Irbid, Jordan.

Research Experience

9/2003-current: My research interest cover the following topics: the design and synthesis of new NLO optical materials based on mixed valence complexes. The optical nolinearity of these novel materials will be evaluated. These systems can be easily modified to and further investigate their potential electroluminescence properties. The design and synthesis of novel piso-electric polymers and photogalvanic nanomaterials.The design and synthesis of novel pyridine based-chelating polymers and investigate their chelating properties with various metals.The design and synthesis of new heterocyclic systems with a potential antimicrobial activity.

4/2000-6/2003: Senior Chemist at Trans Photonics.

In this company I was encharged with the design and synthesis of all projects involved.

  1. Design and synthesis of novel Nonlinear Optical (NLO) polymers bearing a new class of NLO chromophores. Studying the performance of these NLO polymers in optical data storage and optical switching. In this project, NLO chromophores with a wide range of Uv-visible absorption were synthesized; colorless chromophores (320 nm) to red chromophores (600 nm).
  2. Design and synthesis of near Infrared organic light emitting diodes (IR-OLED’s). Various stillbene-based chromophores were synthesized and the electroluminescent emissions were fine-tuned by structural modefication. This was easily achieved by changing the conjunction length and the end groups. The electroluminescence specra of these chromophores covers a range of 500 nm to 1000 nm.
  3. Design and synthesis of organo-soluble polyimides as cladding layers. These polyimide claddings layers can be fabricated carefully to enhance the adhesion and make it incompatible upon processing with active layer. Various cladding layers with controllable refractive index (n0.005) were synthesized.
  4. Synthesis and characterization of novel Water-Soluble polyimides. These polyimides were designed to develop a new class of cladding with enhanced adhesion properties. These materials would be friendly to both chemists and enviromentalists.
  5. Design and synthesis of conducting cladding based on polyimides and polybenzoxazoles. These systems were synthesized by incorporating a conductive moiety into the polymer structure to enhance the its electrical conductivity. These systems were designed so that the optical transperancy of the material is maintained.
  6. Design and synthesis of silicon containing polyimides. These kinds of polyimides will be susceptible to HF etching by virtue of the high concentrations of C-O-Si moieties. These polymers will be capable of being functionalized with NLO chromophores, thereby lending themselves to applications as active in electro-optic modulators and optical switches.
  7. Design and synthesis of smart materials for sensing explosives, heavy metals such as lead (Pd) and biomolecules such as anthrax.

5/1995-3/2000: Graduate Research Assistant ,Department of chemistry, The University of Chicago.

1. Synthesis of Functionalized Polyimides:

Design, synthesis, and characterization of novel polyimides functionalized with nonlinear optical (NLO) chromophores, which exhibit a high thermal stability and large nonlinearity.

2. Polyesterimides:

Design, synthesis and characterization of novel polyesterimides bearing NLO chromophores with a large optical nonlinearity. The approach involves a multiple step synthesis of new monomers.

3. Self-Assembled Supramolecular Materials:

Design and synthesis of novel NLO self assembled supramolecular materials based on hydrogen bonding. Different monomers were synthesized and various NLO chromophores were incorporated. These novel systems exhibited a large optical nonlinearity coefficients (r33 = 70 pm/V). This r33 value is one of the largest values reported.

4. Electroluminescent polymers for light-emitting diodes(LEDs):

Synthesisof light-emitting materials. Various conjugated polymers such as, Polyphenylenethiophene and the novel polyphenylenefuran, were synthesized by utilizing the Stille coupling reaction. Their luminescence properties, photochemical stability and quantum efficiency were studied in details.

5/1992-10/1994: Graduate Research Assistant ,Department of chemistry, Loyola University of Chicago.

1. Heterocyclic Compounds with Antiviral activity:

Design and synthesis of guanine analoges by replacing C=O group at C4 by O=S=O. These analoges were expected to shot down the reproduction of viruses by irreversable binding to the reproduction enzyme active sites.

2/1988-5/1990: Graduate Research Assistant ,Department of chemistry, University of Jordan.

1. Tetrazines from via 1,3-dipole cycloaddition:

Selected series of 6-substitutes 4-aryl-3-heteroaryl-1-methyl-1,2,3,4-tetrahydro-s-tetrazines were synthesized via direct interaction between appropriate nitrile imine and methylhydrazones. Those systems exhibite a ring-chain tautomerizm in solution. The extent of tautomerizm was investigated by 1 HNMR and interpreted in terms of conjugative and electronic effects of substituents.

Special Techniques

Expertise in: synthetic organic chemistry; a wide range of simple and complicated carbocyclic and heterocyclic systems (thiophene, pyrrol, furan, imidazole, pyridine, pyrimidine, indole, azepine, oxatriazines, tetrazines,…..); air and light sensitive chemistry; Spin-coating and casting films; Vaccume deposition of metal electrodes; sublimation; Film thickness measurements by a profile or prizm coupler setup; Viscometry; Flourescence; NMR, IR, HPLC and GC.

Awards and Honors

  1. Nominee for outstanding teaching award, Loyola University of Chicago.
  2. Nominee for outstanding teaching award, The University of Chicago.
  3. Jordanian Councile of Science and Technology award for outstanding graduate student, University of Jordan.

Presentations: The 214th ACS national meeting, September 7-11, 1997, Las Vegas, Nevada. (Saadeh, Haythem; Gharavi, Alireza; Yu, Dong; Yu, Luping “Polyimides with a Diazo Chromophore Exhibiting High Thermal Stability and Large Electrooptic Coefficients”Book of Abstracts, 214th ACS National Meeting, Las Vegas, NV, September 7-11, 1997, Poly-217).

Affiliation: Member of the American Chemical Society.

Supervised Graduate Students:

Ph.D.: Jihad S. Al-Hawadi-2008 (POLYCHLORINATEDTERPHENYLS (PCT)-SYNTHESIS

AND ENVIRONMENTAL ANALYSIS).

Ms: 1. Mervat S. Samour-2007 (SYNTHESIS AND PROPERTIES OF SOME NEW N-(4-

NITROIMIDAZOL-5-YL)-L-A-AMINO ACID, THEIR NEW HYDANTOINS/

THIOHYDANTOINS DERIVATIVES AND MODEL THIENOPYRIMIDINES).

2. Eman A. Abu- Shairah -2007(SYNTHESIS AND CHARACTERIZATION OF NEW

METRONIDAZOLE DERIVATIVES).

3. AhmadT. Al-Masri-2008 (SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL

ACTIVITIES OF NEW COMPOUNDS DERIVED FROM METRONIDAZOLE AND AMINO ACIDS

AND THEIR ESTERS").

4. Eman A.Ahmad-2009 (COMPLEXATION AND STABILITY STUDY OF SUBEROYLANILIDE

HYDROXAMIC ACID).

Publications:

1. El-Abadelah, M.; Hussein, A.; Saadeh, H. “Substituent Effect on Ring-Chain Tautomerizm of 1,2,3,4-Tetrahydro-s-tetrazines”,Heterocycles, 1991, 32, 1063.

  1. Saadeh, H.; Thompson, C.; Fernandeze, E.; Pavkovic, S. “1-Benzyl-5-Methoxycarbonylmethylthio-4-Nitroimidazole”, Acta Crystall. Sec. C-Crystal Structure Comm.1995, 51, 950.
  1. Saadeh, H. Gharavi, A.; Yu, D.; Yu, L. “Polyimides with a Diazo Chromophore Exhibiting High Thermal Stability and Large Electrooptic Coefficients”, Macromolecules, 1997, 30, 5403.
  1. Saadeh, H. Gharavi, A.; Yu, D.; Yu, L. “Polyimides with a Diazo Chromophore Exhibiting Large Electrooptic Coefficients”, Polymer Preprints, 1997, 38, 552.
  1. Saadeh, H.; Goodson, T.; Yu, L. “Synthesis of a Polyphenylene-co-furan and Polyphenylene-co-thiophene and Comparison of Their Electroluminescent Properties”, Macromolecules, 1997, 30, 4608.
  1. Abdul-Jawad, S.; Al-Najjar, A.; Bader, M. M.; Saadeh, H. A.; Yu, L. “AC Electrical Behavior of A Novel Electro-optic Polyimide” Book of Abstracts, 213th ACS National Meeting, San Francisco, April 13-17, 1997, PMSE-195.
  1. Saadeh, H.; Yu, D.; Wang, L.; Yu, L. “Highly Stable, Functionalized Polyimides for Second Order Nonlinear Optics”, J. Mater. Chem. 1999, 9, 1865.
  1. Wang, L.; Ng, Man-Kit; Saadeh, H.; Yu, L. “ Photorefractive Properties of Molecules Containing Oligothiophenes and a Nonlinear Optical Chromophore: The Influence of Conjugation length”, Polymer Preprints, 1999, 40, 1250.
  1. Qing, L.; Wang, L.; Saadeh, H.; Yu, L. “A New Family of Amorphous Molecular Materials Showing Large Photorefractive Effect”, Chem. Comm. 1999, 1689.

10. Saadeh, H.; Wang, L.; Yu, L. “ A New Synthetic Approach to Novel Polymers Exhibiting Large Electrooptic Coefficients and High Thermal Stability” Macromolecules, 2000, 33, 1570.

  1. Saadeh, H.; Wang, L.; Yu, L “Supramolecular Solid State Assembly Exhibiting Electro-Optic Effects”. J. Am. Chem. Soc. 2000, 122, 546.
  1. Al-Noaimi, Mousa Z.; Saadeh, Haythem; Haddad, Salim F.; El-Barghouthi, Musa I.; El-Khateeb, Mohammad; Crutchley, Robert J. Syntheses, crystallography and spectroelectrochemical studies of ruthenium azomethine complexes. Polyhedron ,2007, 26(14), 3675-3685.
  1. Salih, Kifah S. M.; Ayoub, Mikdad T.; Saadeh, Haythem A.; Al-Masoudi, Najim A.; Mubarak, Mohammad S. Synthesis, characterization, and biological activities of new benzofuran derivatives. Heterocycles , 2007, 71(7), 1577-1587.
  1. Alshamaileh, Ehab; Alawi, Mahmoud; Dahdal, Yara; Saadeh, Haythem Kinetic Stability study of Selected Hydroxamic Acids Using HPLC/UV. Jordan Journal of Pharmaceutical Sciences2008, 1(1), 28-37.

15. Saadeh, Haythem A.; Mosleh, Ibrahim M.; Mubarak, Mohammad S.Synthesis of Novel

Hybrid Molecules from Precursors With Known Antiparasitic ActivityMolecules 2009, 14,

1483-1494.

16. Karapanagiotis, I.; Mantzouris, D.; Chryssoulakis, Y. Saadeh, H. A.; Alawi, M. A.; Mubarak,

M. S.; Karadag, R.; Yurdun,T.; AlSaad, Z.; Abdel-Kareem,O.; Puchinger, L.; Sauter, F.

Inter-Laboratory Chemical Study of Natural Materials from the Historical Wiesner

Collection. Jor. J. Chem. 2009, 4, 195-207.

17. Saadeh, Haythem A.; Mosleh, Ibrahim M.;El-Abadelah, Mustafa M. New Synthesis and

Antiparasitic Activity of Model 5-Aryl-1-methyl-4-nitroimidazoles. Molecules 2009, 14,

2758-2767.

18. Saadeh, Haythem Ali; Al-Masri, Ahmed T.; Mosleh, Ibrahim M.; Mubarak, Mohammad S.

Synthesis, characterization, and biological activities of new compounds derived from

metronidazole and amino acids and their esters. Abstracts of Papers, 238th ACS National

Meeting, Washington, DC, United States, August 16-20, 2009 (2009).

19. Saadeh, Haythem Ali; Mosleh, Ibrahim M.; Al-Bakri, Amal G.;Mubarak, Mohammad S.

Synthesis and antimicrobial activity of new 1,2,4-triazole-3-thiole metronidazole derivatives.

Monatshefte Fur Chemie2010, 141, 471-478.

20. Samer Al-Gharabli*, Nafisah Al-Rifai, Haythem A. Saadeh, Ibrahim M. Mosleh and Mohammad

S. Mubarak Solid Phase Synthesis and Antiparasitic Activity of a Library of Peptidyl

MetronidazolesJor. J. Chem, 2010, 5(2), 139-147

21. Al-Noaimi, Mousa Z.; El-Khateeb, Mohammad; Haddad, Salim F; Saadeh, Haythem

Synthesis, X-ray structures, spectroscopic and electrochemicalproperties of ruthenium(II)

complexes containing 2,2'-bipyrdine and thiophenylmodified azomethine ligands.

(Submitted).

Patents:

1. Polyaryl azo dye chromophores and their optical use. Saadeh, Haythem; Gharavi, Alireza.

PCT Int. Appl. (2002) WO 2002033005 A2 20020425.

2. Preparation of water-soluble polyimides. Gharavi, Alireza; Saadeh, Haythem U.S. 6894174

(2005).

3. Preparation of metronidazole derivatives as antiparasitic agents. Abu Shairah, Eman Ahmad

Mohammad; Saadeh, Haythem Ali Mohammad; Mosleh, Ibrahim Mousa Ibrahim; Al Arif, Mikidad

Tawfig Ayoub; Mubarak, Mohammad Suleiman. Eur. Pat. Appl. (2009), 19pp.

Ph.D Thesis:

“Design and Synthesis of Novel Materials Exhibiting Large Electrooptic Coefficients”. Saadeh, Haythem Ali. The University of Chicago, USA. (2000), 204 pp.

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