Table 3

Genes up-regulated in p8+/+ liver after LPS

Fold induction

Protein synthesis, transport and modification

proteasome subunit MECL1 (‡)10.1

heat shock protein 862.6

proteasome subunit (lmp7)4.4

ALANYL-TRNA SYNTHETASE2.6

Signaling

JAB5.8

guanine nucleotide dissociation stimulator for a ras-related GTPase6.0

cytoplasmic phosphotyrosine phosphatase4.5

musculus intracellular calcium-binding protein (MRP8)6.0

intracellular calcium-binding protein (MRP14)3.9

GTPase IGTP4.7

ras-GTPase-activating protein SH3-domain binding protein (G3BP)2.0

suppressor of cytokine signalling-2 (SOCS-2)2.5

suppressor of cytokine signalling-3 (SOCS-3)11.1

SERINE/THREONINE PROTEIN KINASE5.2

interferon-inducible protein homologue4.9

ADENOSINE KINASE2.1

TRA14.2

ARF42.3

T-cell specific protein3.8

mothers-against-dpp-related-13.2

myristoylated alanine-rich C-kinase substrate (MARCKS)3.1

Secreted factors

alpha-1 type IV collagen (Col4a-1)3.5

alpha-2 type IV collagen5.7

serum amyloid A protein5.0

plasminogen activator inhibitor (PAI-1)22.7

monokine induced by gamma interferon (MIG)62.3

interferon-gamma inducible protein (mag-1)21.0

spi2 proteinase inhibitor (spi2/eb4)2.0

presenilin-15.9

IFN-gamma induced (Mg11)2.4

B615.0

adrenomedullin precursor2.7

follistatin-like protein2.0

CHYMOTRYPSIN-LIKE PROTEASE CTRL-1 PRECURSOR4.0

PAP homologous protein2.9

collagen a1 XIX chain2.0

fibroblast growth factor2.3

secretory protein containing thrombospondin motifs4.7

endothelial monocyte-activating polypeptide I5.9

fragment for kappa-immunoglobulin4.3

prolactin-like protein G precursor2.5

gamma-casein2.6

alpha-1 acid glycoprotein (Agp-1B)2.7

cryptdin (Defcr)2.2

Cytoskeletal proteins

cytokeratin endo A2.5

endo B cytokeratin2.9

alpha-tubulin isotype M-alpha-14.7

calpactin I light chain (p11)2.8

alpha-tropomyosin slow13.8

Transcriptional factors and RNA processing

X box binding protein-1 (XBP-1)6.2

gut-enriched Kruppel-like factor GKLF3.8

transcription factor junB (junB)11.1

NUCLEAR RNA HELICASE3.1

apurinic/apyrimidinic endonuclease (Apex)2.2

CArG-binding factor-A2.2

growth factor-induced protein (zif/268)2.2

DNA-DAMAGE-REPAIR/TOLERATION PROTEIN DRT111 PRECURSOR2.4

homeobox protein Pitx32.6

transcription factor PBX3b (PBX3b)3.6

DNA polymerase alpha catalytic subunit p1802.5

homeobox protein (cdx 4)2.6

homeobox HOX8.1 (Msx2)3.2

zinc finger protein (Sna)3.5

NFIL3/E4BP4 transcription factor5.3

helix-loop-helix factor HES-13.9

myocyte nuclear factor (MNF)3.3

interferon consensus sequence binding protein2.0

recombination protein RAD52 homolog2.5

WW domain binding protein 52.1

SON PROTEIN2.0

valosin-containing protein2.3

hypoxia-inducible factor 1 alpha (Hif1a)5.9

U2af1-rs22.9

HAM13.6

mATF42.1

interferon regulatory factor 7 (mirf7)4.3

Apoptotic-related proteins

BTG12.1

Membrane and transporters proteins

interleukin-1 receptor8.0

MHC class I Q8/9d cell surface antigen2.0

chemokine rantes (Scya5)10.0

interleukin-4 receptor (secreted form)3.7

MAJOR VAULT PROTEIN12.2

CD63/ME4917.9

mkf-12.6

Glvr-16.4

adipose differentiation related protein (ADFP)2.0

Sca-2 precursor5.6

Lisch76.5

lymphocyte diffentiation antigen CD38 homologue2.4

retinoic acid receptor gamma2.7

sodium-calcium exchanger (NCX1)2.2

chemokine receptor4.5

CGRP-receptor component protein2.0

ATP-sensitive inwardly rectifying K channel2.8

cystic fibrosis transmembrane conductance regulator (CFTR)3.0

ATP receptor (P2u)2.1

Cytosolic enzymes and detoxification factors

transglutaminase (TGase)16.3

UDP-galactose transporter related isozyme 12.1

tumor-induced 32 kD protein (p32) (heme oxygenase)4.3

tryptophan hydroxylase (Tph)4.3

carbonic anhydrase IV5.2

Growth-related proteins

Gadd457.0

p21 (Waf1)4.9

TIS2110.9

cyclin B12.4

‡ Underlined genes are also up-regulated in liver from p8-/- mice

Table 4

Genes down-regulated in p8+/+ liver after LPS

Fold repression

Protein synthesis, transport and modification

heat shock protein 105 kDa alpha2.1

zeta-crystallin6.7

mannosyl-oligosaccharide alpha-1,2-mannosidase2.3

co-chaperonin cofactor A2.1

chaperonin 102.7

delta proteasome subunit2.2

alpha-D-mannosidase (Man2b1)9.0

26S proteasome subunit 4 ATPase2.1

translation initiation factor (Eif4g2)2.3

beta proteasome subunit (Lmp3)2.5

ribosomal protein S26 (RPS26)2.5

ribosomal protein L8 (RPL8)2.2

heat shock 70 protein (Hsc70)2.6

ribosomal protein S52.7

ribosomal protein L214.1

t-complex polypeptide 1A (Tcp-1a)2.5

eps152.7

SKD1 protein2.8

maternal-embryonic 3 (Mem3)4.3

heat-responsive protein (HRP12)2.8

PHAS-II3.1

L23 mitochondrial-related protein (L23mrp)7.7

MITOCHONDRIAL 60S RIBOSOMAL PROTEIN L32.8

Signaling

antioxidant protein 2 (AOP2) (†)4.1

Selenium-binding liver protein5.1

Wnt-5b2.2

house-keeping protein2.4

Max interacting protein 1 alternatively spliced long form (Mxi1)3.4

mSTI13.0

senescence marker protein-30 (SMP30)6.9

38 kDa Mov34 isologue4.4

BS4 peptide4.1

manic fringe precursor7.4

beta1-syntrophin (SNTB1)3.7

SERINE/THREONINE PROTEIN KINASE2.8

epidermal growth factor receptor-binding protein12.7

guanine nucleotide exchange factor delta subunit (JGR1)3.5

retinoid X receptor interacting protein (RIP14-1No.6)6.8

glycosyl-phosphatidyl-inositol-anchored protein homolog8.6

adenylyl cyclase type 95.3

MAP kinase kinase 6c3.0

phosphatidylethanolamine binding protein2.0

selenophosphate synthetase 26.1

SH2 containing inositol-5-phosphatase (Ship)8.4

protein phosphatase 1cgamma (PP1cgamma)3.5

putative SH3-containing protein SH3P122.5

SH3-containing protein SH3P22.7

protein phosphatase 2A Balpha3 regulatory subunit5.8

protein kinase C inhibitor (mPKCI)3.4

FK506-binding protein 25 homolog (mFKBP25)3.0

MEK kinase 4a (MEKK4a)6.1

protein phosphatase 1 binding protein PTG7.9

retinally abundant regulator of G-protein signaling mRGS-r (RGS-r)2.6

eph-related receptor tyrosine kinase (Mek4)2.1

Dgcr6 protein (Dgcr6)5.3

HS-1-associating protein HAX-1L (mHAX-1s)2.0

lefty gene.5.2

Secreted factors

heparin cofactor II precursor (HCII)6.7

D-dopachrome tautomerase (Ddt)2.0

serine protease hepsin2.0

monoglyceride lipase5.4

Zn-alpha2-glycoprotein2.3

IGIF precursor polypeptide3.1

cystatin C3.7

prolidase (pep4)7.0

coagulation factor VIII2.7

complement factor H-related protein4.2

complement component C5S (pro-C5)2.1

plasma kallikrein (PK)6.7

C10-like chemokine10.4

complement factor I2.5

coagulation factor VII4.3

murinoglobulin (MUG3)2.0

Cytoskeletal proteins

fibroglycan (syndecan-2)3.0

p116Rip2.1

beta III spectrin (Spnb3)5.6

ALPHA-ACTININ 1, CYTOSKELETAL ISOFORM2.4

fast fiber troponin I3.8

neural cadherin (N-cadherin)3.1

desmocollin type 2 (DSC2)4.1

Transcriptional factors and RNA processing

BAP-135 homolog (Diws1t)5.2

zinc finger protein (Zfx)2.0

Rep-3 protein2.1

deleted in split hand/split foot 1 homolog (Dss1)2.4

Supt4h2.3

CCR4 protein4.6

NNP-1 (NNP-1)5.7

embryonic ectoderm development protein (eed)2.6

RecA-like protein (mREC2)4.3

orphan nuclear hormone receptor isoform mCAR221.7

homeobox containing protein (Hox-B3 [2.7])6.8

orphan nuclear receptor RVR2.7

adenine nucleotide translocase-2 (Ant2)2.7

albumin gene D-Box binding protein6.2

muscle-specific transcriptional activator alpha-NAC gp220 (Naca)2.7

zinc finger protein (Zfp64)2.9

11-zinc-finger transcription factor (CTCF)4.4

telomerase protein-12.8

nuclear receptor co-repressor2.4

DNA binding protein NFI-B (NfiB)3.2

Apoptotic-related proteins

bcl-2 binding protein BAG-14.5

EAT/MCL-12.5

TDAG51 (TDAG51)8.0

PS-2short8.5

defender against death 1 protein (DAD1)2.6

Membrane and transporters proteins

multidrug resistance protein18.2

microsomal triglyceride transfer protein3.2

asialoglycoprotein receptor (MHL-1)10.9

NPC1 (Npc1)2.4

retinol binding protein (RBP)2.3

peroxisomal PTS2 receptor3.9

CD13/aminopeptidase N3.9

plasma membrane protein syntaxin-42.3

IL-6 receptor11.9

liver-type glucose transporter protein30.2

FATTY ACID-BINDING PROTEIN2.1

serotonin transporter2.2

Fc receptor2.8

neuropeptide Y-Y1 receptor3.1

plasma-cell membrane glycoprotein PC-13.4

receptor for advanced glycosylation end products (RAGE)9.4

parathyroid hormone/parathyroid hormone related-peptide receptor (PTHR)3.7

high affinity IgG receptor (Fc-gammaRI)3.7

erythrocyte membrane protein band 4.2 (mur42)2.1

polymeric immunoglobulin receptor2.8

mannose-binding protein C (Mbl2)3.0

scavenger receptor class B type I (mSR-BI)2.6

transmembrane transporter (Lx1)21.3

putative transmembrane receptor (frizzled 4)3.5

aquaporin-4 (Aqp4)2.3

Kupffer cell receptor3.3

reduced folate carrier (RFC1)5.3

peroxisome membrane protein PEX24.8

L6 antigen3.0

Fabpi2.8

TR2 (mTR2)2.4

Cytosolic enzymes and detoxification factors

GLYCINE DEHYDROGENASE3.9

carnitine acetyltransferase2.3

TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE2.4

amine N-sulfotransferase (SULT-N)3.3

sulfotransferase-related protein (SULT-X2)7.8

alanine:glyoxylate aminotransferase (Agxt1)20.4

very-long-chain acyl-CoA synthetase (VLCS)3.0

4-hydroxyphenylpyruvate dioxygenase2.1

estradiol 17-beta-dehydrogenase (A-specific)6.5

catalase3.6

hydroxysteroid sulfotransferase (mSTa2)4.0

branched chain alpha ketoacid decarboxylase E1a subunit2.1

ornithine transcarbamylase2.0

adh-1 gene encoding alcohol dehydrogenase (ADH)5.4

malate dehydrogenase2.2

aldehyde dehydrogenase II3.3

fumarylacetoacetate hydrolase (Fah)3.2

alcohol dehydrogenase-B2 (Adh-2)2.3

thioether S-methyltransferase40.3

glucose-6-phosphatase10.8

sorbitol dehydrogenase precursor16.0

homogentisate 1,2-dioxygenase (HGO)19.0

flavin-containing monooxygenase 330.5

flavin-containing monooxygenase 1 (FMO1)13.7

flavin-containing monooxygenase 5 (FMO5)9.2

cytochrome P-4504.4

cytochrome P450 monooxygenase (CYP2J5)6.9

adrenodoxin3.1

glutathione synthetase type A12.0

AGT2 PRECURSOR (alanine-glyoxylate aminotransferase 2)3.6

housekeeping-type protein (MER5)2.6

paraoxonase (Pon)3.4

rhodanese (Tst)2.5

ancient ubiquitous 46 kDa protein AUP1 precursor (Aup1) CDP-diacylglycerol synthase3.9

DIHYDROPTERIDINE REDUCTASE3.6

CHLORDECONE REDUCTASE3.3

GLYCINE CLEAVAGE SYSTEM H PROTEIN PRECURSOR5.4

A-GLUCOSIDASE I4.6

GALACTOKINASE2.5

putative lysophosphatidic acid acyltransferase4.8

testosterone 15-alpha-hydroxylase mRNA type I3.3

glutathione S-transferase class mu (GST5-5)6.7

ferrochelatase3.0

adenylosuccinate synthetase2.6

cathepsin H prepropeptide (ctsH)2.6

uroporphyrinogen III synthase6.8

glutaryl-CoA dehydrogenase3.3

phosphatidylethanolamine-N-methyltransferase 22.6

adenosine kinase3.9

uroporphyrinogen decarboxylase5.3

galactose-1-phosphate uridyltransferase (GALT)5.4

liver glutathione transferase theta class type 219.1

type 1 deiodinase (DIO1)2.9

isocitrate dehydrogenase4.1

liver arginase2.2

ornithine decarboxylase antizyme3.1

carbonic anhydrase III (CAIII)3.3

transaldolase5.8

dihydrolipoamide dehydrogenase (Dld)4.7

sepiapterin reductase4.7

glutathione-S-transferase3.1

glutamate-cysteine ligase catalytic subunit (GLCLC)5.3

preprodipeptidyl peptidase I5.5

NAD(+) ADP-RIBOSYLTRANSFERASE4.0

SUCCINYL-COA LIGASE2.1

2,4-DIENOYL-3-hydroxyacyl CoA dehydrogenase3.0

pyruvate dehydrogenase (pdha-1)4.9

cytochrome P-450 naphthalene hydroxylase4.7

medium-chain acyl-CoA dehydrogenase2.7

long-chain acyl-CoA dehydrogenase2.2

voltage dependent anion channel 23.2

3-hydroxy-3-methylglutaryl-CoA lyase (Hmgcl)2.5

COA REDUCTASE2.9

cytochrome P450 monooxygenase (CYP2J6)4.2

mitochondrial transcription factor A2.2

mitochondrial ATP synthase coupling factor 62.8

Thioredoxin12.3

alpha-methylacyl-CoA racemase3.5

cytochrome c oxidase subunit VIII-H precursor (COX8H)2.8

Growth-related proteins

retinoblastoma-related protein Rb2/p1304.9

p53 responsive (EI24)5.0

growth-arrest-specific (gas2) protein2.0

retinoblastoma-binding protein (mRbAp48)2.6

elav G homolog (MelG)2.9

Csa-192.0

oligodendrocyte-specific protein2.3

Max interacting protein 1 alternatively spliced long form (Mxi1)2.2

p1072.0

Evi-52.6

t-BOP (Bop)6.3

mutated in multiple advanced cancers protein (MMAC1)2.3

acid labile subunit (ALS)6.3

CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 22.0

hepatoma-derived growth factor3.8

fibroblast growth factor2.1

Cdk-inhibitor p57KIP2 (KIP2)3.6

† Underlined genes are also down-regulated in liver from p8-/- mice