9 June 2014 Page 1

SYLLABUS

GENERAL VIROLOGY - MULTIPLICATION OF VlRUSES

Bacteriology/Oncology/Plant Pathology 640

FALL SEMESTER, 2014

1:20 pm Mon, Wed, Fri, Room 125 McArdle Laboratory

Paul Ahlquist841A Bock Labs; Tel: 263-5916; Email:

ProfessorOffice hours: Monday and Wednesday 2:10-3:00 PM

Robert Kalejta641A Bock Labs; Tel: 265-5546; Email:

ProfessorOffice hours: Monday and Wednesday 2:10-3:00 PM

Nathan Sherer501A Bock Labs; Tel: 890-2551; Email:

Asst. Professor Office hours: Monday and Wednesday 2:10-3:00 PM

Bieneke Bron227-7 Hanson Labs; Tel:890-0480; Email:

Discussion LeaderOffice hrs after class or by arrangement. Exam review sessions will be arranged.

DATETOPIC

(Sessions in regular type are led by Ahlquist, in italics by Kalejta; in bold by Sherer; others as indicated)

MonSept1-Labor Day-

WedSept3Course Introduction / Why and how we study viruses

FriSept5Viruses in the real world: Ebola

MonSept8Ebola discussion (Sherer) / Icosahedral virion structure

WedSept 10dsRNA viruses

FriSept 12dsRNA viruses

MonSept 15Picornaviruses

WedSept 17Picornaviruses

FriSept 19Alphaviruses

MonSept 22Alphaviruses

WedSept 24Coronaviruses (SARS, MERS, etc.)

FriSept 26Exam 1 (100 pts)

MonSept 29Papillomavirus

WedOct1Papillomavirus/Adenovirus

FriOct3Adenovirus

MonOct6Herpesviruses

WedOct8Herpesviruses

FriOct 10Herpesviruses

MonOct 13Retroviruses/HIV

WedOct15Retroviruses/HIV

FriOct17Retroviruses/HIV

MonOct20Retroviruses/HIV

WedOct22Exam 2 (100 pts)

DATETOPIC

FriOct 24Rhabdoviruses

MonOct27Rhabdoviruses

WedOct29Filoviruses

FriOct 31Orthomyxoviruses

MonNov 3Orthomyxoviruses

WedNov 5Orthomyxoviruses

FriNov 7Pandemic flu preparations

MonNov 10Plant viruses - initiation and spread of infection

Wed Nov 12Plant (& invertebrate) resistance responses: RNAi

FriNov 14Plant resistance responses: relation to animal innate immunity

MonNov 17Genetic variability in viruses

WedNov 19Exam 3 (100 pts)

FriNov 21Antiviral Drugs

MonNov 24Intrinsic immunity

WedNov 26Intrinsic immunity

Fri Nov 28- Thanksgiving recess, no class -

MonDec 1Innate immunity

Wed Dec 3Innate immunity
FriDec5Adaptive immunity

MonDec 8Vaccines(Bieneke Bron)

WedDec 10Poxviruses(Bieneke Bron)

FriDec 12Emerging viruses

FriDec 19Comprehensive Final Exam (150 points)

7:45 AM – 9:45 AM

125 McArdle

[The final covers the last 9 lectures (~75 pts)

plus comprehensive questions on earlier material (~75 pts).]

Suggested Texts and References

Principles of Virology: Molecular Biology, Pathogenesis, and Control (Third Edition, 2009)

Flint, S. J., Enquist, L. W., Racaniello, V. R. & Skalka, A. M. ASM Press.

Fields Virology (Fifth Edition, 2007)

Knipe, D. and P. Howley (editors). Lippincott, Williams and Wilkins.

Selected Websites

"All the Virology on the WWW"

Universal Virus Database of the International Committee on Taxonomy of Viruses

NCBI Viral Genomes Resource

Virus World - Structures and Images (UW-Madison Institute for Molecular Virology)

Grading

  • Grading is based on exam performance.
  • There are three hour exams (100 points each) plus a comprehensive final exam (150 points) for a total of 450 points.
  • Separate curves are used for graduate and undergraduate students.
  • Examples of prior year exams can be found on the course website. To access this, log on to the MyUW portal at and click on your academic tab. In the list for current courses, this course should contain a link for "library/reserve."

Sample Distribution of Test Scores and Letter Grades in Previous Years

The following grades and scores are listed for illustration only and do not necessarily reflect how grades will be given this year.

Year / % of total course points required for indicated grade
A / AB / B / BC / C / D
Graduate / 2013 / 89 / 85 / 75 / 65
2012 / 85 / 82 / 72 / 63 / 56
2011 / 87 / 82 / 72 / 65
2010 / 86 / 81 / 72
2009 / 83 / 80 / 70 / 65 / 56
2008 / 86 / 83 / 70 / 63 / 55 / 43
2007 / 84 / 81 / 70
2006 / 82 / 78 / 68
2005 / 83 / 79 / 68 / 63 / 55
Undergrad / 2013 / 85 / 81 / 70 / 63 / 55
2012 / 82 / 76 / 66 / 60 / 52
2011 / 82 / 75 / 67 / 60
2010 / 81 / 76 / 67 / 60 / 50 / 45
2009 / 80 / 75 / 66 / 60 / 53 / 45
2008 / 84 / 80 / 67
2007 / 82 / 78 / 67 / 57
2006 / 79 / 75 / 65 / 50 / 40
2005 / 81 / 65 / 56
Number of students with indicated grade
A / AB / B / BC / C / D
Graduate / 2013 / 10 / 4 / 5 / 1
2012 / 7 / 4 / 10 / 1 / 1
2011 / 5 / 8 / 18 / 3
2010 / 6 / 7 / 3
2009 / 14 / 2 / 11 / 5 / 1
2008 / 13 / 5 / 15 / 3 / 2 / 1
2007 / 6 / 2 / 8 / 1
2006 / 5 / 2 / 6
2005 / 14 / 5 / 12 / 2
Undergrad / 2013 / 2 / 4 / 5 / 4 / 5
2012 / 4 / 5 / 9 / 3 / 3
2011 / 5 / 4 / 3 / 2
2010 / 7 / 1 / 6 / 2 / 2 / 2
2009 / 5 / 4 / 3 / 2 / 1
2008 / 2 / 1 / 5
2007 / 5 / 3 / 6 / 2
2006 / 6 / 2 / 5 / 5 / 1
2005 / 4 / 4 / 2