GENERAL INFORMATION ON INTRAVENOUS ILOPROST
Patient information sheet
You may benefit from being treated with a drug called iloprost. This leaflet gives some information about the drug, how it works, and the possible side effects.
What is iloprost?
Iloprost has been shown to have some of the same properties as a naturally occurring chemical produced in your body, called prostacycline. This chemical is found in most tissues in your body.
How does it work?
The main actions of iloprost are as follows:
§ Reduces clumping of the small cells in the blood and therefore reduces clotting
§ Reduces the number of destructive cells collecting in damaged blood vessels
§ Helps to dissolve clots
§ Helps arteries and veins carry more blood to all areas of your body
§ These actions combine to improve the body’s circulation of blood.
How can iloprost help patients with circulation problems?
Because of its effects on the body described above, iloprost may have some helpful effects if given to patients with circulation problems. These patients fall into two main groups:
§ Those with narrowing or blockage of the blood vessels due to thickening and roughening of their lining (known as atherosclerosis)
§ Patients with narrowed blood vessels due to inflammation or spasm in the vessels.
Possible side effects:
§ Facial flushing
§ Headaches
§ Lowering blood pressure causing temporary light-headedness
§ Sickness, vomiting or abdominal cramps
§ Diarrhoea
This treatment has been used for some years with no long-term side effects.
If you are taking a calcium channel blocker (e.g. Nifedipine, Amlodipine, Diltiazem – if unsure check with the Rheumatology Department or your GP practice), then it will need to be stopped 48 hours before your first Iloprost infusion.
During the infusion your pulse and blood pressure will be checked and if side effects occur then the amount of iloprost will be reduced
Iloprost is given by intravenous infusion (directly into a vein) for 6 hours a day over a five-day period. You should not need to stay overnight in hospital.
General enquiries: 01592 648193Updated April 2010 Version 1 due for review April 2011