From:Dr. Haidar Ali,

Preliminary M.S. (Ay) Scholar,

Department of Post-Graduate studies in Shalya-Tantra,

N.K.J Ayurvedic Medical College &Research Centre,

Gumpa, Bidar-585403.

To,

The Registrar,

Rajiv Gandhi University of Health Sciences,

Bangalore, Karnataka.

Through,

The Principal,

N.K.J Ayurvedic Medical College & Research Centre,

Gumpa, Bidar-585403.

Sub: Submission of Completed Proforma for Registration of Synopsis for Dissertation.

Respected Sir,

I request you to kindly register the below mentioned subject against my name for the submission of dissertation to Rajiv Gandhi University of Health Sciences Bangalore, for the partial fulfillment of M.S. (Ay) in Shalya-Tantra.

TITLE OF DISSERTATION:

“THE EFFICACY OF HARIDRA GUDA YOGAIN THE

MANAGEMENT OF MOOTRASHMARI”

Herewith, I am enclosing completed proforma for registration of subject for dissertation.

Thanking you,

Yours sincerely,

Date :

Place : Bidar (Dr. Haidar Ali)

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,

KARNATAKA, BANGALORE

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

  1. NAME OF CANDIDATE :-DR. HAIDAR ALI

& ADDRESSS/O MD. ZEAUDDIN

BHAWANI PUR ZIRAT MOTIHARI EASTCHAMPARAN (BIHAR) – 845401

  1. NAME OF INSTITUTION:- N.K.J.AYURVEDIC MEDICAL COLLEGE &P.G CENTER, BIDAR (KARNATAKA).
  1. COURSE OF STUDY & :-AYURVEDA

SUBJECT M.S(SHALYA-TANTRA).

  1. DATE OF ADMISSION:-28/10/2010
  1. TITLE OF TOPIC:-

“THE EFFICACY OF HARIDRA GUDA YOGAIN THE

MANAGEMENT OF MOOTRASHMARI”

  1. BRIEF RESUME OF THE INTENDED WORK.

A calculus is a stone like substance composed of urinary salts bound together by a colloid matrix of organic material. It consists of a nucleus around which concentric layers of urinary salts are deposited[1].

The process of stone formation is called Urolithiasis. Most calculi arise in the kidney when urine becomes supersaturated with a salt that is capable of forming solid crystals.

According to Sushruta, [2]

The improper purificatory procedure results in residual accumulation of Kapha and Pittaprakopa in mutravahasrotas. Hence all the three doshas collectively result inAshmari formation. However Kapha is considered to be predominant dosha and considered as upadanakarana of the disease. Sushruta also considered apathya is important factor for the cause of disease.

According to AshtangaHridaya

Vegavarodhai.emootravarodha is an important factor in the formation of AshmariRoga.[3]

There are so many compounds described in our ancient text,amongst which HaridraGuda Yoga is a safe and effective with its hypothetic support. The drugs havingLekhana, Mootravirajaniya, Shothahara,Vedanasthapana,Raktastambhaka,Bastishodhaka, Mootrashodhaka,Mutrala etc actions, by which it can curethis disease (Ashmari). Hence, thisdrugstudy will be proposed.

6.1 NEED FOR THE STUDY:

Various management of mootrashmari has been developed in modern system.But inspite of all these techniques, Surgery remainsthe treatment of choice. But recurrence & complication are seen in the majority of cases and surgery is also not affordable every time to average Indian patients. So there is a need to find out an alternative, cost effective, and easily available conservative management. The present treatment is inexpensive, requires no hospitalization, medicine is palatable and mode of administration is also simple. The ingredients are easily available and preparation is also simple. Hence it has taken for study.

6.2 REVIEW OF LITERATURE :

The Haridra-guda is selected from “RasaratnaSamuchchaya” for the management of Mootrashmari.

“WûËUSìÉaÉÑQûMüwÉæMÇücÉÉUlÉÉsÉålÉuÉÉÌmÉoÉåiÉç||”

(UxÉU¦ÉxÉqÉÑŠrÉ .17/15)

1)Ashmari is grave disease, simulating death. It is manageable with drugs when it is of recent onset but when greatly developed, it requires surgical operation. [4],[5]

2)When the aggravated vayu dries up the semen, urine, pitta & kapha located in the urinary bladder, then gradually the stones are formed there; as gorochana is formed in bile inside the gall bladder of the cattle.[6] C.CH.26/36

3)When the Vayu covers the mouth of the bladder, associating with pitta,kapha or shukra and dries up the urine, then stones get formed slowly. Just as the formation of pebbles of gall from the bile in the cow or like sludge even in clean water kept in a mud pot; all of these are supported by kapha.[7]A.S.Ni. 9/6

4)Kulattha drug reference has been taken from Bhavaprakashanighantu 9/60p.no.651[8].

PREVIOUS WORKS

  1. ManjuRane – Role of Varunakaguda in the management of Mootrashmari (Urolithiasis) & assessment with imaging techniques, 2004, Rajiv Gandhi Govt. PG institute of Ayurveda, Himachal University, Shimla, Paprola.
  2. Devadiga K Uday – Effect of Virataravadi Compound in Mootrashmari with special reference to its aetiopathogenesis, 1989- Jamnagar institute for P.G Teaching and research in Ayurveda, Gujarat Ayurveda University, Jamnagar.
  3. ParulChauhan – To evaluate the efficacy of Paneeyakshara in the management of Mootrashmari, a clinical comparative study, 2005. AshwiniAyurvedic Medical College, Davangiri, RGUHS, Bangalore, Karnataka.

6.3 OBJECTIVES OF THE STUDY:

  1. To assess the efficacy of Haridra-guda yoga onMootrashmari.

7 MATERIALS AND METHODS :-

7.1 SOURCES OF DATA

1)Patients will be selected from OPD and IPD of ShalyaTantra department of Sri Siddharoodha Charitable Hospital, attached to N.K.J. Ayurvedic Medical College & PG centre Bidar Karnataka and other associated hospitals .

2)Literary data from Samhitas,modern books of surgeries and medicines.

3)International & National Medical & Surgical Journals, Magazines, digital library and web sites

4)The drugs will be collected from the market with the supervision of Dravya-guna specialist and willbe prepared as per the classicalreferences in the pharmacy attached to the college under the guidance of Rasa shastra and Bhaishajyakalpana specialist.

MATERIALS

Haridra(powder), Guda(Old), kanji (anupana),Kulatthachurna, lukewarm water(anupana) etc.

7.2 METHOD OF COLLECTION OF DATA : Including sampling procedure, (if any)

It is single blind study in which 30 patients will be selected randomly on the basis of clinical presentation and after radiological establishment of the diagnosis and the patients will be registered accordingly to the proforma irrespective of their sex, occupation and socio-economic status & will be divided into two equal groups.

Group-1- Trail Group

15 patients will be administered with Haridragudayoga -1karsha(1/2karshaHaridra powder+1/2karsha old Guda in a mixed form ) daily in divided doses with kanji as anupanabefore food.

Group -2-Control Group

15 patients will be given 5gm of Kulatthachurna,withlukewarmwater as anupanatwice daily before food.

The total duration of the treatment will be 45 days. The assessment will be done on 15th, 30th & 45thdays. Theprogress will be noted in specially prepared case sheet as per the assessment parameters. All the collected data will be evaluated statistically as follows-

STATISTICAL DESIGN

BT1 Vs AT1 / Will be assessed / AT1 Vs AT2 / will be assessed & evaluated by “t” test
BT2 Vs AT2

SELECTION CRITERIA

INCLUSION CRITERIA

Age group between 16-60 years

Size of the calculi up to 3-8mm

Irrespective of site of calculi lodging in the urinary tract

Mild hydronephrosis can be included for the study

EXCLUSION CRITERIA:-.

Calculus with severe hydronephrosis

Obstructive calculi with severe infection

Calculi with severe systemic disorder like Diabetes, Hypertension etc .. .

A. Subjective criteria

Pain abdomen

Haematuria

Dysuria

B. Objective Criteria

Size of stone

Site of stone

Dislodgement of the stone

7.3 INVESTIGATION REQUIRED:

  1. C.B.P
  2. Blood urea
  3. Serum creatinine
  4. Urine microscopic examination and pH of urine.
  5. X-Ray KUB or USG of abdomen and pelvis.
  6. IVP (If necessary)

7.4 HASEthicalCLEARANCE BEEN OBTAINED FROM YOUR INSTITUTION

Yes, obtained.

8. LIST OF REFERENCES:-

[1] S.Das, A Concise text book of surgery, S.Das, 13, Old Mayors Court, Calcutta 3rd

Edition, 1165pp.

[2] ShastriKavirajAmbikaDutta. SushrutaSamhita, Varanasi: Chaukhambha Sanskrit Sansthan Publishers, 1993, 240pp.

[3] PunyashlokShriPanditVaidyaLalchandraShastri. AshtangaHridaya (SarvangasundarVyakhyasahit). Delhi, MothilalBanarasidas publishers, Privata limited. 1990

[4] PunjashlokShriPanditVaidyaLalchandraShastri. AshtangaHridaya (SarvangasundarVyakhyashit). Delhi MothilalBanarasidas Publishers, Private limited, 1990.

[5] ShastrikavirajAmbikaDutta. SushrutaSamhita, Varanasi: Chaukhambha Sanskrit Sansthan publishers, 1993, 240pp.

[6] Dr. TripathyBrahmanandCharakaSamhita. ChoukhambaSurbhartiPrakasan. Varanasi. 1999. p.p. 870.

[7] Prof. Murthy SrikanthAshtangaSangraha. ChoukhambaOrientalia. Varanasi. 2005.p.p199

[8]Sri B.S.Mishra.BhavaprakasanighantuChaukhambha Sanskrit Sansthan publishers,11th edition 2004.pp650

9. SIGNATURE OF THE CANDIDATE:

10. REMARKS OF THE GUIDE:

11. NAME & DESIGNATION OF:

11.1 GUIDE:DR. B.N.Murthy, M.D.

PROF. & HEAD,

P.G. DEPT. OF SHALYA TANTRA.

11.2 SIGNATURE:

11.3 CO-GUIDE: Dr. ChandrakantHalli

ASST. PROF

P.G.DEPT. OF SHALYA TANTRA

11.4 SIGNATURE:

11.5 HEAD OF DEPARTMENT: Dr.B.N.Murthy, MD

PROF. & HEAD

P.G. DEPT. OF SHALYA TANTRA.

11.6 SIGNATURE:

12.

12.1 REMARKS OF THE CHAIRMAN:

& PRINCIPAL

12.2 SIGNATURE:

1