Department of Anesthesiology and Intensive Care Medicine

University Hospital of Besancon

University of Franche Comte

3 Bvd Fleming, F-25000 Besancon, France

Head of Department

Prof Emmanuel Samain, MD, PhD

Prof Mateo Bassetti, Section Eidtor

Intensive Care Medicine Editorial Office

Besancon, March the 28th, 2015

Ref: iCME-D-14-01526R2

Dear Editor,

On behalf of my co-authors, I enclose a revised version of the manuscript entitled: “Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization”, by Ferreira et al., that we submitted for possible publication as an original article in the “Intensive Care Medicine” journal.

We have taken into account in the revised version the comments of the Reviewers, and answered to their question in the point to point response enclosed.

Please, address correspondence to:

Prof Sebastien Pili-Floury, MD, PhD,

Department of Anaesthesiology and Intensive Care Medicine,

University Hospital of Besancon, University of Franche-Comte,

3 Bvd Fleming,

F-25000 Besançon, France

Tel: 33 3 81 82 85 94

Fax:33 3 81 66 90 14

e-mail:

We hope that you will find the revised version suitable for publication and we are looking forward hearing from you soon,

With best regards,

Sebastien Pili-Floury, M.D., PhD.

Secretary: Prof Emmanuel SAMAIN, DAR, Jean Minjoz Universitary Hospital , Boulevard Fleming,

25030 Besançon Cedex

Tel: 33 3 81 66 85 79 Fax: 33 3 81 66 90 14 e-mail: