CURRICULUM VITAE
Professor Dr Fazal Subhan
Department of Pharmacy,
University of Peshawar,
Peshawar, N.W.F.P.
Pakistan.
Office: 091-9216750
Residence: 092-5610876
: 03018805966
@:
Research Interests:Prof. Dr Fazal Subhan and his research group is actively involved on testing compounds from both synthetic and natural origin for their utility in pain, inflammation, pyrexia, depression, anxiety, dependence, tolerance, and vomiting. Research in his laboratories is also conducted in the area of neuropathy where the pathological condition is induced in a rat and mice models. The pain models of allodynia and vulvodynia induced by diabetes, chemotherapeutic agents or surgical procedures are well established and the compounds of interest are evaluated for their effectiveness in neuropathic pain conditions with the help of von Frey hairs and other algesiometric techniques. Research is also in progress both at the preclinical and clinical levels for testing newly developed antipsychotic formulations in comparison to the conventional formulations for their safety and therapeutic efficacy. His research group is also working on natural products against chemotherapeutic drugs induced vomiting and opioid withdrawal syndrome. Biochemical and neurotransmitters studies are conducted for correlating behavioral findings and elucidation of mechanism of action of compounds of interest.
Currently, two projects titled "Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain" and "Novel targeted heterocyclic compound(s) beta hydroxy ketone derivative-Potential candidates for Alzheimer's disease" granted by Higher Education Commission (HEC) of Pakistan under NRPU scheme are in progress.
Research facilities:
Prof Subhan has established state of the art experimental research facilities at the department of Pharmacy, University of Peshawar where research students can work and learn in friendly environment. These research facilities include:
· Animal house having breeding and keeping facilities for rats, mice, pigeons, rabbits and guinea pigs.
· Behavioral laboratory equipped with computer assisted video recording facility for experiments on live animals such as analgesia, anti-inflammatory, antipyretic, anti-emetic, locomotor, anxiolytic and antidepressant activities.
· Toxicological laboratory with facility of tissue embedding and staining, microtome for tissue slicing and a microscope attached with digital camera for histopathological examination of tissue slides.
· Applied Pharmacology laboratory with facilities of -80 oC fridge, tissue homogenizers for processing tissue, temperature controlled centrifuge, HPLC with UV and ECD detectors. ESA, Electrochemical Detector is equipped with high sensitivity analytical cell and guard cell for measurement of minute quantities of neurotransmitters and other biomarkers in biological fluids including different brain areas of interest.
· Universal organ bath, Oscillograph and chart recorders for performing experiments on isolated tissues.
Education:
Institute / Degree / Period / Subject of StudyWelsh School of Pharmacy,
Cardiff University of Wales, UK. / Ph.D. / 1996-2000. / Pharmacy
(Pharmacology)
Faculty of Pharmacy,
University of the Punjab, Lahore, Pakistan. / M.Phil. / 1991-1992. / Pharmacy
(Pharmacology)
Faculty of Pharmacy,
University of the Punjab, Lahore, Pakistan. / M.Pharmacy / 1984-1985. / Pharmacy
(Pharmacology)
Faculty of Pharmacy,
Gomal university, D.I.Khan,
Pakistan. / B-Pharmacy / 1980-1984. / Pharmacy
Special training:
· Successfully completed courses related to animal handling and experimentation (Module 1, 2, 3 and 4) organised by the institute of Biology, University of Wales, Cardiff, UK.
· Personal animal licence holder authorised to perform experiments on standard laboratory animals including Rats, Mice, Guinea pigs and Rabbits in UK.
Teaching Experience:
Employer / Position / Duration / Job descriptionDepartment of Pharmacy, University of Peshawar, Pakistan. / Professor / March 21, 2009 to-date / Professor
Teaching and research
Department of Pharmacy, University of Peshawar, Pakistan. / Associate Professor / June 30, 2003 March 20, 2009. / Teaching and research in the field of Pharmacy
Department of Pharmacy, University of Peshawar, Pakistan. / Lecturer / Oct 8, 1987 to June 29, 2003. / Teaching and research in the field of Pharmacy
Faculty of Pharmacy,
Gomal University, D.I.Khan. / Lecturer / Oct 1, 1986 to Oct 7, 1987. / Teaching the subjects of Pharmacy.
Administrative Experience:
· Successfully completed three years term as chairman of Department of Pharmacy University of Peshawar- (27-08-2008 to 26-08-2011)
Distinctions/ Memberships:
· First Class First Position in Master of Pharmacy.
· COT Scholarship for Ph.D. studies abroad.
· Overseas Research Scholarship (ORS) award for the Year 1997&98 (U.K Higher Education Research Award for Overseas Students).
· Higher Education Commission (HEC) of Pakistan recognised supervisor in the field of Pharmacy/Pharmacology
· Member of the drug court.(2004-2015)
· Member of the National Pharmacy Curriculum Committee.
· Member of Ethical committee of Department of Pharmacy, UoP.
· Member of GSC Department of Pharmacy, UoP.
· Member of GSC department of Zoology, UoP
Presentation in International Conferences During Ph.D. Studies:
British Pharmaceutical Conference held in September 1999 at Cardiff, UK.
British Pharmaceutical Conference held in September 1998 at Eastbourn, UK.
BAP/CCNP Conference held in July 1997 at Cambridge, UK.
Teaching Experience:
· Teaching the subject of pharmacology to pharmacy students.
· Supervising and teaching to M.Phil./Ph.D. scholars in field of pharmacy (Pharmacology).
Research Projects Completed/In-progress:
1. Pharmacological investigation on some indigenous plants/ Hypericum perforatum, potentially useful for depression, pain and addiction (completed).
2. Studies on selective serotonin reuptake inhibitor (SSRI) fluoxetine in the management of opioid (heroin) dependence and analgesia (completed).
3. Biopharmaceutical profile of risperidone (completed)
4. Effect of fasting on serum lithium in preclinical and clinical models (completed)
5. Effect of Bacopa monnieri on morphine dependence and tolerance to analgesia in animal models (completed).
6. Evaluation of some selected medicinal plants and their combinations in cisplatin induced vomiting in vomit model(s); behavioral neurochemical correlates (completed).
7. Effects of selected medicinal plants combination on hypertension, dyslipidemia and depression (in progress).
8. Evaluation of antidepressants on bacterial resistance to antibiotics.(completed)
9. Development and comparative clinical safety and effectiveness evaluation of controlled release tablets vs. conventional tablets of olanzapine & prochlorperazine (completed)
10. Preclinical evaluation of selected synthetic bioisosteric nitrogen containing salicyl alcohol derivatives in inflammation, ulcergeninicity and pain modalities (completed).
11. Hepatotoxicity and nephrotoxicity of morphine and illicit street heroin and its amelioration by extract of Bacopa monniera (completed).
12. Comparative evaluation of selected antioxidants and their combination in cisplatin induced vomiting in pigeons (completed).
13. Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain. (awarded under NRPU)
14. Novel targeted heterocyclic compound(s) beta hydroxy ketone derivative-Potential candidates for Alzheimer's disease.
National Research Collaborations:
· Professor Nazar Ul Islam, Sarhad University of Science and Technology, KPK, Peshawar.
· Professor Dr Syed Muhammad Sultan, Head of psychiatry department, Khyber teaching hospital, Peshawar.
· Professor Jawad Ahmed, Institute of Basic Medical sciences,Khyber Medical University, Peshawar, KPK.
· Professor Anwar-ul-Hassan Gilani, Pakistan Council for Science and Technology and Aga Khan University, Karachi, Sindh.
· Dr. Muhammad Ayaz, Lecturer, Pharmacy Department, University of Malakand Khyber PukhtoonKhawa 18000, Pakistan
· Professor Nasiara Karim, department of pharmacy, university of Malakand, Chakdara, KPK.
· Dr. Khalid Rauf. Assistant professor, department of pharmacy, COMSATS institute of information technology, Abbotabad, KPK.
· Dr Ihsan Ullah, assistant professor, department of pharmacy, University of Swabi, Swabi KPK.
· Zia Ahmed, Department of Pharmacy, Hazara University, Havelian campus, Hazara KPK.
International Research Collaborations:
· Professor Robert D.E. Sewell, Welsh School of Pharmacy, Division of Pharmacology, Cardiff University of Wales, UK.
· Professor, John A. Rudd, School of biomedical Sciences, Faculty of mediceine. The Chinese University of Hong Kong.
· Shafiqur Rahman, Professor of Pharmacology, Department of Pharmaceutical Sciences South Dakota State University College of Pharmacy 1055 Campanile Avenue Avera Health and Science Center, SAV 265 Brookings, SD 57007 USA.
· Dr. Faiz Ur Rahman, PhD Post-Doctoral Research Fellow Laboratory of Supra-molecular and Organometallic Chemistry Fudan University, Shanghai, P. R. China.
Research Grants:
S# / Research Project name / Total Research grant / Source / Remarks1 / Higher Education commission grant for the maintenance / Rs. 10,00000/- / HEC granted / Completed
2 / Pharmacological Investigation on some indigenous plants/Hypericum perforatum, potentially useful for depression, pain and addiction / Rs. 40,000/- / University of Peshawar granted / Completed
3 / Selected Serotnin Re-uptake Inhibitor (SSRI), fluxetine, drug dependence and analgesia / Rs. 1,80,000/- / University of Peshawar granted / Completed
4 / Biopharmaceutical profile of Risperidone / Rs. 4,95,000/- / University of Peshawar granted / Completed
5 / Effects of Selected Medicinal Plants combination on Hypertension, Dyslipidemia and Depression / Rs. 2,76,500/- / University of Peshawar granted / Completed
6 / Evaluation of antidepressants on Bacterial resistance to antibiotics / Rs. 4,62,648/- / University of Peshawar granted / completed
7 / Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain. / Rs.7,153,222/- / HEC under NRPU / In progress
8 / Novel targeted heterocyclic compound(s) beta hydroxy ketone derivative-Potential candidates for Alzheimer's disease. / Rs.58,86,560/- / HEC under NRPU / Approved.
List of M.Phil and Ph.D Students (Supervised):
List of Ph.D. Students:
S.# / Name / Research Title / Year of completion1 / Amir Bad Shah / Development And Evaluation Of Extended Release Matrix Tablets Of Risperidone, Olanzapine and Prochlorperazine Maleate (AntiPsychotic Drugs) / 11/06/2010
2 / Khalid Rauf / Effect of Bacopa Monnieri on Morphine Dependence and Tolerance to Analgesia in Animal Models / 08/03/2012
3 / Sami Ullah / Development and Comparative Evaluation of Controlled Release Tablets vs. Conventional Tablets of Olanzapine and Prochlorperazine for Clinical Safety and Therapeutic Efficacy / 25/6/2014
4 / Gowhar Ali / Preclinical Evaluation of Selected Synthetic Bioisosteric Nitrogen Containing Salicyl Alcohol Derivatives in Inflammation, Pyrexia, Ulcerogenicity and Pain Modalities / 18/2/2014
5 / Ihsan Ullah / Evaluation of some selected medicinal plants and their combinations in Cisplatin induced Vomiting in Vomit model (S); Behavioral Neurochemical correlates / 03/10/2013
6 / Rehmat Shah / Preclinical and clinical evaluation of selected antiphsychotics induced toxicity, biochemical and histoathological approach / Thesis submitted
7 / Shehla Akbar / Evaluation of 6-methoxyflavanone on anxiety and neuropathic pain models; a behavioural and pharmacokinetic study / Completed
2017
8 / Khwaja Fawad / ‘Evaluation Of Synthesized Bis-Aminomethylene Derivatives Of Hydroquinone For Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, And Gastric Ulcerogenic Activities In Animal Models’’ / Experimental completed
10 / Muhammad Shahid / Pharmacological screening of compounded topical preparations in the rodent neuropathic pain paradigms / In progress
11 / Nisar Ahmad / Synthesis and pharmacological profiling of gabapentin and pregabalin derivatives as potential therapeutic agents in the treatment of neuropathic pain / Experimental completed
12 / Muhammad Asif / Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain. / Enrolled
13 / Najeeb Ullah / Synthesis and screening of GABA derivatives as potential therapeutic agents for the treatment of neuropathic pain. / Enrolled
14 / Rahim Ullah
(Co-Super.) / Evaluation of selected flavonoids in Neuropathy and Alzheimer / Enrolled
List of M.Phil. Students:
S# / Name / Research Title / Year of completion1 / Munasib Khan / Pharmacological investigation on indigenous plant, HYPERICUM PERFORATUM, potentially useful for pain and addiction / 27/7/2005
2 / Rukhsana Ghafar
(Co-Super.) / Phytochemical and biological evaluation of Valeriana Wallichii plant / 25/02/2006
3 / Muhammad Tayyab Abbas / Studies on selective serotonin reuptake inhibitor (SSRI) Fluoxetin in the management of opioid (Heroin) dependence and analgesia / 15/5/2007
4 / Nasiara / Pharmacological investigation of indigenous plant Valeriana wallichii for depression in animal models / 07/1/2008
5 / Nematullah Khan / ‘’Effect of Hypericum Perforatum on Naloxone induced Heroin withdrawl symptoms and negative motivational properties’’ / 27/5/2009
6 / Zia Ahmed / ‘’Effect of fasting on serum lithium in preclinical and clinical models / 26/10/2009
7 / Muzaffar Abbas / Effect of Bacopa Monniera on pain perception and depression in animal models / 13/01/2009
8 / Muhammad Ayaz / Evaluation of anti-depressants on bacterial resistance to antibiotics / 01/11/2012
9 / Muhammad Shahid / ‘’Heoatitixicity and Nephrotoxicity of Morphine and Illicit Street Heroin and its Amelioration by Extract of Bacopa Monniera / 20/11/2013
10 / Javaid Alam / Comparative Evaluation of Selected Antioxidants and their Combinations in Cisplatin Induced Vomiting in Pigeons / 14/4/2014
11 / Urooj Aman / Evaluation of Methanol Extract Of Passiflora Incarnata on Pain and Anxiety Models / 23/01/2015
12 / Jehanzeb / Evaluation of topical gabapentine in animal models of peripheral neuropathic pain / 30/05/2016
13 / Anum Muzaffar / Clinical investigation on the impact of cannabis abuse on the thyroid hormones and associated psychiatric manifestations. / 18/11/2016
14 / Amna Nisar / Defensive of vulvudynia in diabetic and non.diabetic middle age female and its association with psychosexual problem / 19/07/2017
List of Research Publications:
1. Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Abdul Sadiq, Gowhar Ali, Muhammad Ovais,Muhammad Shahid, Ashfaq Ahmad, Abdul Wadud, Mohamed El-Shazly, Nisar hmad, Sajjad Ahmad.Anti-Alzheimer's studies on β-sitosterol isolated from Polygonum hydropiper L. Frontiers in Pharmacology (DOI: 10.3389/fphar.2017.00697) (Accepted) (IF: 4.4)
2. Muhammad Shahid, Fazal Subhan, Nisar Ahmad, Robert D.E. Sewell. The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia. Biomedicine and Pharmacotherapy (Accepted, 2017) (IF: 2.326)
3. Muhammad Shahid, Fazal Subhan, Gowhar Ali, Ihsan Ullah, Javaid Alam, Sami Ullah, Khalid Rauf. Neuroprotective effect of Bacopa monnieri against morphine-induced histopathological changes in the cerebellum of rats. Pakistan Journal of Pharmaceutical Sciences (Accepted, 2017). (IF: 0.649)
4. Khwaja Fawad, Nazar Ul Islam, Fazal Subhan, Muhammad Shahid, Gowhar Ali, Faiz-Ur Rahman, Wajahat Mehmood4, Nisar Ahmad. Novel hydroquinone derivatives alleviate pain, inflammation and pyrexia without aspirin-like gastric ulcerogenicity. Tropical Journal of Pharmaceutical Research. ( Accepted, 2017) (IF: 0.569)
5. Nisar Ahmad, Fazal Subhan, NazarUl Islam, Muhammad Shahid, Faiz Ur Rahman, Robert D.E. Sewell. Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. European journal of Pharmacology.( doi.org/10.1016/j.ejphar.2017.08.040) (In press, 2017) (IF: 2.896)