Resume
(Updated on 02/28/2004)
Evgeni Selkov
Present Address
1409 Heatherton Dr.
Naperville, IL 60563-2232
Phone: 1-630-357-5881
Fax: 1-630-729-3161
Mobile: 1-773-343-6172
Email: ,
Education
1981 - Granted rank of Professor of Biophysics from the Russian Academy of Sciences
1980 - Defended doctoral (D.Sc.) thesis on ``Kinetics of open multienzyme systems''. Granted with the Doctor of Physical-Mathematical Sciences Degree from the Russian Academy of Sciences
1972 - Defended candidate (Ph.D.) thesis on ``Mathematical simulation of single-frequency glycolytic oscillations''. Granted with the Candidate of Physical-Mathematical Sciences Degree (Ph.D) from the Russian Academy of Sciences
1967 - Graduated Electronics Engineer, specialization Engineer of Audiotechnics, from the St. Petersburg Institute of Cinema Engineers.
Employment History
Senior Fellow, Computational Institute, Argonne National Laboratory and University of Chicago, Illinois, 2003 – present
Senior Scientist, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, 2001 -- present
Computational Biologist, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, 2001
Vice President, Director of Metabolic Design Division, Integrated Genomics, Inc., Chicago, 1999 -- 2001
President, EMP Project, Inc., New York, 1999--2000
Computational Biologist, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, 1997--2000
Consultant of European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Hinxton, UK, 1996-1997
Adjunct Professor, Institute for Biosciences, Bioinformatics, and Biotechnology, Fairfax, VA, 1996-1997
Visiting Scientist, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, 1994—1997
Head of the Laboratory of Mathematical Simulation of Multienzyme Systems of the Institute of Theoretical and Experimental Biophysics of the Russia Academy of Sciences at the Pushchino Biological Research Center, Pushchino, Russia, 1991--2001
Professor, Physicochemical Biology, Biological Faculty, Moscow State University, Pushchino, 1989--1995
Head, Laboratory of Mathematical Simulation of Multienzyme Systems, Institute of Biological Physics, USSR Academy of Sciences, Pushchino Biological Research Center, Pushchino, Russia, 1972--1991
Junior Research Fellow, Institute of Biological Physics, USSR Academy of Sciences, Pushchino Biological Research Center, Pushchino, Russia, 1964--1972
Leading Engineer in Electronics and Leader of Research Group on Cellular Biophysics, Institute of Cybernetics, Ukraine Academy of Sciences, Kiev, Ukraine, 1961--1964
Senior Engineer of Electronics, Institute of Physiology, St. Petersburg State University, 1961
Senior Engineer of Electronics, Institute of Evolutionary Physiology, USSR Academy of Sciences, 1959--1960
Senior Technical Assistant in Electronics, St. Petersburg Institute of Cinema Engineers, 1957--1958
Teaching Experience
Adjunct Professor, Institute for Biosciences, Bioinformatics, and Biotechnology, Fairfax, VA, 1996--1997
Professor, Physicochemical Biology, Biological Faculty, Moscow State University, Pushchino, 1989--1995
Senior Lecturer, Physicochemical Biology, Biological Faculty, Moscow State University, Pushchino, 1972--1989
Senior Lecturer, Moscow Physicotechnical Institute, 1969--1972
Senior Lecturer, Physics Faculty, Moscow State University, 1968--1969
Supervisor of the following PhD student works:
1. V. G. Nazarenko, Theoretical analysis of infra-low frequency oscillations in cell populations, Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1976
2. V. D. Dynnik, Theoretical study of the glycolytic oscillation mechanisms, Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1977
3. N. P. Kaimachnikov, Theoretical study of the open enzyme reaction dynamics, Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1979
4. S. P. Popova, Analysis of the kinetics and regulatory functions of oligomeric enzymes, Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1980
5. N. I. Markevich, Analysis of the kinetics of the ion transport via controlled ion channels. Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1982
6. A. P. Saveliev, The dependence of zonation rhythm of a Streptomycete on space flight factors, Institute of Biological physics, Academy of Sciences of the USSR, Pushchino, 1983
7. E. L. Shevelev, Mathematical simulation of the kinetics of cyclic enzyme systems. Institute of Biological physics, the Russian Academy of Sciences, Pushchino, 1992
8. I. I. Goryanin, Automation of mathematical modeling polyenzyme systems based on a database of enzymes and metabolic pathways. Institute of Biological physics, Russian Academy of Sciences, Pushchino, 1995
9. A. M. Taranenko, Futile cycles and the deposition effect. Institute of Biological physics, Russian Academy of Sciences, Pushchino, 1996
The above PhD theses have been granted with PhD degrees for physical-mathematical sciences, except the A. P. Saveliev who has been granted with the degree for biological sciences.
Professional Activities
Journal Editorial Boards
Member of the Editorial Board, Bioprocess and Biosystems Engineering, Springer-Verlag, Heidelberg, 2000-- Present
Member of the Editorial Board, Bulletin du Groupe d'etude des rhythmes biologiques, 1972—1995, Clermon-Ferran, France, 1972--1995
Member, Advisory Board, International Journal of Chronobiology, Gordon and Breach, Science Publishers, New York, 1973—1983
Besides, some biological journals (Bioinformatics, BioSystems, Eur. J. Biochem., J. Theor. Biol., Biofisika (Moscow), Biokhimiya (Moscow), Molekularnaya biologiaya (Moscow)) and funding agencies (NIH, USDA) ask me irregularly to review and evaluate submitted manuscripts or grant proposals.
Membership in Professional Societies
Member, Federation of American Societies of Experimental Biology, FASEB, since 1999
Member, American Association for the Advancement of Science, AAAS, since 1998
Member, American Chemical Society, ACS, since 1998
Member, American Society for Microbiology, ASM, since 1998
Leader, Working Group on Creation of Biological Databases on Enzymes and Metabolic Pathways, National Committee of CODATA, Moscow, 1986--1995
Member, Russian National Committee of CODATA, Moscow, 1986--1995
Corresponding member, CODATA Working Group on Biological Macromolecules, Paris, 1988--1989
Corresponding Member, Groupe d'etude des rhythmes biologiques, 1972--1995
Member, Russian Biophysical Society, since 1972
Member, Russian Biochemical Society, since 1968
Main Scientific Results
Theoretical prediction of the existence of trigger phenomena in open biochemical reactions with substrate inhibition, 1966
Theoretical analysis of existence of oscillations in a wide range of open biochemical reaction systems with feedback, 1967
Formulation of a theory of the glycolytic oscillations as the limit cycle phenomenon, 1968
Formulation of a theory of the cell clock and cell cycle as the limit cycle phenomena, 1970
Discovery of the deposition effect, 1971
Prediction that essential nonlinearities in the cell metabolism can be targets for tight stabilizing control, 1972
Demonstration of the dynamical equivalence of a wide class of the oscillatory and trigger biochemical systems, 1972
Theory of hierarchical organization of metabolic pathways, 1973
Theoretical and experimental proof that the glycolytic stoichiometric structure is capable of stiffly stabilizing the adenylate Atkinson charge without any allosteric regulatory mechanisms, 1973
Theoretical proof that the energy wasteful substrate recycling in the central futile cycles of the cell energy metabolism can be effectively suppressed by a self-oscillatory organization only, 1976
Derivation of a generalized Monod-Wyman-Changeux model for the case of a multisubstrate reaction, 1976
Discovery of the resonance and parametric resonance phenomena in simple open enzymatic reactions and in excitable membranes, 1980.
Creation of the database on enzymes and metabolic pathways, DBEMP (currently known as EMP) 1983--
Quantitative theory of the very stable circadian cell clock based on the temporal organization of the cell energy metabolism and the deposition effect, 1987
Discovery of the deposition effect without reactions of fast deposition, 1991
Development of the metabolic and functional reconstruction technology from sequenced genomes, 1993-2001
Metabolic and functional reconstruction from publicly available genomes, 1994-2001
Publications
Books
1. Sel'kov, E. E., ed., Oscillatory Processes in Biological and Chemical Systems, Transactions of All-Union Symposium. Vol. 2., Pushchino, 1971, pp.362 (in Russian)
2. Ivanitsky, G. R., Krinsky, V. I., and Sel'kov, E. E., Mathematical Biophysics of the Cell, Nauka Publishers, Moscow, 1978, pp. 310 (in Russian)
3. Reich, J. G., and Sel'kov, E. E. Energy Metabolism of the Cell. A Theoretical Treatise, Academic Press, London, 1981, pp. 345
4. Selkov, E. E., EMP User Manual. A Guide to the Enzymes and Metabolic Pathways Database, Release 1.0. Superior Printing, Champaign, Illinois, 1995, pp. 2000
Journal Articles and Book Chapters
1. Sel'kov E. E. -- Adaptive properties of enzyme reactions with enzyme-forming system. In: Simulation in Biology and Medicine. (N. M. Amosov, ed.), Kiev, Naukova Dumka Publishers, 1965, pp. 106-116 (In Russian)
2. Sel'kov E. E. -- Polyenzyme system of the cell as an object of bionics studies. In: Bionika. Nauka Publishers, Moscow, 1965, pp. 173-179 (In Russian)
3. Sel'kov E. E. -- Hysteretic transitions in enzymatic reactions with substrate inhibition. Steady state kinetics. In: Some Biocybernetics Problems. Application of Electronics to Biology and Medicine. (N. M. Amosov, ed.), Vol. 1, Kiev, Naukova Dumka Publishers, 1966, pp. 81-101 (In Russian)
4. Sel'kov E. E., Filanovskaya A. N., Demchenko L. I. -- Contribution to the issue of kinetic induction. . In: Simulation in Biology and Medicine. (N. M. Amosov, ed.), Vol. 2, Kiev, Naukova Dumka Publishers, 1966, pp. 126-141 (In Russian)
5. Sel'kov E. – On the possibility of matrix method analysis for studying steady state kinetics of enzyme reactions. In: Simulation in Biology and Medicine. (N. M. Amosov, ed.), Vol. 2, Kiev, Naukova Dumka Publishers, 1966, pp. 118-125 (In Russian)
6. Sel'kov E. – Self-oscillatory biochemical systems. Kinetic and mathematical models. In: Bionics. Simulation of Biological Systems. Naukova Dumka Publishers. Kiev, 1967, pp. 99-121 (In Russian)
7. Sel’kov E. – Amplification properties of enzymatic reactions. In: Bionics. Simulation of Biological Systems. Naukova Dumka Publishers. Kiev, 1967, pp. 146-150 (In Russian)
8. Sel’kov E. – On the mechanism of single-frequency self-oscillations in glycolysis. I. A simple kinetic model. Eur. J. Biochem., 1968, 4(1), 79-86
9. Sel’kov E. E. – Self-oscillations in glycolysis. A simple single-frequency model. Molekularnaya biologiya, 1968, 2(2), 252-256 (in Russian)
10. Sel’kov Ye. Ye. – Self-oscillations in glycolysis. A simple single-frequency model. Molecular biology (New York), 1968, 2(2), 263-267
11. Betz A., Sel’kov E. – Control of phosphofructokinase [PFK] activity in conditions simulating those of glycolysing yeast extract. FEBS Lett., 1969, 3(10), 5-9
12. Deshcherevski V. I., Zhabotinsky A. M., Sel'kov E. E., Sidorenko N. P., Shnol' S. E. – Oscillatory biological processes on the molecular level. Biofizika, 1970, 15(2), 225-234 (in Russian)
13. Deshcherevski V. I., Zhabotinsky A. M., Sel'kov Ye. Ye., Sidorenko N. P., Shnol' S. E. – Oscillatory biological processes on the molecular level. Biophysics (New York), 1970, 15(2), 235-245
14. Sel’kov E. E., Sozinov L. A. – Stabile circadian clocks as a property of cell populations. Life Sciences and Space Research, North-Holland, Amsterdam, 1970, pp. 160-170
15. Sel’kov E. E. – Two alternative oscillatory stationary states in the thiol metabolism – two alternative modes of cell proliferation: normal and malignant one. Biofizika, 1970, 15(6), 1065-1073 (in Russian)
16. Sel’kov Ye. Ye. – Two alternative auto-oscillatory steady states in the metabolism of the thiols – two alternative types of cell multiplication: normal and malignant. Biophysics (New York), 1970, 15(6), 1104-1112
17. Sel’kov E. E. – A study of the glycolytic oscillation mechanism. A relaxation oscillation model. In: Mathematical models of biological systems. (G. M. Frank, Ed.). Nauka Publishers, Moscow, 1971, pp. 5-24 (in Russian)
18. Samoilenko V. A., Sel’kov E. E. – On the possibility of self-oscillations and several alternative steady states in an enzyme reaction with substrate and product inhibition. Biofizika, 1972, 17(5), 862-868 (in Russian)
19. Sel'kov E.E. Nonlinearity of multienzyme systems, In: Analysis and Simulation of Biochemical Systems. H.C.Hemker, B.Hess (Eds). North-Holland, Amsterdam, 1972, pp. 145-161
20. Sel’kov E. E. – Nonlinear theory of regulation of the key step of glycolysis. Stud. Biophys., 1972, 33(3), 167-176
21. Dynnik V. V., Sel’kov E. E. – On the possibility of self-oscillations in the lower part of the glycolytic system. FEBS Letters, 1973, 37(2), 342-346
22. Dynnik V. V., Sel’kov E. E., Semashko L. R. – Analysis of the adenine nucleotide effect on the oscillatory mechanism in glycolysis. Stud. Biophys., 1973, 41(3), 193-214
23. Selkov E. E., Nazarenko V. G. -- Self-oscillatory states in cell population growth. In: Mathematical Simulation of Microbiological Processes. Nauka Publishers, Pushchino, 1973, pp. 113-126 (in Russian)
24. Sel'kov E. E., Betz A. -- On the mechanism of single-frequency glycolytic oscillations. In: Biological and Biochemical Oscillations, (B. Chance, B. Hess, and K. Pye, Eds.), N.Y., Acad. Press, 1973, pp. 197-220
25. Dynnik V. V., Sel’kov E. E. -- On the possibility of self-oscillations in the lower part of the glycolytic system. FEBS Letters, 1973, 37(2), 342-346
26. Sel'kov E. E. -- Autoregulation in biological system. In: Bol'shaya Meditsinskaya Entsiklopediya. Vol. 3. Sovetskaya Entsiclopediya. Moscow. 1973, pp. 149-157 (in Russian)
27. Dynnik V. V., Sel'kov E. E., Semashko L. R. -- Analysis of the adenine nucleotide effect on the oscillatory mechanism in glycolysis. Studia biophysica. 1974, 41(3), 193-214
28. Reich J. G., Sel’kov E. E. – Mathematical analysis of metabolic networks. FEBS Letters, 1974, 40, Suppl., S119-S127
29. Popova S. V., Sel’kov E. E. – Generation of the model by Monod, Wyman and Changeux for the case of reversible monosubstrate reaction S <==> P FEBS Letters, 1975, 53(3), 269-273
30. Dynnik V. V., Sel’kov E. E. – Oscillation generator in the lower part of the glycolytic system. Biofizika, 1975, 20(2), 288-292
31. Dynnik V. V., Sel’kov Ye. Ye. – Generator of oscillations in the lower part of the glycolytic system. Biophysics (New York), 1975, 20(2), 292-297
32. Dynnik V. V., Sel’kov E. E. – Double-frequency oscillations in the glycolytic system. Mathematical model. Biofizika, 1975, 20(2), 293-297 (in Russian)
33. Dynnik V. V., Sel’kov E. E., Ovchinnikov I. A. – Impact of NAD recycling on the mechanism of ATP stabilization in cytoplasm. Mathematical models. Biokhimiya, 1975, 20(2), 288-292 (in Russian)
34. Dynnik V. V., Sel’kov Ye. Ye. – Double-frequency oscillations in the glycolytic system. Mathematical model. Biophysics (New York), 1975, 20(2), 297-302
35. Glende M., Reich J. G., Drabsch H., Sel'kov E. E. -- Zur Stellung des Orthophosphates im Energiestoffwechsel der Zelle. Studia biophysica, 1975, 52, 141-154
35. Kaimachnikov N. P., Sel'kov E. E. -- Hysteresis and multiplicity of dynamic states in an open two-substrate enzymatic reaction with substrate inhibition. Biofizika, 1975, 20(4), 703-708 (in Russian)
36. Kaimachnikov N. P., Sel'kov Ye. Ye. -- Hysteresis and multiplicity of dynamic states in an open two-substrate enzymatic reaction with substrate repression. Biophysics (New York), 1975, 20(4), 713-718
37. Markevich N. I., Sel'kov E. E. -- Analysis of neuron population dynamics. In: Simulation of excitable structures. Pushchino, 1975, pp. 42-60 (in Russian)