Electronic Supplementary Material

Niiranen TJ, Kronholm E, Rissanen H, Partinen M, Jula AM.


Article title: Self-reported obstructive sleep apnea, simple snoring and various markers of sleep-disordered breathing as predictors of cardiovascular risk.

Journal name: Sleep and breathing

Authors’ names: Teemu J. NIIRANEN* M.D.1, Erkki KRONHOLM* Ph.D. 1, Harri RISSANEN M.Sc.1, Markku PARTINEN M.D. 2,3, Antti M. JULA M.D.1


Affiliation of the authors:

1. Department of Health, National Institute for Health and Welfare

2. Helsinki Sleep Clinic, Vitalmed Research Centre

3. Department of Clinical Neurosciences, University of Helsinki

E-mail address of the corresponding author:

Contents:

Table S1. Association between self-reported snoring frequency and cardiovascular risk among snorers.

Table S2. Association between self-reported apnea frequency and cardiovascular risk among snorers.

Table S3. Association between self-reported snoring stertorousness and cardiovascular risk among snorers.

Table S1. Association between self-reported apnea frequency and cardiovascular risk among snorers.

Apnea Frequency / Almost never / <1 nights per wk / 1-2 nights per wk / 3-5 nights per wk / Every night / Can not say
No. of participants / 1608 / 251 / 174 / 62 / 125 / 932
No. of events / 139 / 32 / 30 / 14 / 31 / 141
Crude HR (95% CI) / 1.00 (ref) / 1.50 (1.02-2.21)* / 2.09 (1.41-3.09)** / 2.82 (1.63-4.88)** / 3.22 (2.18-4.76)** / 1.82 (1.44-2.30)**
Adjusted HR (95% CI) / 1.00 (ref) / 0.95 (0.64-1.40) / 1.25 (0.83-1.87) / 2.19 (1.26-3.81)* / 1.65 (1.11-2.48)* / 1.26 (0.99-1.60)

Age, gender, body mass index, smoking, sleep duration, total cholesterol, lipid-lowering medications, diabetes, systolic blood pressure and use of antihypertensive medications were included as covariates in the adjusted models. HR, hazard ratio; CI, confidence interval. *p<0.05, **p<0.001.

Table S2. Association between self-reported snoring frequency and cardiovascular risk among snorers.

Apnea Frequency / Almost never / 1-2 nights per wk / 3-5 nights per wk / Every night / Can not say
No. of participants / 425 / 786 / 358 / 924 / 659
No. of events / 25 / 71 / 33 / 148 / 110
Crude HR (95% CI) / 1.00 (ref) / 1.57 (1.00-2.48) / 1.63 (0.97-2.74) / 2.91 (1.90-4.44)** / 3.13 (2.03-4.84)**
Adjusted HR (95% CI) / 1.00 (ref) / 0.99 (0.63-1.57) / 0.91 (0.54-1.55) / 1.44 (0.94-2.23) / 1.30 (0.83-2.03)

Age, gender, body mass index, smoking, sleep duration, total cholesterol, lipid-lowering medications, diabetes, systolic blood pressure and use of antihypertensive medications were included as covariates in the adjusted models. HR, hazard ratio; CI, confidence interval. *p<0.05, **p<0.001.

Table S3. Association between self-reported snoring stertorousness and cardiovascular risk among snorers.

Apnea Frequency / Quiet and regular / Loud and regular / Very loud and regular / Very loud and irregular / Can not say
No. of participants / 937 / 963 / 265 / 412 / 575
No. of events / 76 / 118 / 37 / 72 / 84
Crude HR (95% CI) / 1.00 (ref) / 1.54 (1.15-2.05)* / 1.77 (1.19-2.62)* / 2.30 (1.66-3.17)** / 1.88 (1.38-2.57)**
Adjusted HR (95% CI) / 1.00 (ref) / 1.30 (0.97-1.74) / 1.36 (0.91-2.02) / 1.82 (1.31-2.54)** / 1.28 (0.93-1.76)

Age, gender, body mass index, smoking, sleep duration, total cholesterol, lipid-lowering medications, diabetes, systolic blood pressure and use of antihypertensive medications were included as covariates in the adjusted models. HR, hazard ratio; CI, confidence interval. *p<0.05, **p<0.001.