Electronic Supplementary Material

Early use of ceftaroline fosamil in the United States Veterans Health Care System

Rachel S. Britt, Kirk E. Evoy, Grace C. Lee, Kelly R. Reveles, Kimberly M. Sorensen, Xavier Jones, Mary Bollinger, Christopher R. Frei

Supplementary Table 1. Diagnosis codes for infectious disease indications a

infections / ICD-9 CM / CCS / ICD-9 CM Mapped to CCS
Skin / 680x 681x 682x 683x 684x 685x 686x / 197 / 0201 0210 0220 0311 03285 035 0390 6800 6801 6802 6803 6804 6805 6806 6807 6808 6809 68100 68101 68102 68110 68111 6819 6820 6821 6822 6823 6824 6825 6826 6827 6828 6829 684 6850 5851 6860 68600 68601 68609 6861 6868 6869
Pneumonia / 480x 481x 482x 483x 485x 486x 487x / 122 / 00322 0203 0204 0205 0212 0221 0310 0391 0521 0551 0730 0830 1124 1140 1144 1145 11505 11515 11595 1304 1363 4800 4801 4802 4803 4808 4809 481 4820 4821 4822 4823 48230 48231 48232 48239 4824 48240 48241 48242 48249 4828 48281 48282 48283 48284 48289 4829 483 4830 4831 4838 4841 4843 4845 4846 4847 4848 485 486 5130 5171
bacteremia / 790.7 / None / N/A
Sepsis / 038x 7907 78552 99591 99592 / 2 / 0031 0202 0223 0362 0380 0381 03810 03811 03812 03819 0382 0383 03480 03841 03842 03843 03844 03849 0388 0389 0545 449 77181 7907 99591 99592
Endocarditis / 421x 424x / None / N/A
Osteomyelitis/septic arthritis / 730x 711x / 201 / 00323 00324 0261 03682 05671 71100 71101 71102 71103 71104 71105 71106 71107 71108 71109 71110 71111 71112 71113 71114 71115 71116 71117 71118 71119 71120 71121 71122 71123 71124 71125 71126 71127 71128 71129 71130 71131 71132 71133 71134 71135 71136 71137 71138 71139 71140 71141 71142 71143 71144 71145 71146 71147 71148 71149 71150 71151 71152 71153 71154 71155 71156 71157 71158 71159 71160 71161 71162 71163 71164 71165 71166 71167 71168 71169 71170 71171 71172 71173 71174 71175 71176 71177 71178 71179 71180 71181 71182 71183 71184 71185 71186 71187 71188 71189 71190 71191 71192 71193 71194 71195 71196 71197 71198 71199 73000 73001 73002 73003 73004 73005 73006 73007 73008 73009 73010 73011 73012 73013 73014 73015 73016 73017 73018 73019 73020 73021 73022 73023 73024 73025 73026 73027 73028 73029 73030 73031 73032 73033 73034 73035 73036 73037 73038 73039 73070 73071 73072 73073 73074 73075 73076 73077 73078 73079 73080 73081 73082 73083 73084 73085 73086 73087 73088 73089 73090 73091 73092 73093 73094 73095 73096 73097 73098 73099
Meningitis/CNS / 320x 321x 322x 323x 324x / 76, 77, 78 / 00321 0360 0470 0471 0478 0479 0490 0491 0530 05472 0721 10081 11283 1142 11501 11511 11591 3200 3201 3202 3203 3207 3208 32081 32082 32089 3209 3210 3211 3212 3213 3214 3218 3220 3221 3222 3229 0361 0462 0498 0499 0520 0543 0550 05601 05821 05829 0620 0621 0622 0623 0624 0625 0628 0629 0630 0631 0632 0638 0639 064 0662 0722 1300 1390 3230 32301 32302 3231 3232 3234 32341 32342 3235 32351 32352 3236 32361 32362 32363 3237 32371 32372 3238 32381 32382 3239 34120 34121 34122 04500 04501 04502 04503 04510 04511 04512 04513 04520 04521 04522 04523 04590 04591 04592 04593 0460 0461 04611 04619 0463 04671 04672 04679 0468 0469 048 138 3240 3241 3249 326 V1202
Diabetic Foot / 250x plus one of the following:
680x 681x 682x 683x 684x 685x 686x 707.10 707.13 707.14 707.15 707.8 707.9 730.06 730.07 730.08 730.09 730.16 730.19 730.26 730.27 730.28 730.29 891.0 891.1 891.2 892 892.1 892.2 454.0 454.1 454.2 454.9 / [49 or 50] plus
[197, 199, or 236] / 24900 25000 25001 7902 79021 79022 79029 7915 7916 V4585 V5391 V6546 24901 24910 24911 24920 24921 24930 24931 24940 24941 24950 24951 24960 24961 24970 24971 24980 24981 24990 24991 25002 25003 25010 25011 25012 25013 25020 25021 25022 25023 25030 25031 25032 25033 25040 25041 25042 25043 25050 25051 25052 25053 25060 25061 25062 25063 25070 25071 25072 25073 25080 25081 25082 25083 25090 25091 25092 25093
PLUS
0201 0210 0220 0311 03285 035 0390 6800 6801 6802 6803 6804 6805 6806 6807 6808 6809 68100 68101 68102 68110 68111 6819 6820 6821 6822 6823 6824 6825 6826 6827 6828 6829 684 6850 6851 6860 68600 68601 68609 6861 6868 6869 7070 70700 70701 70702 70703 70704 70705 70706 70707 70709 7071 70710 70711 70712 70713 70714 70715 70719 70720 70721 70722 70723 70724 70725 7078 7079 88000 88001 88002 88003 88009 88010 88011 88012 88013 88019 88020 88021 88022 88023 88029 88100 88101 88102 88110 88111 88112 88120 88121 88122 8820 8821 8822 8830 8831 8832 8840 8841 8842 8850 8851 8860 8861 8870 8871 8872 8873 8874 8875 8876 8877 8900 8901 8902 8910 8911 8912 8920 8921 8922 8930 8931 8932 8940 8941 8942 8950 8951 8960 8961 8962 8963 8970 8971 8972 8973 8974 8975 8976 8977 9058 9059 9061
Device-related / 996.31, 996.62, 996.64, 999.31 / 237 / 27950 27951 27952 27953 41402 41403 41404 41405 41407 44030 44031 44032 56960 56961 56969 59682 59683 62931 62932 99600 99601 99602 99603 99604 99609 9961 9962 99630 99631 99632 99639 9964 99640 99641 99642 99643 99644 99645 99646 99647 99649 99651 99652 99653 99654 99655 99656 99657 99659 9966 99660 99661 99662 99663 99664 99665 99666 99667 99668 99669 9967 99670 99671 99672 99673 99674 99675 99676 99677 99678 99679 99680 99681 99682 99683 99684 99685 99686 99687 99688 99689 99690 99691 99692 99693 99694 99695 99696 99699 99931 99932 99933

a ICD-9 CM: International Classification of Diseases, 9th Revision, Clinical Modification Diagnosis Codes; CCS: Clinical Classifications Software codes (based on single-level diagnoses; January 1980 to September 2013)

Supplementary Table 2. Diagnosis codes for comorbidities a,b

Comorbidity / ICD-9 CM / CCS
Myocardial infarction / 410, 412 / 100
Congestive heart failure / 428 / 108
Peripheral vascular disease / 441, 443.9, 785.4, V43.4
Cerebrovascular disease / 430-438 / 109-112
Dementia / 290
COPD / 490-496, 500-505, 506.4 / 127
Rheumatologic disease / 710.0-710.1, 710.4, 714.0-714.2, 714.81, 725 / 202
Peptic ulcer disease / 531.0-531.9, 532.0-532.9, 533.0-533.9, 534.0-534.9
Liver disease / 571.2, 571.4, 571.5, 571.6, 572.2-572.8, 456.0-456.21 / 150-151
Diabetes / 250.0-250.3, 250.4, 250.5, 250.6, 250.7, 250.8, 250.9 / 49, 50
Hemiplegia or paraplegia / 342, 344.1 / 82
Renal disease / 582, 583, 585, 586, 588 / 158
Neoplastic disease / 140-172, 174-208 / 11-43
HIV/AIDS / 42-44, V08 / 5
Hemodialysis / V56 / 3995

a All comorbidities, except hemodialysis, are part of the Charlson Comorbidity index.

b COPD: chronic obstructive pulmonary disease; HIV/AIDS: human immunodeficiency virus/acquired immune deficiency syndrome; ICD-9 CM: International Classification of Diseases, 9th Revision, Clinical Modification Diagnosis Codes; CCS: Clinical Classifications Software codes (based on single-level diagnoses; January 1980 to September 2013)

Supplementary Table 3. Adverse Effects a

Adverse Effects / ICD-9 CM
Eosinophilia / 288.3x
Leukopenia / 288.5x
Leukocytosis / 288.6x
Fibromyalgia / 729.0x
Myalgia and myositis / 729.1x
Polymyalgia / 729.9x, 729.99x

a ICD-9 CM: International Classification of Diseases, 9th Revision, Clinical Modification Diagnosis Codes

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