E-Table 1 Frequency of IL-10 -1082/-819/-592 genotypes, allelic polymorphisms and haplotypes in asthmatics and controls

Study / Asthma / Control / HWE
IL-10 -1082A/G / AA / AG / GG / AA / AG / GG
Hussein YM / 82 / 90 / 48 / 23 / 54 / 33 / Y
Trajkov D / 31 / 32 / 11 / 70 / 212 / 17 / N
Karjalaninen J / 72 / 121 / 49 / 123 / 201 / 71 / Y
Movahedi M / 0 / 59 / 0 / 53 / 75 / 12 / N
Li ZF / 20 / 8 / 2 / 16 / 7 / 3 / Y
Chatterjee J / 159 / 91 / 15 / 150 / 122 / 23 / Y
Kim KW / 291 / 40 / 2 / 215 / 30 / 3 / Y
Yang XX / 114 / 175 / 12 / 215 / 49 / 0 / N
Zedan M / 11 / 39 / 19 / 8 / 85 / 5 / N
Daley D / 160 / 320 / 163 / 186 / 376 / 189 / Y
Park BL / 460 / 69 / 3 / 135 / 33 / 2 / Y
Xing F / 27 / 113 / 43 / 19 / 65 / 67 / Y
IL-10 -819C/T / CC / CT / TT / CC / CT / TT
Trajkov D / 35 / 32 / 7 / 155 / 105 / 19 / Y
Karjalaninen J / 146 / 84 / 12 / 232 / 142 / 21 / Y
Movahedi M / 2 / 57 / 0 / 71 / 57 / 12 / N
Li ZF / 6 / 17 / 7 / 7 / 9 / 10 / Y
Chatterjee J / 76 / 144 / 49 / 107 / 147 / 51 / Y
Kim KW / 40 / 138 / 155 / 27 / 108 / 113 / Y
Xing F / 23 / 105 / 55 / 17 / 70 / 64 / Y
IL-10 -592C/A / CC / CA / AA / CC / CA / AA
Trajkov D / 35 / 33 / 6 / 154 / 117 / 28 / Y
Karjalaninen J / 146 / 84 / 12 / 232 / 142 / 21 / Y
Movahedi M / 1 / 58 / 0 / 71 / 57 / 12 / N
Li ZF / 6 / 17 / 7 / 7 / 9 / 10 / Y
Chatterjee J / 79 / 136 / 52 / 115 / 141 / 48 / Y
Xie Q / 14 / 34 / 23 / 1 / 41 / 23 / N
Hang LW / 6 / 58 / 53 / 11 / 22 / 27 / Y
Hakimizadeh E / 69 / 21 / 10 / 22 / 56 / 22 / N
Schubert K / 131 / 86 / 14 / 145 / 109 / 19 / Y
Hakonarson H / 59 / 31 / 4 / 61 / 30 / 3 / Y
Daley D / 372 / 233 / 38 / 461 / 254 / 35 / Y
Kim KW / 44 / 143 / 146 / 31 / 106 / 111 / Y
Li HL / 6 / 24 / 20 / 3 / 17 / 16 / Y
Park BL / 58 / 235 / 239 / 22 / 78 / 70 / Y
Ji X / 74 / 49 / 24 / 117 / 54 / 13 / Y
Undarmaa 1 / 30 / 141 / 154 / 39 / 151 / 146 / Y
Undarmaa 1 / 44 / 167 / 156 / 81 / 307 / 288 / Y
Yu FF / 4 / 29 / 37 / 11 / 38 / 21 / Y
Xing F / 31 / 112 / 40 / 49 / 76 / 26 / Y
IL-10 haplotype / ATA / ACC / GCC / ATA / ACC / GCC
Lim S / 112 / 119 / 139 / 105 / 138 / 238
Karjalaninen J / 107 / 158 / 219 / 184 / 263 / 343
Chatterjee J / 231 / 165 / 114 / 197 / 188 / 148
Li ZF / 31 / 17 / 12 / 29 / 10 / 13
Trajkov D / 45 / 48 / 54 / 161 / 177 / 246
Kim KW / 423 / 163 / 38 / 320 / 122 / 32

Table 2 compared the -1082/-819/-592 genotype frequencies of IL-10 between asthmatic patients and controls. The distribution of genotypes in control group consistent with Hardy-Weinberg equilibrium (HWE) is shown in Table 2 (available at:

E-Table 2 Results for meta-analysis of Interleukin-10 promoter -819C/T polymorphisms and asthma susceptibility

Polymorphisms / Study group / No. of studies / Sample size / Test of association / Heterogeneity
case / control / OR (95%CI) / P / Ph / I2
Overall / CC vs. CT / 7 / 328/577 / 616/658 / 0.69 (0.43,1.11) / 0.13 / 0.000 / 77.8
CC vs. TT / 328/285 / 616/290 / 0.97 (0.73,1.28) / 0.84 / 0.65 / 0.0
CT vs. TT / 577/285 / 658/290 / 1.00 (0.68, 1.48) / 0.99 / 0.04 / 57.8
HWE / CC vs. CT / 6 / 326/520 / 545/601 / 0.97 (0.88,1.07) / 0.51 / 0.48 / 0.0
CC vs. TT / 326/285 / 545/278 / 0.97 (0.74, 1.29) / 0.85 / 0.53 / 0.0
CT vs. TT / 520/285 / 601/278 / 1.00 (0.68, 1.48) / 0.98 / 0.003 / 57.8