APPENDIX e-1

e-1.Balaban RB. A physician's guide to talking about end-of-life care. J Gen Intern Med 2000;15:195-200.

e-2.Wright AA, Zhang BH, Ray A, et al. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 2008;300:1665-1673.

e-3.Wang XR, Robinson KM, Carter-Harris L. Prevalence of chronic illnesses and characteristics of chronically ill informal caregivers of persons with dementia. Age Ageing 2014;43:137-141.

e-4.Arber S, Venn S. Caregiving at night: Understanding the impact on carers. J Aging Stud 2011;25:155-165.

e-5.Lu YF, Austrom MG, Perkins SM, et al. Depressed mood in informal caregivers of individuals with mild cognitive impairment. Am J Alzheimers Dis Other Demen 2007;22:273-285.

e-6.von Kanel R, Mausbach BT, Patterson TL, et al. Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls. Gerontology 2008;54:131-137.

e-7.Lee S, Colditz GA, Berkman LF, Kawachi I. Caregiving and risk of coronary heart disease in U.S. women: a prospective study. Am J Prev Med 2003;24:113-119.

e-8.Schulz R, Beach SR. Caregiving as a risk factor for mortality: the Caregiver Health Effects Study. JAMA 1999;282:2215-2219.

e-9.Carter JH, Stewart BJ, Archbold PG, et al. Living with a person who has Parkinson's disease: The spouse's perspective by stage of disease. Movement Disord 1998;13:20-28.

e-10.Wright AA, Keating NL, Balboni TA, Matulonis UA, Block SD, Prigerson HG. Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health. J Clin Oncol 2010;28(29):4457-4464.

e-11.Ewing G, Brundle C, Payne S, Grande G. The Carer Support Needs Assessment Tool (CSNAT) for use in palliative and end-of-life care at home: a validation study. J Pain Symptom Manage 2013;46:395-405.

e-12.McCluskey L, Houseman G. Medicare hospice referral criteria for patients with amyotrophic lateral sclerosis: a need for improvement. J Palliat Med 2004;7:47-53.

e-13.Mitchell SL, Miller SC, Teno JM, Davis RB, Shaffer ML. The advanced dementia prognostic tool: a risk score to estimate survival in nursing home residents with advanced dementia. J Pain Symptom Manage 2010;40:639-651.

3-14.Petrini C. The Clinical Course of Advanced Dementia. New Engl J Med 2010;362:364-364.

e-15.Higginson IJ, McCrone P, Hart SR, Burman R, Silber E, Edmonds PM. Is short-term palliative care cost-effective in multiple sclerosis? A randomized phase II trial. J Pain Symptom Manage 2009;38:816-826.

e-16.Balboni TA, Vanderwerker LC, Block SD, et al. Religiousness and spiritual support among advanced cancer patients and associations with end-of-life treatment preferences and quality of life. J Clin Oncol 2007;25:555-560.

e-17.Balboni TA, Balboni M, Enzinger AC, et al. Provision of Spiritual Support to Patients With Advanced Cancer by Religious Communities and Associations With Medical Care at the End of Life. JAMA Intern Med 2013;173:1109-1117.

e-18.Stuart B, Alexander C, Arenella C. Medical Guidelines for determining prognosis in selected non-cancer diseases., 2nd ed. Arlington, VA: Hantional Hospice Organization, 1996.

e-19.Reisberg B. Functional assessment staging (FAST). Psychopharmacol Bull 1988;24:653-659.

e-20.Anderson F, Downing GM, Hill J, Casorso L, Lerch N. Palliative performance scale (PPS): a new tool. J Palliat Care 1996;12:5-11.