Dr. Michael Heller
LIST OF PUBLICATIONS
Heller,M. and Shapiro,B.
Enzymatic hydrolysis of sphingomyelin by rat liver.
Biochem. J. 98: 763-769, 1970.
Heller,M. , Aladjem, E. and Shapiro,B.
Phospholipase D from peanut seeds.
Bull. Soc. Chim. Biol. 50: 1395-1408, 1970.
Ascher,Y., Heller,M. and Becker,Y.
Incorporation of lipids into Herpes simplex virus particles.
J. Gen. Virol. 4: 65-76,1970.
Reshef,L. and Heller,M.
Inactivation and protection of Fructose diphosphate Aldolase in rat adipose tissue.
J. Biol. Chem. 244: 766-770,1970.
Heller,M. and Arad,R.
Properties of Phospholipase D from peanut seeds.
Biochim. Biophys. Acta 210: 276-286, 1970.
Ginsburg,l., Heller,M. and Gallis,H.A.
Phosphatase, esterase N-Acetyl glucosaminidase and ATPase of group A streptococci.
Proc. Soc. Exp. Biol. Med. 137: 645-652, 1970.
Heller,M. and Hanahan,D.J.
Erythrocyte membrane-bound enzymes. I. ATPase, Phosphatase and Adenylate kinase in human, bovine and porcine erythrocytes.
Biochim. Biophys. Acta 255: 239-250, 1972.
Heller,M. and Hanahan,D.J.
Human erythrocyte membrane-bound enzymes. 11. Acetylcholine esterase. Biochim. Biophys. Acta 255:251-272,1972.
Heller,M., Mozes,N., Peril. and Maes,E.
Phospholipase D from peanut seeds, IV. Final purification and some properties.
Biochim. Biophys. Acta 369: 397-410, 1973.
Heller,M., Mozes,N. and Peri, I.
Interactions of phospholipase D with lecithin, dodecylsulfate and Cam
Proc. 18th ICBL, Graz, Austria, p. 42, 1973.
Heller,M., Mozes, N. and Maes, E.
Phospholipase Din peanut seeds.
Methods in Enzymol. 35: 226-232, 1974.
Heller,M., Straus,H. and Ben-Gershon,Z.
Lysolecithin hydrolysis by peanut phospholipases.
Proc. 18th, ICBL, Graz, Austria p. 44, 1974.
Heller,M., Edelstein,P. and Meyer,M.
Membrane-bound enzymes. III. Protease activity in leukocytes in relation to erythrocyte membranes.
Bioch. Biophys. Acta 413: 472-482, 1975.
Heller,M.
Aggregation of phospholipase D subunits on the surface of lecithin-dodecylsulfate-Ca2+ "Supersubstrate".
Proc. 19th ICBL, Paris, France, p.60, 1975.
Heller,M. Strauss,H. and Ben-Gershon, Z.
Hydrolysis of lecithin by peanut phospholipases.
Lipids 11: 442-448, 1975.
Michael Heller, Ph.D.-7
Heller,M., Mozes,N. and Peri, l.
Interactions of phospholipase D with lecithin, dodecylsulphate and Ca2+
Lipids 11: 604-609, 1976.
Heller,M. and Harary,l.
Sarcolemma from heart cells in culture. Radioiodination and properties of the membranes.
Biochim. Biophys. Acta 467: 29-43, 1976
Heller,M. and Beck,S.
Receptors for digitalis in membranes of human red blood cells.
Israel J. Med. Sci. 13: 84, 1976.
Schwalb,H. and Heller,M.
On the interactions of 3H-Ouabain with rat cardiac cells in culture.
Israel J. Med. Sci. 13: 85, 1977.
Heller,M., Greenzaid,P. and Lichtenberg,D.
The activity of phospholipase D on aggregates of lecithin, dodecylsulfate and Ca2+
Colloquium on "Enzymes of Lipid Metabolism", Mt. St. Odille France p. 51, 1977.
Pinson,A., Heller,M and Frelin,C.
Fatty acid oxidation by beating heart cells in culture,
J. Mol. Cell. Cardiol. 9, (supp): 37, 1977.
Ulitzur,S. and Heller,M.
A new, fast and very sensitive bioluminescence assay for phosphollpase A and C.
Anal. Biochem. 91: 421-431, 1978.
Heller,M. and Beck, S.
Interactions of cardiac glycosides with cells and membranes. 1. Two receptor sites for ouabain in erythrocytes.
Biochim. Biophys. Acta 541: 332-347, 1978.
Heller,M.
Phospholipase D.
Advances in Lipid Research 16: 267-326, 1978.
Heller,M., Greenzaid,P. and Lichtenberg,D.
The activity of phospholipase D on aggregates of phosphatidylcholine, dodecylsulfate and Ca 2+.
in Enzymes of Lipid Metabolism (eds. S. Gatt, L. Freysz and P. Mandel). Plenum, N.Y., pp. 213-219, 1978.
Benenson,A., Mersel,M., Pinson,A. and Heller,M.
Lactoperoxidase-catalyzed radio-iodination of phospholipids
Proc. 11th International Congress of Biochemistry, Toronto, 1979. W
Mersel,M., Benenson,A., Pinson,A. and Heller,M.
Enzymatic radioidination of lipids in plasma membranes of cultured cells.
Proc. 11th ICB, Toronto, 1979.
Heller,M. and Beck,S.
2. Interactions of ouabain with membrane vesicles from human erythrocytes.
J. Mol. Cell Cardiol. 11 (supp. 2): 23, 1979.
Heller,M., Beck,S., Friedmann,l., Hallaq,H., Pinson,A., Schwalb,H., Smith,E. and Yehiel,E.
Digitalis and the plasma membrane.
J. Mol. Cell Cardiol. 11 (supp.2): 24, 1979.
Mersel,M., Heller,M. and Pinson,A.
Intracellular lipase activities in heart and skeletal muscle homogenates: The absence of tri-erucin cleavage by the heart - a possible biochemical basis for erucic acid lipidosis.
Biochim. Biophys. Acta 572:218-224,1979.
Benenson, A., Mersel, M., Pinson, A. and Heller, M.
A simple automatic changer attachedment for radioactivity counters
Anal. Biochem. (6: 403-406, 1979
Pinson,A., Desgres, J. and Heller,M.
Partial and incomplete oxidation of palmitate by cultured, beating cardiac cells from neonatal rats.
J. Biol. Chem. 254: 8331-8335, 1979.
Benenson,A., Mersel,M., Pinson,A. and Heller,M.
Radioiodination of pure and membrane-bound phospholipids catalyzed by lactoperoxidase.
Anal. Biochem. 101: 507-512, 1980
Friedmann,I., Schwalb,H., Hallaq,H., Pinson,A. and Heller,M.
Interactions of cardiac glycosides with cultured cardiac cells. Biochemical and electron microscopic studies on the effects of ouabain on muscle and non-muscle cells.
Biochim. Biophys. Acta 598: 272-284, 1980.
Mersel,M., Benenson,A., Pinson,A. and Heller,M.
Phospholipid asymmetry in mixed liposomes detected by enzymatic radioiodination. FEBS Lett. 110: 69-72, 1980.
Ulitzur,S. and Heller,M.
A sensitive bioassay for lipase, phospholipases A and C by bacterial bioluminescence.
Methods in Enzymol. 72:, 338-346, 1980.
Aupecle, P., Heller,M., Padieu,P. and Pinson,A.
Disappearance of erucic acid induced lipidosis of the myocardium: The role of lysosmal lipases.
J. Mol. Cell. Cardiol. 13( supp. 1): 5, 1981.
Benenson,A., Pinson,A., Heller,M. and Mersel,M.
Lipids and proteolipids in cardiac sarcolemma.
J. Mol. Cell. Cardiol. 13(supp. 1):7, 1981.
Mersel,M., Benenson,A. Pinson,A. and Heller,M.
Neuraminidase and trypsin effects on enzymatic radioiodination of sarcolemmal proteolipids in cardiac cultured cells.
J. Mol. Cell. Cardiol. 13(supp. 1): 57, 1981
Mersel, M., Amar, A., Benenson,A., Hallaq, H., Heller, M., Padieu, P and Pinson, A.
Membrane fluidity and enzymatic radio-iodination of sarcolemmal phospholipids in cultured cardiac muscle cells.
J. Mol. Cardiol. 13(Supp. 1) 57, 1981
Mersel,M., Amar,A., Benenson,A., Heller,M., Padieu,P. and Pinson,A.
Changes in accessibility of membrane proteolipids to surface labeling induced by modifications of membrane viscosity in cardiac cell cultures.
J. Mol. Cell. Cardiol. 13(supp. 1):58, 1-9, 1981.
Blatt,J., Robin,G. and Heller,M.
Biochemical regulation of muscle contraction in idiopathic scoliosis: Possible structural defects of sarcoplasmic reticular Ca 2+ -Mg2+-ATPase.
Orthopedic Trans., Proc. Annual Meeting of Scoliosis Research, 1982.
Heller,M., Mestel,F., Zahler,P. and Porzig,H.
Conversion of Arachidonic acid to prostaglandins and Leukotrienes by rat reticulocytes.
Proc. 3rd meeting of European Red Cell Club, Bern, 1982.
Schwalb,H., Dickstein,Y. and Heller,M.
Interactions of cardiac glycosides with cardiac cells. 3. Alterations in sensitivity of Na+,K+-ATPase to inhibition by ouabain in rat hearts.
Biochim. Biophys. Acta 689: 241-248, 1982.
Heller,.M., Beck,S., Friedmann,l., Hallaq,H., Mersel,M., Pinson,A., Schwalb,H. Smith,E. and Yehiel, E.
Digitalis and the plasma membrane
Symp. of the Int'l Soc. for Heart Research, Dijon, pp.97-107, 1982.
Benenson,A., Heller,M., Pinson,A. and Mersel,M.
Proteolipid and lipid moieties in sarcolemmal surfaces reflected by external enzymatic labeling with radioactive iodine.
Adv. In Studies on Heart Metabolism (eds. C.M Caldarera and P.Harris) pp. 49-52, Clueb, Bolognia, 1982
Mersel,M., Amar,A., Benenson,A., Heller,M., Hallaq,H., Padieu,P. and Pinson,A.
Membrane fluidity and accessibility of sarcolemmal proteolipids to enzymatic radioiodination in cultured cardiac myocytes.
Adv. In Studies on Heart Metabolism (eds., C.M. Caldarera and P. Harris) pp. 89-93, Clueb, Bolognia, 1982.
Yagev,S., Heller,M. and Pinson,A.
The effects of oxygen and volume restrictions of extracellular medium on enzyme release from heart cells in culture.
J. Mol. Cell. Cardiol. 15(supp. 1) 134, 1983.
Haj-Yehia,A., Yanuka,Y., Heller,M. and Pinson,A.
The effect of quinidine and its synthetic derivatives on the oxidation and contraction of heart cells in culture.
J. Mol. Cell. Cardiol. 15(supp. 1): 135, 1983.
Benenson,A., Pinson,A., Heller,M. and Mersel,M.
Radio-iodination of lipids and proteolipids in membranes of heart cells in culture.
Methods in Studying Cardiac Membranes (ed. N.S.Dhalla) Vol. II, pp.59-82, CRC press, Boca Raton, 1984.
Heller,M.
4. Binding sites for ouabain in erythrocytes and cardiac cells and their plasma membranes.
Basic research Cardiol. 79 (Supp.): 41-47, 1984.
Yagev,S., Heller,M. and Pinson,A.
Changes in cytoplasmic and lysosomal enzymes' activities in cultured rat heart cells.
In vitro 20: 893-898, 1984.
Vemuri,R., Heller,M. and Pinson,A.
Modifying sarcolemma in cultured heart cells alters their response to Ischemia.
Basic Res. Cardiol. 80(supp. 2): 205, 1985.
Vemuri,R., Yagev,S., Heller,M. and Pinson,A.
Studies on Oxygen and Volume restrictions in cultured cardiac cells. 1. A model for Ischemia and Anoxia with a new approach.
In vitro 21: 521-525, 1985.
Vemuri,R., Heller,M. and Pinson A.
Studies of oxygen and volume restrictions in cultured cardiac cells. II. The glucose effect.
Basic Res. Cardiol. 80 (Suppl. 2): 140-144, 1985.
Vemuri,R., Heller,M., Heller,M. and Pinson,A.
Alterations in sarcolemmal properties of ischemic cultured heart myocytes.
J. Mol. Cell. Cardiol. 18(supp): 4, 1987.
Hallaq,H., Yanuka,Y. and Heller,M.
Cardiac Glycosides with wider therapeutic index.
J. Mol. Cell. Cardiol. 18(supp): 5, 1987.
Yanuka,Y., Artoul,G. and Heller,M.
Stereospecific epimerization, oxidation and toxine rearrangement in cinchona alkaloids catalyzed by acetic acid.
Tetrahedron 43: 911-922 1987.
Brandes,R., Pinson,A. and Heller,M.
Transport and metabolism of Free Fatty Acids in cultured heart cells from neonatal rats.
Enzymes of Lipid Metabolism (eds. S.Gatt and L.Freysz), pp. 405-412, Plenum Press, NY, 1987.
Heller, M.
Interactions of Cardiac Glycosides with Cultured Cardiac Cells.
The Heart Cell in Culture (ed.A.Pinson) Vol. III, Chap. 20, pp. 1-15, CRC Press, Roca Raton, 1987.
Vemuri,R., Mersel,M., Heller,M and Pinson,A.
Studies on oxygen and volume restrictions in cultured cardiac cells. Ill. Possible rearrangements of sarcolemmal lipid moieties during ischemia.
Mol. Cell. Biochem. 79:39-46 , 1988
Heller,M., Hallaq,H. and Panet,R.
Interactions of cardiac glycosides with heart cells and membranes. IV. Effects of ouabain and bumetanide on Rb+ transport in cardiac myocytes.
Biochim. Biophys. Acta 939: 595-602, 1988.
Heller,M.
Interactions of cardiac glycosides with cells and membranes. 5V. Effects of inotropic and toxic doses of ouabain on Na+, K+-ATPase and Ca2+,Mg2+ --ATPase of human erythrocyte membranes.
Biochem. Pharmacol. 37: 2293-2297, 1988.
Vemuri,R., De-Jong,J.W., Hegge,J.A.J., Heller,M. and Pinson,A.
Studies on oxygen and volume restrictions in cultured cardiac cells. (IV). High energy phosphate metabolism in cultured myocytes during anoxia and ischemia.
Cardiovas. Res. 23:254-261, 1989.
Arad,M.., Shotan,A.., Lazarovi,G., Heller,M. and Uretzki,G.
Comparison of inotropic effects of ouabain and oxidized ouabain in cat
J. Mol. Cell. Cardiol. 21: 2, 1989
Heller,M.
Cardiac Glycosides - new old ideas about old drugs.
Biochemical Pharmacology ,40: 915-925, 1990
Heller,M., Micanovic,R. and Udenfriend,S.
Molecular Biology and biosynthesis of placental alkaline phosphatase: requirements for processing to the mature form anchored to membranes by a phosphatidylinositol-glycan (PI-G).
in Glycolipid Anchors, ed. A.J.Turner, Chap. 4. pp.87-110; Ellis, Harwood and VCH, 1990.
Forstermann,U., Gorsky,D.L. ,Ishii,K. and Heller,M.
EDRF synthase in N1E-115 neuroblastoma cells is a calcium and calmodulin -regulated enzyme. N.S. .
Arch. Pharmacol. p. R63, 1990
Heller,M., Forstermann,U., Gorsky,L.D., Ishii,K., Pollock,J.S., Schmidt,H. and Murad,F.
Regulation of EDRF synthase in N1E-115 neuroblastoma cells by calmodulin and calcium.
FASEB J. 4: A872, 1990
Schmidt,H., Forstermann,U., Gorsky,L.D., Heller,M., Ishii,K., Pollock,J.S. and Murad,F.
Characterization and purification of a rat brain enzyme system catalyzing formation of EDRF from L-arginine.
FASEBJ. 4: A872., 1990
Heller,M., Fbrstermann,U., Gorsky,L,D., Ishii,K., Pollock,J.S., Schmidt,H.H.H.W. and Murad,F.
EDRF synthase in bovine aorta endothelial cells and N1E-115 neuroblastoma cells: subcellular localization and regulation by calcium and calmodulin.
J. Mol. Cell. Cardiol. 22(supp.l)) 21, 1990.
Gorsky,L.D., Schmidt,H.H.H.W., Pollock,J.S., F6rstermann,U., Kolhaas,K., Huang,R., Heller,M. and Murad,F.
Partial Purification of a rat brain enzyme which catalyzes the formation of an EDRF-like factor from Larginine.
FASEB J. , 5, A 1921,1991 .
Michael Heller, Ph.D.- 11
Pollock,J.S. ,Schmidt,H.H.H.W., Gorsky,L.D. F6rstermann,U., Kolhaas,K., Huang,R., Heller, M. and Murad,F.
Characterization of a rat brain enzyme which catalyzes the formation of an EDRF-like factor from L-arginine..
FASEB J. 5, A1921, 1991
Forstermann,U., Gorsky,L.D., Pollock,J.S., Schmidt,H., Ishii,K., Heller,M. and Murad,F.
Regulation of EDRF synthase in N1E-115 neuroblastoma cells: The enzyme responsible is dependent on calcium and calmodulin.
Europ. J. Pharmacol. 183:647-648,1991.
Murad,F., Pollock,J.S., Schmidt,H., Forstermann,U., Ishii,K., Heller,M. and Gorsky,L.D.
Characterization and purification of a rat brain enzyme system which catalyzes the formation of an EDRF-like factor from L-arginine.
Europ. J. Pharmacol. 183:1625-1626 , 1991.
Forstermann,U., Gorski,L.D., Pollock,J.S., Schmidt,H., lshii,K., Heller,M. and Murad,F.,
Calcium and calmodulin regulate the biosynthesis of EDRF/N0.-like material in N1E-115 Neuroblastoma cells
Mol. Pharmacol. 38: 7-13 1992.
Forstermann, U., Gorsky,L.D., Pollock,J.S., Schmidt,H.H.H.W., Heller,M. and Murad,F.
Regional distribution of EDRF/NO - synthesizing enzyme(s) in rat brain.
Biochem. Biophys. Res. Comm.168: 727-732, 1992.
Murad,F., Ishii,K., Gorski,L., F6rstermann,U., Kerwin,J.F.Jr.,m and Heller,M.
EDRF is a ubiquitous intracellular second messenger and extracellular paracrine substance for cyclic GMP synthesis.
"Nitric Oxide from L-Arginine" - A Bioregulatory system. S. Moncada and E.A.Higgs, ed. Chap. 32, pp.301-315 Elsevier, 1992.
Murad,F. Ishii,K., F6rstermann,U., Gorski,L., Kerwin,J.F.,Jr., Pollock,J. and Heller,M.
EDRF is an intracellular second messenger and autocoid to regulate cyclic GMP synthesis in many cells.
Adv. Cyclic Nucleotides, Calcium and Protein Phosphorylations. Vol 24, 441-448, 1992
Forstermann,U., Gorsky,L.D., Pollock, J.S., Schmidt, H.H.H.W., Ishii,K., Heller,M. and Murad, F.
Regulation of EDRF synthesis in N1E-115 neuroblastoma cells: The enzyme responsible is dependent on calcium and calmodulin.
Europ. J. Pharmacol. 183: 1625-1626, 1993.
Murad,F., Pollock,J.S., Schmidt,H.H.H.W., F6rstermann,U., Ishii,K., Heller,M. and Gorski ,L.D.
Characterization and purification of a rat brain enzyme system which catalyzes the formation of an EDRF-like factor from L-arginine.
Europ. J. Pharmacol. 183: 647-648, 1993.
Chen J., Chang B., Heller,M. and Murad,F.
Visualization of guanylate cyclase in cultured CNS Neurons.
Ann. meeting Soc. for Neuroscience, St. Louis, Missouri. 10.28-11.2,-1993
Hallaq,H., Heller,M., Panet R. and Eilam,Y.
Binding properties and biological effects of oxidized ouabain on cultured neonatal-rat cardiac myocytes. Implications on the mechanism of action of the digitalis-glycosides.
Biochem. Pharmacol. 41: 509-519, 1993
Forstermann, U., Pollock, J.S., Schmidt, H.H.H.W., Heller,M. and Murad, F.
EDRF/NO synthesis in bovine endothelial cells: Evidence for soluble and particulate isoenzymes.
Proc. Nat. Acad. Sci. US, 88:1788-1792, 1994
Mitchell,J.A. Forstermann, U., Warner,T.D., Pollock, J.S., Schmidt, H.H.H.W., Heller,M. and Murad, F.