(E)T 1: Summary of case reports of survivors of cardiac arrest

Study / Case / Age/Sex / Time to Testing / Coma / Category / Memory / Fronto-exec / Visuo-space / Extra-
Pyr / Motor / Cere / Spine / Lang / Other
1 / 43M / 1 m / 5 d / un / ++ / - / + / + / + / Loss of semantic knowledge
2 / 5 / 41M / Yes / severe / + / + / +
6 / 19M / mod / + / + / +
3 / 2 / 45M / 13 m / 42h / severe / ++ / ++ / ++ / +
5 / 47M / 15 m / 15 d / severe / ++ / ++ / ++ / +
4 / 1 / 54M / 3 y / n/a / + / +
2 / 78M / 3 y / n/a / + / + / +
3 / 70M / 3 y / n/a / + / + / +
6 / 60M / 2.5 y / n/a / + / +
9 / 54F / 2 y / n/a / + / + / +
11 / 73F / 1.5 y / n/a / + / + / +
12 / 58M / 1 y / n/a / + / + / +
13 / 74M / 1 y / n/a / + / + / + / +
15 / 81F / 10 m / n/a / + / +
18 / 63F / 7 m / n/a / +
5 / 50M / 2 y / n/a / ++ / + / Delayed onset
6 / 56M / 1 m / 4 d / severe / + / + / + / +
7 / 55M / 1 y / 1 w / severe / + / ++ / + / Apraxia
8 / 53M / 3 m / amn / ++ / + / - / + / -
9 / 57F / 5 m / 6 h / mod / ++ / ++ / -
10 / 4 / 34M / 1 m / 1 w / mod / + / ++ / -
11 / 67M / 2 m / 2 w / n/a / ++ / +
12 / 1 / 64F / 8 y / 4 d / n/a / + / +
2 / 62M / 4 y / 3 d / mod / + / + / +
13 / 49F / 6 y / mod / ++ / + / - / + / Hallucinations
14 / 4 / 49M / 6 m / 5 d / mild / Full recovery
5 / 41M / 11 m / Days / severe / + / + / + / + / + / +
15 / 43F / 1 y / 16 d / severe / + / + / + / + / + / +
16 / 1 / 48M / 2 y / hours / mod / ++ / +
2 / 41M / 2 y / 15 m / mod / ++ / +
3 / 39M / 2 y / 20 h / mod / ++ / +
6 / 56M / 6 m / 24 h / mod / + / +
17 / 1 / 65M / vis / - / ++
18 / 58M / 3 y / Yes / severe / ++ / ++ / + / +
19 / 1 / 40M / 2 y / severe / + / + / +
4 / 31F / 1 m / severe / +
20 / 5 / 54M / 2 m / 24 h / severe / + / +
21 / 43M / 1 m / 8 d / severe
22 / 2 / 42M / 18 m / amn / ++ / - / - / + / -

+ neurological deficit by report or mild deficit verified by neuropsychological testing

++ substantial neurological deficit verified by neuropsychological testing

- no neurological deficit by report or verified by single neuropsychological testing

-- no neurological deficit verified by two or more neuropsychological tests

Fronto-exec = Fronto-executive; Extra-pry = Extra-pyramidal; Cere = Cerebellar; Lang = Language; mod = Moderate; un = unusual; n/a = not available; amn = amnestic; vis = visuospatial.

Case Report References

1.Alexander MP. Specific semantic memory loss after hypoxic-ischemic injury. Neurology 1997;48:165-173.

2.Allison RS, Bedford PD, Meyer A. Discussion on the clinical consequence of cerebral anoxia. Proc R Soc Med 1956;49:609-619.

3.Armengol CG. Acute oxygen deprivation: neuropsychological profiles and implications for rehabilitation. Brain Inj 2000;14:237-250.

4.Bengtsson M, Holmberg S, Jansen B. A psychiatric-psychological investigation of patients who had survived circulatory arrest. Acta Psychiatr Scand 1969.

5.Boylan KB, Chin JH, DeArmond SJ. Progressive dystonia following resuscitation. Neurology 1990;40:1458-1461.

6.Bruni J, Willmore LJ, Wilder BJ. Treatment of postanoxic intention myoclonus with valproic acid. Can J Neurol Sci 1979;6:39-42.

7.Carbonnel S, Charnallet A, David D, Pellat J. One of several semantic systems(s)? Maybe none: evidence form a case study of modality and category-specific "semantic" impairement. Cortex 1997;33:`391-417.

8.Cummings JL, Tomiyasu U, Read S, Benson F. Amnesia with hippocampus lesions after cardiopulmonary arrest. Neurology 1984;34:679-681.

9.Dalla Barba G, Mantovan MC, Cappelletti JY, Denes G. Temporal gradient in confabulation. Cortex 1998;34:417-426.

10.Feve AP, Fenelon G, Wallays C, Remy P, Guillard A. Axial motor disturbances after hypoxic lesions of the globus pallidus. Mov Disord 1993;8:321-326.

11.Govaerts A, Van Zandijcke M, Dehaene I. Posthypoxic midbrain tremor. Mov Disord 1998;13:359-361.

12.Lance JW, Adams RD. The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy. Brain 1963;86:111-136.

13.McNeill DL, Tidmarsh D, Rastall ML. A case of dysmnesic syndrome following cardiac arrest. Br J Psychiat 1965;111:697-699.

14.Norris JR, Chandrasekar S. Anoxic brain damage after cardiac resuscitation. J Chron Dis 1971;24:585-590.

15.Parkin AJ, Miller J, Vincent R. Multiple neuropsychological deficits due to anoxic encephalopathy: A case study. Cortex 1987;1987:655-665.

16.Reich P, Regestein QR, Murawski BL, DeSilva RA, Lown B. Unrecognized organic mental disorders in survivors of cardiac arrest. Am J Psychiatry 1983;140:1194-1197.

17.Rizzo M, Robin DA. Simultanagnosia. Neurology 1990;40:447-455.

18.Ross SJ, Hodges JR. Preservation of famous person knowledge in a patient with severe post anoxic amnesia. Cortex 1997;33:733-745.

19.Rupright J, Woods EA, Singh A. Hypoxic brain injury: Evaluation by single photon emission computed tomography. Arch Phys Med Rehabil 1996;77:1205-1208.

20.Silver JR, Buxton PH. Spinal stroke. Brain 1974;97:539-550.

21.Szlabowicz JW, Stewart JT. Amitriptyline treatment of agitation associated with anoxic encephalopathy. Arch Phys Med Rehabil 1990;71:612-613.

22.Volpe BT, Hirst W. The characterization of an amnesic syndrome following hypoxic ischemic injury. Arch Neurol 1983;40:436-440.