Italian Society for Celiac Disease

/ FC Call for Proposals 2015
Application Form

- AIC -

Associazione Italiana Celiachia

- FC -

Fondazione Celiachia

Foundation for Celiac Disease

FC CALL FOR PROPOSALS 2015

APPLICATION FORM

Section 1 -Principal Investigator’s Personal Data

Please, provide below all the data relating to the researcher who is the only responsible for the proposed research project (Principal Investigator, PI). All the fields below are mandatory

Title
(i.e. doctor, professor, …)
Surname
Name
First and middle initials
PI current position within the Hosting Institute
(associate professor, staff scientist, …)
Affiliation
Gender / FM
Birth date
(dd/mm/yyyy) /
Nationality
Tax Code
(codice fiscale)

Section 2–Principal Investigator’s Contact Details

All the fields below are mandatory

Hosting Institute
Department
Laboratory
Address
City
Zip Code
Country
Landline Phone
Mobile Phone
Fax
E-mail

Section 3 –Administrative Data

Please enter the data of the Legal Representative (LR) of the Institute where the PI will carry out the research (Hosting Institute). All the fields below are mandatory

Hosting Institute
Surname of the LR
Name of the LR
Tax Code of the LR
(codice fiscale)
Address
City
Zip Code
Country
Landline Phone
Mobile Phone
Fax
E-mail

Section 4 –Project Keywords

Please, selectthe research topic, the research area, and the detailed description keywordsthat clearly define the key aspects of your research project.

For selecting, click twice on the appropriate grey box, and a pop up will give you the possibility to select it

Research Topic Keywords

Please, select ONLY one research topic

Celiac disease / Dermatitis herpetiformis
Non-celiac gluten sensitivity

Research Area Keywords

Please, select ONLY one research topic, the one on which your research project mainly focuses upon

Allergology / Anatomic pathology - Histopathology
Biochemistry / Biology (structural, computational, signalling)
Clinics (paediatrics or adult) / Clinical trials
Dermatology / Drug discovery – screening - development
Endocrinology / Epidemiology - Prevention
Genetics - Control of gene expression and epigenetics / Gynaecology
Immunology - Immunobiology / Infection and inflammation
Nutrition / Oncology
Preclinical study / Proteomics

Detailed Description Keywords

Please, select AT LEAST THREE and NO MORE THAN FIVE detailed description keywords. Please, also indicate them by order of importance: in the ‘order’ column you can rank the selected keywords from 1 (the first and more relevant) to 3 onwards up to 5 (the less relevant)

select / order / select / order
Autoimmunity/Autoantibodies / B cells
Bioinformatics / Biomarkers
Biophysics / Body mass index
Carcinogenesis / Cell adhesion
Cell cycle / Chemistry
Chemokines / Clinical practice guidelines
Clinical trials / Costimulatory molecules
Crystallography / Cytokines/Interleukins
Dendritic cells / Diet
Drug discovery/development / Drug screening
Endocrinology / ELISA
Flow cytometry / Gene expression and/or profile
Gene regulation / Genomics
Gliadins / Gluten
Glutenins / HPLC
HLA/MHC / Immunohistochemistry
Immunosuppression / Immunotherapy
In vitro/live cell imaging / Inflammation
Innate immunity / Integrins
Interferons / Lymphocyte differentiation
Mass spectrometry / Membrane biology
Microarrays / Microenvironment
microRNA / Microscopy
Monoclonal antibodies / mRNA processing/translation
Next generation sequencing / Pharmaco-genetics/genomics
Polymorphisms/SNPs / Preclinical studies
Risk factors / Statistics
T cells/TCR / T helpers
Transcription / Treg cells
Vaccine

Section 5 –Duration and Typology of the Project

Please, choose in the list below the duration of your project proposal

1 year
2 years
3 years

For projects with a duration of 1 year, please specify below the nature of the study:

Pilot Study
Exploratory Study
Full Research Study

Please, choose in the list below the typology of your project proposal

Single Research Group
Collaboration Study
Multicentre Study

Section 6 –Project Abstract

Please, briefly describe your project proposal by providing the project title along with synthetic information on the project proposal background, the hypothesis underpinning the research plan, the overall aims of your project proposal, the experimental design and the expected results. Complete the text boxes without exceeding the maximum text allowed

Project Proposal Title

Background

(max700 characters, including spaces)

Hypothesis

(max 700 characters, including spaces)

Aims

(max 700 characters, including spaces)

Experimental design

(max 700 characters, including spaces)

Expected results

(max 700 characters, including spaces)

Is the project proposal submitted for the first time?

YES, it is a first submission to the FC Call 2015

YES, it is a first and last (from the FC Call 2014) submission to the FC Call 2015

NO, it is a resubmission from the FC Call 2014

If NO, please complete Section 7 – Project Resubmission

FC - Fondazione Celiachia –

Scientific Office

Via Caffaro 10, 16124 Genoa, Italy

/ FC Call for Proposals 2015
Application Form

Section 7 –Project Resubmission

- This section is reserved to project proposals submitted for the first time to the FC Call for Proposals 2014 and evaluated by the Reviewers.

- Please provide a point-by-point reply to the criticisms and issues raised by the reviewers, explaining how they have been addressed and indicating all changes (additions, deletions, modifications) introduced in the research plan for this purpose. For doing this, you must refer to the letter received by FC at the end of the 2014 selection process, where comments of reviewers were reported.

- If no criticism/no comment was raised by a Reviewer, please write ‘N/A’ in the corresponding row of the corresponding Reviewer.

Reviewer 1

(for each row, about 300 characters including spaces)

Adherence to FC’s main research priorities
Consistency of the project with the selected duration and typology of study
Consistency of the project with the selected Research Topic
Clearness of the project purpose
Improvement of basic/clinical comprehension
Design an tasks of the project
Preliminary data
Methodological or conceptual innovation of the project
Difficulties and limitations
PI’s expertise
Research team’s expertise

Reviewer 2

(for each row, about 300 characters including spaces)

Reviewer 3

(for each row, about 300 characters including spaces)

FC - Fondazione Celiachia –

Scientific Office

Via Caffaro 10, 16124 Genoa, Italy

/ FC Call for Proposals 2015
Application Form

Section 8 –Proposal Main Body

- Please, describe the research project in detail by filling in accurately all the boxes and tables below, and by respecting the instructions provided. Figures can be embedded within boxes.

- Also note that all the information required in the boxes and tables below is mandatory, and incomplete information will lead to project proposal exclusion.

- When completing each box, please try to keep concise and provide the relevant information required and necessary for peer reviewers to evaluate the project proposal.

Project background

Please, describe in the box below the proposed research background, along with relevant literature reference if any.

Project rationale and aims

Please, describe in the box below the proposed research rationale and aims

Experimental design and methodologies

Please, describe in the box below the experimental design and methodologies. If the methodology is new or unusual, please describe it in sufficient details for evaluation. The description of cumbersome experimental details and protocols, however, is not encouraged and generally detracts from the quality of the proposal.

Research plan

The research plan should be organized in tasks. Given existing difficulties in splitting clinical and epidemiological proposals into tasks, the task subdivision is mandatory only for proposals in laboratory research areas only. Proponents of clinical and epidemiological studies should use subdivision in phases whenever possible, since this facilitates the work of reviewers and, in general, results in a better appreciation of the real value of the proposal. When the description of the research can be subdivided in tasks/phases, each numbered item must describe a precise part of the project with its own experimental design and methodological approach. The objective (milestone) of each task/phase and the experimental design (including methods and time-frame) should be clearly identifiable and will be examined by the reviewers to evaluate the feasibility of the project

Potential pitfalls and caveats

Please, discuss here the potential difficulties and limitations of the proposed procedures, and suggest any alternative approach to achieve the purposes

Project feasibility

Please, discuss here the project feasibility by providing the following elements:

preliminary data – please provide enough preliminary data to support the working hypotheses, including figures

power calculation – for clinical and epidemiological studies, and whenever appropriate, make sure to have adequate sample sizes to ensure meaningful and statistically significant results

Project Innovation

Please, describe in the box below the novelty of the project with respect to the methodological or conceptual approach

Description of PI’s expertise

Please, provide details on PI’s qualification, past experience and accomplishments that are directly relevant to the success of the proposed project

Description of the key expertise of the research team

Please, provide a brief overall description of the key expertise available in the research team that are directly relevant to the success of the proposed project. In case of Partnership and Multicentre projects, please also describe the expertise, role and the added value of each collaborator and/or research centre

Description of the facilities and equipment available for the research

Please, provide a detailed description of the facilities and the equipment available in the institute where the research project will be developed. In case of a partnership, the added value of facilities and equipment offer by those organisations has to be clearly explained. In case of Partnership and Multicentre projects, please also describe the additional facilities and equipment brought by the partner institutes

Bibliography

Please, provide a list of all references employing the following format: S. Red, S. White, I.R. Black, M.L. Green. European Society …, [title]. JPGN 2012; 54: 000–015. When available, please include a paper identification code (PubMedID or doi)

Any Other Relevant Information

Please, provide a brief description of any other relevant issue you consider as relevant for the understanding of the whole research project

FC - Fondazione Celiachia –

Scientific Office

Via Caffaro 10, 16124 Genoa, Italy

/ FC Call for Proposals 2015
Application Form

Section 9 –Personnel/Collaborators/Partners Involved in the Research

You are required to provide specific information on the members of the team involved in the research (including the Principal Investigator). The tables to be completed depend on the typology of project, as explained in the scheme below:

Single Research Group Studies / Table 9.A
Collaboration Studies / Table 9.A + Table 9.B
Multicentre Studies / Table 9.A + Table 9.C(+ Table 9.B only if internal and/ or external collaborators are also involved)

- DO NOT LIST secretaries and/or administrative staff

- DO NOT LIST people devoting less than 4 months per year of their working time to the project.

- All columns are mandatory. Please write N/A if it is the case.

- Add as many rows as you need.

9.A - Personnel of the Research Group of the (Coordinating) Principal Investigator (Unity/Laboratory Conducted by the PI)

- Begin by completing the information relative to the PI; then insert other personnel including technicians.Do not list administrative staff.

- The PI is required to guarantee a time involvement in the project equal or superior to 4 monthsper year (for instance, if the project is planned for a 2 years duration, the PI must guarantee for at least 4 months per year, for both years of the project).

- FC discourages the habit of listing many units of personnel at marginal fractions of time: therefore, the other personnel must guarantee an effort of at least 9 months per year); make sure to have a sizable number of units of personnel devoting at least 9 months per year to the project. A small number of units devoting less than 9 months per year is admitted, but these units must devote at least 4 monthsper yearto the project.

-Units for whom a financial support is required (fellows) must guarantee an effort of 12 monthsper year on the project.Requests for fellowships should not exceed 50% of the total man/year effort within the research unit of the Coordinating PI. Example: To ask for 2 fellowships per year(each must be 12 months per year), it is necessary that the research unit of the Coordinating PI adds up at leastto a total time effort of 4 man/year (48 months total time per year), which corresponds to one of the following possibilities: 2 fellows at 12 months per year + at least 3 units at 9 months per year; or 2 fellows at 12 months per year + at least 2 units at 12 months per year; etc.

- For specifying the role of each member of the team, use the initials indicated in footote 1. A short CV according to the template provided in Annex 2 must be also included (with the exclusion of technical staff) for all units of the PI’s group.

- If a member of the team is already involved in a previously FC funded project, please specify his/her role in the previously funded project proposal by using the initials of the corresponding role as explained in footnote 4

Table 9.A

Name / Affiliation
(institute/university/company) / Clinician / Role[1] / Financial support
required[2] / Effort[3]
(months per year) / Role in a previous FC funded project[4]
(if any)
Y1 / Y2 / Y3
YES NO / PI / N/A
YES NO / €
[…] / YES NO / €

9.B - CollaborationStudy

- Please, provide in the table below the list of internal and externalcollaborators involved in the research project. For both internal and external collaborators, a formal signed letter of collaboration (to be compiled according to the template provided in Annex 1) is required. A short CV according to the template provided in Annex 2 must be also included with the exclusion of technical staff.

- If aninternal/external collaborator is already involved in a previously FC funded project, please specify his/her role in the previously funded project proposal by using the initials of the corresponding role as explained in footnote 7

Name / Affiliation
(institute/university/company) / Clinician / Role[5] / Effort[6]
(months per year) / Role in a previous FC funded project[7]
(if any)
Y1 / Y2 / Y3
YES NO
YES NO
[…] / YES NO

9.C - Multicentre Study

- Please provide in the table below the list of group leaders ONLY of each Italian institute/centre involved in the Multicentre project. For each group leader a formal signed letter of collaboration (to be compiled according to the template provided in Annex 1) is required. A short CV according to the template provided in Annex 2 must be also included, with the exclusion of technical staff.

- If a group leader is already involved in a previously FC funded project, please specify his/her role in the previously funded project proposal by using the initials of the corresponding role as explained in footnote 9

Name / Affiliation
(institute/university) / Clinician / Effort[8]
(months per year) / Role in a FC 2013 funded project[9]
(if any)
Y1 / Y2 / Y3
YES NO
YES NO
[…] / YES NO

FC - Fondazione Celiachia –

Scientific Office

Via Caffaro 10, 16124 Genoa, Italy

/ FC Call for Proposals 2015
Application Form

Section 10 –Description of the Planned Work for Each Unit of Personnel/Collaborators/Partners

- In the table below, please describe in a concise but complete manner the work assigned to each unit of personnel, collaborators and partner institutes listed in the tables 9.A, 9.B and 9.C of the previous section.

- Add as many rows as needed

Name / Work assigned in the proposed research project
(max 5 lines for each)
[…]

FC - Fondazione Celiachia –

Scientific Office

Via Caffaro 10, 16124 Genoa, Italy

/ FC Call for Proposals 2015
Application Form

Section 11 –Budget

11. A – Total Project Budget

- Please, complete the table below by inserting the amount allocated to each Centre(in case of Multicentre Study). Add as many rows as you need. Totalper year must be equal to the sum of the amounts in the same column.

- In case of Single Research Group andCollaboration Studies, only the first row will be completed. Totalper year must be identical to the amount per yearof the first row. In fact, in case of Collaboration Studies, NO funds can be allocated to internal/external collaborators.

- In every case, please note thatthe total per year must not exceed€ 70,000

Centre / Allocation
1st year / Allocation
2nd year / Allocation
3rd year
Hosting Institute of the Coordinating PI / € / € / €
Partner Centre 1 / € / € / €
Partner Centre 2 / € / € / €
Partner Centre … / € / € / €
€ / € / €
Total / € / € / €

11. B - Typology and amount of Costs of the Hosting Institute of the (Coordinating) PI

- This table applies only to the (Coordinating) PI, and thus must be completed for every kind of study (Single Research Group, Collaboration and Multicentre).

- Please, complete the table by inserting the amount allocated to each category of costs. If no expenses are foreseen for any particular category of costs, please indicate it with ‘N/A’.

- The total amount per yearmust be identical to the amountper yearindicated in the row ‘Hosting Institute of the Coordinating PI’ of Table 11.A, and of course must also correspond to the total per year of the same Table 11.A in case of Single Research Group and Collaboration Studies.