Margaret Rosenfeld, MD, MPH
Page 10
January, 2008
Margaret Rosenfeld, M.D., M.P.H.
Curriculum Vitae
CONTACT INFORMATION:
Division of Pulmonary Medicine, A-5937
Children’s Hospital and Regional Medical Center
4800 Sandpoint Way NE, Seattle, WA 98105
EDUCATION
l983 B.S., Molecular Biophysics and Biochemistry, Yale University,
New Haven, CT. Magna cum laude, Distinction in the Major
l988 M.D., Harvard Medical School, Boston, MA
1995 M.P.H., Department of Epidemiology, University of Washington
School of Public Health, Seattle, WA
POSTGRADUATE TRAINING
l988-91 Internship/Residency in Pediatrics, University of Washington School of Medicine/Children's Hospital and Medical Center, Seattle, WA
l992-95 Fellowship, Pediatric Pulmonology, University of Washington
School of Medicine, Seattle, WA
FACULTY POSITIONS HELD
1995-1998 Acting Instructor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
1999-2000 Acting Assistant Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
2000-2005 Assistant Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
2005- Associate Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
HOSPITAL POSITIONS HELD
1995- Attending Physician, Children’s Hospital and Regional Medical Center
2000- Medical Director, Pulmonary Function Laboratory, CHRMC
2003- Co-Director, Fellows’ College
2007- Medical Director, General Clinical Research Center, and Associate Director, Center for Clinical and Translational Research, Children's Hospital and Regional Medical Center
HONORS
1992-98 Leroy Matthews Physician Scientist Award, Cystic Fibrosis Foundation
1993 Physician Scientist Fellowship Award, Glaxo Corporation
BOARD CERTIFICATION
l993, 2000 Diplomate, General Pediatrics, American Board of Pediatrics (expired as of 1/31/2006)
1998, 2005 Diplomate, Pediatric Pulmonology, American Board of Pediatrics
LICENSURE
l988- State of Washington, # 00027801
PROFESSIONAL ORGANIZATIONS
American Academy of Pediatrics
American Thoracic Society
Society for Pediatric Research
Western Society for Pediatric Research
Association for Patient Oriented Research
Association of Pediatric Program Directors
TEACHING RESPONSIBILITIES
Courses:
1991- Housestaff noon conference didactic sessions on chronic cough, obstructive sleep apnea, and common airway disorders (each given annually)
1992- Visiting lecturer, NURS 517 (Pediatric Nurse Practitioner graduate course), University of Washington School of Nursing (annually)
1995- Attending rounds didactic sessions to resident ward team on various relevant topics in pediatric pulmonary medicine (cystic fibrosis, pulmonary physiology, asthma, bronchiolitis)
1995-2002 Visiting lecturer, Core Pediatrics Clerkship,
University of Washington School of Medicine (~ 6 times annually)
2002- 2007 Lecturer, Core Pediatrics Clerkship, ethics session (9 times annually)
2004- Lecturer, HuBio 512 course to 1st year medical students (lectures on cystic fibrosis)
2007 Lecturer and panel discussant, UW Educational Outreach 88597-Intro to Clinical Trials
Trainees:
1997-1999 Graduate thesis preceptor for Toby Lewis, M.D., M.P.H., former fellow, Division of Pulmonary Medicine. Advised her in design, conduct and analysis of her study assessing outcomes associated with urban vs. rural residence among cystic fibrosis patients in the U.S. CF Foundation National Registry. Dr. Lewis is currently an Assistant Professor in the Division of Pulmonary Medicine, Department of Pediatrics, University of Michigan School of Medicine.
2000 Research mentor for Victoria Cartwright, MD, former fellow in Division of Rheumatology, “A Randomized, Controlled Trial of Pain Management Methods for Intraarticular Steriod Injections in Patients with Juvenile Rheumatoid Arthritis.” Dr. Cartwright is currently on faculty in the Department of Pediatrics at Madigan Army Medical Center in Tacoma, WA.
2001 Research mentor to Chris Goss, MD, MSc, now Assistant Professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine. Assisted him in preparation of his successful grant applications to the Cystic Fibrosis Foundation for a LeRoy Matthews Physician Scientist Award and to the NIH for a K23 award. His proposals assess the quality of life in cystic fibrosis patients with end-stage lung disease.
2001- Research mentor to Jason Debley, MD, Assistant Professor, Division of Pulmonary Medicine. Assisted him in preparing three successful grant applications and currently serve as one of his mentors on his NIH K23 career development award assessing predictors of asthma among wheezy infants utilizing infant pulmonary function tests.
2002- 2004 Advisor to Doris Uh, Pharm.D., postdoctoral fellow, Department of Pharmaceutics. Mentored her in investigation of pharmacokinetics of inhaled antibiotics and supervising her role as consulting clinical pharmacist in the Division of Pediatric Pulmonary Medicine.
2003 Research mentor to Martha McKinney, MD, MPH, former fellow, Division of Pulmonary Medicine. Assisted her in her preparing her thesis in fulfillment of the Masters in Public Health degree, assessing the prevalence of smoking among Canadian asthmatics. Sat on her thesis committee. Dr. McKinney is currently an Assistant Professor, Department of Paediatrics, Queen's University, Kingston, Ontario.
2006- Research Mentor to Maida Chen, Acting Assistant Professor, Division of Pulmonary Medicine, on her submitted grant application to University of Washington. Alcohol and Drug Abuse Institute, ”Sleep in Fetal Alcohol Spectrum Disorders,” and for her planned application for an NIH K12 career development award, “Sleep Disordered Breathing in Special Needs Pediatric Populations.”
2007-08 Biology project advisor to Paramita Saha, doctoral candidate in Biostatistics
2007- Member, Scholarship Oversight Committee of Don “DB” Sanders, fellow in Pulmonary Medicine
EDITORIAL RESPONSIBILITIES
Regular reviewer for Pediatric Pulmonology, Journal of Pediatrics, Annals of Epidemiology, Thorax, European Respiratory Journal, Pediatric Infectious Diseases, Journal of Antimicrobial Chemotherapy, Journal of Cystic Fibrosis, Chest, JAMA
2006 Guest Editor, Proceedings of the American Thoracic Society, “Imaging Endpoints in Cystic Fibrosis”
SPECIAL NATIONAL RESPONSIBILITIES
1999-2000 Participant in development of Pulmonology subspecialty examination, American Board of Pediatrics
1999 Correspondent Reviewer, NIDDKM K01 grant application
2002-2003 Member, Nominating Committee, Pediatric Assembly, American Thoracic Society
2002-2004 Member, American Thoracic Society Health Care Policy Committee
2002-2004 Member, Cystic Fibrosis Foundation Therapeutics Development Network Protocol Review Committee
2004- Member, Cystic Fibrosis Foundation Therapeutics Development Network Publication and Presentations Committee
2003 Manuscript judge, 2003 Uniformed Services Scientific Award Competition
2003- Member, Cystic Fibrosis Foundation National Patient Registry Committee
2003-2007 Member, American Thoracic Society Pediatric Assembly Planning Committee
2003-2004 Member, Writing Committee, “The Clinical Utility of Newborn Screening for Cystic Fibrosis” report published in Morbidity and Mortality Weekly Reports in 2004
2005-2006 Chair, U.S. Cystic Fibrosis Foundation task force On Updating Spirometry Reference Equations for the CFF National Patient Registry
2005- Vice-Chair, EPIC (Early Pseudomonas Infection Control) Steering Committee
2005-2007 Member, American Thoracic Society Pediatric Assembly Program Committee
2006 Co-Chair, U.S. Cystic Fibrosis Foundation workshop on Defining a Pulmonary Exacerbation, held Sept 17-18, 2006, Bethesda, MD
2007 Faculty Member, Cystic Fibrosis Foundation Learning and Leadership Collaborative V
2008- Chair, American Thoracic Society Working Group on Infant / Preschool Lung Function
SPECIAL LOCAL RESPONSIBILITIES
1997-2000 Subspecialty Teaching Ad Hoc Subcommittee of the Residency Committee, Children’s Hospital and Regional Medical Center
1997- Residency Program Liaison, Division of Pulmonary Medicine, Children’s Hospital and Regional Medical Center
2002, 2005 Reviewer, Cystic Fibrosis Critical Elements of Care Community Provider Guidelines, Center for Children with Special Needs and Chronic Health Conditions, CHRMC
1998- Member, Scientific Advisory Committee to the Clinical Research Center, UW and CHRMC.
2000-2003 Member, UW Clinical Research Training Grant K-30 Steering Committee – Training Grant Program Track
2001-2002 Member, Newborn Screening Advisory Committee to Washington State Board of Health regarding additional universal newborn screening tests.
2001- Member, CHRMC Pharmacy and Therapeutics Committee
2000- Member, Medical Advisory Board, World Bike for Breath
2003- Member, Faculty Council on Academic Affairs, UW School of Medicine
2004- Member, Education Committee, University of Washington School of Medicine General Clinical Research Center
2005-2006 Member, Institutional Resident/Fellow Advisory Committee (IR/FAC), University of Washington School of Medicine
2006 Member, CHRMC Strategic Plan Task Force on Education
2006 Leader, Workgroup on Family Support Services for Symposium on Creating Institutional Change for Work-Life Balance in Pediatric Careers, CHRMC, October 11, 2006
2007- Member, University of Washington Department of Pediatrics Recognition Committee
2007 Member, Seattle Children’s Hospital Research Institute Center for Health Services and Behavioral Research Strategic Planning Committee
2007 Member, Seattle Children’s Hospital Research Institute Center for Clinical and Translational Research Strategic Planning Committee
2007- Member, Steering Committee, Seattle Children’s Hospital Research Institute Center for Clinical and Translational Research
RESEARCH FUNDING
ACTIVE
OBSERV04K0 (Rosenfeld – PI) 2/1/04 – 3/31/09 3.0 calendar
Cystic Fibrosis Foundation $1,290,917
EPIC Observational Study
A large, multicenter, prospective, descriptive study of the risk factors for and outcomes associated with initial acquisition of Pseudomonas aeruginosa as well as outcomes associated with therapy among CF patients 1 to 12 years of age
1 U54 FF019480 (Knowles – PI) 8/4/04 – 7/31/09 1.6 calendar
NIH (NCRR) (Subcontract from University of $324,692
North Carolina at Chapel Hill) (Rosenfeld – Site PI)
Genetic Disorders of Mucociliary Clearance
Four-center prospective, longitudinal study to define the onset and progression of lung disease in a cohort of patients with primary ciliary dyskinesia (PCD) using standardized procedures.
KERBY04A0 (Kerby-PI) 2/01/05 – 1/31/08 (NCE 1/31/09) .60 calendar
Cystic Fibrosis Foundation $130, 522
Spirometry as an outcome measure in preschool children with CF
Longitudinal 8-center study of three methods of assessing lung funciotn in CF patients 3 to 5 years of age. Dr. Rosenfeld is Seattle site PI, well as study co-PI with Dr Kerby and Dr. Stephanie Davis (UNC).
UL1RR025014-01 (Disis – PI) 9/17/07 – 5/31/08 2.40 calendar
University of Washington (UW), Institute of $947,328
Translational Health Science
Institutional Clinical and Translational Health Science Award CTSA
Dr. Rosenfeld is the Medical Director of the Pediatric Clinical Research Center, overseeing program and infrastructure to conduct clinical research in the Pediatric Clinical Research Center located at Children’s Hospital and Regional Medical Center.
ISIS07K1 (Rosenfeld – PI) 10/1/07 – 9/30/08 2.4 calendar
Cystic Fibrosis Foundation $640,312
Infant Study of Inhaled Saline
A large multicenter randomized controlled trial of inhale 7% hypertonic saline in infants with cystic fibrosis.
ROSENF03AO (Rosenfeld – PI) 2/1/03 – 1/31/08 (NCE to 1/31/09) 0 calendar
Cystic Fibrosis Foundation Therapeutics, Inc. Direct Costs: $910,024
Evaluation of pulmonary function from raised lung volumes as outcome measures for clinical trails in infants with cystic fibrosis. Dr. Rosenfeld has 0 effort during the NCE.
.
ISIS07K1P (Rosenfeld – PI) 10/1/107 – 9/30/08 0 calendar
Cystic Fibrosis Foundation $112,745
A Pilot Study to Evaluate Inhaled 7% Hypertonic Saline in CF Infants
Open-label pilot study to assess the safety and tolerability of exposure to 14 days of 7% HS twice daily in infants with CF who are 12 to 30 months of age at enrollment. Dr. Rosenfeld’s effort on this project is paid under ISIS07K1.
PENDING
Rosenfeld – PI 10/1/08 – 09/30/12 2.4 calendar
NIH (Score 146 – 12th percentile) $1,601,967
Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS) – CCC – Lead Application
A multicenter, randomized controlled trial of 7% inhaled hypertonic saline in infants with cystic fibrosis. If funded, Dr. Rosenfeld will receive funding for her effort on this project under this award rather than ISIS07K1.
Completed
1. K23 RR15529 (PI, Margaret Rosenfeld). Source: NCRR, NIH. Dates: 5/01/2000– 11/30/2005. Annual Direct Costs: $96,333. Percent Effort: 75%. Title: Mentored Patient Oriented Research Career Development Award
2. HR 597004 (PI: Margaret Rosenfeld). Source: Research Endowment Fund, Childrens Hospital and Regional Medical Center. Dates: 1/01/2002– 3/31/2004. Annual Direct Costs: $24,780. Percent Effort: 0%. Title: A pilot study of sputum induction as a non-invasive means to measure serial airway antibiotic concentration in cystic fibrosis.
3. Cystic Fibrosis Foundation, Leroy Matthew Physician Scientist Award (Bonnie Ramsey, MD PI, 1992-95 for my fellowship funding; M. Rosenfeld, PI, 1996-98). Dates: 1992-1998. 1997-98 direct costs: $65,250.
4. Pari Respiratory Equipment, for Study of Efficacy of Cleaning Methods for Small-Volume Nebulizers (M. Rosenfeld, PI). Date: 1997. Direct costs: $1,847.
5. PathoGenesis Corp., Safety Study of Aerosolized Tobramycin in Young Children with Cystic Fibrosis (M. Rosenfeld, PI). Dates: 4/98 – 10/98. Total direct costs: $90,591.
6. PathoGenesis Corp. and Cystic Fibrosis Foundation. A Pilot Study of the Deposition of Inhaled Tobramycin in Young Children with Cystic Fibrosis (M. Rosenfeld, PI). Dates: 4/99-5/00. Total award: $81,968.
BIBLIOGRAPHY
Manuscripts in Refereed Journals
1. Rosenfeld M, Ramsey B. Evolution of airway microbiology in the infant with cystic fibrosis: role of pseudomonal and non-pseudomonal pathogens. Semin Respir Infect 1992;7(3):158-67.
2. Rosenfeld M, Cohen M, Ramsey B. Aerosolized antibiotics for bacterial lower airway infections: principles, efficacy and pitfalls. Clinical Pulmonary Medicine 1997;4(2):101-12. (Also appeared in Infectious Diseases in Clinical Practice 1998:7;66-79)
3. Rosenfeld M, Davis R, Fitzsimmons S, Pepe M, Ramsey B. The gender gap in cystic fibrosis mortality. American Journal of Epidemiology 1997;145(9):794-803.
4. Rosenfeld M, Emerson J, Astley S, Joy P, Williams-Warren J, Standaert T, Yim DL, Crist D, Thykkuttathil J, Torrence M, FitzSimmons S, Ramsey B. Home nebulizer usage among patients with cystic fibrosis. Journal of Pediatrics 1998;132:125-31.
5. Rosenfeld M, Casey S, Pepe M, Ramsey B. Nutritional effects of long term gastrostomy feedings in children with cystic fibrosis. Journal of the American Dietetic Association 1999;99:191-4.
6. Rosenfeld M, Emerson J, Accurso F, Armstrong D, Castile R, Grimwood K, Hiatt P, McCoy K, McNamara S, Ramsey B, Wagener J. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatric Pulmonology, 1999;28:321-328.
7. Rosenfeld M, Pepe MS, Emerson J, Longton G, FitzSimmons S. Effect of different reference equations on the analysis of pulmonary function data in cystic fibrosis. Pediatric Pulmonology 2001;31:227-37.
8. Burns JL, Gibson RL, McNamara S, Yim D, Emerson J, Rosenfeld M, Hiatt P, McCoy K, Castile R, Smith AL, Ramsey BW. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. Journal of Infectious Disease 2001;183(3):444-452.
9. Rosenfeld M, Emerson J, Willians-Warren J, Pepe M, Smith A, Montgomery AB, Ramsey BW. Defining a pulmonary exacerbation in cystic fibrosis. J Pediatr 2001;139(3):359-365.
10. Rosenfeld M, Gibson RL, McNamara S, Emerson J, Burns JL, Castile R, Hiatt P, McCoy K, Wilson CB, Inglis A, Smith A, Martin TR, Ramsey BW. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatric Pulmonology 2001;32:356-366.