Appendix C. Overview of measures identified in the literature review

Table 1. Generic measures and items to assess patient satisfaction with medication.

Generic measures / Domains
Efficacy/ effectiveness / Side effects / Ease of use / Global satisfaction / Additional domains
#1 SATMED-Q Questionnaire
“Treatment satisfaction with medicines questionnaire” / 3 items:
-  Symptom reduction
-  Time to take effect
-  Feeling better / 4 items:
-  Experienced any side effects? (yes or no)
-  Interference with physical activity
-  Interference with my leisure and free time activities
-  Interference with my daily activities / 3 items:
-  Convenient to take
-  Easy to take in present form
-  Suitable timetable / 3 items:
-  Intention to continue
-  Feeling happy
-  Feeling satisfied / Impact of the medicine on everyday life (3 items)
-  Leisure and free time activities
-  Personal hygiene
-  Everyday chores better
Medical follow-up/review (2 items)
-  Feeling informed about medical condition
-  Feeling informed about right way to treat medical condition
#2 TSQM (v1.4, v-II and v-9) “Treatment Satisfaction Questionnaire for Medication” / 3 items:
-  Satisfaction - ability to treat condition
-  Satisfaction - ability to relief symptoms
-  Satisfaction - time to take effect / 4 items:
-  Experienced any side effects? (yes or no)
-  Bothersomeness of side-effects
-  Interference with physical activity
-  Interfere with mental function
-  Impact of side-effects on satisfaction / 3 items:
-  Easy or difficult to take
-  Easy or difficult to plan
-  Convenient or inconvenient to take as instructed / 3 items:
-  Confident that medication is good
-  Balance good and bad things medication
-  Satisfaction/ dissatisfaction

#1. Ruiz MA, Pardo A, Rejas J, Soto J, Villasante F, Aranguren JL. Development and validation of the "Treatment Satisfaction with Medicines Questionnaire" (SATMED-Q). Value Health. 2008;11(5):913-26. doi:10.1111/j.1524-4733.2008.00323.x.

#2. Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M et al. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes. 2004;2:12. doi:10.1186/1477-7525-2-12.

Atkinson MJ, Kumar R, Cappelleri JC, Hass SL. Hierarchical construct validity of the treatment satisfaction questionnaire for medication (TSQM version II) among outpatient pharmacy consumers. Value Health. 2005;8 Suppl 1:S9-S24. doi:10.1111/j.1524-4733.2005.00066.x.

Table 2. Disease or medication specific measures and their domains (and number of items) to assess patient satisfaction with medication.

Disease or medication specific measures / Domains
Efficacy/ effectiveness / Side effects / Convenience of use / Overall / Additional domains
# 1 ARTS Osteoarthritis / Treatment advantages
(7 items) / Treatment confidence (2 items) / Treatment convenience
(3 items) / Satisfaction with physician
(6 items)
# 2 Cancer Therapy Satisfaction Questionnaire (v2008) / Effectiveness (expectations)
(5 items) / Side effects
(4 items) / Satisfaction with Cancer Therapy (7 items)
# 3 COMTOL Ophthalmology / Side effects
(10 items) / Overall, including quality of life
(4 items) / Impact on daily activities
(3 items)
# 4 Diab-MedSat Diabetes / Efficacy (2 items) / Side effects
(5 items) / Burden (4 items) / Overall (1 item) / Other (10 items)
# 5 Medication Satisfaction Questionnaire (MSQ) / Overall opinion
(1 item)
# 6 OAB-SAT-q Overactive Bladder / Effectiveness
(3 items) / Side effects
(3 items) / Convenience
(1 item) / Overall (1 item) / Other (3 items)
# 7 OPSAT-Q Osteoporosis / Side effects
(6 items) / Convenience
(6 items) / Overall satisfaction (2 items) / Daily functioning (2 items)
# 8 PPMQ-R Migraine / Efficacy (11 items) / Tolerability of side effects (10 items) / Functionality
(4 items)
Ease of use
(2 items) / Global satisfaction (3 items) / Cost (2 items)
# 9 PSAM Asthma / Effectiveness/relief (5 items) / Inhaler scale
(8 items) / Overall perception of medication
(4 items) / Comparison with other medications (4 items)
# 10 PTSS Pain / Efficacy (3 items) / Side effects (12 items) / Medication characteristics
(3 items) / Impact of current pain medication (8 items)
Medical care (8 items)
Information about pain and its treatment (5 items)
# 11 SATQ Asthma / Effectiveness
(8 items) / Side effects and worries (5 items) / Ease of use (7 items) / Burden of asthma medication (5 items)
#12 SPM Pain / Speed/duration of effect (2 items) / Adverse events
(2 items) / Overall (3 items) / Functional benefit (3 items)
# 13 TSS-IOP
Intraocular Pressure / Effectiveness
(2 items) / Side effects (4 items) / Convenience of use (3 items)
Ease of administration
(3 items) / Eye appearance (3 items)
# 14 TSQ-C – Crohn’s disease / Symptoms
(10 items) / Bother (2 items) / Satisfaction
(11 items) / Expectations (3 items)
Medical care/doctor (3 items)
Cost (3 items)

#1. Pouchot J, Trudeau E, Hellot SC, Meric G, Waeckel A, Goguel J. Development and psychometric validation of a new patient satisfaction instrument: the osteoARthritis Treatment Satisfaction (ARTS) questionnaire. Qual Life Res. 2005;14(5):1387-99.

#2. Abetz L, Coombs JH, Keininger DL, Earle CC, Wade C, Bury-Maynard D et al. Development of the cancer therapy satisfaction questionnaire: item generation and content validity testing. Value Health. 2005;8 Suppl 1:S41-53. doi:10.1111/j.1524-4733.2005.00073.x.

#3. Barber BL, Strahlman ER, Laibovitz R, Guess HA, Reines SA. Validation of a questionnaire for comparing the tolerability of ophthalmic medications. Ophthalmology. 1997;104(2):334-42.

#4. Brod M, Christensen T, Kongso JH, Bushnell DM. Examining and interpreting responsiveness of the Diabetes Medication Satisfaction measure. J Med Econ. 2009;12(4):309-16. doi:10.3111/13696990903337017.

#5. Vernon MK, Revicki DA, Awad AG, Dirani R, Panish J, Canuso CM et al. Psychometric evaluation of the Medication Satisfaction Questionnaire (MSQ) to assess satisfaction with antipsychotic medication among schizophrenia patients. Schizophr Res. 2010;118(1-3):271-8. doi:10.1016/j.schres.2010.01.021.

#6. Margolis MK, Fox KM, Cerulli A, Ariely R, Kahler KH, Coyne KS. Psychometric validation of the overactive bladder satisfaction with treatment questionnaire (OAB-SAT-q). Neurourol Urodyn. 2009;28(5):416-22. doi:10.1002/nau.20672.

#7. Flood EM, Beusterien KM, Green H, Shikiar R, Baran RW, Amonkar MM et al. Psychometric evaluation of the Osteoporosis Patient Treatment Satisfaction Questionnaire (OPSAT-Q), a novel measure to assess satisfaction with bisphosphonate treatment in postmenopausal women. Health Qual Life Outcomes. 2006;4:42. doi:10.1186/1477-7525-4-42.

#8. Kimel M, Hsieh R, McCormack J, Burch SP, Revicki DA. Validation of the revised Patient Perception of Migraine Questionnaire (PPMQ-R): measuring satisfaction with acute migraine treatment in clinical trials. Cephalalgia. 2008;28(5):510-23. doi:10.1111/j.1468-2982.2007.01524.x.

#9. Mathias SD, Warren EH, Colwell HH, Sung JC. A new treatment satisfaction measure for asthmatics: a validation study. Qual Life Res. 2000;9(7):873-82.

#10. Evans CJ, Trudeau E, Mertzanis P, Marquis P, Pena BM, Wong J et al. Development and validation of the Pain Treatment Satisfaction Scale (PTSS): a patient satisfaction questionnaire for use in patients with chronic or acute pain. Pain. 2004;112(3):254-66. doi:10.1016/j.pain.2004.09.005.

#11. Campbell JL, Kiebert GM, Partridge MR. Development of the satisfaction with inhaled asthma treatment questionnaire. Eur Respir J. 2003;22(1):127-34.

#12. Baro E, Casado A, Garcia-Cases C, Clerch L, Ribas S. Assessing satisfaction with pain medication in primary care patients: development and psychometric validation of a new measure. Clin Ther. 2004;26(7):1124-36.

#13. Atkinson MJ, Stewart WC, Fain JM, Stewart JA, Dhawan R, Mozaffari E et al. A new measure of patient satisfaction with ocular hypotensive medications: the Treatment Satisfaction Survey for Intraocular Pressure (TSS-IOP). Health Qual Life Outcomes. 2003;1:67. doi:10.1186/1477-7525-1-67.

#14. Coyne K, Joshua-Gotlib S, Kimel M, Thompson C, Lewis A, Danilewitz M. Validation of the treatment satisfaction questionnaire for Crohn's disease (TSQ-C). Dig Dis Sci. 2005;50(2):252-8.