Scientific Program (tentative)
ICNPB2012
8th U.S.-Japan Seminar on the Biosynthesis of Natural Products:
Sunday, June 17 – Friday, June 22, 2012
Sunday, June 17, 2012, 18:00−19:30
Session 1：Opening session
Hideaki Oikawa (10+40 min)
Hokkaido University
Recent Progress on Biosynthesis of Fungal and Bacterial Metabolites
David E. Cane (40 min),
Brown University
Mechanism, stereochemistry, and structural biology of modular polyketide synthases
Monday, June 18, 2012, 8:30-12:30
Session 2: Polyketide and PKS
Ben Shen (30 min),
Scripps Florida
Enediyne Biosynthesis: Challenges and Opportunities
Jurgen Rohr (30 min),
University of Kentucky
Combinatorial Biosynthetic Enzymology: Delineation of Biosynthetic Sequences of Event and of Functional Enzyme Assignments
Sheryl Tsai (30 min),
University of California Irvine
The Snapshots of an Aromatic Polyketide Synthase in Action
Adrian Keatinge-Clay (30 min)
The University of Texas at Austin
Biocatalytic Synthesis of Polyketide Fragments by Modular Polyketide Synthases
Ikuo Abe (30 min)
University of Tokyo
Engineering Plant Polyketide Synthases
Yasuo Ohnishi（20 min）
University of Tokyo
Biosynthesis of ferroverdin in Streptomyces sp. WK-5344
Hiroyuki Morita（20 min）
Toyama University
Crystal structure analysis of curcuminoid synthase from Oryza sativa
Nobutaka Funa（20 min）
University of Shizuoka
Biosynthesis of Aromatic Polyketides by Type III Polyketide Synthases
14:30—18:30
Session 3: Fungal PKS & expression
Russell Cox (30 min)
University of Bristol
The Molecular and Chemical Basis for Tropolone Biosynthesis in Fungi
Isao Fujii (30 min)
Iwate Medical University
Analysis of Polyketide Biosynthesis genes in Fungi
Kenji Watanabe (20 min)
University of Shizuoka
Biologically active molecules from fungi
Katsuya Gomi (20 min)
TohokuUniversity
break/ poster session
Tuesday, June 19, 2012 8:30—11:50
Session 4: NRPS & RPS/PKS-NRPS hybrid
Wendy Kelly (30 min),
Georgia Tech University, School of Chemistry and Biochemistry
Biosynthetic engineering of thiostrepton analog
Yi Tang (30 min),
UCLA
Biosynthesis of Fungal Nonribosomal Peptides
Eric Schmidt (30 min)
University of Utah
Biosynthesis of marine natural products from ascidians and mollusks
Christian Hertweck（30 min）
Leibniz Institute for Natural Product Research and Infection Biology
Exploiting Cryptic Biosynthetic Pathways in Microorganisms
Kenji Arakawa (20 min)
Hiroshima University
Isolation, structural elucidation, and biosynthesis of butenolide signaling molecules that induce lankacidin and lankamycin production in Streptomyces rochei
Yoshimitsu Hamano (20 min)
Fukui Prefectural University
A stand-alone adenylation domain catalyzes multiple amide-bond formation
in streptothricin biosynthesis
Toshiyuki Wakimoto (20 min)
University of Tokyo
Isolation of the biosynthetic gene cluster of calyculins from the marine sponge Discodermia calyx
Hiroyasu Onaka (20 min)
Toyama Prefectural University
Combined culture, a new co-culture method for natural product screening
Atsushi Minami (20 min)
Hokkaido University
Unique C-methylation of Prenyl Diphosphate in Isoprenoid Biosynthesis
14:30—18:30
Session 5: Novel transformations and Isoprenoids
Gregory Challis（30 min）
University of Warwick, Coventry
Elucidation and exploitation of novel biosynthetic C-H functionalization reactions
Tohru Dairi (30 min)
Hokkaido University
Molecular breeding of a fungus producing a precursor molecule suitable for semi-synthesis, based on the dissection of the biosynthetic machinery
Tsutomu Sato（20 min）
Niigata University
Biosynthesis of sesquarterpenes (C35 terpenes): identifications of a
new terpene cyclase and a bifunctional terpene cyclase
Hisashi Henmi（20 min）
Nagoya University
Archaeal phospholipid biosynthesis pathway reconstructed in E. coli
Shigehiko Kanaya (20min)
Nara Institute of Science and Technology
KNApSAcK Family Database extended to comprehensive understanding of bio-machinery
break/ poster session
Wednesday, June 20, 2012 8:30—12:30
Session 6: Genomics, Metabolomics, & Functional genomics
Toni M Kutchan (30 min)
Donald Danforth Plant Science Center
RNAseq of medicinal plants – elucidation of alkaloid pathways
Joe Chapell (30 min)
University of Kentucky
Advancing Drug Development from Plants – The Medicinal Plant Consortium Experience
Joe Noel (30 min)
Salk Institute for Biological Studies
Messy Biology and Chaotic Metabolism: Plants as Compulsive Metabolic Hoarders or Sowing the Seeds for Future Innovation?
Kazuki Saito (30 min)
Chiba University
Omics-based dissection of plant natural product biosynthesis - Lessons
from Arabidopsis and beyond
Fumihiko Sato (30min)
Kyoto University
Microbial platform for systematic investigations of benzylisoquinoline alkaloid pathway
Tomoyoshi Akashi (20min)
Nihon University
Isoflavonoid biosynthesis in leguminous and non-leguminous plants
Hikaru Seki (20min)
Osaka University
Molecular Basis for StructuralDiversity of Plant Triterpenoids
Excursion 13:00~
Banquet 19:00~
Thursday, June 21, 2012 8:30—12:30
Session 7: Novel transformations, expression, Drug discovery & Tools
Bradley S.Moore (30 min)
Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences
New enzymatic reactions in marine bacterial natural product biosynthesis
Rolf Muller (30 min)
Saarland University
Unusual Biosynthetic Tricks from Actinomycetes and Myxobacteria
Hung-wen Liu (30 min)
University of Texas at Austin
Mechanistic studies of novel transformations in natural products biosynthetic pathways
Haruo Ikeda (30 min)
Kitasato University
Heterologous expression for biosynthetic gene clusters in a versatile
Streptomyces host
Jun Ishikawa (20min)
National Institute of Infectious Diseases
Fumitaka Kudo (20min)
Tokyo Institute of Technology
Unique enzymes in aminoglycoside antibiotic biosynthesis
Masaki Fujita (20min)
Hokkaido University
Functional Metagenomic Approach to Marine Natural Products
14:30—18:30
Session 8: Novel transformations, Genome mining, DrugdiscoveryTools
Tadgh Begley (30 min),
Texas A & M University
Structural and mechanistic studies on thiamin biosynthetic enzymes.
Joern Piel (30 min),
University of Bonn
Mining biosynthetic pathways from symbiotic bacteria
Taifo Mahmud (30 min)
Oregon State University
Exploration of Unusual Biosynthetic Enzymes Through Genome Mining
Tomohisa Kuzuyama (30 min)
University of Tokyo
Tadashi Eguchi (30 min)
Tokyo Institute of Technology
Molecular Analysis of Macrolactam Antibiotic Biosynthesi
Koji Ichinose (20 min)
Musashino University
Functional Analysis of Oxidative Tailoring Enzymes in the Biosynthesis of Aromatic Polyketides
ShunjiTakahashi(20 min)
RIKEN
Novel compound which up-regulates secondary metabolite gene cluster
17:10—18:30
Session 9 : Closing session
Craig Townsend (40 min)
Johns Hopkins University
Understanding the Rules of NR-PKS Programming
Hiroyuki Osada (40 min)
RIKEN
Comprehensive analysis of biosynthesis and biological
activity of reveromycin A
Friday, June22, 2012
No academic program (breakfast will be served)