Table caption

Gene expression change in the medial prefrontal cortex of rats during PD35 and PD56. Gene titles confirmed using RT-qPCR are written in italics.

Up-Regulated
Ratio / Gene Symbol / Gene Title / Entrez Gene
3.72 / Tfpi2 / tissue factor pathway inhibitor 2 / 286926
3.66 / Hoxa1 / homeo box A1 / 25607
2.80 / Gzmf / granzyme F / 266704
2.50 / Fgf16 / fibroblast growth factor 16 / 60464
2.31 / Pln / phospholamban / 64672
2.27 / Parp14 / Poly (ADP-ribose) polymerase family, member 14 / 303903
2.25 / Acsm5 / acyl-CoA synthetase medium-chain family member 5 / 361637
2.24 / Rab12 / RAB12, member RAS oncogene family / 25530
2.22 / Nppa / natriuretic peptide precursor A / 24602
2.18 / Arl11 / ADP-ribosylation factor-like 11 / 364396
2.16 / Hsd3b7 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 / 246211
2.11 / Faslg / Fas ligand (TNF superfamily, member 6) / 25385
2.11 / Xylt2 / xylosyltransferase II / 64134
2.09 / Mettl7b / methyltransferase like 7B / 366792
2.00 / S100a11 / S100 calcium binding protein A11 (calizzarin) / 445415
2.00 / Pld1 / phospholipase D1 / 25096
1.98 / Krt12 / keratin 12 / 360625
1.96 / Edn1 / endothelin 1 / 24323
1.94 / Fhl3 / four and a half LIM domains 3 / 313582
1.93 / Ntn1 / netrin 1 / 114523
1.92 / Tg / thyroglobulin / 24826
1.89 / Fev / FEV (ETS oncogene family) / 246271
1.88 / Btg2 / B-cell translocation gene 2, anti-proliferative / 29619
1.87 / Olr414 / olfactory receptor 414 / 56821
1.85 / Dspp / dentin sialophosphoprotein / 25254
1.85 / Actg2 / actin, gamma 2, smooth muscle, enteric / 25365
1.85 / Kif6 / kinesin family member 6 / 171291
1.84 / Sult1a1 / sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 / 83783
1.84 / Sfrs2ip / splicing factor, arginine/serine-rich 2, interacting protein / 312030
1.84 / Ero1l / ERO1-like (S. cerevisiae) / 171562
1.83 / Fshb / follicle stimulating hormone, beta polypeptide / 25447
1.82 / Nr4a2 / nuclear receptor subfamily 4, group A, member 2 / 54278
1.80 / Fgfr1 / Fibroblast growth factor receptor 1 / 79114
1.78 / Anxa4 / annexin A4 / 79124
1.78 / Ptprc / protein tyrosine phosphatase, receptor type, C / 24699
1.77 / Myoz1 / myozenin 1 / 498440
1.77 / Trip10 / thyroid hormone receptor interactor 10 / 116717
1.75 / Ada / adenosine deaminase / 24165
1.75 / Fbxo34 / F-box protein 34 / 305830
1.75 / Rnaseh1 / ribonuclease H1 / 298933
1.74 / Egf / epidermal growth factor / 25313
1.73 / Hspa1b / heat shock 70kD protein 1B (mapped) / 294254
1.73 / Kcnk6 / potassium inwardly-rectifying channel, subfamily K, member 6 / 116491
1.72 / Cyr61 / cysteine-rich, angiogenic inducer, 61 / 83476
1.72 / Cipar1 / castration induced prostatic apoptosis-related protein 1 / 286894
1.71 / Tpm4 / tropomyosin 4 / 24852
1.71 / Taf5 / TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor / 294018
1.71 / Foxc2 / Forkhead box C2 / 171356
1.71 / Iars / isoleucyl-tRNA synthetase / 306804
1.70 / Tpm2 / tropomyosin 2 / 500450
1.70 / Yaf2 / YY1 associated factor 2 / 690262
1.69 / Ryk / receptor-like tyrosine kinase / 140585
1.68 / Shmt1 / serine hydroxymethyltransferase 1 (soluble) / 287379
1.67 / Notch3 / Notch homolog 3 (Drosophila) / 56761
1.67 / Pex11a / peroxisomal biogenesis factor 11 alpha / 85249
1.67 / Insr / insulin receptor / 24954
1.67 / Dag1 / dystroglycan 1 (dystrophin-associated glycoprotein 1) / 114489
1.66 / Tubb3 / tubulin, beta 3 / 246118
1.66 / Kcnj3 / potassium inwardly-rectifying channel, subfamily J, member 3 / 50599
1.66 / RGD1561797 / RGD1561797 / 499655
1.65 / Tnfsf4 / tumor necrosis factor (ligand) superfamily, member 4 / 89814
1.65 / Mpp3 / membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) / 114202
1.65 / Gadd45g / growth arrest and DNA-damage-inducible, gamma / 291005
1.65 / Dusp1 / dual specificity phosphatase 1 / 114856
1.64 / Itgb5 / integrin, beta 5 / 257645
1.64 / Fam134b / Family with sequence similarity 134, member B / 619558
1.64 / Lhb / luteinizing hormone beta / 25329
1.64 / Hhipl1 / HHIP-like 1 / 362781
1.63 / Myl1 / myosin, light polypeptide 1 / 56781
1.62 / Myd88 / myeloid differentiation primary response gene 88 / 301059
1.62 / Nup155 / Nucleoporin 155 / 117021
1.62 / Slc5a7 / solute carrier family 5 (choline transporter), member 7 / 85426
1.61 / Zfp36 / zinc finger protein 36 / 79426
1.61 / Krt10 / keratin 10 / 450225
1.61 / Slc2a4 / solute carrier family 2 (facilitated glucose transporter), member 4 / 25139
1.60 / Lsm6 / LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) / 498934
1.60 / Il6ra / interleukin 6 receptor, alpha / 24499
1.60 / Gpr110 / G protein-coupled receptor 110 / 301266
1.59 / Uba6 / Ubiquitin-like modifier activating enzyme 6 / 305268
1.59 / Klf2 / Kruppel-like factor 2 (lung) / 306330
1.59 / Mapkapk2 / mitogen-activated protein kinase-activated protein kinase 2 / 289014
1.59 / Crkrs / Cdc2-related kinase, arginine/serine-rich / 192350
1.59 / Maml1 / mastermind like 1 (Drosophila) / 303101
1.59 / Kcnab1 / potassium voltage-gated channel, shaker-related subfamily, beta member 1 / 29737
1.59 / Kitlg / KIT ligand / 60427
1.59 / Parvb / parvin, beta / 362973
1.59 / Acox2 / acyl-Coenzyme A oxidase 2, branched chain / 252898
1.59 / Ptgr1 / prostaglandin reductase 1 / 192227
1.59 / LOC493574 / notch1-induced protein / 493574
1.58 / Tpm3 / tropomyosin 3, gamma / 117557
1.58 / Sec24a / SEC24 related gene family, member A (S. cerevisiae) / 287275
1.58 / Abcb1 / ATP-binding cassette, sub-family B (MDR/TAP), member 1 / 170913
1.57 / Lilrb3l / leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like / 361493
1.57 / Terf2 / telomeric repeat binding factor 2 / 361403
1.57 / Plxnd1 / plexin D1 / 312652
1.56 / Secisbp2 / SECIS binding protein 2 / 79049
1.56 / C1qtnf6 / C1q and tumor necrosis factor related protein 6 / 315114
1.56 / Crlf3 / cytokine receptor-like factor 3 / 54395
1.56 / Ier2 / immediate early response 2 / 494344
1.56 / Irs3 / insulin receptor substrate 3 / 84021
1.56 / Npap60 / nuclear pore associated protein / 25497
1.56 / Rorb / RAR-related orphan receptor B / 309288
1.55 / Tdrd3 / tudor domain containing 3 / 306066
1.55 / Trpc6 / transient receptor potential cation channel, subfamily C, member 6 / 89823
1.55 / Gnl2 / guanine nucleotide binding protein-like 2 (nucleolar) / 362593
1.55 / Oprk1 / opioid receptor, kappa 1 / 29335
1.55 / Pfkfb3 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / 117276
1.55 / Prlr / prolactin receptor / 24684
1.55 / Akt3 / v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) / 29414
1.54 / Ppcdc / phosphopantothenoylcysteine decarboxylase / 363069
1.54 / Dusp12 / dual specificity phosphatase 12 / 64014
1.54 / Optn / optineurin / 246294
1.54 / Synm / synemin, intermediate filament protein / 308709
1.53 / Map4k3 / mitogen-activated protein kinase kinase kinase kinase 3 / 170920
1.52 / RT1-Aw2 / RT1 class Ib, locus Aw2 / 24737
1.52 / Nr3c2 / nuclear receptor subfamily 3, group C, member 2 / 25672
1.52 / F5 / coagulation factor V (proaccelerin, labile factor) / 304929
1.52 / Cdkn2c / cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) / 54238
1.52 / Htr2a / 5-hydroxytryptamine (serotonin) receptor 2A / 29595
1.52 / Prkcd / protein kinase C, delta / 170538
1.51 / Hacl1 / 2-hydroxyacyl-CoA lyase 1 / 85255
1.51 / Fam18b2 / family with sequence similarity 18, member B2 / 687358
1.51 / Plcl2 / phospholipase C-like 2 / 301173
1.50 / Sh3bgr / SH3 domain binding glutamic acid-rich protein / 498066
1.50 / Lrrc23 / leucine rich repeat containing 23 / 312707
1.50 / Sord / sorbitol dehydrogenase / 24788
1.50 / Gypc / glycophorin C (Gerbich blood group) / 364837
Down-Regulated
Ratio / Gene Symbol / Gene Title / Entrez Gene
0.68 / Yeats2 / YEATS domain containing 2 / 498112
0.68 / Tsta3 / tissue specific transplantation antigen P35B / 300036
0.68 / Hel308 / DNA helicase HEL308 / 360912
0.68 / Yipf3 / Yip1 domain family, member 3 / 301245
0.68 / Map1d / methionine aminopeptidase 1D / 311748
0.68 / Cdc34 / cell division cycle 34 homolog (S. cerevisiae) / 299602
0.68 / Hadh / hydroxyacyl-Coenzyme A dehydrogenase / 113965
0.68 / Syngr2 / synaptogyrin 2 / 89815
0.67 / Casp7 / caspase 7 / 64026
0.67 / Man2b1 / mannosidase, alpha, class 2B, member 1 / 361378
0.67 / Hhip / Hedgehog-interacting protein / 291936
0.67 / Smc3 / structural maintenance of chromosomes 3 / 29486
0.67 / Pdcd10 / programmed cell death 10 / 494345
0.67 / Gabrg1 / gamma-aminobutyric acid (GABA) A receptor, gamma 1 / 140674
0.67 / Rhog / ras homolog gene family, member G (rho G) / 308875
0.67 / Rmnd5b / required for meiotic nuclear division 5 homolog B (S. cerevisiae) / 497900
0.67 / Hes1 / hairy and enhancer of split 1 (Drosophila) / 29577
0.67 / Arid3b / AT rich interactive domain 3B (Bright like) / 367092
0.67 / Prph / peripherin / 24688
0.66 / Tgfb2 / Transforming growth factor, beta 2 / 81809
0.66 / Marcks / myristoylated alanine rich protein kinase C substrate / 25603
0.66 / Tmsbl1 / thymosin beta-like protein 1 / 286978
0.66 / Pllp / plasma membrane proteolipid (plasmolipin) / 64364
0.66 / Mbp / myelin basic protein / 24547
0.66 / Zdhhc9 / zinc finger, DHHC-type containing 9 / 302808
0.66 / Vamp8 / vesicle-associated membrane protein 8 / 83730
0.66 / Bmp4 / bone morphogenetic protein 4 / 25296
0.66 / Pdlim5 / PDZ and LIM domain 5 / 64353
0.65 / Siah1a / seven in absentia 1A / 140941
0.65 / Litaf / lipopolysaccharide-induced TNF factor / 65161
0.65 / Isca1 / iron-sulfur cluster assembly 1 homolog (S. cerevisiae) / 290985
0.65 / Sdc3 / syndecan 3 / 116673
0.65 / Enpp2 / ectonucleotide pyrophosphatase/phosphodiesterase 2 / 84050
0.65 / Slc6a9 / solute carrier family 6 (neurotransmitter transporter, glycine), member 9 / 116509
0.65 / Lamp2 / lysosomal-associated membrane protein 2 / 24944
0.65 / Cd37 / CD37 molecule / 29185
0.65 / Sfrs11 / splicing factor, arginine/serine-rich 11 / 502603
0.65 / Fam176b / family with sequence similarity 176, member B / 362597
0.65 / Drd1a / dopamine receptor D1A / 24316
0.65 / Prkab2 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / 64562
0.65 / Mettl7a / methyltransferase like 7A / 315306
0.65 / Krcc1 / lysine-rich coiled-coil 1 / 312437
0.65 / Cip98 / CASK-interacting protein CIP98 / 313255
0.65 / Pcgf2 / polycomb group ring finger 2 / 287662
0.64 / Exosc9 / exosome component 9 / 294975
0.64 / Car2 / carbonic anhydrase II / 54231
0.64 / Tie1 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / 89806
0.64 / Med16 / mediator complex subunit 16 / 299607
0.64 / Psme4 / proteasome (prosome, macropain) activator subunit 4 / 498433
0.64 / Thra / thyroid hormone receptor alpha / 81812
0.64 / Evi2a / ecotropic viral integration site 2A / 685433
0.64 / Sema6d / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D / 311384
0.64 / Scn7a / sodium channel, voltage-gated, type VII, alpha / 64155
0.64 / Calml4 / calmodulin-like 4 / 691455
0.63 / Cd99 / CD99 antigen / 652929
0.63 / Tnc / Tenascin C / 116640
0.63 / Wif1 / Wnt inhibitory factor 1 / 114557
0.63 / Triobp / TRIO and F-actin binding protein / 362956
0.63 / Wdr47 / WD repeat domain 47 / 310785
0.63 / Trio / Triple functional domain (PTPRF interacting) / 310192
0.63 / Tomm40b / translocase of outer mitochondrial membrane 40 homolog B (yeast) / 304971
0.63 / Dnm1l / dynamin 1-like / 114114
0.63 / Mark1 / MAP/microtubule affinity-regulating kinase 1 / 117016
0.63 / Phlpp / PH domain and leucine rich repeat protein phosphatase / 59265
0.63 / Sox10 / SRY (sex determining region Y)-box 10 / 29361
0.62 / Glb1 / galactosidase, beta 1 / 316033
0.62 / Ccdc53 / coiled-coil domain containing 53 / 299707
0.62 / Thap6 / THAP domain containing 6 / 305244
0.62 / Lpcat3 / lysophosphatidylcholine acyltransferase 3 / 362434
0.62 / Epm2aip1 / EPM2A (laforin) interacting protein 1 / 316021
0.62 / Olig1 / oligodendrocyte transcription factor 1 / 60394
0.61 / Cstf1 / cleavage stimulation factor, 3' pre-RNA, subunit 1 / 311670
0.61 / Cnp / 2',3'-cyclic nucleotide 3' phosphodiesterase / 25275
0.61 / Itgb1 / integrin beta 1 (fibronectin receptor beta) / 24511
0.61 / Gclm / glutamate cysteine ligase, modifier subunit / 29739
0.60 / Alas2 / aminolevulinate, delta-, synthase 2 / 25748
0.60 / Telo2 / TEL2, telomere maintenance 2, homolog (S. cerevisiae) / 302986
0.60 / Ppp1r14a / protein phosphatase 1, regulatory (inhibitor) subunit 14A / 114004
0.60 / Vav2 / vav 2 guanine nucleotide exchange factor / 296603
0.60 / Isca1 / iron-sulfur cluster assembly 1 homolog (S. cerevisiae) / 290985
0.60 / LOC681186 / hypothetical protein LOC681186 / 681186
0.59 / Dcx / doublecortin / 84394
0.59 / Prkd2 / protein kinase D2 / 292658
0.59 / Phf3 / PHD finger protein 3 / 363210
0.59 / Col27a1 / Collagen, type XXVII, alpha 1 / 298101
0.59 / rCG_51406 / neuritin 1-like / 100189544
0.59 / Degs2 / degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) / 314438
0.59 / Myo1d / myosin ID / 25485
0.58 / Ttc8 / tetratricopeptide repeat domain 8 / 299246
0.58 / Neurod2 / neurogenic differentiation 2 / 54276
0.58 / Rreb1 / ras responsive element binding protein 1 / 306873
0.58 / Clec4a3 / C-type lectin domain family 4, member a3 / 362431
0.58 / Spry1 / sprouty homolog 1, antagonist of FGF signaling (Drosophila) / 294981
0.58 / Bche / butyrylcholinesterase / 65036
0.58 / Mobp / myelin-associated oligodendrocyte basic protein / 25037
0.58 / Gpr37 / G protein-coupled receptor 37 / 117549
0.57 / Tspan2 / tetraspanin 2 / 64521
0.57 / Thumpd2 / THUMP domain containing 2 / 313851
0.57 / Rasgef1c / RasGEF domain family, member 1C / 360519
0.57 / Rhobtb1 / Rho-related BTB domain containing 1 / 309722
0.56 / Rad1 / RAD1 homolog (S. pombe) / 294800
0.56 / Josd2 / Josephin domain containing 2 / 292876
0.56 / Slc45a4 / solute carrier family 45, member 4 / 315054
0.55 / Tpo1 / developmentally regulated protein TPO1 / 170907
0.55 / Rab34 / RAB34, member RAS oncogene family / 360571
0.55 / Cnp / 2',3'-cyclic nucleotide 3' phosphodiesterase / 25275
0.54 / Fam135a / family with sequence similarity 135, member A / 367235
0.54 / Bcat2 / branched chain aminotransferase 2, mitochondrial / 64203
0.54 / Mal / mal, T-cell differentiation protein / 25263
0.54 / Neu1 / sialidase 1 (lysosomal sialidase) / 24591
0.54 / Cfl2 / cofilin 2, muscle / 366624
0.54 / Mobp / myelin-associated oligodendrocyte basic protein / 25037
0.53 / Plp1 / proteolipid protein 1 / 24943
0.53 / Slc25a13 / solute carrier family 25, member 13 (citrin) / 362322
0.53 / Rps6ka6 / ribosomal protein S6 kinase polypeptide 6 / 317203
0.53 / Znf213 / Zinc finger protein 213 / 287094
0.53 / Sprr1al / small proline-rich protein 1A-like / 499660
0.53 / Apod / apolipoprotein D / 25239
0.52 / Emp1 / epithelial membrane protein 1 / 25314
0.51 / Rrs1 / RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) / 297784
0.51 / Nes / nestin / 25491
0.50 / Fam107b / family with sequence similarity 107, member B / 498796
0.50 / Lpar1 / lysophosphatidic acid receptor 1 / 116744
0.50 / Mag / myelin-associated glycoprotein / 29409
0.49 / Itga7 / integrin alpha 7 / 81008
0.48 / Klk6 / kallikrein related-peptidase 6 / 29245
0.48 / Hdac1 / histone deacetylase 1 / 297893
0.47 / Mobp / myelin-associated oligodendrocyte basic protein / 25037
0.47 / Lpar1 / lysophosphatidic acid receptor 1 / 116744
0.47 / Mog / myelin oligodendrocyte glycoprotein / 24558
0.46 / Ugt8 / UDP glycosyltransferase 8 / 50555
0.45 / Trappc5 / trafficking protein particle complex 5 / 363858
0.42 / Cldn11 / claudin 11 / 84588
0.42 / Zmynd17 / zinc finger, MYND-type containing 17 / 289904
0.41 / Cldn11 / claudin 11 / 84588
0.41 / Enpp6 / ectonucleotide pyrophosphatase/phosphodiesterase 6 / 306460
0.40 / Tspan2 / tetraspanin 2 / 64521
0.34 / Isl2 / ISL LIM homeobox 2 / 57233