Supplementary Table S1. Genotype- phenotype associations of the NOD2/CARD15 L1007finsC and G908R SNPs in patients with ulcerative colitis

NOD2/CARD15 SNPs
L1007finsC / G908R
Phenotypic features / CHz / HTz / RHz / p / CHz / HTz / RHz / p
Gender
Male (n=26, 42.62%) / 26 / 0 / 0 / - / 26 / 0 / 0 / -
Female (n=35, 57.38%) / 35 / 0 / 0 / 35 / 0 / 0
Age at diagnosis
<40 (n=41, 67.21%) / 41 / 0 / 0 / - / 41 / 0 / 0 / -
³40 (n=20, 32.79%) / 20 / 0 / 0 / 20 / 0 / 0
Race
White (n=33, 54.10%) / 33 / 0 / 0 / - / 33 / 0 / 0 / -
Non-White (n=28, 45.90%) / 28 / 0 / 0 / 28 / 0 / 0
Family History
Yes (n=8, 13.11%) / 8 / 0 / 0 / - / 8 / 0 / 0 / -
No (53, 86.89%) / 53 / 0 / 0 / 53 / 0 / 0
European ascendance
Yes (n=16, 26.23 %) / 16 / 0 / 0 / - / 16 / 0 / 0 / -
No (n=45, 73.77%) / 45 / 0 / 0 / 45 / 0 / 0
Extraintestinal Manifestations
Yes (n= 31, 50.82%) / 31 / 0 / 0 / - / 31 / 0 / 0 / -
No (n= 30, 49,18%) / 30 / 0 / 0 / 30 / 0 / 0
Disease location
Pancolitis (n=30, 49.18%) / 30 / 0 / 0 / - / 30 / 0 / 0 / -
Proctosigmoiditis(n=23, 37.70 %) / 23 / 0 / 0 / 23 / 0 / 0
Left Colitis (n=8, 13.12%) / 8 / 0 / 0 / 8 / 0 / 0
Surgery because of UC
Yes (n= 5, 8.20%) / 5 / 0 / 0 / - / 5 / 0 / 0 / -
No (n= 56, 91.80%) / 56 / 0 / 0 / 56 / 0 / 0
Chronic steroid use
Yes (n=11, 18.03%) / 11 / 0 / 0 / - / 11 / 0 / 0 / -
No (n=50, 81.97%) / 50 / 0 / 0 / 50 / 0 / 0
Anti TNF use
Yes (n=1, 1.64%) / 1 / 0 / 0 / - / 1 / 0 / 0 / -
No (n=60, 98.36%) / 60 / 0 / 0 / 60 / 0 / 0

CHz, common homozygote (G:G); HTz, heterozygote (G:C); RHz, rare homozygote (C:C); UC, ulcerative colitis.